Topics created by cs3000

@cs3000 said in Erosive Arthritis (Osteoarthritis not rheumatoid), ray peats article + case report in fingers using thyroid:

Thyroid + Famotadine should be effective for osteoarthritis restoration

Thiamine (B1) is also a carbonic anhydrase inhibitor. It might be useful here as well.

Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

Btw theres some fuckery going on with some popular supplements, one i got didnt dissolve in water (not gaba)

Things like this keep me up at night. How many kilos of powders from china have I eaten over the years? I don't even want to think about it. Horrifying

@ThinPicking you might like this one one too. Mind blowing stuff. Hope more people start watching RFK more closely. He is certainly a significant player in this game. https://wrenchinthegears.com/2023/04/21/river-keeping-water-programming-upstate-new-york-and-a-camelot-campaign-some-working-notes/

The Multifaceted Roles of Proline in Cell Behavior

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary proteins (astringency, teeth health) and cornifins (skin permeability); (ii) an energy source for pathogenic bacteria, protozoan parasites, and metastatic cancer cells, which engage in extracellular-protein degradation to invade their host; (iii) an antistress molecule (an osmolyte and chemical chaperone) helpful against various potential harms (UV radiation, drought/salinity, heavy metals, reactive oxygen species); (iv) a neural metabotoxin associated with schizophrenia; (v) a modulator of cell signaling pathways such as the amino acid stress response and extracellular signal-related kinase pathway; (vi) an epigenetic modifier able to promote DNA and histone hypermethylation; (vii) an inducer of proliferation of stem and tumor cells; and (viii) a modulator of cell morphology and migration/invasiveness. We highlight how proline metabolism impacts beneficial tissue regeneration, but also contributes to the progression of devastating pathologies such as fibrosis and metastatic cancer.

@cs3000 said in Sonoluminescence:

https://www.youtube.com/watch?v=vpLw5nyu_Pk

Wow that's extremely interesting.

The comments under the video are amazing as well.

I had to think about the ying-yang symbol. You have the fire in the water here , representing the white dot in the black part of the symbol.
But someone applied to the Bible or the Egyptian pyramids as well.
The theory existed for ages that the Egyptians used sound for building the pyramids, maybe they also created electricity with it.
And in the Bible god says he is a pillar of fire in the night and a pillar of clouds during the day. Again, representing the one which combines opposites in itself, as shown in the ying-yang symbol.

Seems like this hits some core truth of reality.

I find the idea of making electricity from this intriguing. Even if tis not enough for fusion, it's still at least tens of thousands degrees warm, which is quite something.

Can we produce this phenomenon by ourselves ?

@cs3000
May be key to use IR light that includes 8-10 uM wavelength , IR-C
https://www.nature.com/articles/s41598-019-48187-0
which is weird because only a tiny amount of IR-C comes from the sun, and doesnt penetrate skin as well as ir-A or B. but was the wavelengths that worked on mitochondria in epithelial cells

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humans might emit infrared around 9-10 uM though which matches the mitochondria study https://www.researchgate.net/post/What_is_the_IR-radiation_emitted_by_the_human_body

& the embryo study used a lamp "at wavelengths ranging from 1 μm to 14 μm, with a peak at 2.9 μm."

@cs3000

in response to stimulation with 1,25[OH]₂ D, upregulation of the inactivating enzyme CYP24A1 curtailed the functional effects of vitamin D in DCs, but not macrophages.

rifampin fixes 1,25 excess in sarcoidosis through inducing CYP 3a4 enzyme

So CYP 3a4 can be used to lower the 1,25 excess coming from macrophages

side note 24,25 vit D increases bone strength / fracture repair where 1,25 does not have this effect https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063485/

Insightful studies below that highlight 24,25 aka 24r,25 looks to be the commonly desirable form of vitamin D.
If in good health it's supposed to rise in ratio to 1,25 as 25 vit D goes up, https://www.nature.com/articles/s41598-019-43462-6

24r,25 form of vit D is likely protective in MS / brain atrophy https://pubmed.ncbi.nlm.nih.gov/21047880/ lower 24,25 compared to 25 = worse outcome

and it actually DECREASES the VD Receptor

Vitamin D3 is metabolized in the liver and kidney in addition to localized tissue-specific biosynthesis. Bone cells are known to metabolize 25(OH)D3 into both 1α,25(OH)2D3 and 24R,25(OH)2D3 via 1α-OHase and 24-OHase, respectively

24,25 DECREASES vdr expression and can lower 1,25,
it inhibits stem cell proliferation like 1,25 also does, but unlike 1,25 it stimulates stem cell maturation / enables their differentiation ,
increasing bone repair / strength https://pubmed.ncbi.nlm.nih.gov/24597546/

(but by my experience cannot get this increased enough simply through vit D without worsening the issue from extra 1,25 in people with this excess issue,
was thinking maybe there isnt enough 24a1 enzyme producing 24,25 here, but upregulating doesnt work to counter 1,25 in macrophages)

targeting less 1,25 through CYP 3a4 should have effect but also degrades 25 vit D though, so losing 24,25.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310418/

Thyroid hormone also increases cyp3a4
(another connection to hypothyroid & vitamin D problems)
and also decreases CYP27B1 , lowering 1,25 (at least in the kidneys, wonder if this also has effect in macrophages keratinocytes etc https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077994/table/T1/?report=objectonly)

lowering Cyp27b1 is a major target for lowering 1,25, it stays expressed even when macrophages are removed from IFN-y inducing environment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077994/

How was it that synthetic 1-hydroxylating activity in macrophages harvested from humans with active disease persisted ex vivo in culture even in the absence of conditioning IFNs? Some of the questions have been answered and some are still coming to light. For example, it is now known that there exists a single gene that encodes the 1-hydroxylase, CYP27B1 [11] and the 24-hydroxylase, CYP24A1 [12]. Further, it is now clear that persistence of mTB in macrophages is an explanation for the continual expression of the CYP27B1 in human macrophages even after their removal from the host and conditioning cytokines present in the inflammatory microenvironment in the host.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508960/
(thyroid hormone & iron key players) & upping 24,25

In this work, we demonstrate that THs induce a significant increase in CYP3A4 mRNA levels, protein expression and metabolic activity through the membrane receptor integrin αvβ3 and the activation of signalling pathways through Stat1 and NF-κB.

