Ask him on twitter if you're there Dk. These are auto-posted from his blog.

@Insomniac 50 mg k2 mk4 high iron intake and b2 cured me.

@cs3000 said in Thymus health:

Looks like a big health unlock , neutrophils are big players in autoimmune problems maybe the biggest, you see them showing up causing big damage in a wide range of health issues covid cystic fibrosis ulcerative colitis heart failure etc

and theyre highly destructive with different weapons, cytokine release, then they have proteases that degrade the structure surrounding the cell (if u inhibit neutrophil proteases in arthritis they dont develop arthritis at all https://pmc.ncbi.nlm.nih.gov/articles/PMC150852/ ), and they can form wild traps where they basically gut themselves & spill out strands of dna laced with proteins to form damaging webs like some kind of arsehole spiderman in the autoimmune situation

There is a lot I don't understand about the adaptive immune system and maybe it's this lack of understanding that betrays my view in seeing autoimmunity to be largely involved with B-cells.

In this regard, autoimmunity is not so much different from being very sensitive to stimulus that the immune system wrongly regards something that is endogenous as being foreign.

I have chronic high blood pressure and it is the result of my neutrophils and macrophages of the innate immune system trying to get rid of heavy metal toxins and periodontal infections with no success, given the persistency of these insults where they don't get permanently removed or killed. It is like Groundhog Day for my immune system where they keep repeating their efforts to get rid of persistent insults that keep bouncing back. Yet I do not consider the inflammatory effects of this endless effort to be an autoimmune condition. But I blame the tenacity of heavy metals refusing to be swallowed up and excreted out, and the ability of synergistic bacteria and fungi to defend against attack by phagocyte activity by neutrophils and macrophages.

But lately I have used techniques and substances to assist my immune system to successfully get rid of the hitherto unremovable toxins and immortal infection. But I had to employ medically unorthodox techniques to achieve these.

Seems to me medical complex is guilty of spreading misinformation and disinformation to label as autoimmune, on the strength of their vaunted research which are in many cases made up stories to lead trusting souls astray.

Yet I do not wish to throw the baby with the bathwater, for a large part of the body of research is valid, and a good filter is needed to separate wheat from chaff.

It is good to know about vitamin D.

Peatbot.com: Based on the context provided, reducing cardiac fibrosis can be associated with the regulation of collagen gene expression and the influence of thyroid hormones. Here are some insights from the studies mentioned:

Thyroid Hormone Treatment: The study by Yao and Eghbali (Cardiovasc Res 1992) suggests that thyroid hormone treatment can lead to decreased collagen mRNA and regression of cardiac fibrosis. In the tight skin mouse model, thyroid hormone treatment resulted in diminished collagen content and the disappearance of cardiac fibrosis. This indicates that thyroid hormone may play a significant role in preventing and regressing cardiac fibrosis through endocrine pathways. Negative Regulation by Thyroid Hormone Receptor: The study by Chen et al. (Mol Cell Endocrinol 2000) provides evidence that thyroid hormone receptors negatively regulate the pro-alphal(I) collagen gene expression. This suggests that maintaining adequate levels of thyroid hormones could potentially reduce collagen synthesis and thus cardiac fibrosis. Avoidance of Hypothyroidism: Hypothyroidism has been associated with increased myocardial fibrosis due to the lack of thyroid hormone, which leads to increased collagen synthesis. Ensuring proper thyroid function might help in reducing the risk of developing cardiac fibrosis.

These studies highlight the potential of thyroid hormones in managing cardiac fibrosis. However, it is important to consult with healthcare professionals for personalized medical advice and treatment options.

@Mossy oh wait I said methylene blue fat thing that doesn't make sense cause u would be taking k2 mk4 instead. nvm. u get what I mean.

@haidut

Yeah.

