@cs3000 said in Psychosis and serotonins 5ht2a receptor , HDAC and chronic anti-psychotic use:

Found one that looks very good

Uncaria. R rhynchophylla

Will detail more on this after i finish a writeup on malate/malic acid , almost done. in people as part of a mix it lowers hallucinations,

it lowers anxiety irritability in mice and as part of a herb mix it lowers the head twitch response when given 5ht2a agonist.
Doesn't on the first day but does by day 14, lowers the 5ht2a receptor density in cortex well

https://doi.org/10.1016/j.pnpbp.2008.05.010

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These findings suggest that the anxiolytic effects of Uncaria hook may involve suppressive modulation of 5-HT2A receptor function via the activation of 5-HT1A receptors.

Its asian uncaria R, not the south american uncaria T thats lighter colored.
(I bought a product labelled cats claw uncaria T and its actually probably asian uncaria R, i blended some crude dried dark uncaria from china and it becomes the same medium brown as what was in it. so some products are crossing over)

uncaria T should be light brown-yellow i think and uncaria R medium brown as a powder or dark as dry stems

Endotoxins sources when eating starch?
Short answer:
LPS toxins don’t come from starch from itself but are the result of died gram-negative bacteria (killed by the milieu or arrived at the end of their life).
Developed theory
Endotoxins, specifically lipopolysaccharides (LPS) from Gram-negative bacteria, can be a concern when eating starch, but the primary source is not the starch itself. While some LPS may be present in food, including those containing starch, the major source of endotoxins in the body is from the bacteria that naturally inhabit the gut. Starch, especially resistant starch, can influence the gut microbiome and potentially impact the amount of LPS produced and absorbed.
Endotoxins from Gut Bacteria
Gram-negative bacteria, which are a normal part of the gut flora, have LPS in their outer membrane. When these bacteria die or their cell walls are disrupted, they release LPS into the gut. Some LPS can be absorbed into the bloodstream from the gut, potentially contributing to inflammation. (…)

In essence, while starch itself isn't a direct source of endotoxins, its impact on the gut microbiome can influence the amount of endotoxins produced and absorbed, with resistant starch potentially playing a beneficial role in mitigating the effects of LPS if, and only if, there is no stagnation of the feces (optimal transit, with a functional MMC), the liver isn’t overburdened (neutralization of side-effects), the way-out is free …
Note: The kind of stuff used in the 2 studies is deprived of fiber. An isolated “nutrient”.
Potatoes induce a higher insulin reaction than sugar cane. When I eat 2 medium potatoes, I mix them with butter, one egg and pieces of broccoli or some frozen spinach. (+ a calcium source to neutralize the very high source of oxalates from spinach: 660 mg for 100 gr spinach).
The capacity of the body is 50 mg oxalate/d. 150 - 200 mg if not every day.

I think im gonan create a document that includes all of rays books, newsletters, interview transcripts and the email advice thread...

@Samyo said in Suffering, getting worse:

@Hando-Jin said in Suffering, getting worse:

ngs that are easy to digest- milk, cheese, fruit juices, gelatin, certain ice creams.

Ok but you know that wont make me have bowel movements? they will come out like bristol chart 1 from that.

I can digest fiber easy. But that doesnt mean I will be symptom free. E.g smelly body odor, and skin races/inflammation

Beef, eggs also easily digestable, yet make my armpits smell

You might be hypothyroid. Low stomach acid, Intestinal fermentation, constipation etc can be the symptoms. What's the rest of your health like? Your pulse and temperature?

Have you also experimented with the gut drugs like cypro and use of pregnenolone?

@Corngold go to Spain or western Canada for a vacation xD

or le south de Francé

@Corngold, I find the most accurate reading is a rectal reading. Compared to orally and axillary, my temp is at least 1° higher when taken rectally. When the temp is low in comparison to how warm one feels, it’s likely due to adrenaline compensating for poor thyroid function by keeping the core temp up. Often, one or more of the extremities (feet, hands, nose and ears) will be cooler as adrenaline cuts off circulation to them to keep vital organs warm. One way to tell is by taking the temp about 20–30 minutes after eating. If running on adrenaline, the temp will, in most cases, be lower.

@yerrag 100%!

Similar to what alot of the keto and carnivore ones thought about reducing/eliminating carbs, and later on realised their mistake(s) (e.g. Thomas Delauer, Mercola, Paul Saladino etc.), though I'm still waiting for Eric Berg to come to that realisation too 😉

Youtube Video

Not just for those who want to learn to write poetry. It explains the basic principles of lyric poetry, so it can also be helpful for those who just want to read poetry.

I've noticed that with eod 500mg dexpanthenol i.m., the previously noticed effect of significantly smoother skin (e.g. on the back of my hands) disappeared.
I need at least 1,000-1,500mg dexpanthenol per day (p.o.) for this effect to acutely come back (within a day) and to maintain.
It would be interesting to know the equivalent dose of pantothenic acid to reach this individual effect threshold but I don't have any PA left to find out. All I know is that 4-8grams of PA per day is not uncommong among bodybuilders to contain their skin breakouts. And similar quantities of PA are necessary in some few non-steroid-abusing people.
Maybe someone on this forum who's doing PA could compare his/her necessary dosage with Dex?

It makes one wonder why those PA levels can become so low!

