Posts made by LucH

@bowser said in Milk/protein digestion:

Although I still need to get protein and calcium and I want to use milk for that but every time I even try small amounts I get bad bacterial reactions and temps go down. Any suggestions?

Hi,
Most people loose the capacity to digest lactose (lactose is half glucose and half galactose).
When an individual consumes more lactose than what the enzyme lactase can digest, the non-digested lactose molecules remain in the intestine, attract water molecules and then cause gastrointestinal discomfort such as: bloating; abdominal pain; diarrhea.

And you don't need milk to get sufficient calcium. Ca from milk is only absorbed +/ 30%. 66 % from broccoli.
Have a look at oat to get the right amount of fiber and Ca at breakfast. I use Jordan's oat with hazelnut milk, 5 half pecan nuts and 1 tbsp raisins (organic because without sulfites). Adapt the ingredients to your tolerance.
If you balance with phosphorus and Ca, Gouda cheese is interesting. Few lactose in hard cheese.
I take 1/4 càc of calcium citrate powder when there is no sufficient Ca (650 - 850 mg Ca ) (no need for 1200 mg !) It also depends on the acido-basic balance. Enough potassium from fruits and vegetables.
What about your vitamin K2, in order to assimilate Ca?
Mind the fruits if dysbiosis. When stabilized, eat your fibers at first. 20-30' time for digestion.

Right with what has been said.
But you need to optimize the context:

• 30 gr fibers, functional MMC and gut motility.
  MMC= Motor Migrating Complex. I can develop / explain if wanted.
• Some useful nutrients for the communication between the brain and the intestines, through the vagus nerve.
  Thiamine as cofactor for autonomic nervous system
  When cells lack thiamine (B1) the lower regions of the brain – responsible for the coordination of the autonomic nervous system – there are metabolic derangements in the brain susceptible to produce dysfunctional autonomic outputs and misfiring, which goes on to exert detrimental effects on every bodily system – including the gastrointestinal organs.
  Thiamine is one of them.
• Some useful nutrients to feed gut bacteria. Make a search with “Biosynthesis of Vitamins by Probiotic Bacteria”. Or I can give you a link.
  Hope it can help.

When I say apart, it means you take coffee apart from digestion.
Most Vitamins B mut be taken with food.

@pittybitty said in What Vitamin B cofactors should I supplement?:

Is there anything I should add? I heard supplementing Thiamin causes Magnesium depletion, is there any other cofactors I should be aware of?

Hi,
You need enough sodium and particularly high level of potassium.
I take potassium citrate (oxalate prevention).
Shaker at breakfast and midday.
I won't take Vit B with coffee (diuretic) but appart from digestion. You lose +/ 0.5 gr salt (urinary excretion). + reabsorption difficult if too high in caffeine.
Do it according to taste (needs).
400 mcg folic acid is not the optimal form when taking high dose B9. However it's the maximum tolerated. Impact on B12 possible. Upper limit advised is often 1 000 mcg B9 but that's too high. 400 mcg is the advised limit.
doi: 10.1093/advances/nmab106
But as you take the complex every other day, it's more or less OK with your choice. Half-life must be taken into account. After one week, I would rather take the complex 2x/wk. that what I do,
For other readers:
Get informed on too high B6 with Pyridoxine HCL (PNP) Here, it's ok with 50 mg.
I can give a link if wanted.

@Mostlylurking
Thanks for your input. I really appreciate the comments. It emphasizes very well the efficacy / the value of HDT (high physiological dose).
I’d like to put this point into excerpt:
*) Why to give HDT?

When giving supra-physiological doses of thiamin to the cells, enzymes come back to normal operating state. (1)

=> We aim to increase the exchange through passive and active ways. The active way is made through enzyme transporters. The passive way is through cell membranes, if there aren’t too many blockers (from oxidative stress and chronic low-grade inflammation e.g.).
We know that the traditional way of transport of B1 TPP (from food) is through gastrointestinal phosphatases, before reaching blood flood. This B1 was thought to be only a water-soluble vitamin. It’s not. TPP can also be transported across cell membranes (2) but likely less well absorbed than benfotiamine or TTFD.
TPP = thiamine pyrophosphate.
*) Why and when nutritional intake is not sufficient.
If we read the conventional recommendations from authorities there is only a problem for 6% of the US population. (3) That’s what the blood tests mention. Right but what about your optimal energy level or your brain functioning? See here the difference of appreciation: an impaired metabolism with a metabolic disorder of thyroid or glycemia if left untreated (not perceived before it’s too late because the Gauss’s curve has said so). Traditional medicine sees the failure but doesn’t always / usually anticipate the problems from slow carburation. That’s just one example.
Gauss’s curve