I ask about Georgi a few hours ago, and BOOM. He posts!

lot more studies about smoking

http://www.longecity.org/forum/topic/61248-the-intelligent-smoker-what-should-a-smoker-take-to-nullify-harm/#entry564686

https://web.archive.org/web/20150506014136/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389609

https://web.archive.org/web/20200519095149/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/

https://web.archive.org/web/20170725172009/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389478

https://web.archive.org/web/20170725172009/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389478

https://web.archive.org/web/20171029181630/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-16#entry390790

https://web.archive.org/web/20170725172009/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389717

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001541/ - Improves cognition

https://www.york.ac.uk/depts/maths/histstat/smoking.htm

https://cfrankdavis.wordpress.com/2015/08/06/william-whitby-smoking-is-good-for-you/

https://www.scribd.com/document/125915399/Smoking-is-Good-for-You?ad_group=&campaign=Skimbit%2C+Ltd.&content=10079&irgwc=1&keyword=ft750noi&medium=affiliate&source=impactradius

http://www.thetreeofliberty.com/vb/showthread.php?202165-Smoking-Helps-Protect-Against-Lung-Cancer&p=2362638

@cs3000
This stuff is all so fascinating to me! I had never seen that before in the old forum. I am a total novice lay person. I just like finding things that I heard Ray talk about and share with people like yourself who can run with these ideas! I personally love the quinones from Pau D’arco bark, cascara sagrada. I also love emodin from aloe Vera juice. Emodin is a natural hydroxyanthraquinone compound found in Aloe vera juice, specifically in the latex of the plant. Antibacterial, antifungal, and anticancer effects. But, yes! Thanks for diving into Kocks stuff and sharing! It’s helping me explore it more too!
Peace!

@Lejeboca - thank you for taking the time to respond. I got things twisted around in my mind and it is embarrassing.

I think of the relationship between the eNOS and iNOS isoforms of nitric oxide synthase as being analogous to Dr. Jekyll and Mr. Hyde. The "i" in iNOS is related to inflammation, ischemia and intoxication all of which are generally bad. Whereas the "e" is related to the endothelium and is very healthy to have on board. Caldwell Esselstyn had his cardiac patients eat greens all day to maintain high levels of eNOS as part of his successful plan to reverse heart disease.

In 1998, the Noble Prize in Medicine was awarded to 3 people for their work on NO (see press release). This encouraged people to supplement with L-arginine to lower their blood pressure. The excessive iNOS from the supplementation had long term consequences that were not good.

Incidentally, aspirin releases eNOS.
Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action (2009)

The role of melatonin in bone regeneration: A review of involved signaling pathways
Abstract
Increasing bone resorption followed by decreasing bone mineralization are hallmarks of bone degeneration, which mostly occurs in the elderly population and post-menopausal women. The use of mesenchymal stem cells (MSCs) has raised many promises in the field of bone regeneration due to their high osteoblastic differentiation capacity and easy availability from abundant sources. A variety of compounds, including growth factors, cytokines, and other internal factors, have been combined with MSCs to increase their osteoblastic differentiation capacity. One of these factors is melatonin, whose possible regulatory role in bone metabolism and formation has recently been suggested by many studies. Melatonin also is a potential signaling molecule and can affect many of the signaling pathways involved in MSCs osteoblastic differentiation, such as activation of PI3K/AKT, BMP/Smad, MAPK, NFkB, Nrf2/HO-1, Wnt, SIRT/SOD, PERK/ATF4. Furthermore, melatonin in combination with other components such as strontium, vitamin D3, and vitamin K2 has a synergistic effect on bone microstructure and improves bone mineral density (BMD). In this review article, we aim to summarize the regulatory mechanisms of melatonin in osteoblastic differentiation of MSCs and underling involved signaling pathways as well as the clinical potential of using melatonin in bone degenerative disorders.
https://www.sciencedirect.com/science/article/abs/pii/S0300908422002127

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures
https://pubmed.ncbi.nlm.nih.gov/28130552/

tea is very high in fluoride. The more expensive teas are harvested from young shoots, which are much lower in fluoride due to less time growing to accumulate it. But that is the issue, the cheaper assam teas can have 2mg per cup.

@Lejeboca - I did not know that one could search Sci-Hub by ISBN. Thanks.

Pantethine
Because of pantothenic acid’s role in triglyceride synthesis and lipoprotein metabolism, experts have hypothesized that pantothenic acid supplementation might reduce lipid levels in patients with hyperlipidemia [19].

