Subcategories

• Literature Review

  Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.
  641 Topics

  4k Posts

  A

  Abstract Alcoholic beverages produced by fermentation (e.g., beer and wine) are powerful stimulants of gastric acid output and gastrin release in humans. The aim of this study was to separate and specify the gastric acid stimulatory ingredients in alcoholic beverages produced by fermentation. Yeast-fermented glucose was used as a simple model of fermented alcoholic beverages; it was stepwise separated by different methods of liquid chromatography, and each separated solution was tested in human volunteers for its stimulatory action on gastric acid output and gastrin release. Five substances were detected by high-performance liquid chromatography and were analyzed by mass spectrometry and 1H-13C nuclear magnetic resonance spectroscopy. At the end of the separation process of the five identified substances, only the two dicarboxylic acids, maleic acid and succinic acid, had a significant (P < 0.05) stimulatory action on gastric acid output (76% and 70% of fermented glucose, respectively), but not on gastrin release. When given together, they increased gastric acid output by 100% of fermented glucose and by 95% of maximal acid output. We therefore conclude that maleic acid and succinic acid are the powerful stimulants of gastric acid output in fermented glucose and alcoholic beverages produced by fermentation, and that gastrin is not their mediator of action. ... When tested separately, oxalic acid, acetic acid, and L(+)-lactic acid had no stimulatory effect on gastric acid output. Maleic acid and succinic acid, however, significantly increased gastric acid output by 76% and 70%, respectively, of fermented glucose (Figs. 2 and 4). When given together in the concentrations present in beer, maleic acid and succinic acid significantly increased gastric acid output by 95% of MAO(maximal acid output) and 100% of fermented glucose. J. Clin. Invest. 103:707–713 (1999) https://pmc.ncbi.nlm.nih.gov/articles/PMC408116/
• Ray Peat Resources

  Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.
  62 Topics

  702 Posts

  C

  Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
• Not Medical Advice

  Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.
  1k Topics

  10k Posts

  L

  @user73636 said in Low soluble fiber = leaky gut?: research indicates that when gut bacteria are starved of dietary fiber, they can begin to consume the protective mucus lining of the intestines. => Need a context and a study. Yes, this is accurate and refers to a well-known, seminal study on gut microbiome health. => A combination of host genetic susceptibility, low dietary fiber and intestinal bacteria exacerbate colitis. doi: 10.21203/rs.3.rs-2518251/v1 2023 Mar 13. Context: The "If You Don't Feed Them, They Eat You" Mechanism • The Problem: The mucus lining (largely composed of MUC2 glycoproteins) protects the intestinal epithelial cells from being directly attacked by bacteria. • The Mechanism: When gut bacteria are deprived of dietary fiber (their preferred food source), they turn to the next best source of nutrients: the carbohydrates in the protective colonic mucus layer. • The Result: This erosion of the mucus layer makes the intestinal lining thinner and significantly more vulnerable to inflammatory pathogens. • Significance: This finding provides a direct mechanism for why low-fiber, high-fat "Western diets" are associated with increased risk of ulcerative colitis, Inflammatory Bowel Disease (IBD), and metabolic disorders. Key Study "A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility" Authors: Desai et al. (Lead researchers include Eric Martens at the University of Michigan and Mahesh Desai). Journal: Cell (Nov 17, 2016). Comment (LucH): Not only when deprived but when some phyla take the lead. When you decide to correct and tend towards 30 g (1 oz.) fiber, you need to begin progressively and adapt yourself to transit. We need 4 colors to optimize the different effects.
• Products

  From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.
  386 Topics

  4k Posts

  B

  @alfredoolivas said in Best thyroid type in context of combining with hormones?: @BioEclectic said in Best thyroid type in context of combining with hormones?: hypothyroid. Don't go hyper thyroid. People act like it's fun lol. It's completely different to being hyperandrogenic or hyperdopaminergic. Understood, and thank you, will follow that wisdom. Low and slow, will even cap the total thyroid dose even if i don't "feel" a benefit, mostly because it would be hard to discern which substance is causing it. If i may ask, and if it were you, which thyroid type would you choose? Reasons why aren't necessary, i can even make a choice based on consensus, and the responsibility would be totally my own.
• The Kitchen

  Recipes, food, meal prep, brands. Discuss them all here.
  236 Topics

  2k Posts

  L

  A single portion (240ml) of UHT milk is like welcoming just one tourist in Venice. Not overcrowded. You get the value of the nutrient, but the load is manageable, allowing your small metabolism to process and keep the not-well-fit amino-acid under control (not used). If someone overloads himself with one gallon at a time, twice a day, it won't make you "more nourished." It will make you tired and leave your body feeling crowded and overworked by the demands of processing it all, when something is not well manufactured / recognized. Management is all. Even if you don’t perceive it. And don’t tell you know someone who … Finally: Think, perceive and act, as someone not far from here would say “If UHT milk is the only option, a single portion (~240 ml or half a gallon) is manageable. Think of it like one extra car on a quiet road — the system absorbs it without stress. Moderation keeps the metabolism in control. A moderate amount keeps the metabolism in control of what it can process and discard.
• The Gym

  Discussing pistol squats, concentric exercise, resting, and other forms of strength training.
  86 Topics

  1k Posts

  R

  @LunaticRed what @alfredoolivas said along with inhibiting cortisol, positive androgenic effects like increased strength, bone growth, anti-anxiolytic, controls blood sugar, controls inflammation from endotoxin. The list goes on. In reality, it is the TRUE male hormone.