@lykos, what LucH said. Along with fatigue and poor copper metabolism, having low iron despite adequate intake is another sign of an under-active thyroid. Despite my intake of iron-rich foods like red meat and supplementing with food-based iron, my ferritin was down to 6 and didn’t budge until I started taking thyroid (Armour). I was also diagnosed with mold toxicity and gut dysbiosis (SIBO), which cleared up when I targeted my thyroid. To rule out your symptoms being thyroid related, if you haven’t done so already, you may find it useful to track your temps (including extremities) first thing in the morning, and before and 20–30 minutes after you eat, and also your pulse rate, for two weeks. And in case you haven’t read it, here is Ray Peat’s article on TSH, temperature, pulse rate, and other indicators in hypothyroidism:

https://raypeat.com/articles/articles/hypothyroidism.shtml

@RandomUser I’ve tried both and think it’s worth trying both Cynomel and Tyronene. Ideally crush (pulverize) Cynomel then start off with no more than about a 1/16th of the powder with food and only very gradually increase the dose.
Cyproheptadine initially will make people sluggish or sleepy coz it reduces the stress hormones. Once (after weeks or months) the proper hormones start kicking in, eg thyroid, then it’ll still be working but not making you so tired.
As far as the aspirin maybe try starting taking it in smaller doses and not on an empty stomach. Taking it with baking soda, diluted in a little warm water, with gelatin or caffeine might also be things worth trying.
I’m cautious about MB and have only .once or twice tried a small dose because of Ray’s caveats. So can’t really tell any thing about it. I might try a little again at some point if i run out of other things that work.

@lobotomize-me said in "The dopamine system of healthy, highly creative people is similar to that found in people with schizophrenia":

antipsychotic medicine increases D2 density and lowers dopamine, so one can argue that high baseline dopamine reduces D2 density

BTW, I had some doubts about the statement above, so I've asked gpt to refine it...

"Antipsychotics block D2 receptors, which can lead the brain to upregulate D2 density over time. This suggests that the brain responds to dopamine levels dynamically: when dopamine signaling is low (due to receptor blockade), D2 density may increase; when dopamine signaling is chronically high, the brain may compensate by reducing D2 receptor density. Thus, baseline dopamine levels may influence D2 receptor availability through feedback mechanisms."

@Osteo said in Coffee and AMPK:

That's why I'm confused reading articles about how coffee diminishes cerebral blood flow... Or how coffee changes behavior..

Context matters.

Coffee is beneficial if you maintain a proper diet and a healthy lifestyle.

For someone (most average people?) who eats junk food, fast, or does keto, and undersleeps, coffee may be problematic...

@lobotomize-me - Reuteri yogurt is a very good suggestion. I have been making it since Nov 2023. I have it for breakfast.

@gg12 - There are videos on YouTube describing how to make the Reuteri containing yogurt. Search YouTube for "SIBO yogurt".

The theory behind how and why it works for SIBO is that pharmaceutical antibiotics can permanently disrupt the balance of bacteria in the GI tract and the naturally occurring reuteri that resides in the small intestine is one of the bacterial species that is permanently lost (along with other species). The imbalance of bacteria creates a situation that allows bacteria that normally only reside in the colon and large intestine to spread or "overgrow" into the small intestine, thus the term SIBO (small intestinal bacterial overgrowth).

The reuteri yogurt reintroduces the lost species and some balance is restored. Digestive issues associated with the imbalance are resolved within about 30 - 45 days. Unfortunately, if you stop eating the yogurt the digestive issues return over time.

@BearWithMe said:

what CT means in this context

Calcitonin, in the context of (GI) hormones.
Running celiac diagnostics makes sense.

@Hando-Jin i could have gone on forever but i stopped after 2 months so i can go out and eat with friends again but i will probably continue with near 0% fat diet for the rest of my life when i can

many shaving creams use palmitic and stearic acid in them so that may be a accessible source for transdermal application

@gg12 said in Receipt protection ideas?:

I may finally get a job

can I talk you out of it

I’ve just started taking shilajit again this week after a long break (I honestly forgot about it for some reason), and it’s put me in a really social and calm mood, something I’d compare to phenibut. It improved my soccer performance, confidence, humorousness and overall calmness, giving me that “no fucks given” type of assertiveness. . This isn’t the first time it’s happened to me with shilajit, I remember it being so effective that I tried cycling off it during the holidays (to prevent tolerance when i really need it although i never got any tolerance build up to it ) and then just completely forgot it even existed.

i am hoping this first week wasn't just a honey moon effect. i will keep yall updated

interesting posts about shiljat: https://lowtoxinforum.com/threads/anyone-try-shilajit.18326/post-990710

https://lowtoxinforum.com/threads/anyone-try-shilajit.18326/post-990816

@schemingfonzie said in A histamine answer?:

Is there a worry of taking in too much magnesium?

Too much, not really except it could become laxative.
One exception more: if your vitamin D is not right (min. 35 ng/ml; 45 ng target), do not take more than 420 mg Mg element a day, until you reach your target. Exception if it's a cure (so, ok, because limited in time, when a nervous problem arises).

@BearWithMe, you’re welcome.