The Gauss's curve analogy here emphasizes the concept of the "tail end" of the curve, where about 5% of cases fall outside the normal range. In this context, it suggests that there's a small percentage of cases where the metabolic disorder isn't perceived until it's too late. ## Traditional medicine tends to focus on the majority of cases within the normal range and may overlook or underestimate the significance of these outliers.
So, while traditional medicine might not see a problem because the majority of cases appear normal, it fails to anticipate the issues that arise from the small percentage of cases where metabolic disorders aren't detected early. This leads to the problem being left untreated, as it's not recognized until it's already advanced.
In summary, the Gauss's curve illustrates how the small percentage of cases falling outside the normal range can be overlooked, leading to the problem being untreated until it reaches a critical stage.
Metabolic Block
Are you exposed to “stress” factors that block your assimilation for the brain? As already seen, “thiamine (vitamin B1) is critical for the metabolism of food into cellular energy or ATP. Without sufficient thiamine, cellular energy wanes, and with it, the capacity to maintain the energy to function declines. Chronic, unrelenting fatigue is a common characteristic of insufficient thiamine. At its root, fatigue is the physical manifestation of poor energy metabolism”. (4)

Your appropriate blood test is then not going to explain anything.

Here are some case reports mentioning the insufficiency of the DRI (Daily Recommended Intake).
Diabetes
The proportion of people with type 1 or type 2 diabetes who have poor thiamin status based on erythrocyte transketolase activity ranges from 17% to 79% in studies conducted to date [40]. In a study of 76 consecutive patients with type 1 or type 2 diabetes, for example, 8% had mild thiamin deficiency and 32% had moderate deficiency based on assays of the transketolase enzyme [33].
Heart failures
The rates of poor thiamin status in patients with heart failure have ranged in studies from 21% to 98% [47]. Explanations for this association include older age, comorbidities, insufficient dietary intake, treatment with diuretics, and frequent hospitalizations [48].
The authors of one study reported that 33% of 100 patients with chronic heart failure had thiamin deficiency compared to 12% of 50 healthy volunteers [49]. Rates of deficiency were even higher when the investigators excluded those who used thiamin supplements.
Alzheimer’s disease
Thiamin deficiency produces oxidative stress in neurons, death of neurons, loss of memory, plaque formation, and changes in glucose metabolism—all markers of Alzheimer’s disease. Autopsy studies have shown that transketolase and other thiamin-dependent enzymes have decreased activity in the brains of people with Alzheimer’s disease [52,53].
Few studies have assessed the prevalence of thiamin deficiency in people with Alzheimer’s disease. One of these studies found that 13% of 150 patients with cognitive impairment and acute-onset behavioral disturbances were considered thiamin deficient based on plasma levels [26].
Note: Analysis based on plasma level gives only indication on short term. And not what is burned or blocked further in the process of assimilation.
Maintenance and Performance of the Brain
As already seen, thiamine plays a key role in the maintenance of brain function: Thiamine diphosphate is a cofactor for several enzymes involved in glucose metabolism whereas thiamine triphosphate has distinct properties at the neuronal membrane. (5) We need different forms of B1 to optimize different functions, and particularly to reach effects onto mitochondrial respiration.
Sources and References

1. Elliot Overton
2. How is B1 from food assimilated?
   DOI: 10.1534/genetics.104.028605
   Dietary thiamine (vitamin B1) consists mainly of thiamine pyrophosphate (TPP), which is transformed into thiamine by gastrointestinal phosphatases before absorption. It was believed that TPP itself cannot be transported across plasma membranes in significant amounts, which forms TPP from thiamine at the expense of ATP inside cells. (…) These observations indicate that, in contrast to expectation from previous evidence, TPP can be transported across cell membranes. We also find that thiamine supplementation partially rescues the phenotype of partial loss-of-function mutants of the Na/K ATPase, providing genetic evidence that thiamine absorption, and/or redistribution from the absorbing cells, requires the full activity of this enzyme.
   => Comment Luch: We need the transketolase enzyme to absorb well this type of B1 (TPP from food). To fully absorb the benefits of TPP, passive transport through membranes is required.
3. The average daily thiamin intake from foods and supplements in adults age 20 and older is 4.89 mg. An analysis of data from the 2003–2006 National Health and Nutrition Examination Survey showed that only 6% of the U.S. population has a usual intake below the EAR.
   https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/#h6
   The World Health Organization recommends daily oral doses of 10 mg thiamin for a week, followed by 3–5 mg/daily for at least 6 weeks, to treat mild thiamin deficiency.
4. Dr. Chandler Marrs talking about Thiamin. April 2022
   Introduction to a video, talking with Scott Scott Forsgren, FDN-P.
   https://www.hormonesmatter.com/talking-about-thiamine/
5. Thiamine diphosphate is a cofactor for several enzymes involved in glucose metabolism whereas thiamine triphosphate has distinct properties at the neuronal membrane
   https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29713

