Talk with AI (Claude)
How efficient is the intake of a MK4 supplement, (with enough fat, hereby 25 g fat with some MUFAs), when taking 1 mg (1 000 mcg) K2 MK4?
Question of vehicle only? No intermediate change into menadione, I suppose, since there is no digest process. Need a confirmation, whenever there is a target amount limited to 2-3 mg K2 supplement.
Note: 2 takes of 1 mg MK4 at breakfast and midday meal, with 1 000 UI D3 (both at the same time, AKA 2 x 1 000 UI D3). Brain target.
AI says (Claude):
Summary:
A moderate amount of D3 and K2 are co-absorbed in the same chylomicron pathway; so simultaneous intake is fine.
Brain target and dose adequacy: 2 mg/day total is a reasonable range for a brain-focused protocol.
Step 1 — Chylomicrons (intestinal phase, 0–4h postprandial)
Step 2 — Chylomicron remnants → liver (4–6h)
Step 3 — VLDL → IDL → LDL (hepatic re-export, hours to days)
A possible route for extra-hepatic tissue supply is that part of the K-vitamins are re-packed into LDL, which forms a major transport system from the liver to peripheral tissues. ScienceDirect This is the key insight for your brain target — the liver processes the chylomicron-delivered MK4 and re-exports it via VLDL, which is then progressively remodeled into IDL and LDL for peripheral tissue delivery.
Agarose gel electrophoresis of lipoprotein fractions after K2 supplementation revealed distinct chylomicron bands and variations in VLDL and HDL mobility, influenced by dietary lipids and VK2 supplementation. Wiley Online Library
