Posts made by Serotoninskeptic

What does FGF21 do?

• Induces autophagy
• Protects the liver
• Browns fat (makes it thermogenic)
• Prevents DNA damage/telomere dysfunction
• Causes weight loss
• Mediates life-extending effect of protein restriction
  

Idk why everyone takes growth hormone secretagogues: Ibutamoren, Tesamorelin, CJC-1295/Ipamorelin, etc.

These things are probably making you age faster. They are not anti-aging.

If you wanna grow, increasing steroid hormones or follistatin are much more anti-aging.

• Hypothyroid individuals have melanoma at much higher rates
• TSH (increased in hypothyroid) is a growth factor for melanoma
• UV light deficiency raises TSH and causes hypothyroidism
• Melanoma is negatively associated with sunlight exposure
  

A leaky gut makes it so that your sleep is not restorative.

During the night, you experience “glymphatic flow,” where your cerebrospinal fluid washes your brain and removes amyloid, waste, etc.

Endotoxin, the bacterial component that leaks thru your gut, impairs this flow.

DHT protects your neurons from endotoxin's inflammatory effects -- may improve cognition if you have a leaky gut.

DHT improves spatial memory, while testosterone improves verbal memory (may be from aromatization to estrogen?)

The linoleic acid content of adipose tissue (fat) has steadily increased since the 1950s in US adults.

Sparkling water has very posditive effects against constipation & stomach discomfort. It also empties the gallbladder of bile, which lowers cholesterol.
(High cholesterol can be caused by impaired bile flow. Gallstones are made of cholesterol.)
Not to mention the Co2 and mineral content you get from natural carbonated springs

5.1 is virtually the optimal HbA1c for lifespan in non-diabetics as far as I can gather.

Anything lower looks riskier to me

Collagen has a special building block: 4-hydroxyproline.

Proline is a common amino acid building block which gets incorporated into collagen and then modified before the final structure can form.

Vitamin C is needed to facilitate this modification: conversion of proline to 4-hydroxyproline.¹

4-hydroxyproline consumption (preferably thru gelatin) can enhance collagen synthesis, alongside muscle growth and performance.²

Increasing dietary carbohydrate, but not fat or protein, led to a significant reduction in cortisol following a social stress task.

Eating sugar also reduced cortisol release induced by cold water.

Thesis from 1959 but the methods are simple. The higher the serum salicylate, the higher the O2 consumption, consistent across healthy, recovering, and sick individuals.

Topical lisuride, a compound similar to LSD, prevented restless leg syndrome in women, probably through a dopaminergic mechanism.

Excessive serotonin may contribute to restless leg syndrome by reducing the action of dopamine.

@Milk-Destroyer Yea definitrly could be a result of poor farming practice. Glysophate in the feed, artifiical hormones and vaccines, poor conditions. I would recommend investing on high quality pasture-raised beef to see if you react any better

Naloxone nearly 10x’d testosterone in adult male rabbits.

No difference between high and low dose.

Naloxone generally has the same effects as naltrexone (LDN).

@LetTheRedeemed Yea i think he did say it could be irritating to the gut. I think he didnt recommend coconut flour for the same reason

@Milk-Destroyer Is the beef 100% grass-fed? You could be allergic to the corn/soy/grains in their feed if not.

@RawGoatMilk88 I would say its safe to give it a try. Just start with small doses and track his pulse often

@scamp T3 is quick acting and has a short half life. T4 release slowly and has a lower half life. I would recomend adding some T4 to your regimen

“…ancient Chinese even used animal thyroid in the treatment of goitre: thus, in the book Shen Shi-Fan (420-501 A.D.) mention is made of the use of deer thyroid for this purpose.”

• P Langer

@mag-me https://www.amazon.com/Perfect-Collagen-Brazilian-Container-Pesticides/dp/B01HQEVVZA

i use this one