@Ismail You're welcome 🙂

@Mauritio said in Random, interesting studies:

@Mauritio said in Random, interesting studies:

3,8-Dihydrodiligustilide
Strong phytoprogestogen.
https://en.m.wikipedia.org/wiki/3,8-Dihydrodiligustilide

It has almost the same potency as progesterone (80% of it). And it has no estrogenic or anti-androgenic effects.

"EtOH extracts of the dried rhizome of L. chuanxiong demonstrated strongest
progestogenic activity, reaching 80% of that observed with progesterone (100 nM) and had an EC50 of 8 lg/ml (Fig. 1b). The bioactivity of L. chuanxiong extract was spe-
cific to the PR, and the extract was at least 200-fold less active on other related members of the steroid receptor family like androgen, estrogen and glucocorticoid receptors."

https://www.sci-hub.wf/10.1016/j.phytochem.2006.01.024

The plant Ligusticum sinense chuanxiong from which it is extracted is traditionally used to treat uterus issues. It also has been studied to treat strokes and Parkinson's.

In this review they look at the anti inflammatory effect of it.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7591981/

HED about 20g of the extract.
"Effect-time studies indicate that injection of MPA and L. chuanxiong extract raised area-under-curve of progestogenic activity in sera by 8.2-fold (p<0.001) and 4.5-fold (p<0.01) respectively, compared to sera from rats administered vehicle only. Administration of MPA and L. chuanxiong extract by the oral route resulted in a 5.4 (p<0.001) and 2.3-fold (p=0.07) increase respectively. Our data suggest that PR-responsive reporter gene bioassays can measure bioavailability of compounds, known and unknown, of complex botanicals for hormone replacement therapy. L. chuanxiong extracts exert progestogenic activity in vivo, and may have utility for progesterone-replacement therapy."

https://pubmed.ncbi.nlm.nih.gov/16650443/

good review on it
https://www.tandfonline.com/doi/full/10.3109/13880209.2011.576346#d1e665

HED = 850mg of the extract.
L. Chuanxiong completely prevented weight gain on a high fat diet. It increases antioxidants and cholesterol conversion into bile acids. Genes related to steroid biosynthesis were also upregulated so I guess that was another way it lowered cholesterol.
https://iadns.onlinelibrary.wiley.com/doi/full/10.1002/fft2.249

@LetTheRedeemed Have you seen any improvement since your last update?

@CrumblingCookie sadly dopamine agonists are not usually prescribed to patients, even in Parkinsons, as they usually just prescribe Levodopa, so of course none of these drugs are commonly prescribed.

Pramixepole is the new dopamine agonist and that increases noradrenaline, and as far as I know, Amantidine and especially memantine, are commonly prescribed off-label, for many conditions such as MS and depression.

Why isn’t Bupropion a good DA reuptake inhibitor? It’s even combined with naltrexone, in a formula called Mysimba, which creates an anti-opioid, anti endotoxin, pro dopamine and noradrenaline effect

@William-Shat said in Effects of Maca on Physical Performance in Animals and Humans:

flattered or baffled

Humour in the middle.

https://www.sott.net/article/221013-Health-Benefits-of-Smoking-Tobacco

https://www.sott.net/article/338885-A-comprehensive-review-of-the-many-health-benefits-of-smoking-Tobacco

https://www.sott.net/article/139304-Lets-All-Light-Up

https://www.sott.net/article/229156-Lies-Damned-Lies-400000-Smoking-related-Deaths-Cooking-the-Data-in-the-Fascists-Anti-Smoking-Crusade

Green Tea Catechins and Skin Health (2024)

