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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    Despite the mountain of evidence that messing with cholesterol is a bad idea, especially when it comes to muscle and mitochondrial health, statins remain one of the most widely prescribed drugs. Even toddlers are now on the list of potential patients eligible to receive a statin prescription and the list of conditions compatible with statin medication keeps growing. Unbeknownst to even most doctors, in 2018 the US FDA quietly removed its warnings about dietary cholesterol and its link to cardiovascular disease (CVD). Namely, FDA no longer claims that there is a risk of eating high-cholesterol food and developing CVD. The same group of studies that led to the FDA revoking its dietary cholesterol warning also vindicated saturated fats (SFA), but the FDA did not dare revoke its dietary warning on SFA, at least for now. The study below once again demonstrates the absolutely crucial role cholesterol availability plays in cellular health. Not only is cholesterol the precursor of all steroids and is also a crucial component of cellular structure, it now seems that cholesterol has a functional (bioenergetic) role too. Namely, inhibiting cholesterol synthesis (which is what statins do) or its transport into the cell (which is partially what dietary cholesterol restriction does) literally poisons the cell through the accumulation of mitochondrial debris and free fatty acids. Both of those entities have indisputable toxicity, with the former robustly activating systemic inflammatory pathways through the endotoxin receptor TLR4, while the latter is toxic simply by its presence in large amounts (hence the medical term lipotoxicity) and also through the inflammatory mediators it serves as the precursor for (if the fatty acids are PUFA). In addition, the study may provide part of the answer to the question why cholesterol levels increase with age. Ray said this increase is adaptive, to compensate for decrease in steroid synthesis due to declining thyroid function with age. However, the study provide an additional explanation. Namely, the cells need more cholesterol in order to handle the increasing rate of mitochondrial breakdown and increase in lipid accumulation that also increase with advancing age. So, it seems that one of the most reliable methods of ensuring premature cell aging and death is simply to follow the official recommendations of mainstream medicine – i.e. restruct dietary cholesterol as much as possible and take a statin daily. https://dx.doi.org/10.1038/s41467-026-77423-1 https://phys.org/news/2026-09-cell-chain-cholesterol-cellular-recycling.html “…Mention cholesterol, and most people will think of clogged arteries or health warnings. But inside the microscopic universe of the human cell, cholesterol has a drastically different job description as an indispensable cellular lifesaver. A study led by the Lee Kong Chian School of Medicine (LKCMedicine) at Nanyang Technological University, Singapore (NTU Singapore), shows how cells rapidly dispatch cholesterol to reinforce their “recycling centers” called lysosomes, preventing them from bursting while breaking down worn-out cellular machinery.” “…Every second inside our cells, mitochondria generate the energy that fuels life. However, mitochondria eventually wear down. Left unchecked, toxic fragments from these broken power stations can trigger cell death. To prevent that, cells execute a precision cleanup operation known as mitophagy, engulfing worn-out mitochondria and sending them to the cell’s highly acidic recycling centers, called lysosomes. Here, lysosomal enzymes break them down into reusable materials. While scientists have long understood this process, a critical mystery remained: How do lysosomes maintain the harsh acidic environment and withstand the stress required to digest such massive cargo without bursting? Now, the study has uncovered the unlikely answer—cholesterol.” “…When damaged mitochondria land inside a lysosome, an enzyme called PI4KIIα flags the lysosomal surface with a specialized signaling lipid called PI4P. This flag attracts a transport protein named OSBP, which acts as a cellular bridge, rapidly shuttling cholesterol from another cellular network, known as the endoplasmic reticulum (ER), straight into the lysosomal membrane. As cholesterol leaves the ER, the cell senses a temporary shortage and activates a master genetic switch, ramping up cholesterol production to keep the supply chain flowing. Corresponding author and associate professor Yasunori Saheki, Irene Tan Liang Kheng chair professor in neuroscience at LKCMedicine, said, “Lysosomes need to maintain an extremely acidic interior to digest cellular waste effectively. We discovered that as lysosomes take in damaged mitochondria, they reinforce their membranes with cholesterol. This process helps keep the lysosome resilient and ensures that its digestive functions remain fully active.” “…The research team’s analysis also revealed another intriguing finding. Once the lysosome successfully digests the mitochondrial membranes, it releases a surge of lipids known as free fatty acids. If left free in the cell, these fatty acids can become toxic. To solve this, the cell uses a series of enzymes to package these fatty acids into safe storage units called lipid droplets. This process effectively converts toxic waste into stored energy reserves for future use. When the research team experimentally blocked cholesterol transport or synthesis, the consequences were significant. The lysosomes lost their acidity, became fragile and prone to rupture and failed to break down damaged mitochondria. The cells were also unable to form protective lipid droplets.” Via: https://haidut.me/?p=3137
