@Mauritio its mostly inhibiting just the variant there (not normal androgen receptors) splice variants lack parts that de-activate them so continually active https://www.nature.com/articles/nrurol.2015.13

ironically depleting androgens in prostate cancer can induce more of them (and more significant amounts in the extracted cells part but idk how much they contribute)
https://aacrjournals.org/clincancerres/article/20/6/1590/211454/Rapid-Induction-of-Androgen-Receptor-Splice

AR-FL (normal receptors) arent getting inhibited much but AR- variants gone

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1 found mild estrogenic activity in vitro in cancered cell lines which doesnt match with the in vivo anti tumor activity,
but mainly on ERRy and ERRa estrogen related receptor, 30% max transcriptional activity of estradiol on estrogen receptors, (maybe displacing estrogens for milder effect lower transcription? but potent on ERRs in these cells)
,

https://www.sciencedirect.com/science/article/abs/pii/S0300483X21001281

They found some hormone reducing effects in fish but idk how relevant to mammals

In adrenocortical cancer cells it reduced hormones production at nM concentration,
https://academic.oup.com/jcem/article/103/10/3706/5056322

• It has a mutagenic effect at higher end dose

humans show lymphocyte abnormalities from treatment at higher end dose. apparently its lethal in 100% of some strains of mice injected at low dose 7.5mg/kg. needs to be transformed in the gastrointestinal tract first & go through the liver https://pubmed.ncbi.nlm.nih.gov/3278217/

orally 60mg/kg ~300mg-400mg human dose starts to give a rise in abnormal sperm

its a mild effect there but thats only with 5 consecutive days

in humans the mutagenic effects on lymphocytes with 1g-2g for a day then 6 days of 500mg increased. (i'd guess red blood cells might be more vulnerable) doi: 10.1016/0165-7992(86)90015-1)

so to be on the safer side i wouldn't take >100mg of this regularly, 25mg has effects. and maybe good to have a few days off a week just incase.

@Mauritio said in Niclosamide reduces serotonin and glutamate:

Didn't you write something about cancer and pH? Niclosamide seems to affect that :
https://pubmed.ncbi.nlm.nih.gov/22474287/

cool thanks , yeah lowering pH to a certain level helps make the apoptosis process more effective

@Mauritio wow impressive one thanks. how are you taking it & what do you notice, if you still do? so far im thinking day on day off, after bowel movement, maybe pm use, 25mg-50mg, or to have handy for a serotonin state occasionally

thats a big effect on serotonin induced itching (could be very useful for lightening the effects of mast cell activation syndrome , as thats not just histamine mediated its through serotonin and others too via the TRPv trpa receptors). thats the best effect ive seen for this

an upside of only needing a small amount of a normal tablet assuming cant get powder, u get a lot less of all the shite its mixed with

it decreases the clearance of some compounds through inhibiting some kidney transporters, something to be aware of (& maybe day on day off is best)
https://www.sciencedirect.com/science/article/abs/pii/S0009279724000322

another reason should be good for cystic fibrosis, (on top of the anti fibrotic effect u mentioned) lowers the mucus secretion toward controls https://pmc.ncbi.nlm.nih.gov/articles/PMC10794189/#Sec2

and showing the anti fibrosis effect (reversed fibrosis / ED in penis of diabetic rats) https://academic.oup.com/jsm/article-abstract/21/12/1111/7822244?redirectedFrom=fulltext
"Both functional and molecular alterations in DMED were effectively reversed by Nic-treated diabetic rats without a glycemic alteration. Nic could be a promising candidate for the treatment of DMED due to its antifibrotic effects."

https://aacrjournals.org/cancerres/article/71/12/4172/567782/Antihelminth-Compound-Niclosamide-Downregulates
showed a good slowing effect but not massive on fast growing tumor, but for a slow growing tumor it stopped growth for a while
(i guess tolerance built using 6 days a week for 18 days? controls surged then too so maybe not tolerance & less effective at end stage)

@gg12 https://www.reddit.com/r/EyeFloaters/comments/c9lj81/floaters_after_thyroidectomy/

