@cs3000 said in β-Sitosterol has potent antiviral activity against influenza viruses:
https://www.mdpi.com/2076-393X/11/2/228#
Effective against 2 strains, directly viricidal and inhibiting infectivity / replication , at a low concentration ~1ug/ml
Note this lowers DHT (inhibits 5-ar) at the 1ug/ml dose used there, but not a concern for me temporarily when getting rid of infection.
if someone can find out pharmacokinetics / concentration orally would be useful to see. i am guessing thats in the 100s of miligrams
more than 1ug/mL plasma beta sitosterol (anti viral dose) in people eating high amounts, 300mg should give at least this in blood if not 5ug/ml
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535768/pdf/jcinvest00221-0116.pdf
using 5x the dose of flu that it takes to kill 50% of mice,
50mg/kg orally ~ 300mg human dose was effective at increasing survival
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273125/ (the mg/kg -1 is the same as mg/kg)
- IAV infection resulted in 100% (13/13) mortality by 12 days p.i. and rapid and continuous weight loss (Fig. 6f, g). Remarkably, the survival rate of mice that were treated with 50 and 200 mg/kg β-sitosterol was significantly increased to 61.5% (8/13) and 84.6% (11/13), respectively.
It both lowers inflammation, and directly viricidal
maybe best to take in evening as noticed more tiredness trying it. And does lower DHT so maybe good to replenish some dhea for a week after in the pm for a boost in getting levels restored when out of system & infections cleared
{side study, b sitosterol ~200mg worked in restoring B cells % in diabetes model, 30d, recovered from most of the insulin resistance https://link.springer.com/article/10.1007/s10616-020-00382-y}