https://lowtoxinforum.com/threads/vitamin-k-can-regenerate-the-liver.44932/

@AlphaZance - There is some controversy associated with the claim that Jeanne Calment was the world's oldest-ever person. World’s oldest-ever person was fraud who stole mother’s identity, researchers claim

https://bioenergetic.forum/post/5891 https://github.com/peatysharing

Regular Glucosamine Use Linked to Fewer Chronic Diseases

@Mauritio - Your not alone the market is with you. [image: 1769277123438-8bda1116-3cc9-482d-9a03-557a26dfadba-image.png] https://www.thebusinessresearchcompany.com/report/fisetin-global-market-report I think it is over rated. This graph my indicate that the control diet was not very good. I have a very good diet and so I do not expect to get similar results from supplementation. [image: 1769277394875-0d5f3553-3825-42fd-a91e-f4b36cdaea4f-image.png] https://novoslabs.com/novos-anti-aging-longevity-supplement/fisetin-anti-aging-supplement-longevity/

@DavidPS said in Lifespan-Extending Endogenous Metabolites: I am wondering if the endogenous increase is a compensatory mechanism for the lower protein. I think it is. A compensation for the low levels of sulfur amino acids to be precise.

@engineer I wouldn't call it a goal, because high endogenous production of T would cause scrotal T+DHT to be high. But there is no benefit of adding androgenic or estrogenic substances to the testicles. The precursor steroids at least pregnenolone has shown to be protective. Not sure what you mean about the DHT/estrogen balance.

estrogen too [image: 1769143712211-9d9f6c7b-b9ea-4511-97db-0ca809e17fe3-image.png]

Repost from my reddit 2 months ago. Currently trying 1.25 mg patches. To match the oral dose fo 2.3mg

Niacin is the the most potent substance to raise HDL (up to 35%). Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein (1996) [image: 1768937767460-4330412e-970e-4013-bc99-d131cbab7111-image.png]

@engineer SSRIs have a much more generalized effect than a direct 5-HT1a receptor agonist since serotonin will be divided among all other receptors From another study 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats [image: 1768918294031-3d46999d-9aad-44ea-8bf1-36bfb5e7c66b-image.png] Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis [image: 1768920594623-d36fbbc0-87ea-42bd-be31-d2f3fde2633a-image.png]