@Tarzan17 I guess

@heyman I didn't, I still have that problem. It's better than it was though.

I think it improved a bit as I cured Hashi's earlier this year.

It's also helped a lot to not irritate it directly, by avoiding certain things like vinegar, chewing raw apples, and for some reason ground beef.

And, in the last month, Dr. Ellie's teeth protocol is definitely improving it too.

@sunsunsun lmao

bump.......

@sunsunsun

do you think the idea would work? I am not 100% on the idea

but it seems easier than buying the powder

@Ibshaver23 said in Low pulse issues:

@Jonk I’ve not, I tend to think my nutrition is top tier. Eggs, oysters, liver, fruit juice, mushrooms, coffee, gelatin. That’s all I eat and it covers almost everything (except b1 and maybe manganese)

Do you think you get enough calcium, enough carbs relative to protein and enough calories, in general? Also, when you say you seem to get unhealthier with more T4, what symptoms do you experience? Could you benefit from more T3 and less T4? A chronically low pulse rate and SIBO does hint at an under-active thyroid, but some people manage to overcome it through diet alone. I wish I were one of them. lol

@NoeticJuice can you describe letting it go?

sr 9011 looks interesting/peaty check this thread out https://lowtoxinforum.com/threads/stenabolic.27227/
a list of its benefits mentioned

All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [R].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production [R, R].

REV-ERB is mainly found in liver, muscle, and fat tissue:

Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) [R, R, R, R].

Muscles: REV-ERB promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria [R].

Fat cells: REV-ERB turns off the genes responsible for storing fat and decreases triglyceride production [R].
In animal and cell studies, SR9009:

Increased oxygen consumption [R]

Decreased generation of new fat cells in the liver [R]

Decreased production of cholesterol and bile acids in the liver [R]

Increased the number of mitochondria in muscle [R]

Increased glucose and fatty acid use in muscle [R]

Decreased fat storage [R]

@brotherwentcrazy
relevant thread https://bioenergetic.forum/topic/6398/psychosis-and-serotonins-5ht2a-receptor-hdac-and-chronic-anti-psychotic-use/4?_=1750496348424

@biolife123 I don't have a solution for you but if you but hope you find one. If you have the have time to answer, what do these ridges feel like? Is it like ravines in your skull of more like the skin and tissues are folding in on themselves (so the ridges are malleable?).

@Ibshaver23 I am so sorry to hear that. Something similar happened to me when I was sprinting and that is why I am hesitant to restart sprinting. I had for weeks pain in the leg (so not as bad as your case) and only a skilled osteopath could reset me and my nervous system.
I did not try progesterone though. In the past I was using progesterone but I had the impression that I was growing manboobs. At your high levels do you not experience that as well?

@Corngold elastin fibers are a main factor to look into restoring too so the skin can keep good form. some enzymes degrade the elastin fibers elastase & a couple of the MMPs are most relevant from what ive read ,
frays & thickens the fibers

so looking for things that target those,
https://pmc.ncbi.nlm.nih.gov/articles/PMC9060010/#ski258-sec-0070
76ea9335-6470-4e27-8578-d6a583ed052d-image.png
things i put in a document:

ergothionene (not from mushrooms because of beta glucan & androgens) , hit 1.5mg copper , hit 3000iu-5000iu Vitamin A, 30 minutes exercise sessions twice a week , 4g total glycine intake (maybe, not really a lack of collagen as problem?) , take 200 mg TUDCA most days to sort ER stress , boswellia (restores cartilage, so fits it restores skin function or prevents it being degraded) https://sci-hub.ru/10.1055/s-0029-1240581 BAs also enhance the metabolism of fibroblasts and, at the same time, they inhibit human leukocyte elastase [24] and hyaluronidase [25], as well as TNF-α-induced transcription, expression, and activity of MMP-1, MMP-3, MMP-10, and MMP-12 in human microvascular endothelial cells [5]. All these enzymes have a key importance in the degradation of the extracellular matrix, collagen, and elastic fibers reverse hypothyroid hypoxia lower H2O2-induced matrix metalloproteinase (lower h2o2) lower neurophil elastase and neutrophil induced metallopreoteinase (lower neutrophil response, il-8) Inhibit MAPK ? (mmp-12 -> mapk -> mmp9) Drink a glass or 2 of OJ a day https://pmc.ncbi.nlm.nih.gov/articles/PMC5791357/#Sec14 keep inflammation (macrophages) low , if need more, support fibroblasts

@PissBoy I haven’t but it does enlarge during the higher estrogen part of my cycle. So that’s a good point.

@eduardo-crispino you mean Sam Harris! Yes that was hilarious.