@cs3000 said in Oxidative metabolism reflects our biological age, metabolic dysfunction drives frailty/aging:

neutrophil - lymphocyte ratio is a common marker of poor health,

I have this high ratio myself, yet I consider having it high, with the latest CBC showing 66% to 21%, or higher than a 3:1 ratio. But I've had this way 25 yrs ago, coinciding with the time my blood pressure started going up from the safe value of 120/80.

But I have been healthy despite the high BP, which I never (until 2 yrs ago) treated with hypertensive prescription drugs (until I had to when I developed heart failure and had to go to the ICU after my heart stopped and I had to be revived at the ER). I'm saying this because I developed heart failure not because of high BP, but because I had allowed a self-induced bronchitis to be taken for granted and the hypoxemia that was left unresolved cascaded into heart failure. I say this to emphasize that it wasn't my high BP, as left un- intervened by hypertensive drugs, that caused it.

If only to support my contention that a high neutrophil/lymphocyte ratio, in my experience, while not ideal, was something tolerable, though it definitely was associated with my high BP situation. Because during that time, I wasn't suffering from any issues. This meant zero allergies, no flu for the past 25 years (nor fever), which I would say counts for high immunity. No body aches, stomach aches nor headaches. No overweight, great sugar control, normothyroid. High endurance running, and an ability to dry fast for 3 days. Also high internal metabolism, which did not require me to work out or walk to maintain s normal weight. Which meant, despite (or because of) high BP, I was very healthy.

But I have lead toxicity, and a low grade (ie no fever) internal infection I attribute to a periodontal infection that translocated, both of which persisted and caused a continual immune response that produced a persistent level of oxidative stress. Which caused my high BP.

The high BP came from having low blood volume that my body had to increase BP to compensate for, in order to ensure the lower blood volume can still provide adequate circulation and perfusion of blood through the tissues and organs without fail.

The low blood volume resulted from lower serum albumin, which was lower from its being used daily as an extracellular antioxidant to counter the oxidative stress arising from spillover ROS resulting from the immune system creating ROS to kill pathogenic microbes that was never totally eliminated, as well as the oxidative stress from the lead toxicity that never got resolved as well.

But I could not say my immune system was overactive and dysfunctional. It did what it had to do to protect me from lead toxicity and periodontal infection that needed more external intervention (heavy metal chelation and use of better methods of infection control other than pharma antibiotics) in order to eliminate.

Through it all, I had high BP which did not cause my health to deteriorate (I feel high BP was a protective adaptation though our doctors would say otherwise), and the albumin that was constantly being used up and lost, was a renewable resource in the sense that the liver kept producing more of it to replace the ones used. In this way, my body was kept from suffering any tissue destruction that may have resulted from the constant oxidative stress from heavy metal toxicity and spillover ROS my immune system generates. My tissues and organs are protected and intact.

So, I guess, what would be portrayed by mainstream medicine as dysfunctional isnt really so. And what really is dysfunctional could just be the response of medicine to try to intervene when it shouldn't. In all the ways modern medicine could.

Maybe something to do with tonicity, vascular tone and everything thereafter. Onset in reverse, I wonder what causes that.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11293686/
(Only a sample.)

If "the next pandemic" had an energy mandate as or opposed to a vaccine mandate. I wonder what would happen.

the study in women athletes had them taking ridiculously high doses, something like 1g a day of TTFD iirc.

it is dopamingeric, the first time i took a 25mg alinamin f tablet i got pronounced euphoria. it’s popular in japan.

@Mauritio said in Random, interesting studies:

Anybody tried bees bread ?

In this study it did wonders for steroid health.
They gave mice on a HFD about 5-7g(HED) of bees bread and it completely rescued the levels of their steroidogenic enzymes.
Not only that, in many cases, giving them bees bread, increased the values above the normal control group.

Testosterone was increased by about 60% above control levels.
StaR mRNA levels doubled !
Unfortunately estrogen was increased as well, but only to the level of the control group not above that.

1000014499.jpg

https://journals.physiology.org/doi/full/10.1152/ajpendo.00093.2021?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

I was wondering where the strong androgenic effect from this study was coming from, it seemed hard to believe that it was only from an antioxidant effect.