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    Funnily enough I've settled into the 1-2 times a week for vitamin E routine as well, just from going on how im feeling. Always nice to see research backing up "the feels."
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    How do I take thyroid anyone have a guide on dosing and such? also what form of thyroid to take and im looking to take thyroid to increase my metabolic rate as much as possible through various methods and i want to start taking t3, i will take it with b1 current supplements and drug stack testosterone anastrozole thiamine vitamin d3 and k2 glycine magnesium glycinate
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer I can relate to being an information junkie; though, with the internet age, I've met my match — there is far too much information to take in.  Your religious history is fairly similar to mine, in that my mother was a non-practicing Catholic; my father grew up with Protestant influence, but never practiced himself.  That is horrible about the teachers holding back capable students, to get funding.  So many religious institutions turn into a façade of a once real thing; in essence, contradicting their very teaching, in order to get ahead. I believe that is the rule, not the exception, in the west, for most religious education institutions.  I'm personally not too concerned with denomination (though I do have preferences), it's the truths being taught that is the value.  As a child, the biggest religious influence outside of my mother's teaching was Baptist.  As an adult, non-denominational, Christian churches I've attended most; today, I would call myself non-church going, though a believing Christian. I've had Maple Hill yogurt, but I forget how it matches up with the others. If I recall, Alexandre and Kalona were better, but costlier.  I'm not familiar with Family Farmstead.  4 liters is a lot of dairy.  I've always wondered how much we really absorb and make use of minerals and vitamins by way of food; your results would show quite a bit. I used a masticating juicer, so minimal heat.  It was like a jolt of nutrition and energy, that I had not gotten from other foods — I'd say primarily due to poor digestion.  That is crazy how sensitive a subpar, broken body is.  Mine was broken pretty bad, but not as bad as yours.  Time tends to heal all wounds; even physical, it seems.  Though, I don't think my digestion will ever be wholly the same.  I attribute that weakness to my inability to take most supplements.  Speaking of, I am actually testing a variation of the Linus Pauling protocol, which consists of vitamin C, lysine, and proline. The lysine is really sedating for me, so if I come across as as zombie, that's why!  I don't consume a lot of mushrooms, though I do like them.  I have seen the Monterey brand, but didn't realize they had actually exposed them to UV light. I had read about companies doing that, but failed to find them at the stores.  I'll keep my eyes peeled for them.  Thanks for the suggestion!  I think it's worth sharing, that I stumbled upon a study referenced (from the old RPF) that showed low levels of zinc were found to be a predictor of vitamin D deficiency.  Though, the study involved only girls and women: https://lowtoxinforum.com/threads/optimal-vitamin-d-intake-may-be-at-least-2-000-iu-daily.52621/post-985157 Indeed, I do have some Italian cooking influence; but minimal.  I'd say my brothers are the ones who have gleaned that the best and put it to use the most.  I'm the last to the cooking game, among my siblings.  Funny...from your profile pic, I guess I could see Latin, or even Northern Italian.  I'm not too up on 40's actresses, though I do know some; but not too many British.  Margaret Lockwood comes to mind, but maybe she was after the 40's.  I know of a character, from a cult-classic from the 80's, Better Off Dead, that maybe resembles you; or maybe I'm being influenced because she played a light skinned, French girl with dark hair.... https://www.imdb.com/title/tt0088794/mediaviewer/rm1305830400/?ref_=ttmi_mi_48_1 You're welcome for the olive oil info. With your research, I'm sure it will be hard to really pass along something you haven't discovered already.  I mean the thread is, Cooking with Jennifer. What are you using for animal fat?  I just purchased beef tallow, which makes for good French fries.  I think better than coconut oil, but I will have to do more testing.  I do seem to be doing okay with the banana bread.  For me, it has surpassed the cinnamon raisin bread.  It's richer and more like cake.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    @Tskull sounds like you don't need to add anything else if you feel good and are losing weight
  • Raw liver safe?

