CATALASE

Been looking into catalase again.

1.Thyroid hormones increase catalase.
https://lowtoxinforum.com/threads/thyroid-hormone-increases-anti-oxidant-enzymes-glucocorticoids-lower-them.49877/

I found this clip of Ray talking about it very useful. Often peaters will dogmatically oppose anti-oxidants, because "you want oxidation", but as Peat says here, anti-oxidants like T3, will inhibit the random harmful oxidation in the ETC and keep the electrons flowing, so actually more, good oxidation can happen.
Youtube Video

2.Catalase knock out mice experience increased lipogenesis and ER stress.
https://pubmed.ncbi.nlm.nih.gov/31877356/

@LucH

Thanks for the info!

There are some animal studies on restricting only omega-6, and the effect is to increase the metabolism of omega-3 and decrease that of omega-6:

Fifteen weeks of n-6 PUFA deprivation compared with adequate diet decreased the mean unesterified plasma concentration of n-6 PUFAs by 84% (Table 1). The change in the total unesterified n-3 PUFA concentration was statistically insignificant, although unesterified DHA and EPA concentrations were increased by 53% and 79%

The total n-3 PUFA concentration in brain was increased by 15%, reflecting largely an 11% increased DHA concentration (Igarashi et al. 2009). Expression of enzymes of the 20:4n-6 cascade, cPLA2-IVA and COX-2, was downregulated, whereas expression of DHA-preferring calcium independent iPLA2-VIA (Garcia and Kim 1997; Strokin et al. 2004; Ramadan et al. 2010; Basselin et al. 2011) and of 15-lipoxygenase (LOX) was up-regulated (Kim et al. 2011).

COX-2 mRNA was decreased significantly (−23%, p b0.05) (Fig. 3A) in the n-6 PUFA deprived rats compared with adequate rats, as was COX-2 protein (−32%, pb0.05) (Fig. 3B). The deficient diet did not change COX-1 or mRNA significantly

@Hando-Jin oh yeah. Now psychedelic therapy is in vogue and I think legal in several us states. Mind-body relations. Bessel van der Kolk also mentions psychoactives for ptsd therapy.

"Green tea inhibits Helicobacter growth in vivo and in vitro"
https://pmc.ncbi.nlm.nih.gov/articles/PMC2694061/

Mice were infected with H. pylori and given either tea or water. The group that was given tea had both greatly reduced inflammation and H. pylori population. In fact, mice that were given tea both before and after the infection had no inflammation and no H. pylori population at all.

I suspect it is the L-Theanine in the tea but nobody has studied that so I have no proof. I think so because high dose L-Theanine completely suppresses H. pylori symptoms for me.

@springsnow haiduts arguments are that most of the benefit comes from restricting inflammatory amino acids like methionine. This seems to be in line with studies that show all the benefits of calorie restriction just with protein restriction.

@DavidPS the satiety one is interesting since milk has been traditionally considered a breakfast item. Another piece of evidence as to why people used to be much leaner.

See the reference 3
Glutathione Depletion Prevents Diet-Induced Obesity and Enhances Insulin Sensitivity
Hannes M. Findeisen et al. 2012 https://doi.org/10.1038/oby.2011.298
Abstract
Excessive accumulation of reactive oxygen species (ROS) in adipose tissue has been implicated in the development of insulin resistance and type 2 diabetes. However, emerging evidence suggests a physiologic role of ROS in cellular signaling and insulin sensitivity.
In this study, we demonstrate that pharmacologic depletion of the antioxidant glutathione in mice prevents diet-induced obesity, increases energy expenditure and locomotor activity, and enhances insulin sensitivity. These observations support a beneficial role of ROS in glucose homeostasis and warrant further research to define the regulation of metabolism and energy balance by ROS.
Excerpt
(…) Since glutathione peroxidase (GPx) constitutes the principal antioxidant defense system to scavenge physiological concentrations of H2O2 in mammals (6), we investigated in this study the role of pharmacological glutathione depletion on diet-induced obesity and insulin sensitivity. Surprisingly, depletion of endogenous glutathione protected mice from obesity, preserved insulin sensitivity, and increased energy expenditure, pointing to a more complex role of endogenous ROS in diabetes and energy balance than previously anticipated.

=> There is a contradiction and a bias in the title as well in the abstract.
To be reminded: too much of a good thing is bad. No need for more than 2x/wk 100 mcg. Diet with meat and eggs brings +/ 50 % of the RDA.
Supplement is only bioavailable at +/ 60%.
More info (In French, translator needed)
https://mirzoune-ciboulette.forumactif.org/t1953-selenium-too-much-of-a-good-thing-is-bad#27971
=> Selenium forms, bioavailability, enzymatic functions, synergy with other antioxidants,
Sources and References.

For a moment I wondered why capsules with 50mg BAM15 are being sold much more expensively than capsules with the combination of BAM15 with SLU-PP-332 (an alleged exercise mimetic agonist of Estrogen receptor alpha, beta, gamma).
But upon a closer look, the SLU-PP-332/BAM15 are sold in micrograms (300mcg total, 50mcg BAM15). In contrast to the BAM15 in milligrams (50mg).

@Mauritio if you dont mind my asking, what does the damage look like?

OJ for the Win !

@stag wtf i love emf now

@solarfall

No, but that Allopreg product costs $1.20 per mg, and idealabs' discontinued AlloP product had a cost of $0.16 per mg, which means that the product you linked to is 7.5 times more expensive. I can't imagine wanting allopreg so badly that I would be willing to pay that steep of a price. But I suppose it's nice to know that someone out there is still selling it.

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

Another interesting fun fact is that the high carb diet increased the concentration of palmitoleic acid by almost 150%. Its interesting that when the body makes new fat that it is a pro-metabolic MUFA. Palmitoelic acid is contained in macadamia nuts a lot.

"Diabetes induced a decrease of monounsaturated fatty acids and particularly palmitoleic acid in all studied tissues: liver,
aorta, plasma."
https://www.sciencedirect.com/science/article/abs/pii/095528639500026V