@VehmicJuryman said in Chris Masterjohn: Salicylates are Toxic:
That would explain why aspirin doesn't help my insomnia
CM advises to take take between 1 - 3 grams glycine to help get rid excess salicylates. Begin with 1 or 2 g. (2 doses of 1 g).
I'd take L-theanine 1 hour before bedtime (150-250 mg).
Aspirin users are at risk of impaired folate status.
https://medicationsandnutrition.com/aspirin-folic-acid-interaction
Inhibition of RFC-1. The reduced folate carrier-1 (RFC-1) transports reduced folate into the brain, and its inhibition will likely result in cerebral folate deficiency. The aspirin hydrolysate salicylic acid is a likely low-affinity inhibitor of RFC-1. Unmetabolized folic acid.
Dihydrofolate reductase enzyme (DHFR) is inhibited by salicylic acid. We can’t then assimilate folic acid. Need bioavailable folate to bypass this handicap. The active form 5-MTHF is required.