@sunsunsun Merci!
Below is a summary in case someone in need will be reading this in the future:
Introduction
Combination of vitamins E+D about as effective as antibiotic for treating bacterial sepsis/infection
daily 1-2k IU D3 + 8.75mg/kg (700-800mg) Vit E (d-alpha-tocopherol or mixed unesterified d-isomers of all 4 tocopherols)
The tetracyclines protect against sepsis independently of their antibiotics effects
Tetracyclines might be the preferred antibiotic treatment (i.e. doxycycline in a HED of 0.25 mg/kg (intraperitoneal route, so orally one would need ~0.4 mg/kg to achieve the same effects)
Endotoxin/LPS is a major driver of blood clotting, sepsis, heart attacks and strokes
Aspirin (although only acts downstream of the endotoxin/LPS cascade)
Substances that can limit the amount of endotoxin/LPS produced and entering the blood:
easily digestible food; avoiding “resistant” starches
carrot salad, charcoal (*not really applicable after appendectomy)
Niacinamide and vitamin E to help restore the gut barrier
pregnane steroids (and especially bioidentical progesterone) to directly bind endotoxin in the bloodstream
Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate
least risky of FAS-Inhibitors is probably orlistat (Still severe side effects)
aspirin might be good alternative; adding niacinamide + thiamine might improve its effectiveness against sepsis by improving glucose oxidation and reducing lipolysis respectively
Inhibiting fatty acid synthesis reverses bacterial antibiotic resistance
Aspirin (80mg-100mg daily) inhibited FAS by +50%
Aspirin As A Cure For Sepsis
excellent thread https://lowtoxinforum.com/threads/aspirin-as-a-cure-for-sepsis.15753/post-215210
Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis
(!) Note: research involved in vitro work only + oral route probably not applicable after appendectomy
see Haidut comment
Caffene restores lowered cytochrome C oxidase activity + Caffeine restores cytochrome C damaged by sepsis
one cup of coffee or about 80mg-100mg of caffeine
probably better to do in recovery, not with acute sepsis
DHEA Protects From Endotoxin Effects And Lethality
single HED dose of as little as 5mg - 7mg DHEA daramatically increased survival of lethal endotoxins
DHEA protects from endotoxin (even lethal doses)
IV B1+Vit. C+ Cortisone Prevents Septic Induced Death
(!) this is the most promising treatment so far
Full interview with Dr. Paul Marik
his 2017 paper in question for early treatment protocol
Vit C (1.5 g every 6 h for 4 days or until ICU discharge)
Thiamine (200 mg every 12 h for 4 days or until ICU discharge)
Hydrocortisone (50 mg every 6h for 7 days or until ICU discharge followed by a taper over 3 days)
https://www.amjmed.com/article/S0002-9343(19)30699-0/fulltext
Bottom line: If you have a family member dying of sepsis on an intensive care unit, demand that Dr. Marik’s protocol be immediately instituted. If you are denied this option, make sure your physician understands that immediate legal action to initiate the therapy will ensue, and that the death of your loved one will assure the initiation of a malpractice suit against them. However, only sue the physician in charge, as physicians have a herd mentality and are scared to death of being the sole focus of a malpractice suit or medicolegal challenge.
s/o @mauritio
T3 levels are a predictor of mortality from sepsis
This study (and this one) shows that lactic acid is an independent risk factor for death due to sepsis. CO2 lowers lactic acid, T3 increases CO2. So it makes sense that T3 was so strongly correlated with survival in sepsis patients.
-> improve CO2 / lower lactate (thiamin, niacinamide)
This study shows a significant increase in survival time of people who take aspirin before hospitalization (by 1.3 days)
Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections
especially its activated form riboflavin '5 phosphate (R5P)
minimum effective human equivalent oral doses for the combination of R5P and valine were approximately 0.2mg/kg and 25mg/kg respectively. This assumes bioavailability of 90% and 70% for R5P and valine.
The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy
"A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis"
Septic Shock:
Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock
Anti-Serotonin (Cyproheptadine) + Aspirin
Famotidine & Anti-histamines Protect Organs In (septic) Shock
Both an H2 blocker (Famotidine, Cyproheptadine) and an H1 blocker (Chlorphenamine) were each offered protection
Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation
s/o Koveras
Anti-Serotonin, Cypro, Tryptophan Metabolism, Vitamin C, Hydrocortisone, Thiamin
https://lowtoxinforum.com/threads/do-not-forget-to-give-thiamine-to-your-septic-shock-patient.12006/
See also:
Haidut on radiation exposure due to x-ray
https://bioenergetic.forum/topic/3037/advice-on-lowering-endotoxin/18
https://bioenergetic.forum/topic/2140/any-info-on-sepsis-bacteremia-antibiotics-used/16
Citrulline to restore immune function after sepsis
L-Citrulline restores immunity & T Cell mitochondria function acutely
highest food sources: 1 cup of red flesh watermelon might have ~150mg per cup. or ~400mg for yellow flesh watermelon
https://bioenergetic.forum/post/42939
Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats
https://bioenergetic.forum/post/60444
(!) avoid mitophagy enhancers like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. (especially in the initial stage of sepsis)
https://lowtoxinforum.com/threads/aspirin-in-the-context-of-endotoxin-tolerance.49865/