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@Mauritio yea and a decent amount an hour or so before sleep could be good for sleeping through the night if wake up too soon. as would spare the glycogen for longer . i just got some coconut milk powder

there's 2 types of palm oil , that kernel oil which has a bunch of lauric acid / very different profile to the other palm oil with no MCTs or lauric acid. so probably used the 2nd type https://www.researchgate.net/figure/Fatty-acid-composition-of-palm-oil-and-palm-kernel-oil_tbl1_282129563

Thanks, B-5 is now on my radar screen. It is one of the B vitamins that I have overlooked.

I am interested in maintaining my cognition for as long as possible. I think that the current environment is making it increasely difficult to to do just that.

@Mr-X said in Edema with water logged lungs / heart atrial fibrillation / pleural fluid around the lungs - approach to fix:

@yerrag

Thanks for all of your help.

Yesterday when I came she was so nervous panicy. She talks all the time that she wants to go home. I can understand after 2 1/2 months in the same room same bed never was outside since then. Couldn’t speak clearly told weird stuff let me first change my clothes before were going home the want to poison me here and so on i was so in shock
She was so nervous, i put out magnoil and ithink i squeezed 25-30 drops on here legs.

What a hell of a transformation in 30 minutes. She was calm was speaking full sentences we looked sport on TV she remembered old players and so on. Eyes where open, we could sit for half an hour on the bed.

Also 3 different nurses said wow she so good today than long time before.

than i put 5 drops of energin on her. One squeeze of Glass pimpette of vitamin d oil

And gave her her multivitamin pill / 125mg thiamine hcl / 150mg benfothiamine

She felt asleep into deep sleep since yesterday she also dont need the oyxgen machine anymore. She got 96% SPo2 oxygen tested on the machine from the nurse. Im so glad because I saw a thread on RPF yesterday how toxic oxygen is for the brain.

I think the most common issues at the moment
she has a little bit of heart valve inflammation also after 6 weeks of antiobiotics IV. COPD was before, the kidneys are weak but its also known long before chronically but was so worst that by the start of the last week she put her on dialysys.

I want to help her for the heart valve inflammation. I think next they will also stop the IV antibiotics. What do you guys think of Vitamin E (TocoVit) for this purpose? Anti estrogen, anti inflammatory, energy promoter.

What she has before hypothyroidism. (only gets t4 so I also thinking givin her 1mcg of t3 to start with maybe next week)
Panic and anxiety shes takin SSNRI Venlafaxin and oxazepam 😞
high blood pressure shes gettin beta blocker and other blood pressure medication.

I let go on the idea of pyrucet

I think today i hold back on the b1 to 125mg and 75mg benfothiamine

I cant give here energin because the nurses saw their yellow stain on her legs 2 days in the row. I wanted to put it on wash it off after 1 hour but they came before unfortunately.

Takeaway from yesterday u can throw all your mag pills away the days before i gave her 450 mag bisglyicinate pills saw not so good improvement. I think the only option to get magnesium into our body is either haiduts magnoil topically with DMSO or magnesium bicarbonate. But thats hard in germany because of lack of milk of magnesia

I'm concerned she started dialysis as doctors don't know squat about acid base balance and it doesn't get better the longer she stays in the hospital the worse and her more acidic her ecf is. The longer the acidic condition holds up, the worse it is for the organs as they calcify, especially the kidneys. the meds are a major cause of it unfortunately.
one day she's being treated for this, and next day it's another it's like playing whack-a-mole except it's not fun. and it's also like a roller coaster of one day she's on a high and the next few days she'll be sleeping endlessly. doctors are used to seeing patients that way and are desensitized to their plight and soon they treat it as normal. They truly have no idea.

But it's not easy going home either because .ost people are so dependent on doctors and they're helpless. And caring for elders is not easy either.

The better ones know more about nutrition from food and can cook.

C3G has similar activities . It's high in elderberry juice as reported in this thread.
(https://bioenergetic.forum/topic/847/cyanidin-3-o-glucoside-c3g-the-next-polyphenolic-star?_=1724528336146)

And elderberry juice is traditionally given when you have the flue in Germany.

There's also some study showing anti-viral effects specifically in Covid.

https://pubmed.ncbi.nlm.nih.gov/35807916/

https://pubmed.ncbi.nlm.nih.gov/35431537/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856223/

@Verdad

https://raypeatforum.com/community/threads/why-is-this-serotonin-receptor-type-bad.25497/

"there is a difference between plasma and platelet serotonin, and it's my understanding the 5HT2B is plasma, which is the very bad serotonin" by user alywest

and then

https://raypeatforum.com/community/threads/vitamin-k-and-other-naphthoquines-are-pro-dopamine-and-anti-serotonin.21548/

"1,4-naphthoquinones stimulate serotonin uptake in platelets in a manner similar to other SSRE such as tianeptine and in opposition to SSRI drugs like Prozac (fluoxetine)." by user haidut

So it seems like a good effect

replied with more discussion on HSP at https://bioenergetic.forum/post/32387

A cohort of cancer patients with no reported cases of SARS-CoV-2 infection : the possible preventive role of Methylene Blue

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