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  • Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

    4k Topics
    34k Posts
    engineerE
    @Mauritio I don't have anything more to say about 11 keto T specifically because I haven't used it since my last post. However, since then, I've been experimenting with T isocaproate. The general feeling with that is very similar. Thermogenic, more energy consumption, with more muscle growth too. However, despite being aromatizable, I don't feel estrogenic at all because of other Peaty things I'm doing, so the net effect is basically identical to 11 keto. This is all what a good cortisol blocker would be. So, my point still stands: XI-KT is good if you want T's effects but want a simple, readily available bottle you can just put on your skin.
  • Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

    229 Topics
    2k Posts
    W
    i am now re thinking this idea after finding another patent using losartan for hair US20160081901A1 - "Compositions and methods for hair growth"
  • 182 Topics
    4k Posts
    LukeL
    https://www.youtube.com/watch?v=WYeDsa4Tw0c
  • Conversations about Bioenergetic Forum

    86 Topics
    1k Posts
    C
    @LetTheRedeemed https://www.diningandcooking.com/2025190/new-study-suggests-link-between-cheese-and-long-life/ " The study, published in the Journal of Agricultural and Food Chemistry, suggested that fermented dairy products such as cheese could contribute to longevity and health." https://www.guentensperger-kaese.ch/en/post/news-cheese-and-life-expectancy
  • Off-topic or unclear threads sent here. But dig around and you might find some gems.

    510 Topics
    14k Posts
    LucHL
    After a search, perhaps these clues could help limit the sides-effects of aluminum. Attenuating microglia (non-causal effect): Theracurmin + citicoline Curcumin acts at several levels: ↓ NF-κB → ↓ pro-IL-1β transcription ↓ NLRP3 activation ↓ caspase-1 Mitochondrial antioxidant effect Theracurmin improves bioavailability → more stable plasma concentration. This is therefore a partial upstream and downstream modulation. Chelating: can be effective, but ensure adequate silicon (orthosilicic acid) intake. I know G5 (organic silicium). Reduces the circulating aluminum pool. This acts on: • ROS • NF-κB • NLRP3 • IL-1β • Plasma aluminum load This is a "gentle, multi-target" approach rather than radical blockade. Silicon in the form of orthosilicic acid (Si(OH)₄) can: Form soluble hydroxyaluminosilicates Prevent renal tubular reabsorption Increase urinary excretion What it does: Increases the elimination of circulating aluminum What it does not prove: That it removes intracerebral aluminum Alpha-lipoic acid (ALA) Mechanism: • Crosses the blood-brain barrier (BBB) • Regenerates glutathione • Reduces microglial oxidative stress • Modifies NF-κB Logical synergy with NAC (one acts as a GSH precursor, the other as a recycler).