@engineer I wouldn't call it a goal, because high endogenous production of T would cause scrotal T+DHT to be high. But there is no benefit of adding androgenic or estrogenic substances to the testicles. The precursor steroids at least pregnenolone has shown to be protective. Not sure what you mean about the DHT/estrogen balance.

NMN looks very interesting because its sibling niacinamide is a cheap commodity yet has almost identical pharmacology.

@Mauritio said in Lifespan-Extending Endogenous Metabolites: Interestingly a lot of the benefits of dietary/protein restriction seem to be due to an endogenous increase inH2S synthesis. I am wondering if the endogenous increase is a compensatory mechanism for the lower protein. [image: 1769206520127-3d8d62d5-8ef1-40ce-a961-2bd28fc73873-image.png] Impact of diet on hydrogen sulfide production: implications for gut health (2023) [image: 1769206673256-78538c46-a4cf-4a23-bea3-73ca5164503c-image.png]

@Mossy said in Vitamin K2 reverses fatty liver disease: Would anyone happen to know why MK7 gives me heart palpitations, but MK4 does not? MK-7 is not an essential nutrient. What is essential is that you stop taking it if it gives you heart palpitations. MK-7 has a half-life of around 70 hours. MK-4 has a half-life of around 4-6 hours. Researchers like the around-the-clock effects of the MK-7 form of K2. Adequate MK-4 is what we need in our diet. https://minbalance.com/articles/K2-MK4-the-grass-fed-vitamin.html

estrogen too [image: 1769143712211-9d9f6c7b-b9ea-4511-97db-0ca809e17fe3-image.png]

Repost from my reddit 2 months ago. Currently trying 1.25 mg patches. To match the oral dose fo 2.3mg

Thank you @CrumblingCookie. Good information. But I see no financial advantage in citrate, here in the UK potassium citrate powder costs £14/kg and potassium bicarbonate £4/kg.

Niacin is the the most potent substance to raise HDL (up to 35%). Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein (1996) [image: 1768937767460-4330412e-970e-4013-bc99-d131cbab7111-image.png]

@engineer SSRIs have a much more generalized effect than a direct 5-HT1a receptor agonist since serotonin will be divided among all other receptors From another study 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats [image: 1768918294031-3d46999d-9aad-44ea-8bf1-36bfb5e7c66b-image.png] Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis [image: 1768920594623-d36fbbc0-87ea-42bd-be31-d2f3fde2633a-image.png]

@Hearthfire Appreciate the detail. Great news on the vellus hair growth.

@sunsunsun Thanks for chiming in. The dosages really are not self-evident, ever. Given the general amount of animal studies wherein astrononimcal concentrations are being used to draw conclusions, it's difficult to say what is uncalled for timidness and waste of effort and what's straight out daftly excessive, wasteful and potentiall harmful at the other end. E.g. there are still people believing they need 5000 IU hGC per week when actually 250 IU (400IU max) every other day is pretty much enough for the whole effect. Also, IFN-y is only being used at 100mcg. Its precursor Interleukin-12 (IL-12) appears to must be used only in single digit mcg amounts, if at all. Have you gained any experiences with the thymic peptides? I'll restart with the Glu-Trp thymogen and begin with the TA1.

@Mauritio - I am a whole foods type of person. I encourage others to get their nutrients from food.

@engineer - Vitamin A & D is probably not the full story. Chris MasterJohn has a checklist which uncludes other things that you are probably doing as well. https://chrismasterjohnphd.substack.com/p/what-everyone-should-be-doing-for