I think I found the answer.
IL-10 has been shown to be responsible for the 5-10x increase in Testosterone from L. Reuteri in animal studies.
https://bioenergetic.forum/topic/2188/l-reuteri/50?_=1747639248664

And bee bread drastically increased Il-10 in this study.

Compared to the control group the mrna increased about 10x and compared to the obese high fat group probably 30x . So that might be part of the androgenic effect.

I took 2.5g yesterday and today my muscle look insanely full, also notice higher libido and drive.

Screenshot 2025-05-19 09.18.51.png

https://pmc.ncbi.nlm.nih.gov/articles/PMC8868291/#sec3-antioxidants-11-00255

@haidut

How timely. 🙂

Hi Haidut, nice to see you here!

@haidut
I remember the announcement and recruiting for this study in 2020 iirc.
Then everything vanished and reportedly the project's budget was cut and the study shelved.
WTF was going on there. How did they finish it anyway? Who allowed them to now release their results? Too many polito-economic-corruptory questions.

@haidut Wow no surprise the SSRIS are really from the bad guys.

Do you have a recommendations for what a person with PSSD should do?
(Post ssri sexual dysfunction)
Would love to hear your thoughts…….

Thanks

@wester130 i think we’re talking about two different types of massage intensity. I began just rubbing by pushing my fingers to the top of the scalp to make it feel good, and trying to move the scalp from side to side, as if to stretch (pleasure is a good sign of a safe stimulation imo). With time, moving the scalp can become a small victory. I can now pinch my scalp skin between two fingers on my well rested days, but many days i cannot… i just rub my fingers on it and move the skin how ever much it will.

@CrumblingCookie I wouldn't call it anti-serotonergic , the mood lift felt more like a neurosteroid boost. Which is a little different from a dopamine boost. Both are good though.

Not sure about it's androgenicity , I didn't experience any detrimental effects . But I only tried it twice and I was also sick with a cold so not the best test run.
I certainly would be willing to try it again if it wasn't for the constipation, but I'm sure I'll give it another go.

Ive tried the old version of gonadin today with phytol in it. that was quite nice . I'm also having great results with diosgenin in the last months.

@Mauritio heh

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@CrumblingCookie said in Repairing Knee Osteoarthritis and Cartilage Degeneration with the combination of Boswellia and Celery Seed::

Both celery extract and apigenin, and flavonoids in general (?), seem to promote breakdown of calcium oxalate.

Digging into this I discovered the term Chondroprotective agents. These agents "include both endogenous and synthetic chemicals." No mention of exogenous natural sources. A quick search of 2025 pulbications:

Anthocyanins and Anthocyanidins in the Management of Osteoarthritis: A Scoping Review of Current Evidence

Potential Chondroprotective Effect of Artemisia annua L. Water Extract on SW1353 Cell

Chondroprotective effect of pomegranate seed oil in papain-induced knee osteoarthritis through animal modeling

Butchered and banned.

Why China. Why.

@Mauritio Thanks 🙏

@evan-hinkle said in Visceral fat reduction by enteric-coated lactoferrin:

@Ismail hey man, doing well! I was taking 500mg Jarrow freeze-dried lactoferrin.

And just a general update: I’ve been taking the enteric coated for a few months now, and I actually think I prefer the ones I was taking before. I replicated the study above taking 300mg of the enteric coated, and really didn’t notice anything at all, (which is odd because I respond to most everything I try, (good or bad)).

TMI: I saw an undigested enteric coated lactoferrin in my stool last week, (great, they’re making it past the stomach-bad, I’m literally shitting my money away…).

Lol! I guess the enteric coating is working erm too well!

Since this event I’ve begun chewing the enteric coated pills, (now we’re really defeating the purpose, lol) and this has not made any difference. Still not noticing any effect. I’ll swap back to my old brand for a month and see what I think.

Yes will def be interesting to see how you respond if you go back again 🙂

@samson -Thanks for your thought. For me, maintaining muscle mass is more about anti-fragility and avoiding disability.

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Sarcopaenia (muscle loss) impact ones health in many ways.
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source

I have a 'smart scale' that I purchased at amazon and it allows me to monitor changes in my muscle mass, bone weight and other things. Here is the typical cartoon image showing how muscle is replaced by fat tissue as one ages if your not paying attention.
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@alfredoolivas lol they made their Chinese peptide company sound like sigma Aldrich