For Candida, you need to do a biofilm disruptor + a strong anti fungal, especially If you’ve had it for many years.

@LucH I understand, there is no way for you to assess the unique situation of my father; I was just curious if you cycled this like the others. I appreciate the additional information.

@Luke

@sunsunsun Merci! Below is a summary in case someone in need will be reading this in the future: Introduction Combination of vitamins E+D about as effective as antibiotic for treating bacterial sepsis/infection daily 1-2k IU D3 + 8.75mg/kg (700-800mg) Vit E (d-alpha-tocopherol or mixed unesterified d-isomers of all 4 tocopherols) The tetracyclines protect against sepsis independently of their antibiotics effects Tetracyclines might be the preferred antibiotic treatment (i.e. doxycycline in a HED of 0.25 mg/kg (intraperitoneal route, so orally one would need ~0.4 mg/kg to achieve the same effects) Endotoxin/LPS is a major driver of blood clotting, sepsis, heart attacks and strokes Aspirin (although only acts downstream of the endotoxin/LPS cascade) Substances that can limit the amount of endotoxin/LPS produced and entering the blood: easily digestible food; avoiding “resistant” starches carrot salad, charcoal (*not really applicable after appendectomy) Niacinamide and vitamin E to help restore the gut barrier pregnane steroids (and especially bioidentical progesterone) to directly bind endotoxin in the bloodstream Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate least risky of FAS-Inhibitors is probably orlistat (Still severe side effects) aspirin might be good alternative; adding niacinamide + thiamine might improve its effectiveness against sepsis by improving glucose oxidation and reducing lipolysis respectively Inhibiting fatty acid synthesis reverses bacterial antibiotic resistance Aspirin (80mg-100mg daily) inhibited FAS by +50% Aspirin As A Cure For Sepsis excellent thread https://lowtoxinforum.com/threads/aspirin-as-a-cure-for-sepsis.15753/post-215210 Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis (!) Note: research involved in vitro work only + oral route probably not applicable after appendectomy see Haidut comment Caffene restores lowered cytochrome C oxidase activity + Caffeine restores cytochrome C damaged by sepsis one cup of coffee or about 80mg-100mg of caffeine probably better to do in recovery, not with acute sepsis DHEA Protects From Endotoxin Effects And Lethality single HED dose of as little as 5mg - 7mg DHEA daramatically increased survival of lethal endotoxins DHEA protects from endotoxin (even lethal doses) IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Full interview with Dr. Paul Marik his 2017 paper in question for early treatment protocol Vit C (1.5 g every 6 h for 4 days or until ICU discharge) Thiamine (200 mg every 12 h for 4 days or until ICU discharge) Hydrocortisone (50 mg every 6h for 7 days or until ICU discharge followed by a taper over 3 days) read on the other forum this one failed to replicate, although some studies exist that show somewhat sig improvement https://www.amjmed.com/article/S0002-9343(19)30699-0/fulltext s/o @mauritio T3 levels are a predictor of mortality from sepsis This study (and this one) shows that lactic acid is an independent risk factor for death due to sepsis. CO2 lowers lactic acid, T3 increases CO2. So it makes sense that T3 was so strongly correlated with survival in sepsis patients. -> improve CO2 / lower lactate (thiamin, niacinamide) This study shows a significant increase in survival time of people who take aspirin before hospitalization (by 1.3 days) Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections especially its activated form riboflavin '5 phosphate (R5P) minimum effective human equivalent oral doses for the combination of R5P and valine were approximately 0.2mg/kg and 25mg/kg respectively. This assumes bioavailability of 90% and 70% for R5P and valine. The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy "A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis" Septic Shock: Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock Anti-Serotonin (Cyproheptadine) + Aspirin Famotidine & Anti-histamines Protect Organs In (septic) Shock Both an H2 blocker (Famotidine, Cyproheptadine) and an H1 blocker (Chlorphenamine) were each offered protection Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation s/o Koveras Anti-Serotonin, Cypro, Tryptophan Metabolism, Vitamin C, Hydrocortisone, Thiamin https://lowtoxinforum.com/threads/do-not-forget-to-give-thiamine-to-your-septic-shock-patient.12006/ See also: Haidut on radiation exposure due to x-ray https://bioenergetic.forum/topic/3037/advice-on-lowering-endotoxin/18 https://bioenergetic.forum/topic/2140/any-info-on-sepsis-bacteremia-antibiotics-used/16 Citrulline to restore immune function after sepsis L-Citrulline restores immunity & T Cell mitochondria function acutely highest food sources: 1 cup of red flesh watermelon might have ~150mg per cup. or ~400mg for yellow flesh watermelon https://bioenergetic.forum/post/42939 Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats https://bioenergetic.forum/post/60444 (!) avoid mitophagy enhancers like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. (especially in the initial stage of sepsis) https://lowtoxinforum.com/threads/aspirin-in-the-context-of-endotoxin-tolerance.49865/