Remind: 3 pillars of thiamine repletion

1. Identify which vitamin B1 your body needs / is accepted by your metabolism (transport capacity, genetic deficiency).
2. At least these cofactors are needed: magnesium, potassium and sodium (in proportions, for the two last ones).
3. Some vitamins handles as B-vitamin cofactors. Interaction with other B-vitamins.
   Figure: circle with Vitamins B interaction (B1 B2 B6 Biotin, underlined in yellow)
   

Hi,
I said I would come back and give a comment. I did some research and compile what I’ve understood, so far. An input would be appreciated, if you feel so and have time to deal with. Too many people struggle with so-called auto-immune pathologies when we don’t understood the etiology entirely. Partly true but …
This information could give an alternative, possibly the opportunity to perceive an improvement, if the tissues are not too destroyed. We won’t recuperate the lost synapses but as we only use 10 % of our brain, we are able to bypass and create new connections.

Anti-Stress & Neuro-Protective Effects of Thiamine (B1)

Mitochondrial Energy Uploaded thanks to Optimized Enzyme Communication

Key points
• Thiamine (B1) has also neuro-protective effects: Brain & Digestive System.
• B1 must be seen as the fuel for a power plant the bioavailability of which is dependent on enzyme functionality.
• Oxidative and chronic low-grade inflammation induce a metabolic block.
• When giving supra-physiological doses of thiamin to the cells, enzymes come back to normal operating state.
• Universal anti-stress properties of thiamine.
• Impact on mitochondrial respiration: link with ATP production.
• The role of thiamine insufficiency in lower brain dysfunction.
• Connection between the brain, the digestive system and the vagus nerve: Dysautonomia and adaptation to the stress environment when fuel is re-loaded.
• Understanding nutritional deficiencies & functional insufficiencies / dependencies.
Cases reports on pathologies: Energy, SIBO, diabetes, fibromyalgia, Parkinson’s, CVD, thyroiditis, multiple sclerosis, etc.

Full post on this link, with explanations, figures, studies links and case reports if you want details and see how to manage in practice.
https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712

Info continuation
Main points in practice

1. Support you own endogenous production of DAO with useful nutrients. ## Be sure to get enough of vitamin C B6 (P5P) and coper.
   Pay attention:

• Not a vitamin B complex. 50 mg B6 is OK. B6 must be co-enzymed (P5P), without additive preferably.
  • Swanson, P-5-P-pyridoxal-5-phosphate, 20 mg, 60 capsules. 3.51 € iherb.com, 0.18 €/gel.
  =>Advised choice for dosage if neuronal pathology (hypersensitivity). 1x/d.
  Pay attention: Too much of a good thing is bad. ## There is a threshold not to overload with B6 PLP, depending on your underlying degree of low grade inflammation and neuro-pathologies. pauses are required with PLP (effective form).
  • Thorne, Pyridoxal 5'-phosphate, 180 capsules. 33.8 mg. With dioxide Si. 47.28 € - 10% by iherb..com, 0.263 €/gel.
  • Nutrabio 100 mg, 60 capsules. 14.72 €, 0.25 €/ gel. My choice because without excipient. 1x/ every other day (every two days).
• Chelated Coper (bisglycinate coper 10-15 mg, twice a day if suffering from dysbiosis).
• Vitamin C must be identified with CAS N° 50-81-7 (or with Specific Optical Rotation, between +20.5°~+21.5°) (without HM => certificate). Otherwise it’s half not assimilated (rubbish). Mine comes from Scotland, organic source (not from China). Labelled acid ascorbic quali-c (nutrimuscle.com 125 gr 22.95 €). Surfine powdered vitamin so that it dimots well, without residue.

• Magnesium bisglycinate (mind the origin: well diluted and taste) we lack Mg.

