Dandruff or scalp irritation? Try BLOO.
Looked into the effect of sodium butyrate on causing senescence / stopping cells proliferate. it can do that to normal fibroblasts (even tho showed increased wound healing). but effect is selective
pretty good one showing this helps recovery after brain injury , https://pmc.ncbi.nlm.nih.gov/articles/PMC2726719/#S10
during continued poor blood flow to the brain it helped restore brain cells
Day 14 after injury
@Mauritio all of it combined probably with methylgloxal being the main effect, maybe the low protein helps improve response rate,
In the modern trial ~40% of the people got complete remission of their tumors taken orally daily, without dietary changes mentioned just added vitamin C. Koch injected it just 1 time into muscle, then waited a couple weeks and repeated that twice more if needed
they tested some other stuff with efficacy on animals (human study mentioned low toxicity for the methylgloxal tho when done in vivo and as just methylglyoxal form)
other ones , they're "unsaturated diketones" or things that form them as "peroxides of substances that liberate free carboyl groups to form the unsatured diketone"
"Unsaturated diketones are organic compounds containing two ketone (carbonyl, C=O) functional groups and one or more double or triple bonds within their molecular structure. These unsaturated bonds make the molecule chemically reactive and allow for unique properties."
Something interesting, some of those substances create carbon dioxide when they degrade. or relates in some way
Quinones are unsaturated diketones
part of curcumin molecule is an unsaturated β-diketone https://casereports.bmj.com/content/2017/bcr-2016-218148 but generally they havent shown remission like the methylgloxal
some ketones like acetylacetone
@LetTheRedeemed coconut oil
for some reason i noticed it gives me joint pain though but uncommon reaction. similar to what i get from aspirin. apparently its not high in salicylates
its anti inflammatory on cytokines ~10g
https://sci-hub.ru/10.2174/138161210790945922
https://pubmed.ncbi.nlm.nih.gov/27779477/
NSAID ulcer incidence in humans varies widely from 10% - 70%,
when feeding 0.3% -> 3% dietary insoluble fiber it escalates the amount of lesions NSAIDs create
replacing the fiber with only pectin fiber instead (forms a gel kind of), they basically dont cause lesions at least lower down
0.3% fiber vs 3% ^
C & A refer to gastric, D duodenum, the numbers progressively through small intestine distance
(~3g vs ~30g fiber probably.
1% might still develop)
10% pectin instead, no lesions
(replacing with pectin or guar gum is important instead of just removing, for bowel movements, and so it can be processed by bacteria to keep SCFA production up instead of eating the mucosa which gets degraded if u just go low fiber otherwise)
for reoccurrence, >10g apple pectin a day made it worse in the duodenum https://pubmed.ncbi.nlm.nih.gov/3278367/ and the earlier image showed it worse in the duodenum for some reason
takeaway:
if want to heal chronic ulcers in small intestine & probably early part of the large intestine / colon until the insoluble fiber gets broken down by bacteria, its optimal to have max 3g insoluble fiber over a day, and the rest replaced with pectin to keep bowel movements.
{its interesting fruit has pectin basically matching the insoluble fiber content}
& alternatively
can match the insoluble fiber intake with grams of pectin (bumping up a little extra) or guar gum simultaneously at meals , can be enough to protect. (but pectin might especially bind minerals when taking high amounts simultaneously with food and wouldnt give the same effect separated from insoluble fiber intake)
https://sci-hub.ru/10.1007/s10620-009-0893-2
@cs3000 WIlliam Koch the chemistry of natural immunity, cases at the bottom pages showing amazing recoveries
@cs3000 said in Studies showing cancer reversal / shrinking:
Human trial with methylglyoxal {aka pyruvaldehyde} (william Koch compound)
https://web.archive.org/web/20161017113947/http://www.cancer-therapy.org/CT/v4/B/HTML/17. Talukdar et al, 205-222.htmlLong term in a variety of cancers, ~80% of the people had remission or stability
,
@NoeticJuice ty & for the update, cool it lasted so long. and useful to see the 2 tested ur experience matches the part about mesembrine being more serotonergic. the headache fits with the pge2 increase i read probably this, its pro-inflammatory (+ the serotonin) so not good to take often but if it gives a long lasting fix great ,
did u swallow after? and how long did you keep it in mouth? also did u notice improvements leading into it with the other 2?
@James carrot was a bit mixed for me too. i got more success adding a meal of whole wheat pasta/spaghetti (rinsed before and with sugar added + milk balancing the phosphate) + 150mg bromelain a day empty stomach. (but bromelain can lower mucin so i dont think its good to take every day, maybe 1d on 1d off). before mine was extreme routinely going 1 week without any movement
also a couple 10 minute walks a day, 1 in day 1 in evening can see if creates a move
interesting find - if u target a main 2% subset of melanoma cells the tumor goes in most cases without destroying the other part. if some are left theres potential for the regression to return
(does doxycyline help these ones get destroyed when combined with inhibitors?)
https://www.pnas.org/doi/10.1073/pnas.1009069108
we revealed that established tumor lesions can be efficiently eradicated by targeted elimination of the less than 2% subset of melanoma cells with the CD20+ high molecular weight melanoma-associated antigen (HMW-MAA)+ phenotype without targeting the tumor cell mass, whereas targeted elimination of any minor subset is less effective.
These data provide a strategy for improving the biological therapy of melanomas and, moreover, for redesigning current drug development paradigms used in the treatment of cancer.
HMW-MAA+ cells gave rise to melanomas upon transplantation, whereas sorted HMW-MAA− cells from the same melanoma did not.
indicating that these cells exhibit melanoma-initiating capacities.
T cells with redirected specificity for CD20 eradicated established melanoma lesions in four out of five melanoma biopsies, although the targeted cells represented less than 2% of melanoma cells.
It is noteworthy that transplanted tumors of patient 5, in which no CD20+ melanoma cells were detected, could not be eradicated by a CD20-redirected T-cell attack.
Where tumors were eradicated, no tumor relapse occurred during the observation period of >36 wk.
Because no tumor relapse was observed in any case during the >36 wk observation period, such melanoma eradication is obviously long lasting
We conclude that CD20 is not functionally crucial but marks a specific cell population. The unexpected observation, however, is that targeting the minor CD20+ melanoma cell population is as effective as targeting the majority of tumor cells. A caveat for a broad therapeutic application is that obviously some melanomas, in our cohort one out of five patients, do not harbor CD20+ melanoma cells
The observation that the specific elimination of a minor subset of tumor cells results in eradication of established melanoma lesions is crucial for the understanding of the biology of melanoma. Continuous melanoma growth obviously requires the presence of a minor population of cells, which displays the CD20+ HMW-MAA+ phenotype;Elimination of these cells is obviously required to eradicate the melanoma irrespective of the bulk of tumor cells
Natural compound Physachenolide C (but not commercially available yet) gave complete remission in melanoma. in 1/3 of the mice it stayed regressed. (in the other 2/3, maybe doxycycline could have brought back the effect)
its a highly potent BET inhibitor
https://pmc.ncbi.nlm.nih.gov/articles/PMC8571524/#sec0011
enhanced immunotherapy for regression (enhance with b-glucan?)
https://pmc.ncbi.nlm.nih.gov/articles/PMC8802328/#S19
@16charactersitis
yeah , its a bit more acid than baking soda from what i remember but practically its basically the same. a few grams of each per L water