@Tarzan17 hi some common recommends are carrot salad , cascara ,

for me some daily bromelain + eating a meal with some organic wholegrain for the fiber worked for the most part after many months of severe constipation (would go a week without any bowel movement). 10 minute walks i think give you a chance in right conditions,
in an emergency you can use magnesium citrate or very high salt in a big glass of water and turn into a human pressure washer for a few rounds

@highseabasch used to get it, tried to move my toes first like that scene from kill bill https://www.youtube.com/watch?v=vHl24Kjp5Vs
think i usually had to relax and accept it was gonna take a bit of time as a process underway for things to flip back online

@dapose thanks for the reminder, wanted to look into this guy since i heard peat mention his stuff on immunity without reliance on the immune system. seems like one of the grand masters . some stuff is going over my head but parts that stood out so far

• buildup of clunky large molecules (polymers) when a surplus of oxygen isnt supplied to the cell (or low amount of oxidation catalysts) , only a small amount of things that can join are taken out so more stuff combines and makes cellular process inefficient with these in the way:

• hard to burn peroxides
  

• malignancy of cancered cells and their loss of oxidizing power going together, and showing higher amounts of polymers , duplicating as attempt to dilute the molecule faster than its being added / created

• importance of carboxyl groups
  

• (interestingly he says all carcinogenic compounds have a fluorescent property)

• ? providing a competitive energy carrier with similar structure that doesn’t divert sugar / fatty acids away from being fully utilized and to cell division instead, supplying a normal oxidation carrier, that has 2 types of unsaturated groups which can competitively absorb heat and redirect energy to sugar & fat oxidation instead of hyperactivating other processes without being able to be carried far enough

• ,
  

@ThinPicking
Billions of farts must end

Farts must be stopped at all costs. billions will die

(Farts in public)
Lamp post speaker:
"Citizen 7754271 - you have - 9 - farts remaining"

@Milk-Destroyer tried ocado (m&s) goats milk and it was thicker & tasted better than others

@Insomniac said in Major retailers join forces with UK dairy farmers to trial methane-reducing feed additives:

reverse dragons, the enemy

On the bright side, one day the whole world will be cow fart safe even if dairy is no longer edible..

continued from #1 https://cs3001.substack.com/p/a-bunch-of-quick-health-and-biology

1. Surgery causes a big acute drop in pyruvate dehydrogenase activity through depleting thiamine (needed to use carbs fully, converting pyruvate from carbs to acetyl-coa & co2)
   https://pmc.ncbi.nlm.nih.gov/articles/PMC4472607/

takeaway: need a thiamine boost after surgery

Measurements of PDH activity and quantity and thiamine were obtained prior to surgery, at the completion of surgery, and 6 hours post-surgery. Study subjects had a mean 41.7 % (SD: 27.7) reduction in PDH activity after surgery and a mean 32.0% (SD: 31.4) reduction 6 hours after surgery (p < 0.001). Eight patients were thiamine deficient (≤ 7 nmol/L) after surgery compared to none prior to surgery

2. Monolaurin protects well against staph infection https://pubmed.ncbi.nlm.nih.gov/20021093/ http://visordocs.sic.gov.co/documentos/Docs019/docs20/2014/2014006996OF/2014006996OF0000000003.PDF?713
   killed all 14 control mice within 1 week. 50% survived for 30 days when given monolaurin orally.
   3.2mg monolaurin given to mice weighing 15 to 20g so 160g/kg = shown effective at 800mg-1g human dose. (higher dose might not be better).

Human milk contains monolaurin around 3 mg/mL. When the monolaurin is eliminated, the anti-inflammatory and antimicrobial activity is low

3. Constipation -
   daily physical movement (walking) plays a big role in bowel movements. inactivity for 2 weeks = bowel movements went from average of 9.5 a week -> 4.5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748072/

Our results showed a new onset of functional constipation at the end of 35-days of bed rest in 60% of healthy volunteers as diagnosed by Rome III criteria

4. More https://cs3001.substack.com/p/some-quick-health-finds-2