Still wondering whether it's all down to (aquired, medically induced) insufficiency of SMVT function,
or whether there's strongly increased expenditure of B5 and CoA in today's people which surpass the once physiological uptake capacities.
I was thinking: Wouldn't it be morbidly funny if even aluminum was involved and a known inhibitor of SMVT? But I couldn't find anything further on SMVT inhibition.

What I did find was the novel discovery (only in 2017) of CoA-lation, which is posttranlational modification of important proteins:

Coenzyme A first shows up as CoA-SH and can form dimers of itself to CoA-S–S-CoA. Just as that, it can also associate with the cysteine in over 500 cellular and predominantly metabolic enzymes. This happens in response to increased cellular, oxidative stress. By this way the CoAlated proteins are reversibly protected from irreversible oxidation. It depends on protein structure whether it requires CoAlation or glutathionylation.

In essence, CoAlation is about as important to protect cellular proteins as glutathione,
and they cannot replace each other's functions.

Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells
Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells

There's also a finding that the increased levels of malonic acid encountered in vitamin-B12-deficiency strongly stimulates CoA synthesis. I.e. the sequestration of CoA to malonyl-CoA (or propionyl-CoA) strongly stimulates more CoA synthesis.
Effectively, there are significantly increased intracellular CoA reserves in B12-deficiency because of that.
What this means practically is not yet quite figured out.
As soon as someone corrects a rather common and widespread B12-deficiency those increased CoA reserves will decrease.
I suspect what this means is that when supplementing B12 one (unknowingly) becomes committed to also tackle this topic of B5 uptake, SMVT, CoA availability. Not doing so could open up another and steeper pit.

@16characterstwas have not tried either yet

@Mulloch94 said in For those of you FGF21maxxing or otherwise eating low protein, what are you eating?:

I'm interested in hearing what all you are eating right now?

I didn’t think my diet was low protein, but I average the same amount as you and get upwards of 3,000 calories daily so I guess it is. In hopes of overcoming my dependency on thyroid supplementation, something that has been especially challenging since my mum’s passing in 2022 and my dad’s cancer diagnosis in March of 2024 (I’m his caregiver), I experimented with different protein sources and intakes last year and settled on 65 g daily, which has allowed me to maintain my muscle and bone mass, however, it took upping my fat intake from coconut sources to maintain my cycle and lower my Armour dose from 3 grains to 1. My diet consists of:

CARBS (65%)
• Bananas (extra ripe)
• Spaghetti squash
• Sukkari dates
• Jackfruit (Pitaya Foods)
• Fuji apples (juiced)
• Honeydew melon (juiced)
• Watermelon (juiced)
• White peaches (juiced)
• Strawberry guava juice (Whole Foods)
• All fruit spread (St. Dalfour)—strawberry, black raspberry, blueberry, apple & cinnamon, fig royale, French grape, mango & passion fruit, pineapple & mango
• Apple sweetener (Dolcedi)
• Coconut water (Symbiosis and Whole Foods)

FATS (25%)
• Coconut milk (MALK)
• Coconut yogurt (Coconut Cult)
• Young Thai coconut meat (Symbiosis)
• Coconut butter (Artisana and Tropical Traditions)
• Coconut oil (Whole Foods and Tropical Traditions)

PROTEINS (10%)
• Heirloom eggs (local and low PUFA)
• Sea scallops

MISCELLANEOUS (for extra minerals and/or flavor)
• Dill pickles (Bubbies)
• Mung bean sprouts
• Coconut aminos (Coconut Secret)
• Mushroom “umami” powder (Trader Joe’s)
• Instant decaf coffee (Mount Hagen)
• Three mint tea (Pukka Herbs)
• Vanilla bean powder (Bakto Flavors)
• Ceylon cinnamon (Simply Organic)

EXAMPLE DAY OF EATING

Breakfast: Flourless banana crêpes stuffed with strained yogurt and blueberry spread, and sweetened (coconut) milky coffee

Snack: A liter of honeydew melon juice

Lunch: Fried eggs or spaghetti squash fritters topped with strained yogurt and pineapple & mango spread, and jackfruit “nice” cream

Snack: A liter of strawberry guava juice

Dinner: Cantonese omelette or seared sea scallops with a mango & passion fruit teriyaki glaze, and piña colada (coconut) milkshake

Before bed: Sweetened three mint tea

In Paul's defense, the dude has a jawline that I bet surpasses any of you neckbeards commenting on here... and also has muscle tone and output that none of you porch monkeys could match.

However, sure, his face looks like it has more wrinkles and is aged more than your typical 47 yr old! (Or does it... have any of you actually seen what the average 47 year old looks like?)

But influencers and health gurus are held to a higher standard....

I personally believe if he wasn't so scared of starch and incorporated more of them in his diet, he would make face gains.

Being a public figure and subjecting yourself to the stress involved with that also likely isn't helping at all.

Aging is truly down to minimizing stress and maximizing metabolism.

@heyman that sushi is winning in life, W sushi 🔥🔥🔥

@jamezb46 ya serotonin stimulates HPTA directly, thus inducing cortisol

thanks guys

@heyman umlauts help too

@16characterstwas

This is interesting but I think it can be helpful to take breaks from coffee. Like, try to go to sleep and just wake up naturally on time, have the energy to sleep deeply. Not saying it's easy I just feel less reliant on coffee though. It helps, but I used to rely on it very heavily.

@ThinPicking pretty sure she's posting actively on another forum