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  • Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

    4k Topics
    35k Posts
    C
    @sunsunsun said: there is a published paper by Lorne pickhardt (sp?) using it on a constant drip for 7-10 days and it is something like 10-100x more effective than taking a singe larger dose everyday. it's something like use a 100mg vial on a constant drip over a week Do you have a link to that publication? I cannot find it neither by Loren Pickart nor anyone else. Thanks for your suggestions and yes I've started GHK-Cu at the same time, 1-2mg pd. I also got NAD+ and pinned that once but NAD+ is of much inferior priority. As is resveratrol. And then all the vitamins, except perhaps folate and B12, and the stimulants like choline, quinones, CoQ10, MB etc which demand already well-functioning mitos as a prerequisites. I assume my body will have plenty to do with its mitos plus already the bpc and ghk-Cu stimuli. SS-31 slightly stings btw. Wrt to the retina there are only rodent studies (which are wrong to make human conclusions of in many cases) showing that timing of administration does matter https://pubmed.ncbi.nlm.nih.gov/1582795/ https://pubmed.ncbi.nlm.nih.gov/18078931/ Long-term and in humans I read about MEL possibly improving serious ocular diseases: AMD, IOP (glaucoma). I'm going to add 1mg/ml MEL and BPC to 3% DMSO eye drops in a while. methylene blue and riboflavin are also not a great idea apparently to take at high doses and go in strong sunlight I agree. I could strongly feel that sensitivity by MB in my skin even in wintertime. The antimicrobial effects of MB+PDT are really poor anyway and for antitumour effects there are better dyes like locally injected bengal rose. Melatonin is totally different from MB though and not an oxidant but even its metabolites are still protective. There just may or may not be some kind of signalling to the eyes like "hey it's nighttime, relax, no need to worry about strong light until dawn". @alfredoolivas said: Melatonin inhibits cardiolipin peroxidation in mitochondria Yes! That's what I had read as well. Thanks for posting it. It also strongly brings about all these SIRT3 activation cascades: @Mauritio said: Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria https://pmc.ncbi.nlm.nih.gov/articles/PMC7493682/ Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer https://pubmed.ncbi.nlm.nih.gov/31269804/ "SIRT3 reduced the expression of stearoyl-CoA desaturase 1..." https://pubmed.ncbi.nlm.nih.gov/31160717/

  • Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

    239 Topics
    3k Posts
    LetTheRedeemedL
    Nicotine is a vasoconstrictor, and bromocriptine is a vasodilator. The positive effects of nicotine is pretty established here. It Lowers all the stress hormones. I’ve experienced it’s vasoconstriction effects as well, and it led me to stop. My nose gets cold to the touch and to inhale thru. The impact of that after 20 years is definitely not worth it. For this reason, Ray said nicotine would cause premature wrinkles, and should be limited to use by old people. Bromocriptine is a very strong vasodilator, and many people get closed nostrils from the loosened veins in the peripheral tissues — I get it pretty terribly. I took a whole bromocriptine tablet, which clogs my nose for over a day every time, then smoked a cig, and my nose was maybe 20% closed the following morning. The next day, I took a bromo tablet after eating dinner, and smoked a whole cigar about 20 minutes later. Up front, I started getting a cold nose. After about an hour, my nose was warm. My nose remained warm the rest of the night and this morning, with almost no discernible swelling in my nostrils. I should definitely take bromo on an empty stomach. biobabes we gonna be forever young!

  • Discussion of culture, literature, and politics

    190 Topics
    4k Posts
    sunsunsunS
    @gg12 even if people are eating a lot they can be nutrient deficient.

  • Conversations about Bioenergetic Forum

    86 Topics
    1k Posts
    M
    @ThinPicking , Definitely. But I would like to talk with the administrator.

  • Off-topic or unclear threads sent here. But dig around and you might find some gems.

    519 Topics
    15k Posts
    LetTheRedeemedL
    @Gaston Thirty ought six, carrot salad. [image: 1780011639454-55a687d1-f7bc-44b9-898d-1df8e6be50e1.jpeg]