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    Raw is not safe.
  • Dark peating

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    @raypeatinger What ancils are you running with this
  • Silicon the dietary nutrient

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    LucHL
    Hi, Ultrasil is bamboo silicon. As most plant silicon, the molecule has not the right size to enter the mitochondria. Only 30 % reach the membranes when the molecule has been stabilized. 30% of 6.300 = 189 mg from one liter. I’d rather say 3%, in the best case, here. Why: nothing has been said about the process. • Silica 63.750 mg • Silicic acid 6.300 mg => 1/10th • Elemental silicon 30.750 mg • Dry bamboo extract 75.000 mg Advise: You’ll get the same result with the first four leaves from a nettle infusion. It’s a question of molecule size and stability. I can develop if interested what you should pay attention to.
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    MossyM
    @bio3nergetic said: • In an aging, stressed, calcified scalp: Natural DHT accumulates to help, but inadvertently contributes to the downstream shutdown of the follicle. DHT is responding to protect the environment but also creates metabolic demand! Seems the Peaty, sugar-based solutions (2-deoxy-D-ribose) may be beneficial in helping to meet this metabolic demand.
  • coffee against creativity ?

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    MossyM
    @lobotomize I think there is another thread on this very subject. (Maybe it was on the RPF.) As someone who used to do creative work daily, I feel coffee hindered my ability for nuance and subtlety. It did supply energy and drive.
  • NAC reduces cystiene ?

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    LucHL
    @lobotomize said: according to the study nac can be used to recduce cystine No problem if you manage the dose and the interaction.
  • The Mysterious Case of Pufa Depletion

    pufa diet thyroid dnp
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    @TexugoDoMel kinda figured that was the case. I think Buddy still needs thyroid or some sort of intervention at this point too or he’ll never be a 120 year old Lean Balkan dairy farmer
  • is the goal to never get an x-ray again for the rest of our lives?

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    Maybe it depends what it is for? A CT scan is really terrible. It has a lot more radiation than an X ray. I have an ascending aortic aneurysm. I get usually checked up with an echocardiogram. But a lot of people take yearly ct scans since it is more accurate in detecting growth. My cardiologist suggested to do a ct scan next time to make sure there is no growth. I don't really want to do it but then again an aortic aneurysm is a silent killer and I definitely want to stay alive for a bit more. Just my thoughts. When it comes to regular X rays I usually just decline them. Also at the dentist which is sometimes hard. I had to change dentists because my previous one didn't want to have me as a patient if I declined X rays.
  • DHT Source Discussion or PM For A Treat

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  • Dental question - Dr Ellie's Protocol

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    I applied her protocol when I suddenly started to have cavities in my front teeth and thinning of enamel. This came after years of no cavities at all, probably decades. I did not change anything else in my daily routine. After just a month 2 of my small cavities had completely disappeared and I did not get any new ones.
  • intresting chems source bounty

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    I was able to aquire fenclonine from a regular chemical supplier, same goes for all the other chemicals aswell. Its not hard you just have to jump through the hoops they give you and then they dont care.
  • B1 thiamine for memory

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    Does anyone know what type of B1 Peat recommended? HCL? He never seemed to specify.
  • There might be therapeutic benefits in increasing fat intake

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    @LucH said: I can develop if interested how I would manage. Yes I would be interested in your methodology...
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    I bet you could get away with taking 1/10th of the recommended dose due to first pass bypass, similar to skin absorption id prefer skin application if the solubility wasn't so ass and required me tasting and smelling like dmso for hours
  • I never have a good sleep and I'm always tired during the day.

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    HEAR ME OUT AND OBEY. Gaze at the sky, the great blue sky. Never directly at the sun. Everyday. Initially it will strain your eyes. Dont overstress. Just do what you can do. It will regulate your biologic watch. Make your bedroom extremelly dark to get a restful sleep. Look for ways to rest and regenerate your eyes. Ex. Eating raw egg yolk makes my eyes less prone to light sensibility, eating salted raw carrot with little lemon improves guts health and lowers estrogen - great cause of eye health decay. "I will stay behind, to gaze at the sun. The sun is a wondrous body. Like a magnificent father! If only I could be so grossly incandescent!"
  • Ray Peat HATED manganese

