Despite the mountain of evidence that messing with cholesterol is a bad idea, especially when it comes to muscle and mitochondrial health, statins remain one of the most widely prescribed drugs. Even toddlers are now on the list of potential patients eligible to receive a statin prescription and the list of conditions compatible with statin medication keeps growing. Unbeknownst to even most doctors, in 2018 the US FDA quietly removed its warnings about dietary cholesterol and its link to cardiovascular disease (CVD). Namely, FDA no longer claims that there is a risk of eating high-cholesterol food and developing CVD. The same group of studies that led to the FDA revoking its dietary cholesterol warning also vindicated saturated fats (SFA), but the FDA did not dare revoke its dietary warning on SFA, at least for now.
The study below once again demonstrates the absolutely crucial role cholesterol availability plays in cellular health. Not only is cholesterol the precursor of all steroids and is also a crucial component of cellular structure, it now seems that cholesterol has a functional (bioenergetic) role too. Namely, inhibiting cholesterol synthesis (which is what statins do) or its transport into the cell (which is partially what dietary cholesterol restriction does) literally poisons the cell through the accumulation of mitochondrial debris and free fatty acids. Both of those entities have indisputable toxicity, with the former robustly activating systemic inflammatory pathways through the endotoxin receptor TLR4, while the latter is toxic simply by its presence in large amounts (hence the medical term lipotoxicity) and also through the inflammatory mediators it serves as the precursor for (if the fatty acids are PUFA). In addition, the study may provide part of the answer to the question why cholesterol levels increase with age. Ray said this increase is adaptive, to compensate for decrease in steroid synthesis due to declining thyroid function with age. However, the study provide an additional explanation. Namely, the cells need more cholesterol in order to handle the increasing rate of mitochondrial breakdown and increase in lipid accumulation that also increase with advancing age. So, it seems that one of the most reliable methods of ensuring premature cell aging and death is simply to follow the official recommendations of mainstream medicine – i.e. restruct dietary cholesterol as much as possible and take a statin daily.
https://dx.doi.org/10.1038/s41467-026-77423-1
https://phys.org/news/2026-09-cell-chain-cholesterol-cellular-recycling.html
“…Mention cholesterol, and most people will think of clogged arteries or health warnings. But inside the microscopic universe of the human cell, cholesterol has a drastically different job description as an indispensable cellular lifesaver. A study led by the Lee Kong Chian School of Medicine (LKCMedicine) at Nanyang Technological University, Singapore (NTU Singapore), shows how cells rapidly dispatch cholesterol to reinforce their “recycling centers” called lysosomes, preventing them from bursting while breaking down worn-out cellular machinery.”
“…Every second inside our cells, mitochondria generate the energy that fuels life. However, mitochondria eventually wear down. Left unchecked, toxic fragments from these broken power stations can trigger cell death. To prevent that, cells execute a precision cleanup operation known as mitophagy, engulfing worn-out mitochondria and sending them to the cell’s highly acidic recycling centers, called lysosomes. Here, lysosomal enzymes break them down into reusable materials. While scientists have long understood this process, a critical mystery remained: How do lysosomes maintain the harsh acidic environment and withstand the stress required to digest such massive cargo without bursting? Now, the study has uncovered the unlikely answer—cholesterol.”
“…When damaged mitochondria land inside a lysosome, an enzyme called PI4KIIα flags the lysosomal surface with a specialized signaling lipid called PI4P. This flag attracts a transport protein named OSBP, which acts as a cellular bridge, rapidly shuttling cholesterol from another cellular network, known as the endoplasmic reticulum (ER), straight into the lysosomal membrane. As cholesterol leaves the ER, the cell senses a temporary shortage and activates a master genetic switch, ramping up cholesterol production to keep the supply chain flowing. Corresponding author and associate professor Yasunori Saheki, Irene Tan Liang Kheng chair professor in neuroscience at LKCMedicine, said, “Lysosomes need to maintain an extremely acidic interior to digest cellular waste effectively. We discovered that as lysosomes take in damaged mitochondria, they reinforce their membranes with cholesterol. This process helps keep the lysosome resilient and ensures that its digestive functions remain fully active.”
“…The research team’s analysis also revealed another intriguing finding. Once the lysosome successfully digests the mitochondrial membranes, it releases a surge of lipids known as free fatty acids. If left free in the cell, these fatty acids can become toxic. To solve this, the cell uses a series of enzymes to package these fatty acids into safe storage units called lipid droplets. This process effectively converts toxic waste into stored energy reserves for future use. When the research team experimentally blocked cholesterol transport or synthesis, the consequences were significant. The lysosomes lost their acidity, became fragile and prone to rupture and failed to break down damaged mitochondria. The cells were also unable to form protective lipid droplets.”
Via: https://haidut.me/?p=3137
