Viral infections are rising high right now. maybe combined with bacteria & symptoms higher than usual, and bird infections apparently gaining a lot of momentum
Good to share insights here on what we can use to gain extra protection / recovery.
if youre aware of some please add more to this. especially if readily accessible & interventional
(if posting in vitro cell studies they're best to be in physiologically relevant concentrations, which depends on the substance but usually is at nM or low uM/ml concentration, or higher as /L instead if ml is not shown)
- 1 piece is eliminating the virus or lowering replication,
- another piece is blocking viral entry,
- and another piece is preventing extreme immune over-reaction damage to cells / organs
Helpful compounds might be harmful if taken at the wrong stage.
E.g immune cell activating substances at early signs of symptoms or for preventative effect, are probably not good to take when symptoms are in full effect with immune dampening substances needed to keep things from going overboard. live virus can peak early with immune cells / symptoms still active.
Preventative effect -
zinc picolinate
the picolinate has effect too so this form is important , picolinate 20mg/kg mice dose but i.p, oral dose would be a bit higher for this for full effect but these mice were given extreme doses of the virus so probably wouldnt need so much
https://pmc.ncbi.nlm.nih.gov/articles/PMC10439173/#sec2
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100% of the mice survived given preventatively, vs 0% without. the viral load was way lower.
theraputic was given 1 day after for 3 days
prophylactic was given 3 days leading into the infection
It had theraputic effect too started later, but mainly protective
The drug was cleared faster in the lungs and was detectable at 30 min and 1 and 2 h but not at 6 and 24 h (Figure S6E). However upon 3 repeat doses, PA could be detected even at 24 h posttreatment at a concentration of 100 ng/gm in the lungs, indicating drug accumulation in the lungs
Here in humans,
10mg zinc as picolinate prevented symptomatic covid infection. 2% of the picolinate group got symptoms vs 10% without.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.756707/full
zinc picolinate is ~ 22% zinc so 15mg zinc = 55mg picolinate. both probably played a role combined.
- theres a problem with taking this preventatively. zinc is mentally activating and can build up into creating an anxious state. and some people get problems with low copper. i notice an extra anxious state building up when taking zinc for more than a few days. and i dont know about long term safety of picolinic acid. maybe best reserved for specific times.
Symptom resolving effect (later stage of infection)
Ferulic acid is very effective at lowering neutrophils in lungs in viral infections (big part of the damage in covid came from the neutrophil response)
(neutrophils main function is to peak early in infection to kickstart the process & attract other cells, by the time symptoms are noticed theyre probably already peaking or close)
doi: 10.1055/s-2006-958060
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^ usual peak is 2 days of neutrophils in mice.
il-8 rises with this then drops off if things are functioning well, they're not supposed to be staying around for a long time. but with people in poor health there can be sustained neutrophil activation.
~200mg human equiv dose lowered neutrophils in lungs a lot , and giving it on day 0 the viral count increased only a little. but still probably better holding for a day or 2 of symptoms before using
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should be very effective for people hit hard by symptoms / to bring them down quick after allowing them for a couple days
interestingly a derivative also given during first 3 days of infection in a highly lethal dose of virus protected them well, where dexamethasone wasnt enough https://pmc.ncbi.nlm.nih.gov/articles/instance/1781695/pdf/11405556.pdf