@Abaris Good idea, though the morning groginess might not be overcomable with modafinil. Not sure though

Useful info on LPS toxins (in French, translator required) Excerpts Comprendre les endotoxines LPS – Comment moduler la réaction immune Understanding LPS endotoxins – How to inhibit LPS endotoxins https://mirzoune-ciboulette.forumactif.org/t2003-inhiber-les-endotoxines-lps#29343 https://mirzoune-ciboulette.forumactif.org/t1161-effets-protecteurs-du-cholesterol-sur-les-endotoxines?highlight=endotoxines (with RP comments and forumer’s comments) Carpooling for the transfer of LPS endotoxins. How to mitigate the reactive response to LPS toxins. Beneficial substances, antagonists of TRL4 molecules, thus blocking LPS-induced signaling (neutralizing the inflammatory response). Favorable context (thyroid and cholesterol conversion, Vit A D & E, riboflavin, niacinamide, butyrate, other protective factors against cell excitation, like red light therapy or appropriate levels of carbs and fats). With studies to justify. Understanding the dual role of LBP, keeping host infection under control. => Mechanism of action of LBP (The lipopolysaccharide binding protein) LBP has a dual role in immune responses based on its concentration: at low concentrations, it enhances the immune response by transferring LPS (lipopolysaccharide) to receptors like CD14 and TLR4, which triggers an inflammatory cascade. Conversely, at high concentrations, LBP may inhibit LPS-induced stimulation, helping to dampen excessive inflammation and promote LPS clearance, thus acting as a regulator of the host's innate defense.

Try the topical red dicopperoxide. Or better yet, topical Cu(II)-(acetyl salicylate)2. Association /= causation. Estrogen is elevated to increase copper availability through enhanced ceruloplasmin synthesis and cellular copper uptake transporter. Women after menopause accumulate iron without being replete in copper to compensate for this wrt to their ferroportin 1 and superoxidedismutase etc. In lab models rosacea is typically induced by administration of the antimicrobial peptide LL37. LL37 of course is a product of D3 isomerization to 1,25-OH-D3 and IFN-y to tackle infection or as a response to significant endoplasmic reticulum stress. Therefore it may just be a convenient but replacabe means for inducing local inflammation at the intracellular level. Anyhow it's amazing how much nonsense RP blasted out sometimes in a potpourri of the usual keywords and how he was all about the dangers of PUFA and iron and even in that linked article above mentioned that "it can spread the damage to other components of the mitochondria, including the cytochromes and the polyunsaturated fatty acids" but never once pointing to copper which is necessary to control the intracellular iron accumulation, the ferrophagy, the Fenton reaction, the resulting lipoxidation, the conversion to iron's safe and stable Fe3+, the folding and stabilization of the fatty acids for cytochrome c, control blood viscosity through keeping Factor VIII in check and last but not least of course the collagen and elastin crosslinking to maintain sufficiently thick and supple skin. as for iron overload, impaired mitochondrial function, impaired cytochrome C and the mentioned functional oxygen deficiency enjoy: [image: 1767922888306-upload.jpg] from https://ashpublications.org/blood/article-pdf/48/1/77/579793/77.pdf

@sunsunsun said in Supplementation of L-Citrulline and Glutathione: @engineer im considering eating one of those mini watermelons + some of the rind , apparently it will give like 5g of citrulline Did you do it I can't decide if I should keep using citrulline or not

@sunsunsun These are great finds! Thank you for the helpful reply. I had never heard of the heat treatment, or the weekly fluconozole. Those are both far better options then the daily dosing. For the last five days i have carefully washed my hands to remove any lotion, And then applied colorless iodine to the top of my finger and back of the hand where the lesion is located. I follow this with one drop of dmso, and let it dry. I used this protocol to cure a fungal nail a couple of years ago, and it is very easy and effective. So far i can tell the lesion on my hand is shrinking, and the pain is gone out of it. Unless i press on the lesion, I don't know its there! And it was very much hurting before. If i weren't having such success with the iodine and dmso, i would try heat therapy or order fluconozole. I should say i have done two ten minute red/infrared light sessions as well.

@jamezb46 Well, I used 40mg+ of topical pregnenolone and DHT both dissolved in DMSO for 6 months before the cycle began, and I didn't notice any change in my testicles or semen then. But I can't compare the two, I didn't experiment them whilst on cycle.

Check out r/steroids they have quite a few cycle logs of DNP use and discussion threads

@Insr ethically tenuous world it seems

honestly for me having good breakfast cereal or pop tart type things works for me

^^^^what he said. He’s always taking about his labs and dropping some numbers, but I’ve never seen them posted, especially not in a comprehensive fashion. Maybe they’re behind a paywall, I don’t know.

@hwisdom It's not artifically fluorinated. It's treated obviously, like all ground water is. Otherwise you would be drinking pebble soup. But yes, it contains an amount of fluoride naturally, that is comparible to fluorinated water. So you are half right, and I take back my comment about you not drinking high fluroide water

@alfredoolivas you didnt read my reply the same way u didnt even read ur own studies, bcus u didnt send 8 u sent 6, literally posted 2 studies two times each but yea anyhow, all ur studies were pretty much done on cell cultures of tobacco, the last one u sent were done on rats, but the first quote was literally "Each of the compounds tested was found to inhibit in vitro brain glycolysis." while u said that aspirin increases glycolosis? u take 200mcg of t3 (for some reason without t4)+ 25mg of nictone and 10x that in caffeine as well as 2grams of test, all of which become super expensivfe and taxing on the body, dont u think that the aspirin was what broke the camels back the 2 grams of test converting into 5ar metabolites are exceptionally expensive since all what estrogen is, is just a safety break on ur metabolism because it can't support having this excessive anabolism, ofc any small amounts of uncoupling would be damaging me personally ion take roids ion take shit barely so I think mega doses of aspirin would be rlly goated for me

@lobotomize this is the issue I was having, the trend seems to be lower SHBG -> /\ free T -> /\ estrogen but the data is just lacking due to low interest

@jamezb46 I agree that lean is the way to go, but achieving fat loss requires that fat be metabolized for energy when in said deficit. I don't know if aspirin may cause a great slowing of this by keeping the switch turned to carb burning. I'm also not sure how much of a deficit is safe without causing issues with thyroid and stress hormones, but that's a whole story I suppose.