2. DAO enzyme. 1 000 000 units.
   I take NaturDAO 10-15’ before meal 3x/d. Gradually stop treatment (amazon.fr)
   I won’t eat liver more than once every 5 days. And from organic source or from poultry (young chicken).
3. Support your methylation: For example with betaïne HCL (Now Food, with pepsin) or with TMG supplement (Now Food, TMG 1000 mg or 2x 500 mg). I take TMG (tri-methyl-glycine) 2250 mg from Super Smart (with a 30 % discount). No need to be so high.
   NDLR: Chris Masterjohn has recommended TMG when taking B3 (niacin).
   What is the difference between betaine HCl and trimethylglycine?
   Betaine HCl has an acidic taste whereas anhydrous TMG ("anhydrous betaine") tastes sweet with a metallic aftertaste and is usually produced from sugar beets (as is betaine hydrochloride). Both are active as methyl donors, as 'betaine' is retained in both forms.
4. Mast cell control
   I take quercetin anhydride 500 mg (nutrixeal.com) once a day. With a meal because some fat is required. In cure. Or every other week (every two weeks).
   Mind some foods:
   We should not only worry about foods that contain large quantity histamine (H3 in the PDF list), but also foods that release histamine (L3 in the PDF list, in French) (L stands for liberation). For example, tuna is classified H3 (high contribution), the orange fruit is L3 (leads to a high reaction of histamine release).
5. Histamine Diet
   See PDF list.
   Useful info (in French)
   https://mirzoune-ciboulette.forumactif.org/t1745-traiter-lintolerance-a-lhistamine?highlight=histamine
   => How to deal with histamine intolerance + short list of food high in histamine.
   See beneath for an English source.
   L3 (power 3/3) (L stand for liberator => set free)
   Walnut, lemon (lime), orange, grapefruit, wine and balsamic vinegar, alcohol, iodine. Other examples on this link (list of incompatibility for histamine, in French):
   Noix, citron vert (lime), orange, pamplemousse, vinaigre de vin et balsamique, alcool, iode.
   Autres exemples sur ce lien (Liste d’incompatibilité à l’histamine) :
   https://www.mastzellaktivierung.info/downloads/foodlist/31_FoodList_FR_alphab_avecCat.pdf
   It is not because a food brings little histamine that he does not cause a release of histamine. So be careful not to be based only on a single info source. It is above all the accumulation that must be avoided, and be careful in more sensitive times, of course.
   Traduction : Ce n’est pas parce qu’un aliment apporte peu d’histamine qu’il n’entraine pas une libération d’histamine. Donc, attention à ne pas se baser seulement sur une seule source d’info. C’est surtout le cumul qu’il faut éviter, et faire attention en période plus sensible, évidemment.
6. Alcohol and other drugs
   Alcohol overburdens liver detox. There are many drugs with prohibited molecules.
   See link. I made a copy in a docx in order to make a search easily. By the way, I made 2 mistakes: curcumine and High dose thiamine (B1) before recovering. + pineapple (L2) in crisis.
   This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration:
   *) Thiamin as histamin liberator and DAO inhibitor
   Sattler 1985 (PDF with reference on histamine active substance, in English)
   Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4.
   https://pubmed.ncbi.nlm.nih.gov/3925736
   (Liste unverträglicher Medikamente (DAO-Hemmer))
   *) Low histamine Diet Anit Tee factvsfitness.com (pdf with info I English)
   *) Liste de compatibilité alimentaire – Histamine
   Triée par ordre alphabétique, avec catégories.
   Communauté d'intérêts Suisse de l'intolérance à l'histamine (SIGHI) www.mastzellaktivierung.info | www.histaminintoleranz.ch => rubrique téléchargement / Liste détaillée de la compatibilité des aliments de base (rubrique : Régime alimentaire pour éliminer l'histamine > Téléchargement).
   Info en anglais / français / allemand.
   Liste PDF en français
   FoodList histamine, FR, alphabétique, avec catégories
   https://www.mastzellaktivierung.info/downloads/foodlist/31_FoodList_FR_alphab_avecCat.pdf
7. Fix the gut
   => Dysbiosis – Probiotics? – Strengthen gut walls – Target diet if intolerant gut

Sources and references
0. Useful Info

• Dr. Becky Campbell – Free Histamine Guide.
• https://lowhistamineeats.com/clear-histamine-naturally/
• Reversing Histamine Intolerance Takes More Than a Low-Histamine Diet
  https://caplanhealthinstitute.com/reversing-histamine-intolerance-takes-more-than-a-low-histamine-diet/
• https://drtaniadempsey.com/5-natural-antihistamines-to-combat-allergies/
  Sources and references