@user2, I meant to ask you, when you mentioned highest well-being and energy state, would you mind sharing what foods work best for you to put you in that state? I’m curious if they’ve changed since you last shared and if you’ve found any new fruits that are working well for you.

@Corngold Yes it could be SIBO. Or maybe you are getting too much of the "wrong fibre" or some other compound in your diet that is causing the bloating. For instance some people have a hard time digesting fructose and fructans found in garlic and onion and wheat.

I am really no expert on SIBO and it seems very individual how to best tackle this issue. Antibiotics have always given me good results, but often the postive effects wear off over time. I think figuring out which foods are ok, and which ones are not, is really important and that depends on individual sensitivities/allergies, nutrient deficiencies, gut microbiome, etc...

@anub
Hi,
Things to be taken into account.

Don’t trust blood test with results if you’re borderline. Trust your feeling. How to manage is another problem. When modifying the dose, the connection between the brain and the thyroid requires 10 days to adapt.
Get informed on deiodinase action too because you could lack some useful nutrients like iodine, magnesium, or event zinc if you don’t eat meat.
If you eat carbs from cereals at 3 meals, you lack thiamine (B1).

From Google AI:
Thiamine (Vitamin B1) impacts dysautonomia by being essential for energy metabolism in nerve and muscle cells, and its deficiency can cause or mimic autonomic nervous system (ANS) dysfunction. Symptoms like fatigue, dizziness, and muscle weakness, seen in thiamine deficiency, also occur in dysautonomia. Correcting a thiamine deficiency with supplementation can lead to significant symptom relief in some dysautonomia patients

See Elliot Overton (nutritionist) if you want confirmation on dysautonomia (3) and Dr. Antonio Constantini (neurologist).
Note that some people aren’t suffering from what we call a nutrient deficiency but from a metabolic block. Dependent-B1 enzymes are blocked / inactivated due to some “stress factors” (see figure): chemical and environmental toxins, chronic inflammation and infection.
Figure: Thiamine-dependent enzyme blocked in the metabolism
Thiamine-dependent enzyme blocked.png
KGDHC = α-ketoglutarate dehydrogenase complex = dependent-B1 enzymes.
Credit: Elliot Overton (nutritionist) and Dr. Antonio Constantini (Italian neurologist)
Warning: When taking high dose thiamine, there is a protocol to follow. There is interaction with other vitamins. For example taking 100 mg, then afterwards 500 mg of thiamine (the TTFD kind is advised for the brain penetration) will deplete the other cofactors involved in the assimilation of thiamine.
Useful links

Taking T3 and T4 synthetic supplement improves metabolism for a while
https://mirzoune-ciboulette.forumactif.org/t2108-english-corner-taking-t3-and-t4-synthetic-supplement-improves-metabolism-for-a-while#30193
=> Roles of deiodinases. Required nutrients for thyroid health. Time adaptation is required
=> "Since the body normally produces about 4 mcg of T3 in an hour, taking 10 or 20 mcg at once is unphysiological" - Ray Peat
“With too much t3 the liver starts converting any T4 into reverse-t3”. - Ray Peat Brain Regions affected by thiamine deficiency
How to Apply High-Dose Thiamine Protocols in Clinical Practice: Part 2
Practical Guidance
https://www.youtube.com/watch?v=RFZUzS_xP9A
EONutrition – Elliot OVERTON (nutritionist) (multiplex) – Part 2 – Video 2:04:02
This is the second of two lectures I gave to a group of medical/health professionals on the clinical application of high-dose vitamin B1. In this video I outline the difference between nutritional deficiency and the concept of "functional dependence". I then discuss the practical aspects of forming a protocol including: - Which form to use and why - How to dose for different conditions - When to use this therapy and when not to use this therapy - Managing patient side effects.

*) 10 hallmarks of the video
0) 1.45”: recap of part 1.

07.059”: Basic Definitions 08.21”: Nutritional Deficiency 08.40”: High Calorie Malnutrition 11.12”: Functional Dependency 29.49”: Symptoms of B1 Deficiency 32.22”: Therapeutic Use of B1 34.40”: Forms of Thiamine Can You Use 45.05”: Peripheral Neuropathy 47.12”: Disulfide Derivatives 49.47”: Heavy Metal Chelating Ability

*) The Art and Science of Mega-Dose Thiamine Lecture: Part 1 – Video 1:34:21
https://www.youtube.com/watch?v=-Uf1D2KdTn0
EONutrition – Elliot Overton (nutritionist)

I have not raised low cholesterol. This article has suggestions for lowering cholestrol and if by happenstance you are doing those things then you might consider changing.

50fa52ed-319e-4712-8517-5807020cd15d-image.png

Functional Foods for Cholesterol Management: A Review of the Mechanisms, Efficacy, and a Novel Cholesterol-Lowering Capacity Index (2025)

@Ilias-Ant

Do you take any type of thyroid supplement? I can’t say for sure what’s going on, but if you are unable to tolerate sugar it is unlikely that your metabolism is thriving. Whatever kind of infection you have is likely impairing your metabolism, while also being a symptom of low metabolism. Someone with a high metabolic rate is not very susceptible to bacterial or fungal infection.

In addition to thyroid supplementation, eating the carrot salad daily would probably beneficial.