@DavidPS
Gominak is predominantly "thinking out loud" in her writings. It's all hypotheses, incomplete observations and in a context of an IMO very false underlying premise of what the Ds actually do.
Dropping her latter false assumption she's essentially saying:
"The change in the make-up of the intestinal bacterial population ... has resulted in an accompanying pandemic of B5 deficiency." Which I think may be very true.
Her observations of immediately worsened sleep and feelings of slight agitation in her 50 test patients on 400mg PA per day are reasonable.
Her decision to have immediately dropped the PA within 1-2 days and build her deductions and strange contradictions on this immediate effect, however, was not.
And here's why: B5 will have such an immediate effect even (or perhaps especially so?) in deficiency. Not least because of its essential influence on reinstating ACTH-responding adrenal hormone release.
IME this lasts for a few days to a week upon starting B5 supplementation as a transient adaptation effect.

Her observations of overdoing B100 causing issues are likely to stem from biotin (which drastically worsens PA availability) or the excessive pyridoxine (crap B6) and excess folate (which was probably even folic acid).
Wrt to too much biotin and impaired B5 this could be a typical example of how B complex products actually severely screw things up.

My total protein intake on a daily basis ranges between 60-70 grams ordinarily. Sometimes a little lower.

I don't know the total caloric intake, I'm not really counting but I imagine it's lower. It's really hard to cram in nothing but sugar and hit certain caloric goals. So since I normally eat around 2800 calories before I started this, I would imagine I'm getting closer to 2400-2500 calories now.

@dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman:

My question is, anabologies honey diet formulation was eating one pound of ground beef a night… every night. Are you guys @ThinPicking @Mauritio calling this MR or protein restriction? That seems wrong if you are

No you're right that's not protein restriction. The honey diet would fall under the category of "intermittent protein restriction".
The sugar diet/ sugar fast would be real protein restriction.
They're all grouped together in this video and in my response as well, because they all increase FGF21. And contrary to Jay's statement it does not take 7 days to increase FGF21 significantly, but less than 2 h. See the OP.
So, the honey diet qualifies for " things that increase FGF21" since for a significant part of the day you do get the FGF21 increase.

@dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman:

Jay was slamming on fgf21 increasing reductive stress.
Well maybe it balances out?

I have a part on that in the OP. Look for "Reductive stress" and the following part on the ETC. If you read those quotes and studies it seems clear to me that FGF21 isn't a cause of reductive stress but a reaction to it.

@dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman:

Then Georgi chimes in later on fructose lowers phosphorus to calcium ratio, by conversion of fructose into glucose consumes phosphorus

Klotho lowers phosphate. And FGF21 increases Klotho. So FGF21 lowers phosphate, thereby increasing the calcium/phosphorus ratio. Making it possible to have a decent ratio while mostly consuming fruit and sugar and little dairy.
I have a post about Klotho and FGF21 on X.

@dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman:

Id be interested in hearing actual criticism of the honey diet rather than Jays knee jerk reaction.

Same! I'm not saying the honey diet is the end all be all. Or that it is the perfect diet.

I think it's a good diet, for some people, for a limited amount of time.
It's a good tool.

I'd love to hear a more nuanced criticism, because what Jay put out was quite twisted and one sided. It's like he had his conclusion first and then looked at the studies.

I also plan to add Lactobacillus Reuteri to the yogurt and see what happens

https://pubmed.ncbi.nlm.nih.gov/38487926/

@GlucoseGal glad to hear that, made my day honestly 😊

@Testiclies just the one of each, I am adding simple syrup to them now to up the calories

@NoeticJuice said in Did you replace Dr. Ray Peat after he died or are you living gurulessly? (pls include serviceable rayplacements):

I'd rather not follow any guru. Instead, I prefer to use my own judgement, and work on improving the quality of my judgement. After all, how could anyone other than myself know my full context?

Listening to others can still be very useful, as it gives you more information to work with.

Good attitude, but not for everyone here as not everyone can think for themselves, and not everyone is willing and able to learn Ray Peat's essense, as evidenced by the many posters here and there on the other side- who evidently haven't internalized Ray's ideas and give advices that are neither Peaty nor bioenergetic.

If they did, we would be having members reporting daily or weekly or even just monthly on their progress , if just in losing weight alone. Most lack enough knowledge that is available to them if they read Peat more and begin to connect the dots and apply to themselves what they really learned.

And even more would rather embrace the instant gratification of taking drugs that give instant results (the heck with side effects) than have the patience to take necessary steps to transform themselves slowly over time. It is ingrained in the culture, it is kinda hopeless expecting people to realize this because they have been programmed and conditioned this way.

What makes it hard also is there is no support group here that can find common ground that Rome wasn't built in a day, so those who choose the long and hard but effective way will need to take the lonely process of building one's metabolic health.

