@user73636 sounded like a gimmick at first but its well studied theres a lot on it, decent amount from japan , another way to get it without a machine is buying some elemental magnesium metal sticks or ribbons (safer to avoid as fine powder tho unless stored right). can add a stick or ribbon chunk to water and it will make hydrogen bubbles (added a small amount of malic acid to speed up getting past the oxide surface and a bit more hydrogen , then rinsing after drinking. i added it without malic and it still bubbled) https://bioenergetic.forum/topic/9291/hydrogen-dissolved-in-drinking-water-or-via-gastric-acid i reckon 200ug hydrogen at once would be good. trying to figure out how much a 10cm 130mg ribbon would give. max water saturation you can get is 1mg - 1.5mg per L but it reacts slow and without a lot of acid it forms a black layer. i read some papers where they dipped it for a short time and it had effect still

@LunaticRed I shave my arms and apply it there and the inside of thighs currently.

@cs3000 I interesting ! Oleanolic acid sounds interesting, too. I took ursolic acid today for the first time. And it caused some hair loss but also a profound sense of relaxation that haven't felt in a while.

"Phytates are not a health concern for those who eat a varied and balanced diet. However, for those on a poor, monotonous diet, high levels of phytates increase the risk of mineral deficiencies, which is why various techniques are used to reduce phytate levels in food." I guess the question is, why would someone take to a variation of a "a poor, monotonous diet". And could that include some interpretations of advisories found around bioenergetics.

does the free acetyl also have this interactions with CAII?

@sphagnum I wouldn't worry about the ratio, just consume enough Calcium and Magnesium foods/supplements to your well-being and tolerance. Also in the cited study above, the ratio is 2.3, not 2:3, so it's more than two times elemental calcium than magnesium. 2:1 seems to be the recommended ratio in health institutions. Calcium to Magnesium Ratio Higher Than Optimal Across Age Groups Objectives The ratio of calcium to magnesium (Ca: Mg) intake has gained immense attention in recent years, since a ratio above 2:1 has been associated with increased risk of metabolic, inflammatory and cardiovascular disorders. The objective of this study was to assess Ca: Mg ratios across age groups and to determine the relationship between Ca: Mg ratios and markers of inflammation. https://pmc.ncbi.nlm.nih.gov/articles/PMC6574898 Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial Conclusion Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5. https://pmc.ncbi.nlm.nih.gov/articles/PMC6889387 Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study Our findings suggest that high dietary intake of Mg is associated with an increased risk of dementia mainly among older adults with low Ca:Mg intake ratios. Proper balance of Ca to Mg in the diet may be critical to the relationship between Mg intake and risk of dementia. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12362

@LunaticRed said in Fatty acid oxidation drives senescence: I recommend you to use Claude-opus-4-6-search instead of Gemini3, it's more powerful and better at searching information Thanks for the info. I appreciate. Here is a link for my first try / search on Vit k2 MK4 (in French): AI Conversation No. 3: HD Vit. K2 MK4 to target vascular, cerebral and hormonal aspects. https://mirzoune-ciboulette.forumactif.org/t2185-conversation-avec-lia-n3-hd-vit-k2-mk4-pour-cibler-les-aspects-vasculaire-cerebral-et-hormonal#30719 Need [image: 1775046783689-aa.emoticon-coffee.gif]

It would make sense if the thyroid won't get much damaged at the time of hypothyroidism, but a better question i was never really answered is, what actually happens with thyroid when it stops functioning.

@alfredoolivas I don't think so because it's entirely possible to have a state of high dopamine and low prolactin. It might just act as a secondary mechanism apart from some other dopamine pathway solely to prevent a prolactin overload. The fact that it uses dopamine to prevent such an overload is an irrelevant implementation detail because it's not common you see people in a high dopamine but high prolactin state.

@alfredoolivas said in Are microdoses of mifeprestone the ultimate receptor level anti-glucorticoid?: it would likely occupy all progesteorone receptors, it's birth control, you can get it through online pharmacies I think. Then I don't think it's really worth the hassle. Id still be curious to hear how something like this feels and affects a person...

@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: If it enhances autophagy through AMPK it should not be limited to mitophagy but also cover xeno-autophagy Good point. That might make it helpful for fighting infections. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: So a shift away from carbohydrates to FAO People often paint uncouplers as FAO-increasers. But they increase FAO and carb oxidation. The above article mentions it increasing TCA cycle, which can be fed by carbs and fat. It probably also depends on which tissues we are talking about. If you want to lean out your liver increasing FAO there is probably a good thing. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: The MOA of BAM15 would then be a combination of inducing UCP and something along the line of metformin or berberine or spermidine (but lacking the Beclin-1 upregulation). (A comparison with resveratrol is less suitable since, although it lowers intracellular ATP through AMPK, I dare say its most important effect is through Sirt1) AMPK increases SIRT1. So BAM15 should do that, too.

But astrocytes are known to be basically glycolytic, so klotho seems to me to be just reinforcing their mode of operation. Glycolysis is bad when it shouldn't happen there, but sometimes it's a better option than OXPHOS, even if it's inefficient. Just imagine how quickly oxygen would be depleted if the brain chose to do OXPHOS predominantly with fatty acids, as is the case with the heart, or how much superoxide would be generated...

@user73636 I just bought some royal jelly that arrived in a cold pack. It should be very good quality. Thanks for bringing this up. Have you tried it?

@user73636 Got it: Keeping to piña coladas, caipirinhas and pear nectar tequila or gin henceforth! Good call! Or do these ingredients indeed require a mutually synergistic blend?