@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:

@Hando-Jin said in Reversal of hair loss in Mice with “sugar gel”:

@Serotoninskeptic

"Ray Peat: I've been thinking that with a concentrated glucose solution, you could probably activate hair growth just by keeping your scalp moistened with glucose."

https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat

"...excessive glucose is able to increase the expression of hair inductive genes and elongation of hair shaft."
https://pmc.ncbi.nlm.nih.gov/articles/PMC7078220/

In the above study they used a concentration of 10mM to boost hair growth and mimick excessive glucose . That is just 180mg per 100ml . The issue is that the hair shaft sot relatively deep in the scalp and not much /everything will reach the shaft so to account for the loss i would go for 50mM or approximately 1g or 1% of glucose per 100ml .

EDIT : just saw they used d-glucose aka Dextrose . I wanted to use sucrose (table sugar) but I don't think sucrose can substitute as the scalp lacks the enzymes to split up table sugar into glucose and fructose and sucrose is a much bigger molecule, making absorption even trickier

On top of that i would use 30% percent alcohol and 10% propylene glycol which sterilize the solution and help absorption and penetration. This is inspired by the formula of Minoxidil, which seems to be absorbed well.

So the updated formula would look like this :

30% ethanol
10% propylene glycol
1% NMN
1% Apple polyphenols
1% of dextrose
Rest: Water
(add taurine ,caffeine,... to your liking)

Total Solids:

Dextrose: 1 g Apple Peel Polyphenols: 1 g NMN: 1 g Total: 3 g

Total Liquids:

Water: 70 mL Ethanol: 20 mL Propylene Glycol: 10 mL Total: 100 mL

@Gaston

Bro that’s a king post

I wonder if the water is not playing a role in the 29 month old mice who are showing signs of reversal of age? For instance, water can be structured many different ways, (red light, vortexing, filtering through rock like media). I wouldn’t be surprised if the ultrasound is structuring/energizing the water, and it’s the mice being bathed in this substance that is exerting the effects.

I have heals many maladies in the past simply structuring water and then soaking my feet in that water. For whatever reason that I can only guess about, my best results have always come from using sea-water, (structuring that, and then soaking my feet in that). The results are systemic. A rough patch of skin on say my knee is returned to normal by soaking my feet. An increase in energy, (not driven by cortisol) can be observed by soaking my feet.

I say all of this to say: water may be playing a key role in these findings, (though if ultrasound is capable of structuring fluid, the fluids of the body may suffice too). I just personally have had remarkable success with “bathing” in structured water.

Heres a rather disappointing rat study using 5a hydroxy laxogenin.

It showed no androgenic or anabolic effect. It was even catabolic at some doses.
The androgen receptor density was increased .

Quite odd ...the authors think the dosage might be too low or the fast degradation into inactive metabolites might play a role.
Maybe the metabolism is different in humans. We'll see as I've already ordered it.

https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/dta.3881

Nicotine acts on thyroid receptors.

"...nicotine and learning uniquely acted to increase TR activation..."

"Acute nicotine enhances learning and these effects may involve processes regulated by the transcription factor TRβ."

https://pmc.ncbi.nlm.nih.gov/articles/PMC4387063/

@cs3000 well said 👌🏻

@evan-hinkle said in Visceral fat reduction by enteric-coated lactoferrin:

My wife has had issues with SIBO in the past and I was hypothesizing that perhaps a reduction in iron, (as lactoferrin is known to bind) especially in the small intestine might be a more holistic/environmental change dissuading bacterial colonization in the area vs antibiotics alone with no change in environment.

I was never diagnosed with SIBO, but have been eating a special high potency yogurt made using L. Reuteri bacteria. It is not a cure but it keeps my sensitivity to nightshades at bay. I have written about it here. Dr. Davis has recently written a book about the benefits of the yogurt entitled "Super Gut: A Four-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight?

In addition, YouTube has many videos about L. Reuteri yogurt.
https://www.youtube.com/results?search_query=l.+reuteri

Increase of FGF21 in humans leads to reduction in liver far in clinical trial .

"Furthermore, some researchers have recently synthesized a long-lasting FGF21 fusion protein, PsTag600-FGF21, and found that it enhances liver FAO and reduces hepatic steatosis and inflammation via the FGF21-adiponectin-IL17A pathway [47]. Encouragingly, in a phase 2a trial of efruxifermin (long-acting Fc-FGF21 fusion protein) in patients with NASH, patients with stage F1-F3 NASH showed a significant reduction in liver fat fraction after treatment [48]."

FXR activation might increase FGF21.

FXR agonists:
androsterone , bile acids , progesterone/pregnenolone metabolites, diosgenin, certain polyphenols e.g.cafestol,
...

"Finally, activation of FXR also increases FGF21 transcription and expression. In vitro studies have also shown that FXR can induce FGF21 production by inducing the expression of FGF19, but this has not been confirmed [65], [66]."

https://www.sciencedirect.com/science/article/pii/S0753332222009660?via%3Dihub

Red light is a top 3 topic Ray touched on. Yea I know he didn't invent nor was he a pioneer, but he highlighted the importance of light balance, exposing a huge rabbit hole for anyone to jump in.

Set up a red incandescent strip years ago and never looked back.

Cinnamon smell for the win.

"The strategy of using flavor/fragrances compositions such as cinnamon flavor and cinnamon mint may be useful to protect widespread of SARS-CoV-2 in their daily lives."

https://pubmed.ncbi.nlm.nih.gov/39835268/

Very interesting. Despite its magnificent effects on healthspan, it lacks in the department of life extension. There isnt many studies on it and in the ones that exist, the results aren't very impressive.

But a 8.5% life span increase in females is still decent. And at least in males it increased health span.

So for better anti aging proposes it would be good to combine NMN with something that will likely increase lifespan as well, like selegiline, rapaymcin or ergothioneine.

@jamezb46 said in High-Fat Diet Triggers Memory Decline Within Days:

I usually get about 2-3g per day for context. You will find the same gaslighting when it comes to studies "showing" that high saturated fatty acid diets cause inflammation. All of those "high SFA" diets are confounded by PUFA.

Good point. But only a few look under the hood of such studies...

@Corngold

gotta wonder what the result would be if it was 90% saturated fat instead of 36%.

It should look better, but it is still far from perfect. 60% fat is not a healthy amount... I guess.

@FTMarinetti does it lower DHT

@Gaston I got 30g for less than 30€ , I think that's ok. Cheap enough to give it a try.

He also has a curious obsession with hemodialysis.

Light mockery is fine I think, obviously. Just decode what you're mocking, lest ye become the mocked.

Allulose can foster the growth of beneficial bacteria and stimulate the production of short-chain fatty acids.

THE ROLE OF ALLULOSE AND SUGAR ALCOHOLS IN GUT MICROBIOTA MODULATION AND METABOLIC HEALTH: A REVIEW 2025

if you literally unironically
have h pylori literally unironically you could do the sprouted and frozen for 48/72 hrs brocolli sprout smoothies. it’s not peaty (le cruciferous… is …. le bad!!!) yet i think it works. the sulforaphane content like this from 15g of seeds is more than comes in expensive supplements.

you could eat raw red cabbage (the spicier the cabbage the better, and i’ve heard organic raw red cabbage is the spiciest) for the same type of effect just at a lower dose. this also has sulforaphane but not as much as the brocolli sprouts. might be milder.

other than that honey and coconut oil apparently works too.

@bio3nergetic thank you, I think it's okay to share the link. its in the name of science 😉