@Mauritio It's difficult to do without cholic acid as the most crucial primary bile acid... the conjugated bile acids are protective to fungi yet the unconjugated CA allegedly isn't.
Perhaps this requires to temporarily dial back on any supplemental glycine and taurine in case of fungal issues?
UDCA and TUDCA appear to be rather neutral towards fungi from what I can find.
I'had looked into therapeutic DCA use as well but it's also strongly cytotoxic to human cells. Or perhaps I'm not remembering correctly and endogenous DCA abundance is always being mixed up with a concurrent abundance of the more harmful LCA.
Any way, DCA is tough to get if. I couldn't. Maybe straight from Asia. Supplementation was propagated by a medical practitioner from Eastern Europe who went on to sell the raw powder directly but eventually even that has become suppressed. It used to be available as a pharmaceutical raw material but that has been utterly stomped whilst at the same time it's still classified as a pharmaceutical so it's illegal to import.
Still available for lab and research use, however, if you can buy it via a certifiably appropriate company.
Obfuscations and intransparancies everywhere one goes or looks.
Peak serum levels of FCy/5-FC came in just under the therapeutic optimum.
Therefore raising it to 118mg/kg BW for the last week which by linear extrapolation should push peak serum levels up to a solid 62 µg/mL.
@Mauritio said in Bile can serve as a reservoir for funghi, making them harder to treat:
The main reason for taking tudca is to thin the bile and support the liver - gallbladder axis. That seems to be the bottleneck for me.
In the past I had notable success with that, but not anymore. A mild version of the "liver/gallbladder cleanse" olive oil/grapefruit juice blend but without the Mg-SO4 really unclogged things and whilst gentian and taraxacum are the basic cholagogics I believe tincture of gold coin grass aka Lysimachia aka Jin Qian Cao or glechoma hederacea was a profoundly effective addition back then, too.
