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• Bioenergetics Discussion

  Place to discuss the work of Ray Peat, Otto Warburg, Albert Szent-Györgyi and the interdependence of energy and structure

  Literature Review Ray Peat Resources Not Medical Advice Products The Kitchen The Gym
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  @Gaston said:

  What about ornithine a-ketoglutarate?

  Good find. I can't wrap my head around it all atm so maybe someone else may elucidate.
  I remember ornithine works for scavenging/converting ammonia to urea and that less ammonia spares a-KG for more energy from the TCA. Then ornithin-aKG could be doubly beneficial.

  It would be great if anyone can find the equivalent study to this study Intermediary metabolism of the human hair follicle but done on the dermal papilla.
  According to this ex vivo/in vitro study the human hair follicles (and skin) mainly rely on

  aerobic glycolysis of glucose, i.e. predominantly foregoing mitochondrial oxphos which only accounts to about 10% of all the glucose used up. energy from glutamine by peripheral consumption of circulating amino acids or protein catabolism.

  So glutamine and glucose seem to be an equally important energy substrates for hair follicles.
  Replacing the 1% glucose with 1% L-glutamine may be an option. Or using both L-Glut and glucose in combination, which in the study above lead to much higher follicle ATP content than only glucose (in case that higher ATP content is a good thing and not sign of a backlog).

  Yet I'm thinking that feeding other substrates (like a-KG) directly into the mitochondrial TCA of skin or hair follicles could unleash significant, additional metabolic energy capacities.

• Case Studies

  Discussion of individual human or animal cases. "There is no foreseeable limit to the qualitative development of the economy." - Ray Peat, Generative Energy

  Experimental Logs
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  @GlucoseGal of course, wish you the best. Honestly, I wonder if a lot of people who come to the Peat space take baggage from past dietary ideas with them — my insistence on fat for satiety from my carnivore days definitely contributed to weight gain — but if I had just put less butter in my rice and ate more rice and less chocolate, I don’t think I’d have gained 40 lbs Peating — and of course I got on actual thyroid meds (not glandulars) well after the weight gain.

• The Noosphere

  Discussion of culture, literature, and politics

  Art Current Events Bioenergetic Development Philosophy Esoteric, Paranormal, & Consciousness
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  "lol" - this subject and anything derived are not funny. "they" aren't doing anything.

  I and others have left a number of sources in other places alluding to the potential for behavioural and therefore perceptual consequences of inhibiting angiotensin conversion. This phenomenon isn't unique to the vaccine you're referring to, as it can also be found in traditional blood pressure medications.

  It's also not immediately unique to that mechanism allegedly targeting that virus. As the proposed target for a "H5N1" vaccine is also likely to have consequences for that system (1, 2). In fact, they probably all do.

  Most importantly. We know the RAAS has homeostatic set points that move naturally through life, but also as a consequence of our behaviour, probably our reception of the behaviour of others, and definitely pharmaceutical interventions. Perhaps also other (currently) less tangible things.

  @ThinPicking said in Tell me your opinion on the covid vaxx:

  go running or swimming a few times and continue eating like a horse

  There is a reason this would be a good idea for you. So do it.

  @ThinPicking said in My thoughts on Le Great Reset:

  Get a hold of yourself.

• Meta

  Conversations about Bioenergetic Forum

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  The connection between coffee, Lawsonibacter, quinic acid, and other microbe-derived metabolites could be how coffee might be exerting its beneficial effects.

  Coffee consumption is associated with intestinal Lawsonibacter asaccharolyticus abundance and prevalence across multiple cohorts (2024)

• The Junkyard

  Off-topic or unclear threads sent here. But dig around and you might find some gems.

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