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  • Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

    4k Topics
    36k Posts
    LucHL
    If I try to decode: During the TCA cycle (energy for mitochondria), mi-infrared photons are released, at 87 THz frequency, derived from the reduction of NAD+. At this frequency light particles enter in vibration when meeting CH2 (carbon-hydrogen bonds) in membrane lipids. This “coupling” share a 𝐂𝐎𝟐 connection (called polariton). The researchers hypothesize that this arrangement boosts TCA cycle and add a 10% energy gain. Haidut said: “Red / infrared light forms a quantum system with the lipids present inside the mitochondria and CO2, which results in boosting ATP synthesis when cells are exposed to red/infrared light and enough CO2 is present. I suspect most of the effect are driven by the lipids composing cardiolipin, and the effect can probably be modulated (up or down) based on the nature of those lipids – i.e. PUFA, MUFA or SFA.” => Importance of cardiolipin connected with IR light. Cardiolipin is a unique phospholipid located exclusively in the inner mitochondrial membrane. It plays a structural role (featuring an inverted-cone curvature), acting as a waveguide (a quantum phenomenon). Naturally, it is important to ensure an intake of MUFAs (e.g., oleic acid) to maintain membrane fluidity, while keeping PUFA levels low. AI says: "Enriching mitochondrial membranes with monounsaturated fatty acids stabilizes cardiolipin against free-radical damage. By protecting the physical integrity and curvature of the cristae, these lipids maintain the strict structural conditions that allow polaritons to exist and catalyze ATP production via a quantum effect. Cellular nutrition and quantum physics converge to lock in the energy efficiency of living systems." — (1-2) DOI: 10.1186/s12944-019-0990-y (Double bonds of unsaturated fatty acids differentially regulate mitochondrial cardiolipin remodeling) 2019. Scientists propose a light-matter quantum state inside living cells https://www.thebrighterside.news/post/scientists-propose-a-light-matter-quantum-state-inside-living-cells/ Excerpt: • Researchers report an unexplained 71-terahertz vibration in living cells, mouse tissues and isolated mitochondria that disappears when mitochondrial structure is disrupted. • A theoretical model proposes that the signal could arise from a quantum hybrid state, or polariton, created by coupling infrared light with collective vibrations of lipid molecules inside mitochondrial cristae. • Weak infrared illumination at 71 and 87 terahertz increased ATP production by about 10% in cultured human cells, but the preprint has not been peer-reviewed and does not directly prove that mitochondria use a functional quantum state.
  • Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

    244 Topics
    3k Posts
    alfredoolivasA
    [image: 1790179057064-d64cc2f3-8102-48a6-ae97-2e90cee84651-image.jpeg]
  • 195 Topics
    4k Posts
    JenniferJ
    https://www.youtube.com/watch?v=UnPMoAb4y8U https://www.youtube.com/watch?v=GtPD0sAhCUo https://www.youtube.com/watch?v=Fa0E7A2EGKQ
  • Conversations about Bioenergetic Forum

    87 Topics
    1k Posts
    K
    @lobotomize Good framework, though the evidence-grade weighting in the default sort might bury solid animal/mechanistic work under mediocre human studies. Letting people re-weight it themselves could help. Bigger gap: how do contested claims get handled? If a newer RCT contradicts an older one, does the old card get flagged/archived, or do they just sit side by side? That seems like the whole point of avoiding rediscovery. Also worth adding a required sample size field to the submission template — two "Evidence B" studies can carry very different weight depending on n, and that gets lost if it's folded into the letter grade alone. Export for meta-analysis is a nice touch though.
  • Off-topic or unclear threads sent here. But dig around and you might find some gems.

    524 Topics
    15k Posts
    engineerE
    @sunsunsun did you try this? I'm curious about alcohol for the lipofuscin clearing and nothing else