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  • Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

    4k Topics
    36k Posts
    LucHL
    Tocotrienols: The ultimate shield against ROS and atherosclerosis Excerpt Fighting oxidative stress at the source: tocotrienols are a game-changer if... It’s the head (chromanol ring)—and not the tail—of the tocotrienol that sacrifices itself in the presence of ROS. If the alteration occurs on the chromanol head, the isomer can continue to move and will be recycled or restored in the presence of Vitamin C; the alteration is thus temporary if... A systematic review published on PubMed (NCBI) confirms that delta- and gamma-tocotrienol are the two most potent isomers for suppressing endothelial activation and inflammation via the NF-κB pathway. [1] However, it is often recommended to combine at least two forms—for example, 80% alpha-tocopherol and 20% gamma- or delta-tocotrienols. Useful link (in French, translator required) : https://mirzoune-ciboulette.forumactif.org/t2236-tocotrienols-le-bouclier-ultime-contre-les-ros-et-l-atherosclerose#31035
  • Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

    244 Topics
    3k Posts
    alfredoolivasA
    [image: 1790179057064-d64cc2f3-8102-48a6-ae97-2e90cee84651-image.jpeg]
  • 195 Topics
    4k Posts
    JenniferJ
    https://www.youtube.com/watch?v=UnPMoAb4y8U https://www.youtube.com/watch?v=GtPD0sAhCUo https://www.youtube.com/watch?v=Fa0E7A2EGKQ
  • Conversations about Bioenergetic Forum

    87 Topics
    1k Posts
    K
    @lobotomize Good framework, though the evidence-grade weighting in the default sort might bury solid animal/mechanistic work under mediocre human studies. Letting people re-weight it themselves could help. Bigger gap: how do contested claims get handled? If a newer RCT contradicts an older one, does the old card get flagged/archived, or do they just sit side by side? That seems like the whole point of avoiding rediscovery. Also worth adding a required sample size field to the submission template — two "Evidence B" studies can carry very different weight depending on n, and that gets lost if it's folded into the letter grade alone. Export for meta-analysis is a nice touch though.
  • Off-topic or unclear threads sent here. But dig around and you might find some gems.

    524 Topics
    15k Posts
    engineerE
    @sunsunsun did you try this? I'm curious about alcohol for the lipofuscin clearing and nothing else