I take 0.5mg lithium orotate from time to time and it helps with panic attacks. If I take it more that twice a week it seems to lose it's effect.

I have high whole blood histamines and from what I've read is that high histamine causes high glutamate activity in the brain. Lithium helps to dampen a glutamate storm from what I understand (I'm no expert). If I feel my head getting hot, panic setting in and uncontrollable rumination, Lithium helps with that. If my anxiety is more of a "body high" with heart palpitations, it doesn't help with that.