Green tea catechins (GTCs) are a group of bioactive polyphenolic compounds found in fresh tea leaves (Camellia sinensis (L.) O. Kuntze). They have garnered significant attention due to their diverse health benefits and potential therapeutic applications, including as antioxidant and sunscreen agents. Human skin serves as the primary barrier against various external aggressors, including pathogens, pollutants, and harmful ultraviolet radiation (UVR). Skin aging is a complex biological process influenced by intrinsic factors such as genetics and hormonal changes, as well as extrinsic factors like environmental stressors, among which UVR plays a pivotal role in accelerating skin aging and contributing to various dermatological conditions. Research has demonstrated that GTCs possess potent antioxidant properties that help neutralize free radicals generated by oxidative stress. This action not only mitigates cellular damage but also supports the repair mechanisms inherent in human skin. Furthermore, GTCs exhibit anti-carcinogenic effects by inhibiting pathways involved in tumor promotion and progression. GTCs have been shown to exert anti-inflammatory effects through modulation of inflammatory signaling pathways. Chronic inflammation is known to contribute significantly to both premature aging and various dermatological diseases such as psoriasis or eczema. By regulating these pathways effectively, GTCs may alleviate symptoms associated with inflammatory conditions. GTCs can enhance wound healing processes by stimulating angiogenesis. They also facilitate DNA repair mechanisms within dermal fibroblasts exposed to damaging agents. The photoprotective properties attributed to GTCs further underscore their relevance in skincare formulations aimed at preventing sun-induced damage. Their ability to screen UV light helps shield underlying tissues from harmful rays. This review paper aims to comprehensively examine the beneficial effects of GTCs on skin health through an analysis encompassing in vivo and in vitro studies alongside insights into molecular mechanisms underpinning these effects. Such knowledge could pave the way for the development of innovative strategies focused on harnessing natural compounds like GTCs for improved skincare solutions tailored to combat environmental stresses faced by the human epidermis.

@Mauritio said in Niacinamide as effective as minoxidil at treating “androgenic” hair loss:

@Mossy I stopped using them topcically, because it was such a mess to apply. But looking backon it that was because of the apple juice i diluted it in.
So maybe I'll give the polyphenols another run mixed with niacinamide and glucose and water.

I hear you. If there's one thing I've learned over the years with these topicals, at least for me, they're impossible to use on a regular basis, apart from during sleep, due to the mess.

The glucose would seem to be a mess, no matter the form. On those lines, I've been thinking of using the common D-Ribose supplement, as opposed to the much more expensive variant of it used in the studies.

@Serotoninskeptic And muscle building isn't everything, maybe one can build a little more muscle on a way higher P-diet, but at what cost?

there's human trials

cognitive improvement
https://www.ls-corporation.co.jp/wp-content/uploads/2022/10/ergothioneine_congitive.pdf

and over 1 year, with people aged > 60
https://www.medrxiv.org/content/10.1101/2024.07.08.24310085v1.full.pdf

f92ec67d-100b-4fa5-a512-86ba1002478b-image.png
at 6 months, and still gaining at 12 months

. Following ET intake, an increase in Z-scores was observed in RAVLT assessments (immediate and delayed recalls), which evaluates learning ability and memory (Figure 4a&b). In contrast, no significant increase was observed in Z-scores across all NCA components, in the subjects given the placebo.
Block design scores, which assess visual-motor coordination and problem-solving skills, declined over time in both ET and placebo groups (Figure 4g). Although not measured at baseline, Z-scores of SDMT (written format) in the ET group showed a trend to increase from visit 7 to visit 14 (Figure 4i)

(at 4 weeks visit 1 ergo group also had a better lymphocyte-neutrophil ratio)
dec0b3e9-1154-4776-acb4-5b5f54bd831c-image.png

@haidut

yo, didnt you post something months or years ago on RPF about retinol destroying or detoxing micro plastics?

The Insane Biology of: Humans

This article appeared in my inbox. More support for apigenin protecting the liver.

Apigenin as an emerging hepatoprotective agent: current status and future perspectives (2024)

d2d64e2f-533e-4b0b-be95-813d96a150c3-image.png

The big issue with this is something that I noticed when I was doing the warrior diet.

You really can’t metabolize more than around 25 or 30 g of protein at a time.

So your protein may be too low if you’re doing only one protein meal.

And you’re loading yourself with a lot of protein at one time, which increases ammonia levels and stresses your kidneys.

@alfredoolivas it appears you are correct on that one! Finally, real progesterone.

@alfredoolivas
Thanks, interesting.

The problem with this study is that it considers the level of TSH below 8–9 mIU/L "normal"...