@lobotomize said in less salt = more social bell curve?: Coincidentally, when I'm sick, I'm also extremely social Hi, Not the same when you feel tired. Energy is derived towards temperature. Why aggressive when you lack Na? Na is required for osmolarity and balance. Brain function is impaired. This imbalance disrupts cognitive control, leading to irritability, confusion, and reduced impulse control. You may possibly feel as if your were threatened too (survival instinct) if you've already lived such a deficiency.

@alfredoolivas like Ik all of this but im just asking, I have a bag of mk7 that I dont wanna use bcus of its negative effects compared to k1 and mk4, im gonna be needing to take a massive amount of mk7 and more than 150mcg ish has been shown in some cases to be problematic and if Im gonna be taking 4g of aspirin my needs of vit K will go up to the point where this small dose aint enough, but Im just not sure about this whole mk7 thing atp so this is why im asking

@LucH i feel good having 2 cups a day perhaps is the ltheanine in it and small amount of caffeine

@scamp said in Feeling worse in warm weather?: I know warm weather is supposed to provide relief from hypothyroid symptoms Not necessarily. The extra daylight that accompanies warm weather can but with hypothyroidism, the body has a hard time regulating its temperature so both cold and heat, especially heat that accompanies high humidity, can exacerbate symptoms. Prior to supplementing thyroid, I was just as intolerant to heat as the cold and had often overheated to the point of passing out, and Ray talked about how his thyroid shut down when he was in Florida, due to the heat and humidity.

@CrumblingCookie if he's getting those effects from only 10mg then that is weird. Many people take upwards of 100mg and are just fine

LOL, the doctor prescribes three months of anti fungals for something a hot bath will fix!

Have you tried activated charcoal? I’ve turned many people with skin issues on to it, and in my experience skin problems are almost always endotoxin. When I first cured my own issues I used two tablespoons of charcoal in about 8oz of water after meals for two weeks. Now I just pop a few pills here and there if needed, but I’d consider myself cured.

@Abaris Good idea, though the morning groginess might not be overcomable with modafinil. Not sure though

Useful info on LPS toxins (in French, translator required) Excerpts Comprendre les endotoxines LPS – Comment moduler la réaction immune Understanding LPS endotoxins – How to inhibit LPS endotoxins https://mirzoune-ciboulette.forumactif.org/t2003-inhiber-les-endotoxines-lps#29343 https://mirzoune-ciboulette.forumactif.org/t1161-effets-protecteurs-du-cholesterol-sur-les-endotoxines?highlight=endotoxines (with RP comments and forumer’s comments) Carpooling for the transfer of LPS endotoxins. How to mitigate the reactive response to LPS toxins. Beneficial substances, antagonists of TRL4 molecules, thus blocking LPS-induced signaling (neutralizing the inflammatory response). Favorable context (thyroid and cholesterol conversion, Vit A D & E, riboflavin, niacinamide, butyrate, other protective factors against cell excitation, like red light therapy or appropriate levels of carbs and fats). With studies to justify. Understanding the dual role of LBP, keeping host infection under control. => Mechanism of action of LBP (The lipopolysaccharide binding protein) LBP has a dual role in immune responses based on its concentration: at low concentrations, it enhances the immune response by transferring LPS (lipopolysaccharide) to receptors like CD14 and TLR4, which triggers an inflammatory cascade. Conversely, at high concentrations, LBP may inhibit LPS-induced stimulation, helping to dampen excessive inflammation and promote LPS clearance, thus acting as a regulator of the host's innate defense.

@sunsunsun said in Supplementation of L-Citrulline and Glutathione: @engineer im considering eating one of those mini watermelons + some of the rind , apparently it will give like 5g of citrulline Did you do it I can't decide if I should keep using citrulline or not

@jamezb46 Well, I used 40mg+ of topical pregnenolone and DHT both dissolved in DMSO for 6 months before the cycle began, and I didn't notice any change in my testicles or semen then. But I can't compare the two, I didn't experiment them whilst on cycle.

Check out r/steroids they have quite a few cycle logs of DNP use and discussion threads