@fucker I and several others have cured it with topical caprylic acid triglycerides.

The future is here.

Futurama Suicide Booth
https://youtu.be/Y5qQxkrfcjY?si=eC9ACKJK1ML_cmlb

The synthetic stuff is with downsides. Just eat whole foods. Medium rare (at least) beef organs. Heat reduces B12 content significantly, this is very often neglected.

@DavidPS https://bioenergetic.forum/topic/3294/interview-with-r-peat-about-pregnenolone-dosing

@Insomniac Well, sodium is a lighter element, so if we're taking about making a co2 bath then the difference in molar mass might start to become significant especially from a cost perspective over time.

@yeehawyinzer Do you sweat in summer? I don't sweat a lot most of the time even in the gym, but I sweat a lot if I workout in summer. Also have you tried walking more than 1h? It makes me sweat more than working out.

@Fructose Additionally, the notion of maintaining a constant equilibrium in a complex system is open to question. The system is in a state of constant fluctuation, moving in and out of equilibrium. Consequently, the assumption of true equilibrium may be invalid. The equilibrium of a complex system can be readily disrupted by a multitude of factors.

With regard to CO2, it seems plausible that it functions as a stock-flow principle, analogous to a process such as pregnenolone from a technical standpoint. The body accumulates CO₂ to an optimal level, thereby facilitating the attainment of equilibrium within the system. Furthermore, evidence suggests that CO₂ is sequestered in bones, which lends support to the hypothesis that the body is constantly striving to maintain an optimal level of CO₂ within the system.

Haidut makes a topic spray that has aspirin in it and caffeine and maybe niacinamide I believe. Ok I looked it up. Idealabs
Called Solban.
Niacinamide / Nicotinamide - 40 mg
Caffeine - 10 mg
Salicylic acid - 10 mg
Succinic acid - 10 mg

It’s in like a mist spray bottle.

@GRay, my pleasure. 🙂 The results of your experiment are very interesting. Thank you for sharing! I take thyroid right before my meal or during it—I oftentimes remember to take it after I’ve started eating—and I take my last dose around 7 pm and go to bed around 10 pm.

@DavidPS thanks I sent you a request .

@NNight said in Carbon Monoxide Poisoning from Heme Oxygenase Breaking Down Hemoglobin:

I don't know if it will be useful to you (you've already been there and done that), but TonEBP/NFAT5 activation could help deactivating HO-1:

We found that TonEBP is a potent suppressor of HO-1 in human and mouse macrophages.

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00850/full

The FXR might help too to rebuild heme:

FXR orchestrates the expression of multiple heme biosynthetic enzymes. Finally, human HepG2 cells and primary human hepatocytes treated with obeticholic acid, showed increased expression of several heme biosynthetic genes.

(In the liver...)

https://pubmed.ncbi.nlm.nih.gov/37695073/

Seems like the directions would be complicated, or materials not easily available. But thanks.

@LucH first sentence I do not understand. Second, if you think I have kidney stones why say it in greek? On oxalates: I do not think that is an issue for me, I consume little of it, and if I consume I feel ok, seems fine. Lastly, if I was to have a problem with oxalates isn't that related to the kidneys more than liver?

More likely is I have gallstones (cholelithiasis).

@sphagnum Really interesting, thanks for sharing. I’ve had zero starches for a week now and feel like I’m dying. It’s truely a struggle to get enough calories. Might try a little of your approach with the starches.

@Uncover said in Open-label trials - how is this allowed?:

The most fun part about it is there is awlays something to learn even when I think im almost done I find a new part of the puzzle

Yeah, I've similar feelings here - it's probably nested like a Russian doll... One can think that he is out of the cage, but then turns out one is still inside a bigger cage... 😉

& @MarkusAllenUSA
Regarding Open-label trials - besides what has been already written - and I agree with, another reason is that they are simply cheaper... And knowing that double-blind study can be sophistically manipulated too, then what's the difference? 😉

https://medium.com/@vohchenwei/the-risks-and-realities-of-data-manipulation-in-clinical-research-a-critical-analysis-for-medical-aea5d9207887

Especially knowing that today most researchers are not aware of the limitations of their own work... Ray wrote about this:
https://raypeat.com/articles/articles/authoritarians.shtml
https://raypeat.com/articles/articles/adaptive-substance.shtml
https://raypeat.com/articles/articles/intuitive-knowledge.shtml

@yerrag Sorry to hear about your troubles, I wish you well and a quick recovery!

