@functionalgirl - Bruce Ames explains the need for folate in this video linked below. I found his explanation to be quite memorable (after all these years). It ties into red blood cell, radiation and cancer. The full story in the video is about 14 minutes long.

https://youtu.be/ZVQmPVBjubw?si=4d1_lMnYnyxV_9aC&t=492

It was good for me for a few days, but then I suspect it irritated my intestine. Must be taken with plenty of food. It also lowers blood sugar.

@foxgelb Makes no sense to me either, just reporting the news.

I'm guessing illegitimate operations (apparently it's too easy to create a pharmacy in Mexico), then substances from suppliers who offer something that will provide some feeling that's far cheaper than an actual lab compound like t3/t4 (say they wanted to scam you with something that gives some excitatory effects but diluted enough to not attempt to harm you).

@sphagnum said in Are Nuts In Their Natural State Used Differently By The Body Than Their Processed Oils?:

@Butter-Girl
Are you asking about how the body uses specifically just the oil in the whole nut, as opposed to the pure oil after processing? Or are you asking about how it uses everything else in the nut as well, like the fiber and protein?

Since I'm uncertain of the exact question at hand, I'll give some general info and hope that it manages to answer in some way.

Just about any nut (or seed) oil that is processed for consumption as a food is going to be almost all polyunsaturated fatty acids (PUFA.) Exceptions that I'm aware of would be macadamia nuts, and palm kernel oil. To avoid any confusion, some other food oils that are not mostly PUFA are coconut, palm, olive, and avocado oils, but these all come from the fruit flesh of the plant and not their nut/seed.

just a heads up about the avocado oil; Ray Peat warned about the toxicity of avocados here: https://raypeat.com/articles/articles/vegetables.shtml
"Not all fruits, of course, are perfectly safe--avocados, for example, contain so much unsaturated fat that they can be carcinogenic and hepatotoxic."
from the references: In Vivo 1998 Nov-Dec;12(6):675-89. "The promotive tumorigenic effects of other high-fat diets (avocado, soybeans) were associated with high content of some polyunsaturated fatty acids (linoleic and alpha-linolenic)."
also: Ann Nutr Metab 1991;35(5):253-60. "Effect of dietary avocado oils on hepatic collagen metabolism. Wermam MJ, Mokady S, Neeman I Department of Food Engineering and Biotechnology, Technion - Israel Institute of Technology, Haifa. The effect of various avocado and soybean oils on collagen metabolism in the liver was studied in growing female rats for 8 weeks and in day-old chicks for 1 week. In comparison with rats fed either refined avocado oil, refined or unrefined soybean oils, rats fed unrefined avocado oil showed a significant decrease in total collagen solubility in the liver, while there were no changes in total collagen, protein and moisture content. Chicks fed unrefined avocado oil as compared to those fed refined avocado oil also showed a decrease in hepatic total soluble collagen while hepatic total collagen remained unaffected. Electron micrographs and light-microscope examinations of rats' liver revealed collagen accumulation in the periportal location. This is suggestive of the early stages of fibrosis."

PUFA, even when not processed, is prone to oxidation, which is in large part why it is often considered toxic to the body. Extracting the oil greatly increases its surface area exposed to oxygen, thus making it much worse in this sense. However, even whole nuts are going to be exposed enough to risk rancidity.

The problem with PUFA is that it is highly susceptible to oxidation after it is eaten. Chew up some nuts, even nice fresh ones, extract the oil from the chewed mass, get it into the blood stream that is 98.6 degrees and highly oxygenated and that oil will oxidize.

@brad

Thank you!

This is not asking for medical advice. Wrong channel.

@happyhanneke my understanding is that some people have trouble converting T4 to T3 in the body. For example if you have bad liver health. This may be a reason to take T3 without T4.

@wrl thank you!!

@Imprtr11 purple panda

@Imprtr11 What are they?

@happyhanneke I tried a mag glycine version and actually slept amazing for the first time in forever. Worth a shot even if it was just a fluke

@madmac unrelated but what has been your experience with taking DHT?

@LucH
Ok thanks I see

@AndrewPeatMatrix This one may also be of interest:
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

@idealabsrat glycine induces sleepiness

taurine would be better in my opinion

@mostlylurking said in Endotoxin Inflammation Stack:

@Butter-Girl said in Endotoxin Inflammation Stack:

@LucH said in Endotoxin Inflammation Stack:

Some target points to deal with

B1 is needed for communication between the brain and the stomach (vagal innervation).
High dose B1 is needed for passive assimilation, with staples. I’d take Mg bisglycinate every day (300 mg x 2 or x3, according to stress); and B2 50 mg (every other day, thrice a week). B2 is needed when taking B1. B1 for gut motility
Dr Costantini and bacterial overgrowth
SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? – June 2020
https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/
To understand how thiamine impacts gut function we have to understand the GI tract. The GI tract possesses its own individual enteric nervous system (ENS), often referred to as the second brain. (vagal innervation). Enteric neurons also use acetylcholine to initiate peristaltic contractions necessary for proper gut motility. Thiamine is necessary for the synthesis of acetylcholine and low levels produce an acetylcholine deficit, which leads to reduced vagal tone and impaired motility in the stomach and small intestine.
=> choline or glycine needed.
For Dr. Constantini, a chronic thiamine deficiency can indirectly produce an inability to digest and absorb foods, and therefore produce a deficiency in most of the other vitamins and minerals. In fact, this is indeed something I see frequently. And sadly, as thiamine is notoriously difficult to identify through ordinary testing methods, it is mostly missed by doctors and nutritionists. To summarize, B1 is necessary in the gut for:
 Stomach acid secretion and gastric emptying
 Pancreatic digestive enzyme secretion
 Intestinal brush border enzymes
 Intestinal contractions and motility
 Vagal nerve function
If I have problem to digest protein, Betaine HCL, at the evening meal. Digestion is optimal at midday.
If I have problem to digest fats: Enzymedica Lypo Gold for fat digestion.
Note: you’re not going to solve this kind of problem with 100 mg B1. Passive assimilation is needed when targeting High dose B1, in several staples, not only with B1 HCl. I can give a link for the protocol of Dr. Allil Overton, on my forum, if wanted (“mirzoune et ciboulette”)
Dr. Overton says, when talking about Thiamine (nod need to listen to):
https://www.hormonesmatter.com/talking-about-thiamine/
“Thiamine (vitamin B1) is critical for the metabolism of food into cellular energy or ATP. Without sufficient thiamine, cellular energy wanes, and with it, the capacity to maintain the energy to function declines. Chronic, unrelenting fatigue is a common characteristic of insufficient thiamine. At its root, fatigue is the physical manifestation of poor energy metabolism.
Why is this nutrient such a problem? Two reasons. First, B1 is the gatekeeper to energy metabolism and so if it is low, everything downstream gums up and does not work well. Second, modern diets, medicines, and other chemical exposures contain numerous anti-thiamine factors that derail thiamine absorption and metabolism. This pushes many people into states of chronic deficiency, one that is simple to correct if identified. Unfortunately, however, patients can go years before the deficiency is recognized.”
Additional info
Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?
Elliot Overton – Nutrition and Functional Medicine – 2019
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo Thiamine deficiency - A consequence or cause of SIBO? How can thiamine deficiency cause gut dysfunction?
Key points:
Thiamine's key role in energy metabolism of the brain regions responsible for controlling autonomic balance, coupled with its role in acetylcholine synthesis, indicate that a deficiency could easily cause the symptoms which we associate with SIBO.
The autonomic nervous system is involved in:
 Secretion of stomach acid, pancreatic enzymes, and brush border enzymes
 Release of bile from the liver
 Maintaining regular intestinal peristalsis (motility)
 Reducing intestinal permeability (leaky gut)
 Reducing inflammation

I take 150-200 of Lipothiamine daily in addition to a B complex. How much B2 is necessary to take with this?
My B- complex has 50mgs. in it.

I think the amount of B2 needed is tied to multiple things. For example, I do take B2 because I high dose thiamine hcl, but I also was having some eye trouble: cataracts, floaters, difficulty focusing. I've been taking about 100mgs of B2 four times a day for the past 3 years. I believe this is the reason for my greatly improved eye health, including the improvement in the cataract situation. See here: Riboflavin: The Health Benefits of a Forgotten Natural Vitamin
"Cataract formation is a result of protein aggregation which causes the lens to become cloudy. RF intake from food and supplements was associated with decreased risk of nuclear lens opacities [81]. Cataract formation in the general public seemed not to be associated with RF deficiency while in the elderly it might be increased due to a RF deficiency [82]. High dose of RF, 400 mg/d, appears to have a preventive effect or some beneficial effects on the development of age-related cataracts [3]. RF concentration influences the GSH concentration in the lens, while GSH protects the lens against oxidative damage and cataract development. In total, 80% of the cataract patients showed a shortage of RF [83]. "

Here is another article about riboflavin that might be of interest: A newly discovered anti-senescence function of vitamin B2
"The research team discovered a phenomenon whereby resistance to cellular senescence occurred as a result of increasing the amount of SLC52A1 produced. SLC52A1 is the protein responsible for transporting vitamin B2 into cells (vitamin B2 transporter). When SLC52A1 production was increased, cellular senescence did not occur immediately even under stress conditions (where human cells were treated with a drug to injure the DNA and induce aging). Following on from this, the researchers conducted an experiment where they exposed the cells to stress and then increased the amount of vitamin B2 in the culture solution. They found that resistance to senescence increased in accordance with the amount of vitamin B2 in the solution. Inside the cell, vitamin B2 is converted into a substance called Flavin Adenine Dinucleotide (FAD), a coenzyme that promotes the chemical reactions necessary for biological activities such as energy production. In fact, the amount of FAD in cells exposed to stress increased, which resulted in the vitamin B2 that had been transported into the cells to be converted into FAD, thus suppressing senescence."

Interesting information thats good to know.

taurine

b complex

zinc/copper/selenium/iodine

coconut oil

Aspirin thins out the blood effecting Vitamin K, maybe try to supplement it if you aren’t already to thicken the blood