@jamezb46 Interesting thank you.
"The 17b-hy- droxy-2-oxaestra-4,9(10)-dien-3-one analog
(III) showed a similar large increase in myo- trophic activity and enhancement of androgenic potency. The 17a-methyl-2-oxa analog (IV) was by far the most potent compound tested in this series, being 550 times as myotrophic and, de- pending on the response organ studied, 22 or 47 times as androgenic as 17a-methyltestosterone."
So my interpretation is that assuming the non-17 alkylated 2-oxa trenbolone has a much lower bioavailability and half life than 17a-methyl testosterone, these results are astonishing, as it can achieve the same androgenic and myotrophic effects despite being poorly absorbed and heavily metabolised by the liver.
And when it is given the same bioavailability and half life as methyl testosterone, via the addition of the methyl group on position 17, it is of course, insane.
Have you got any thoughts on 2-oxa steroids such as anavar? What does replacing the carbon atom with the oxygen atom do?