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  • Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

    4k Topics
    34k Posts
    U
    Dopamine directly affects mitochondria, particularly in neurons, by inhibiting complex I of the electron transport chain, reducing membrane potential, and causing swelling. Excessive dopamine oxidation leads to mitochondrial dysfunction, decreased ATP production, and increased oxidative stress, which are relevant to neurodegenerative diseases like Parkinson's. Key Impacts of Dopamine on Mitochondria: Complex I Inhibition: Dopamine specifically inhibits mitochondrial complex I, reducing the efficiency of energy production. Oxidative Stress: The oxidation of dopamine produces reactive oxygen species (ROS), causing mitochondrial National Institutes of Health (NIH) | (.... https://pubmed.ncbi.nlm.nih.gov L-DOPA causes mitochondrial dysfunction in vitro by S Giannopoulos 2019 Cited by 23 - L-DOPA causes mitochondrial dysfunction in vitro: https://www.nature.com Impairment of neuronal mitochondrial function by I-DOPA ... by P Hörmann 2021 Cited by 25 - Further mechanistic analysis indicated that I-DOPA reprogrammed mitochondrial metabolism PLOS https://journals.plos.org Dopamine Inhibits Mitochondrial Motility in Hippocampal Neurons by S Chen 2008 Cited by 99 - In the present study, we found that dopamine exerts a net inhibitory effect on mitochondrial movement Thoughts on all this?

  • Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

    229 Topics
    2k Posts
    loessL
    @engineer How's your experience with this setup going so far? I just moved into a house that receives very little natural light coming in through the windows, as it's squeezed tightly in between two other shotgun-style houses, and I'm looking into my various options for tackling the problem. I've got plenty of chicken clamp-lamps, and a red light panel that I use for spot treatment directly on my body, but I need a broader solution that'll cover an entire room and make working from home without adequate natural sunlight tolerable.

  • Discussion of culture, literature, and politics

    180 Topics
    4k Posts
    JenniferJ
    https://www.youtube.com/watch?v=2cZ_EFAmj08

  • Conversations about Bioenergetic Forum

    86 Topics
    1k Posts
    C
    @LetTheRedeemed https://www.diningandcooking.com/2025190/new-study-suggests-link-between-cheese-and-long-life/ " The study, published in the Journal of Agricultural and Food Chemistry, suggested that fermented dairy products such as cheese could contribute to longevity and health." https://www.guentensperger-kaese.ch/en/post/news-cheese-and-life-expectancy

  • Off-topic or unclear threads sent here. But dig around and you might find some gems.

    508 Topics
    14k Posts
    alfredoolivasA
    @bio3nergetic It doesn't matter. Your body will break down the PC into lysophosphatidylcholine + free fatty acids. Back in the body, your body will a join the lysophosphatidylcholine with circulating fatty acids. When the enter the cell, it breakds down back into lysophosphatidylcholine, and rejoins with fatty acids in the cell back into PC.So as long, as you eat saturated fat with the PC, then basically, you will be receiving saturated PC. It's not a scam by Haidut, because he is selling what it says on the label, but it's useless when compared to alternetive forms of PC, which are sold for much much cheaper.