Several clinical trials have shown that the form of pantothenic acid known as pantethine reduces lipid levels when taken in large amounts [20], but pantothenic acid itself does not appear to have the same effects [1]. A 2005 review included 28 small clinical trials (average sample size of 22 participants) that examined the effect of pantethine supplements (median daily dose of 900 mg for an average of 12.7 weeks) on serum lipid levels in a total of 646 adults with hyperlipidemia [20]. On average, the supplements were associated with triglyceride declines of 14.2% at 1 month and 32.9% at 4 months. The corresponding declines in total cholesterol were 8.7% and 15.1%, and for low-density lipoprotein (LDL) cholesterol were 10.4% and 20.1%. The corresponding increases in high-density lipoprotein (HDL) cholesterol were 6.1% and 8.4%.

A few additional clinical trials have assessed pantethine’s effects on lipid levels since the publication of the 2005 review. A double-blind trial in China randomly assigned 216 adults with hypertriglyceridemia (204–576 mg/dl) to supplementation with 400 U/day CoA or 600 mg/day pantethine [21]. All participants also received dietary counseling. Triglyceride levels dropped by a significant 16.5% with pantethine compared with baseline after 8 weeks. Concentrations of total cholesterol and non-HDL cholesterol also declined modestly but significantly from baseline. However, these declines might have been due, at least in part, to the dietary counseling that the participants received.

Two randomized, blinded, placebo-controlled studies by the same research group in a total of 152 adults with low to moderate cardiovascular disease risk found that 600 mg/day pantethine for 8 weeks followed by 900 mg/day for 8 weeks plus a therapeutic lifestyle change diet resulted in small but significant reductions in total cholesterol, LDL cholesterol, and non-HDL cholesterol compared with placebo after 16 weeks [19,22]. Increasing the amount of pantethine from 600 to 900 mg/day did not increase the magnitude of reduction in the lipid measures.

Additional studies are needed to determine whether pantethine supplementation has a beneficial effect on hyperlipidemia independently of, and together with, eating a heart-healthy diet. Research is also needed to determine the mechanisms of pantethine’s effects on lipid levels.
https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/#h9

@Mauritio said in Glycine is an anti-biotic, restores sensitivity to antibiotics:

In light of this thread, the findings of this old thread by haidut are even more interesting.

https://lowtoxinforum.com/threads/gut-bacteria-overgrowth-drives-cocaine-addiction-glycine-can-reverse-it.48285/

I'm puzzled. How can glycine be helpful if it feeds the bacteria? Aren't we supposed to deprive the bacteria of its food source to have an antibiotic effect such that the bacteria would just not be able to multiply and become a thriving colony by being deprived of its food source? How is providing more gelatin going to help?

@yerrag
Yes, although this study shows rapamycin has thymus weight lowering effect in mice. Although there was clearly a dose dependant effect and the HEDs were like 15-60mg per day which is really high, so I'm not sure if there would be any such effect if you were to take just 1-5mg / week .
So the weekly dose of this study was about 30-100 times higher than what most humans take.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9360838/

It increases dopamine .

"MPTP-induced reduction of dopamine contents in the striatum and hippocampal CA1 region was improved by nobiletin administration (50mg/kg i.p.). Acute intraperitoneal administration of nobiletin also enhanced dopamine release in striatum and hippocampal CA1,..."

https://pubmed.ncbi.nlm.nih.gov/24316474/

NOB could restore memory impairment via the improvement of neurogenesis by ameliorating neuroinflammation in the hippocampushttps:

//pmc.ncbi.nlm.nih.gov/articles/PMC10181043/

@sneedful said in vitamin k2 mk4 levels elevated in covid patients, k2 mk7 and k1 depleted:

is it because k2 mk7 and k1 are being rapidly converted into k2 mk4 which is then detected at high levels in blood?

No, I don't think so. K2 MK7 is preferably used for clotting problems. More soluble and also "reactive". Reactive to ox-agression.
But mind the peremption of K2 MK7: very fragile (3 months) if not well encapsulated and protected by e.g. rosmarinus.

Source: Chris Masterjohn
There is reason to think MK-7 would be better at supporting blood clotting.
“MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.”
https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/

It's advised not to take vitamin E at the same time as vitamin K when taking high dose.
Since I take 1 mg (1 000) K2 MK4 at breakfast, I never take vit E at the same time. 2x/wk for 400 UI mix toco.