A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome

[A Former User]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715943/

Got a real puzzle for you folks.

Is it only pasteurised milk that does this (causes folate receptor autoimmunity)? Maybe raw milk IS the future?

[jamsey]

Travis talked a lot about this on rpf, if you want to read a more in depth dive. He believed the issue lies in the homogenization and micelles being formed around proteins, preventing their complete digestion. If raw milk is too expensive/unavailable, he said “ Yet it has been demonstrated that (6S)-methyltetrahydrofolate will displace anti-FRα antibodies from FRα, and also that folinic acid will bypass FRα altogether through the 'reduced folate carrier.' This means that even should anti-FRα antibodies be present, they can be effectively antagonized and circumvented. ” Don’t have the time to find the study he’s referencing, but I assume he was correct.

[A Former User]

@jamsey

My brain is too fkin fogged to think about this

Does this mean unhomogenised is ok?

[jamsey]

@questforhealth
From this perspective yes. I personally prefer raw milk, but have not had noticeable issues with ultra pasteurized homogenized milk. However, if drinking lower quality milk, it can’t hurt to get a little extra folate, either from supplements or food.