1. “Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women”
   https://pubmed.ncbi.nlm.nih.gov/28606572/
   Results: Serum DAO activity in both phases was positively correlated with intake of long-chain fatty acids, saturated fatty acids, and monounsaturated fatty acids (P < 0.05). Intake of phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 during the luteal phase was positively correlated with serum DAO activity (P < 0.05).
2. “Nutrient-induced inflammation in the intestine – PMC –NCBI.”
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520304/
   Understanding the relationship between nutrient absorption and intestinal inflammation is important. We need a better understanding of the interaction between enterocytes and the intestinal immune cells in nutrient absorption and the gut inflammatory responses.
3. The increased release of histamine and DAO is specific to fat feeding and is not shared by carbohydrate or protein feeding.
   Wollin A, Wang XL, Tso P. Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. 1998;275:R969–R975. [PubMed] [Google Scholar]
4. Adopting a leaky gut protocol or a diet rich in anti-inflammatory foods and high in antioxidants, can be instrumental in addressing the root-problem.
   Improving gut health and taking DAO are pillars of histamine intolerance treatment.
   https://caplanhealthinstitute.com/reversing-histamine-intolerance-takes-more-than-a-low-histamine-diet/
   Useful nutrients include vitamins B6, copper, iron, magnesium, phosphorus, zinc, and vitamin C. (a,b) Each of these nutrients both support and modulate immune function for the better.
   a. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85(5):1185-1196. doi:10.1093/ajcn/85.5.1185
   b. Miyoshi M, Ueno M, Matsuo M, et al. Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women. Nutrition. 2017;39-40:67-70. doi:10.1016/j.nut.2017.03.004
5. Le syndrome d'activation des mastocytes et l'activation inappropriée des mastocytes
   Les symptômes proviennent principalement de la libération de médiateurs et comprennent un prurit, des bouffées de chaleur et une dyspepsie due à une hypersécrétion gastrique.
6. Mastocyte activation syndrome and inappropriate activation of mastocytes
   Symptoms come mainly from the release of mediators and include pruritus, hot flashes and dyspepsia due to gastric hypersecretion.

@Sugar said in What to do about histamine intolerance?:

What do you guys think can help me get back to normal?

Hi,
Some time will be needed to evacuate metabolites when taking High Dose Niacin.
Never above 20-25 mg B3 if not niacinamide.
When taking B3, we need B6. Not necessarily at the same time.
I would take a 50 B complex co-enymed 2x/wk. interaction.
Here is some info How I dealt with histamine intolerance due to overgrowth bacteria, flatulences and gas.
Histamine intolerance – Chris Masterjohn Lite.
The English corner: Fix the gut – 7 steps to cure histamine intolerance
https://mirzoune-ciboulette.forumactif.org/t2028-the-english-corner-fix-the-gut#29578
https://youtu.be/sv70d1OVXHs (copy the link and put in a search internet motor)
Excerpt (video of Chris Masterjohn, under-titled) (With benchmarks at the 7 stages)

1. Video 47’’: Support you own endogenous production of DAO,
   DAO is supposed to clear off all the histamine from food.
   DAO = de-amine oxidase = enzyme able to degrade produced histamine.
   Be sure to get enough of vitamin C B6 (P5P) and coper.
2. Video 1.48”: Supplement with DAO enzyme: kidney, liver worst, kidney supplement (= DAO supplement)
3. Video 2.49”: Support your methylation (=> e.g. with TMG supplement)
4. Video 3.37”: Mast cell control.
   Mind lack of Se and retinol (vit A).
   Mind inflammation (see medical doctor to handle the problem). Some molecules are prohibited (histamine producer and liberator).
5. Video 4.27”: Histamine from your diet
   Mind the most offended food: aged, fermented or preserved food.
   Examples of food high in histamine: semi- and hard cheese, canned anchovies, smoked fish, deli meat, curry, mustard, soy sauce, yeast, avocado, banana, dried food, dried nuts, lemon, mandarin, and pineapple.
   NDLR: These are only some most common examples, of food containing histamine (H). Some food cause the release (R) of histamine when they don't really contain it.
   If you eat these foods you can’t get rid of intolerance, you can’t get cured: you’re only managing the intolerance (the excessive reaction of mast cells).
   After healing, you may reintroduce some banned foods and see how you tolerate a slight amount of them.
6. Video 5.55’’: Alcohol and other drugs
   Alcohol and some drugs interfere with histamine clearance. A sweet spot of alcohol can be tolerated 3 times a week. Many medications are concerned. See listing.
7. Video 6.48’’: Fix the gut.
   If inflamed, there could be a poor production of DAO enzyme, a mast cell burning and a microbiome dysbiosis.
   To be continued on next post.

