1. We need 20-25 UI per day, according to Chris Masterjohn, in the flower of age (let’s say up to 45 years old).
2. Half-life of Vit E is rather short (3-4 hours in the blood, to at least 20 hours in tissue) but it could accumulate in liver (quinones). We are going to accumulate if we take 400 UI every day.
   Vit K E ALA (α-lipoic acid) and Q10 are some members of the same family.
3. Tocos are very useful but HD tocos have side-effects: too much of a good thing is bad.

High dose Vit K can interfere with Vit E and vice-versa. Why?
Preambule
I recently read this post:
“Preventing Lipid Peroxidation with Tocotrienols: themselves an unsaturated form of Vitamin E”.
https://bioenergetic.forum/post/66269 (from AlphaZance).
In short, tocotrienols target multiple pathways involved in liver cell damage and lipid accumulation. OK, I agree. But … Shortly said, too much of a good thing is bad. I won’t take only one kind of toco, except in cure, with a specific target, e.g. against virus, inflammation …

Short explanation:

• Anything exceeding metabolic needs places a burden on the liver. Derivatives (quinones) unnecessarily saturate elimination pathways (CYP450) and deplete molecules needed elsewhere—particularly for endogenous detoxification (via glutathione S-transferase).
• An effective and safe product must contain the full spectrum (totum) or a mixture of at least two natural isomers (e.g. alpha + gamma) to respect cellular efficacy and avoid enzymatic competition. The body prioritizes alpha-tocopherol, yet we also require the other forms. There are eight isomers: alpha, beta, delta, and gamma tocopherols and tocotrienols.
• The half-life of vitamin E ranges from 48 to 60 hours. Spacing out doses (every 2 or 3 days) is more than sufficient to maintain a steady state.
• The body needs vary from additional 20-25 UI (Chris Masterjohn) to 150 UI (Ray Peat), and more if you follow a diet, losing weight (to neutralize AA cascade).

Excess tocopherols antagonizes Vit K
They are all fat-soluble vitamins and can compete with each other for absorption into the micelle. We could simplify by saying vitamins A and E are antagonists of vitamin K because they interfere with its absorption and metabolism.
Taking a high dose Vit K2 requires transporters that are in limited amount for transport in circulating lipoproteins for subsequent uptake by tissues.
How much is too much is not clearly defined.
The reduction in assimilation appears to be partly related to the phenomenon that Vitamin E and K share similar transporters/metabolizing enzymes. When high dose Vitamin E is given it may block the transporters/enzymes that are needed to integrate Vitamin K into the appropriate tissues. So similar to Aspirin, we should consider supplementing Vitamin K when trying high dose Vitamin E. Otherwise we may risk Vitamin K deficiency which can cause downstream problems.
Moreover excess Vit E, K and Q10 leaves quinones but our liver has a limited capacity to deal with, as already metioned.
I never take Vit A supplement at the same time as the other lipovitamins. Nor 5 000 Vit D with K at the same meal since we need a lot of fat to absorb Vit K (35 gr lipid is optimal: 14 – 25 – 35 g fat are thresholds impacting the degree of absorption. I target minimum 25 g fat).
Edit: Now I limit my intake of Vit K to 1 000 mcg K2 MK4 twice a day, with 1 000 UI Vit D3, both at the same time, so that I don’t saturate the transporter, and so I enhance interaction. Twice a week, I differ the intake to the next meal, because I take 5 000 UI retinyl palmitate. Interaction between liposoluble vitamins.
See additional info on the links beneath.