@engineer said:
@alfredoolivas this is exactly why you don't want to plummet E2 too low with an AI.
Really? So you can experience rapid prostrate growth to the point where it becomes problematic?
The whole point of this study was an attempt to replicate some of the conditions of BPH. The castrated dogs injected with estrogen may have seen tighter binding of DHT in the prostrate, but this isn't necessarily a good thing. The prostate may have been attempting to protect itself from a massive amount of stress hormone, and sucked up as much protective DHT as it could find.
Remember, these were freshly castrated dogs, and the all the dogs were sacrificed after six weeks, some much sooner. We don't know what would have happened had things progressed longer, but it's reasonable to to assume that DHT levels would have dropped and the effect of the supplemental estrogen would have been unopposed over a longer timeframe.