@mostlylurking
Thanks for developing. I appreciate.
I'm going to read further (links) and come back soon after when digested.
See you later.
Correcting Mast Cell Activation Syndrome - Histamine Intolerance - Mastocytosis - Biologix Center for Optimum Health
https://biologixcenter.com/allergies/correcting-mast-cell-activation-syndrome-histamine-intolerance-mastocytosis/
This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration:
HIT > Therapy > Medicaments
https://www.histaminintoleranz.ch/en/therapy_medicaments.html#antihistamines
*1 => Thiamin as histamin liberator and DAO inhibitor
Sattler 1985 (PDF with reference on histamine active substance)
Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4.
https://pubmed.ncbi.nlm.nih.gov/3925736
(Liste unverträglicher Medikamente (DAO-Hemmer))
Büttiker (same PDF with reference on histamine active substance)
*) Lack of magnesium
Specific change of histamine metabolism in acute magnesium-deficient young rats. - PubMed - NCBI
*1 ## Incompatible medicaments
Histamine liberators
Many agents in medicaments (active substances as well as additives) have the negative effect that they cause mast cell degranulation which leads to release of histamine and other mast cell mediators. They have to be avoided where ever possible according to the agreement with your physician.
DAO-Inhibitors
Many agents in medicaments have the negative effect that they are diamine oxidase inhibitors or inhibitors of other histamine degrading enzymes. They have to be avoided where ever possible according to the agreement with your physician.
List of incompatible active substances in medicaments
This list needs to be completed. Please let us know your experiences with other substances.
Set in excerpt (LucH): Acetyl-cysteine (NAC), aspirin, many barbiturates, bile acid, codeine, gelatin (bone broth), NSAID, quinine, thiamin and tyramine.

@mostlylurking said in High-dose thiamine troubleshooting:

by supplementing enough thiamine so that my autonomic nervous system could function normally. "insufficient electrical contractile bowel movements" are insufficient because the autonomic nervous system is not sending the electrical impulses via the vagus nerve needed for peristalsis to happen. It's a communication problem between the brain and the intestine via the vagus nerve.

The reasoning is good. Thanks for developing.
Could you give details about your "protocol". The posology of thiamin: posology and duration, please. It could help other readers too. + interaction with B2, I suppose.
I had to stop high dose thiamin because of histamine.
Next post for details to come, after your answer, to avoid interference
Thanks for comprehension.

B1 / Thiamine Causing Histamine Issues

Hi,
The order in which you eat your food plays a huge role in the metabolic effect. Eating carbs last versus first is more beneficial in reducing insulin and glucose, which plays a big role in weight gain. To maximize weight loss, eat the carbs last. Dr Jason Fung reviews the studies showing this effect.
https://www.youtube.com/watch?v=o8TeVf6rR7k

Note that the first meal of the day has a huge impact on insulin secretion for the whole day.
Source : doi: 10.2337/dc15-0429
Shukla AP, leesbuRG, Thomas CE, Aronne IN. Food Order has a Significant Impact on Post-prandial Glucose Levels. The obesity society’s 2014 Annual Scientific Meeting. Diabetes care. 2015

@mostlylurking

I agree with your analyze on excess serotonin and 5-HTP (targeting SSRI, thus increasing central nervous system synthesis of serotonin).
SSRI = Selective Serotonin Reuptake Inhibitor.
Saying that, prucalorid is taken, not as a laxative – at the usual dose of 2 mg – but as a stimulus (0.5 mg resolor). The dose is very weak but sufficient for re-educating a lazy gut.
Here we’re trying to find a solution for colonic motility dysfunction. And the solution has not to be found with a laxative. This is not because of a lack of electrolytes, fibbers or exercises. By the way, 30 grams fibbers is needed, with soothed fibbers (progressive).
When suffering from insufficient electrical contractile bowel movements, between 2 meals, we aren’t targeting a problem of transit. The muscle contractions are called peristalsis. This process must be re-educated. Of course, the IBS problem (high-amplitude propagating contractions) must be taken into account. First calming down irritation, afterwards stimulation of the stasis.
Note that when I took resolor 0.5 mg, I took it 2 hours before bedtime (3-4 days adaptation period).
A box of 28 tablets cut into two parts = 56 days of treatment (cut with a sharp kitchen knife). No need for a second box.
Once a day for stools wasn’t enough to get rid of excess / unbalanced intestinal bacteria. Some bacteria had nothing to do in the second part of the colon.
The problem in now under control, with the help of diamine oxidase. Too much histamine. (NaturDAO, 1 000 000 units).
Note: The warning concerns the usual employment to a high dosage of 5-HTP and against an excess of serotonin. The excesses are obviously counterproductive. Here, it is rather a homeopathic treatment / dosage. The difference between a poisoning treatment and a treatment that stimulates. Only the dose makes the poison. I would add the duration too.

