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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    @haidut

    Are you referring to white blood cells when you talk about PMNs specifically neutrophils, macrophages, and eosinophils?

    As rbc's as rbc's do not have mitochondria.

    As PMNs use respiratory burst to create ROS to destroy pathogens, and this ability protects our body via the innate immune response which when sufficient keeps us from having to tap into our adaptive immune response, which keeps us from having to use b-lymphocytes and the use of antibodies, the use of which involves the highly stressful responses involving allergies and worse, autoimmune complications.

    So, yes, I can see the benefits in having an active and highly functional innate immune system in keeping the body from aging.

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    @Zachs Looking forward to updates, experiments can be fun, and walking (lots) is awesome too 🔬 🚶

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    @GRay said in Do we count gelatin/collagen protein towards total daily protein/macro?:

    this may open another discussion how the biological value of plant protein even if combined, is lower than animal meat, also often less bioavailable due to antinutrients in plans, therefore, protein requirement in this case may increase substantially. Conclusion Gelatin decreases food efficiency and high-quality protein bioavailability in protein-restricted diets.
    Well seen. I won't trust this study. Why? the type or protein used and the way it has been done.
    a) casein induces an immune reaction, by everybody, even if you don't perceive it. The reaction is high by 50% people (cross-reaction with the agglutinin from whey).
    b) collagen contains glycine and proline that are fragile. So, susceptible to be altered in the manufactured process. The experiment has given bad results in the experience: weight loss of the liver in the two cases. A test is not supposed to be done with powder extract to prove anything!!!

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    Has anyone tried making their own D3/K2 DMSO solution?
    What dosage have you tried and what should be the oral/transdermal equivalent?

  • Recipes, food, meal prep, brands. Discuss them all here.

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    From another reddit thread on mushroom supplements and coffee:

    All Cordyceps bioactives are water-solubles. Never combine Cordyceps with coffee or milk.

    Coffee w/caffeine is an adenosine antagonist. Adenosine is one of the main quality markers of Cordyceps. The other is cordycepin, a related adenosine derivative. Cordycepin i.p. is responsible for the energising effects of Cordyceps: it's responsible for the vasodilating and testosterone-inducing properties.

    Milk contains lactose. Lactose binds to polyphenols, rendering them useless. Polyphenols are mainly antioxidants, also present in Cordyceps. They have their own benefits.

    Skeptical of this post because the posters says "coffee with caffeine is an adenosine antagonist."

    From AI:

    Other Notable Effects

    Adenosine levels increase in response to cellular stress, acting as a protective signal to limit tissue damage.

    Caffeine and related compounds act as antagonists to adenosine receptors, which is why caffeine promotes wakefulness by blocking adenosine’s sleep-promoting effects.

    It seems like the argument is that coffee + cordyceps basically means you're nullifying cordyceps because caffeine blocks some of its main structure. In other words just paying for expensive coffee.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    @jamezb46 said in getting super lean sickkunt:

    @Zachs Where is the proof of any of that? Show me the bodybuilder who cut on 50 grams of protein per day and kept all his muscle. Where is the evidence that adding creatine to a 50g protein diet preserves muscle? Recent study showed creatine doesn't do much for muscle gain, as expected.

    Why would your advice be something that is completely experimental? Experimental is fine for an experiment, not for someone who is looking to retain muscle.

    I'm sorry but the sugar diet (low protein low fat high carb) is a fad. There is no evidence that it works for preserving muscle mass. Even the most radical followers of this fad suggest eating a high protein meal in the afternoon (100 grams of protein alone in that meal)

    There's no point in him showing you a body builder who cuts with 50 grams of protein while retaining his muscle mass, because he didn't talk about body builders and Samson himself didn't mention being a body builder, and if a body builder would lose muscle by consuming 50 grams of protein a day, that would be a positive because there's absolutely no point in having the muscle mass of a body builder. Optimal health for children, women or men is 0% associated with a bulky or body builder physique. What's more, Zach didn't even mention 50 grams of protein in his previous answers. Just eating 4kilos of fruits you Can get 60g of proteins in theory, and on a high ripe fruits diet you Can eat more than that with out feeling disconfort, i have personally eaten 5/10/15 kilos at once or a day with out disconfort, if you look at monkeys/apes, gibbons wich are like 10 kilos max eat up to 2 kilos of ripe fruits a day, apes such as orangutan can eat like 5kilos of ripe fruits. A day if available according to internet.

    Personal experiences> studies.

    Also, the higher our energy level, the stronger and more elastic our joints, the less we need to contract and stiffen our muscles to perform a movement, so a reduction in muscle mass can be a positive.

    Bulging muscles isnt optimal at all.

    Also, binging is common in the majority of animals we see, whether they eat meat, grass, fruit, it's not bad in itself, it depends on the food, the quantity we can ingest before manifesting negative effects varies.

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