And no, Ray Peat is irreplaceable. There are plenty of talking heads, but they are more flawed than Ray Peat, as they have more knowledge gaps in them than he does. And a lot of them are a cross between Peat and Asprey, and that's not saying much good considering than Ray himself have an openness to using antibiotics and to pharma drugs such as acetazolamide that the apex Peatepr would not need. But Ray has that license I guess, as he can get weary on how bad programming and conditioning dies hard, and for most people that like short easily digestible answers a doctor's typical approach is the only sane way to get rid of them like "take this drug and tomorrow you'll be free as a bird."

too much cholinergic stuff can cause an awful depression/nausea after enough time on it.

@Wabi-sabi said in megadosing different magnesium supplements:

Quinoa, Buckwheat, Amaranth, or even W

What about it?

@Mulloch94

identity politics is dumb.

Correct, identity politics is objectively rightist.

The Marxian class theory is junk.

Ultraleftism is bad. Xi Jinping called the class struggle of the late Mao period a "leftist mistake". The class structure of a society is a powerful explanatory factor in its functioning, though. India is worse off than China, despite starting in a similar place in the 1980s, because of the caste system's retardation of development. The typical "indian factory" video online consists of almost early-industrial constructions from the 1800s. Similar story for UK vs USA. Or Nazi Germany vs USSR. Less class tension means more coherence, productivity, war-fighting prowess. Which is why the US will lose to China in the next few decades, BTW, unless something incredible happens internally (it won't, though, until the bitter end)

The same social networks that enabled Capitalism to rise are the same ones that allow Communism to function.

Yep.

And when those networks fail, you get a breakdown in the system (which we have seen).

Sure. Requiring the establishment of new networks, and re-definition of the existing ones. This is the revolution and the historical-materialist development, et c.

@doorflamme oh dam

@Androsclerozat I think it's the screen itself - can't be good to look INTO light for hours.

https://www.nature.com/articles/2261278b0.pdf

Read sleepless harvest in the top left.

@samson I'm going to restore aromatase and 5α-reductase naturally by removing blockers.
and the beer was just for testing, glyphosate is not used in my country

@sabupa I believe it's too much sunlight without or with minimal protection, He lives in Costa Rica.
Daytime exposure should not be super high.

Still think it's a troll account. Taking isotretinoin proactively because testosterone could give him acne... not even 14 year old me could have come up with that.

He's the guy that gave that famous talk at the ancestral health symposium about CO2. Pretty great. It's funny because that meet-up is like mostly low carbers, and here this guy is just casually destructing the whole process of fat metabolism and why it sucks lmao. https://www.youtube.com/watch?v=nGv4JZB2yws&t

Youtube Video

I've seen some pretty crazy results with head massage on Perfect Hair Health website, I dunno. It definitely works, but the results pairing it with other things are usually better.

@lobotomize-me interesting, thanks. There are good points, but there are also some things I disagree with or want to add nuance on.

It would be wrong (depending on context) to say that there's increased right hemisphere activity, but I don't think it would be wrong (although not the whole picture) to say that there's increased access to (or reliance on) right hemisphere functions. There's a difference there.

While the left hemisphere is often thought of as analytical and logical, the right hemisphere is also involved in reasoning, including in deductive reasoning and some types of mathematical reasoning.

This is a better summary of the main differences between the hemispheres:

@NoeticJuice said in Quotes from books:

"If one had to encapsulate the principal differences in the experience mediated by the two hemispheres, their two modes of being, one could put it like this. The world of the left hemisphere, dependent on denotative language and abstraction, yields clarity and power to manipulate things that are known, fixed, static, isolated, decontextualised, explicit, disembodied, general in nature, but ultimately lifeless. The right hemisphere, by contrast, yields a world of individual, changing, evolving, interconnected, implicit, incarnate living beings within the context of the lived world, but in the nature of things never fully graspable, always imperfectly known — and to this world it exists in a relationship of care. The knowledge that is mediated by the left hemisphere is knowledge within a closed system. It has the advantages of perfection, but such perfection is bought ultimately at the price of emptiness, of self-reference. It can mediate knowledge only in terms of a mechanical rearrangement of other things already known. It can never really 'break out' to know anything new, because its knowledge is of its own representations only. Where the thing itself is 'present' to the right hemisphere, it is only 're-presented' by the left hemisphere, now become an idea of a thing. Where the right hemisphere is conscious of the Other, whatever that may be, the left hemisphere's consciousness is of itself."

The Master and His Emissary (2019), pp. 174-175
Ian McGilchrist

There's of course much more detail to be added about the differences, which is why there's an entire book (or half of a book) about it.

@torobravo
Not really. High carb makes me hungry and I haven't seen much results with low fat milk or low fat in general. Lots of sunlight seems to help but between cold climate and chemtrails it's rare. There was a time I dropped a decent amount, I was eating yogurt and fruit daily. But that basically ended by winter which is >7 months where I'm at. My theory is lots of pufa early in life, stress, emf radiation are keeping things stagnant. I don't lift or run but have a lot of walking / physical work. I'm almost certain sugar is being stored as fat.