@OrpingtonClose said in Whats the deal with "Vitamin" A?:

Is it good or bad?
Here is some info I collected through my decoder
Note that all people won’t agree with what follows.
*) ## High intake of vitamin D (5 000 UI) or a deficiency of Retinol
An excessive intake of vitamin A (retinol) can cause a deficit of Vit D by antagonism. U-shape activity. Retinol (the active form of vitamin A) is an antagonist of vitamin an excess or a deficiency of one or the other of these vitamins will counteract the functioning of the VDR receptors, leaving them unoccupied or inactive.
Moreover “Any intracellular capable of producing a substance that blocks the VDR would have an effective strategy for disabling the immune system!”
https://mpkb.org/home/pathogenesis/vitamind/metabolism
Excerpt: Bacteria and the VDR
Hormonal changes result from change in 1,25 dihydroxyvitamin-D
*) Technical explanation, in short.
An excess of vitamin A (or a vitamin D deficiency) prevents the formation of heterodimers: essentially homodimers (RXR-RXR) will be formed, leaving the VDR unoccupied and inactive.
Source: Zoëhlo (French Pharmacologist)

*) I eat once a week 2 chicken livers (lightly roasted, with one onion), in 250 ml soup. Or I take 10 000 UI retinyl palmitate (once softgel) with a meal (fat required).
It’s not a good idea to take more than 3 000 mcg in once. The Tolerable Upper Intake Level (UL) for adults is set at 3,000 μg/day. Most vitamin A is stored in the liver. ## The half-life of vitamin A is estimated to be 128 days, so it can take many months for retinol levels to normalize after vitamin A toxicity. (4)
10 000 UI = 3 mg = 3 000 mcg
Conversion :
*) Retinol: UI in mcg => x 0.33.
6 000 of retinol Estroban x 0.33 = 1980 mcg.
4. Institute of Medicine (US) Panel on Micronutrients
Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academies Press (US); 2001. Google Scholar
*) Vitamin A has effects of thyroid hormone
Vitamin A lowered TSH and increased T3 in both lean and obese humans. “The effects of vitamin A supplementation parallel the effects of supplementing T3 - i.e. lower TSH and T4 and higher T3 levels”. Haidut
http://www.ncbi.nlm.nih.gov/pubmed/23378454

*) ## Interaction between fat-soluble vitamins
Vitamin K2 is the substance that allows dependent proteins A and D to be activated / come to life. While vitamins A and D act as signaling molecules, indicating to the cells to produce certain proteins, vitamin K2 activates these proteins by giving them the physical capacity to link calcium.
In order to truly understand the fat-soluble vitamins, however, we must understand that vitamins A, D, and K cooperate synergistically not only with each other, but also with essential minerals like magnesium and zinc, with dietary fat, and with key metabolic factors like carbon dioxide and thyroid hormone.
Useful info:
https://mirzoune-ciboulette.forumactif.org/t2017-english-language-corner-1-liposoluble-vitamins#29442
https://mirzoune-ciboulette.forumactif.org/t667-vitamine-a-sous-estimee#5923 (studies links)

• Bioconversion of dietary pro-vitamin A carotenoids to vitamin A in humans
• Half-life of carotene
• The Role of Retinoic Acid in Tolerance and Immunity
• Vitamin A (retinol) is Endotoxin (LPS / TLR4) Antagonist.
  Note:
• Hypothyroidism can lead most people to a vitamin A deficiency (especially in vegetarian).
• Vitamin A is one of the Keys to a Tolerant Immune System?
  https://mirzoune-ciboulette.forumactif.org/t721-vitamine-a-la-cle-dun-systeme-immunitaire-tolerant#6555

• Vitamin A works as an estrogen antagonist

The greatest use of vitamin A is at the level of production of pregnenolone, progesterone and the other steroid hormones associated with youth.
“Vitamin A is for the production of pregnenolone, progesterone, and the other youth-associated steroids”. http://raypeat.com/articles/articles/alzheimers2.shtml

@mostlylurking said in High-dose thiamine troubleshooting:

Please tell me what is "MMC"

The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

We’ll have to work on## 4 levels:

• Thyroid for energy
• Dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).
• Leaky gut and foodstuff tolerance
• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming. Mind this point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