Never trust GenAI about nuanced, subtle, or fuzzy topics. GenAI doesn't think or reason; it just makes statistical inferences between words.

In technical terms, fennel seeds can increase serotonin, but practically not - the amounts are insignificant!
(It is about weak MAO inhibitions)
https://pmc.ncbi.nlm.nih.gov/articles/PMC3521852/

The most probable mechanism is significantly increasing GABA, which should help with deep sleep.
https://ppj.phypha.ir/article-1-664-en.html

BTW be careful with fennel it can also increase estrogen...

Substances known to potentially lower serotonin: S. Boulardii, lavender, Shilajit, beta-alanine, Ca, Mg, glycine, lysine, Tyrosine/DLPA + BCAA, Aspirin, vitamin B9, B1, quinones, caffeine, creatine, Schisandra, inosine, theanine, propolis, Siberian ginseng, PRL-8-53, LSD, and Manganese; avoiding PUFAs…

Two more months have passed. Healing from the thing in September was very slow, until I realized cutting down on nicotine was a good idea. Now limiting nicotine to after eating.

Still not doing great, my body just doesn't seem to function very well. Trying to reintroduce things (like ketchup) made some symptoms come back, and then it's back to slow healing from that. At least now it's obvious that gastritis has been a problem all along.

Definitely not doing as great now in fall and winter, although B vitamins seem to keep me going somewhat. No appetite, losing weight, no libido, barely enough energy to keep up with I need to get done, let alone having any energy to enjoy my free time. Is chronic gastritis enough to explain most of this, I don't know. Feels a little bleak.

Considering trying an H2 blocker, just accepting being exposed to the excipients.

A good thing is eating soft bland food has practically gotten rid of the constipation problem. I had been eating carrot salads for a long time out of pure inertia but they were actually constipating.

Endoscopy coming up in a month.

I developed visual snow a month ago after around 3 months of adding 1g L-Pyroglutamic Acid, Kestose, and Dioscorea Nipponica. I'm still dealing with it, and it seems to fluctuate in intensity. Sometimes I can read things well enough, other times I struggle. I'm still trying to pin down the cause and confounding factors.

My guess as to what caused mine was the L-Pyroglutamic Acid supplement increasing glutamate too much, the only other thing I can suspect are gut issues from the Kestose or liver issues from Dioscorea Nipponica which contains protodioscin just like Tribulus which is known to be hard on the liver as well. The only other possibility is that this is some sort of COVID after effect, as a family member had a confirmed case just before this occurred, though I never tested positive.

@haidut Any experience or input with these type of symptom, especially in relation to pyroglutamic acid?

We should really dig into this more, since like PFS at one point, there seems to be little information as to what can cause this and what relieves it specifically.

@DavidPS Holymoly

@cs3000 said in Muscle twitches/acute “cramps”. Help appreciated:

@ejmcc27 generally a sign of lower atp / hypoxia (eyelid is very common place to get twitches 1 area that shows hypoxia & hypothyroidism obviously, e.g darkens or droops down, with very high usage. atp is used in reversing muscle contraction, with twitches the muscle is failing to stay in the relaxed state),
could try stopping vitamin D and limiting UV light for a few weeks to confirm if its that making it worse. thats what i found. + eating more calories if you have low intake (fat release of stored vit d otherwise). in poor health vitamin D can excessively convert to a form that inhibits mitochondria. it could be from a range of things causing the hypoxia / lower atp though

I don’t believe/show signs of being hypothyroid. But will try to limit vitamin D and see what happens.