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    @user1 To some degree, yes. The Orsense device measures hemoglobin via light sensors. When I have donated blood over the past 2 years, they have used this device to measure hemoglobin- https://www.youtube.com/watch?v=PkeD7ybugHk I don't know if you could tell much difference with the naked eye. Plus, if you see blood outside the body, it's going to be reacting with oxygen and clotting, both things that would make it darker and thicker. Also, while people with higher iron levels tend to have higher hemoglobin, it's a very rough guideline. People with certain types of anemias can even have high iron levels. And for most people, you can raise hemoglobin levels with a B complex. During de-ironing, I actually got hemoglobin to go up while ferritin was going down by using a B Complex and/or an iron free multivitamin with the same B Vitamins.
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    @sunsunsun said: apparently detection of viruses in ill people isnt really proof that this is causing the illness This is obviously true. You can observe all sorts of things on a sick person that probably have no effect on them being sick, like dandruff. Many sick people have dandruff, but is dandruff the cause of the illness? Even just sticking with microbes, it's obviously true. Both sick and healthy people have a gut biome, which is made up of several strains of bacteria, numbering into the trillions of individual cells. In any so called "viral" disease, the presence of trillions of bacteria in the gut are overlooked as a factor. Truthfully, even other "viruses" are neglected to be tested. As an example, when people were tested for the "Novel Corona Virus," they neglected to test for all the previous "Corona Viruses," as well as other "common cold and flu viruses." If you ran tests for 20 different "viruses" that are thought to cause cold and flu symptoms (and therefore, "Covid Symptoms" because there is a 100% overlap), and 7 came back positive, how could you claim that any single "virus" was responsible for the symptoms? It's actually worse than that, because EVERY "virus detection" test is actually a surrogate test. There is no way to directly test for ANY virus, not for the general public or in scientific studies. If there is no way to directly detect any virus, then how can you possibly create a remotely accurate surrogate test? Simply stated, there isn't, and in the case of Covid, the hundreds of millions of "asymptomatic patients" prove that. some people say covid isnt real, there's that tanksnowgood guy on rpf who constantly goes on about how there no such thing. when I got wuflu (I assume thats what it was) I got obscenely ill for 2 weeks and also experienced the weird sewage smell stuff and various other similar weird symptoms a lot of people describe. The claim that "covid isn't real" is really a claim that the alleged "Novel Corona Virus," aka SARS-Cov2 doesn't exist. Obviously, the symptoms people got when they got so called Covid are real. Things like coughing and fever can be easily observed in the real world. But the symptoms don't prove the cause. If you read the "Covid Isolation Reports," you can see that in truth, they never "isolated" anything. They took a sample from a sick person, along with all the potential other microbes, added to it a mixture of monkey kidney cells (aka, Vero cells), some antibiotics, some digestive enzymes like trypsin, Fetal Bovine serum, and cultured it in a medium that didn't provide adequate nutrients for cell survival. Then, when the cells showed signs of dying or breaking apart, they claimed that it was the result of an alleged "virus," and dismissed concepts like cell starvation, or the cell being poisoned by the antibiotics, or being ripped apart from the digestive enzymes. Since these "isolation tests" are the ONLY proof of a virus, the conclusion a lot of people have drawn is that SARS-Cov2 (and likely all other viruses) don't actually exist.
  • Anyone here diagnosed with POTS/MCAS/Dysautonomia?

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    LucHL
    @jd_au said: Keep it simple folks. Still fine for you. However, when taking HD B1, there is a protocol to follow. In short, there is interaction between several vitamins and trace elements. I then asked AI to help clarify the why and the how for other readers. AI says, as if LucH were speaking to JD: Glad it has lasted for you, JD! That is fantastic personal success, and it actually makes perfect sense given the specific combination you used. When you take thyroid hormone alongside thiamine, you are directly addressing the systemic metabolic bottleneck. In the bioenergetic framework Dr. Ray Peat talked about, low thyroid impairs the liver's ability to clear excess estrogen. High estrogen triggers nitric oxide, which over-relaxes (smoothes out) the blood vessels in the lower extremities, causing blood to pool and forcing the heart to beat faster to compensate (POTS). By taking thyroid and thiamine together, you restored cellular energy and vascular tone simultaneously, which is why your results have been so stable. However, for other readers looking to replicate this, it is crucial to understand why standalone High-Dose Thiamine (HD B1) protocols usually require cofactors. Skipping them can cause issues for the average person due to several factors: Magnesium is Mandatory: Thiamine cannot be converted into its active, usable form (thiamine pyrophosphate) without magnesium. Mega-dosing B1 alone rapidly depletes magnesium stores. This frequently triggers severe muscle cramps, anxiety, and heart palpitations, which people often mistake for a worsening of their POTS. The "Paradoxical Reaction": High doses of B1 can kickstart dormant mitochondrial pathways so suddenly that it causes a temporary, severe flare-up of autonomic symptoms. Adequate magnesium, potassium, and baseline nutrition help buffer this transition and prevent a metabolic shock. B-Complex Imbalance: Flooding the system with massive doses of a single B vitamin can eventually create a functional deficiency in other B vitamins (like B2 and B3) that share the same cellular energy pathways. In short, JD's success is a great example of the bioenergetic approach working perfectly because the underlying thyroid and estrogen pieces were addressed. But for most people starting a high-dose thiamine protocol on its own, skipping cofactors like magnesium is a frequent cause of metabolic stalls or severe symptom regressions. Keep it simple, but keep the underlying biochemistry in mind!