*) Amizon says:
“I’m attempting to treat more-or-less lifelong chronic fatigue issues”
=> The thyroid acts as the carburetor of a car. Energy level.
*) Amizon says:
“Any suggestions would be much appreciated, thanks”.
=> I’ll take a Vitamin B complex 2x/w (3x at the beginning). A co-enzymed form.
*) Amizon says:
My digestion is still super out of sorts.
I wouldn't have called my gut sensitive--just constipated. Slow slow bowels my whole life.
=> Get informed on MMC. If you …
*) Amizon says:
"I started having gastritis (…) Things have been much funkier and more sensitive since then in the gut department. A low fodmap diet did [seem to] solve the problem. (…)
If I eat more than incidental amounts or frequency of FODMAPs, I get gastric pain and fibromyalgia symptoms. If I follow my restricted diet my symptom set is more chronic fatigue, very little pain. The only thing that helps the constipation though is miralax. All of this low energy and constipation is one of the main things that had me interested in the high-dose thiamine therapy."
Answer

We’ll have to work on 4 levels:

• thyroid for energy
• dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).
• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming.
  Mind this last point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

Read the following info too and come back to discuss and have a plan.
*) The English Corner: Auto immune reaction
Intolerant to foodstuff – Severe Dysfunctional Digestive System
https://mirzoune-ciboulette.forumactif.org/t2022-the-english-corner-auto-immune-reaction#29492
*) Cereals and pseudo-cereals
As far as vegetables are concerned, raw for enzymes but not at the beginning when your bowels are irritated. We’d better eat them steam-cooked and according to what you can tolerate. Adapt yourself.
As far as pseudo-cereals are concerned, they are admitted but moderately. I advise to limit them once a day, a small portion. Buckwheat and rice do contain antinutrients. Like all cereals.
Not good for endothelial cells. Cereals cause zonulin secretion. Zonulin increases intestinal permeability (leaky gut). Tight junctions are no longer operational (by people suffering from poor digestion).
As far as I’m concerned, I try to limit cereals. Let’s say 2x/3 because I’m not perfect
Additional link if you want to know why grains are not advised.
“Why grains are bad?”
http://www.thepaleomom.com/2012/03/how-do-grains-legumes-and-dairy-cause.html
From “How Do Grains, Legumes and Dairy Cause a Leaky Gut?” Part 1: Lectins.

• Part 2: Saponins and Protease Inhibitors of grains and legumes
  From “How Do Grains, Legumes and Dairy Cause a Leaky Gut?”
  http://www.thepaleomom.com/2012/03/how-do-grains-legumes-and-dairy-cause_29.html

*) The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

@LucH said in High-dose thiamine troubleshooting:

-) English corner. Potential roles of Vit B6 in inflammation and immunity
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633

I’m going to put some points in excerpt. I’ll develop if you are interested in.
Mind the following behavior: If you don’t agree now with one point, don’t throw away the baby with the bath-water. You may disagree but you have to say why if you want some help.
I’m not a nutritionist. I’m a teacher and I’m the administrator of a French site based on health and nutrition.
*) Former take of high dose thiamine HCL.
High dose Thiamine must be taken with some B2. Doses progressively raised. High dose thiamine has an impact on the detox pathway and histamine degradation (Cyp450 enzymatic pathway).
There is interaction between other B vitamins, especially B1 B2 B3 for glycemia. If you take B3 (niacinamide to avoid a flash reaction), you’ll need B6 + probably a methyl support (TMG) according to the type of B3. If you take B6, PLP mustn’t exceed a threshold, depending on the consumption by the body (low grade inflammation, immune reaction). Otherwise, you’ll get a problem with GABA-like symptoms (depravation) (a lack of / shortage due to a protection process of the brain: Too much of a good thing is bad).

B6 is needed / required for brain balance in the event of problems like you described. Vitamin B6 is well documented for its role as a modulator of steroid hormones: This vitamin contributes to the proper functioning of the nervous system. It participates in the synthesis of neurotransmitters, such as serotonin and dopamine, who play a crucial role in the regulation of mood, sleep and mental well-being.

But if you suffer from inflammation (low grade inflammation from bowel irritation or arthrosis if you are over 35 years old), your B6 will be burnt / exhausted.

Useful info (to read later)
-) English Corner – Vit B6: How much is too much?
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
-) B6 modulates the activity of GABA. B6 as antioxidant and antipain.
https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
-) English corner. Potential roles of Vit B6 in inflammation and immunity

@amizon said in High-dose thiamine troubleshooting:

my silly sensitive gut--and see if that can help my digestion and liver out,

Give details, please:
Dysbiosis (flatulence, gaz, bile, etc.). What about the MMC and the feces (2x/day)?

Need to follow a relaxation therapy, perhaps with supplements to optimize GABA (collagen, L-theanine,) + magnesium bisglycinate.
First soothing gut and stomach linings before eating carrot salad.
Need some glutamine too but not if dysbiosis.
Hope it will help.