I think this lines up generally with PUFAs/increased serotonin/increased cortisol being associated with ASD (autism spectrum disorder) symptoms. Very nice that you keep collecting these studies!

Not specifically related to PUFA, but more to the endotoxin part, I have noticed that a lot of people I know with ASD have somewhat of a "pot belly". The evidence here is of course anecdotal, but I was wondering if this could be bloatedness associated precisely with endotoxin? The correlation with increased bacterial activity in the gut seems likely via the serotonin/cortisol connection in people with ASD, and I guess increased bacterial activity could lead to bloating. It would also line up with what you have mentioned for long distance runners in this connection, the "subclinical Cushing's disease", if I'm not mistaken.

Could you kindly comment if you consider this makes sense? Much appreciated!

For anyone researching the related topics of myopathy, muscle weakness/endurance, NAD and lactate, be sure to check out the RP forum for more info. There you'll find info on how Thiamine and especially Niacinamide can be helpful.

Good post 👍

https://raypeatforum.com/community/threads/war-is-coming-in-2024-be-prepared.52436/post-999500

@haidut

This is a different angle on Vitamin C I had never thought about. As the molecule is very close to glucose, vitamin C could take on the properties of glucose and be used by the body for energy as needed by our immune system to counter pathogens. On this alone, I have a newfound respect for vitamin C that goes beyond its usual association to being an antioxidant.

I have been monitoring my oxygen saturation every night for 3 years already, and I follow with interest the nightly spO2 charts (at 4 second intervals), and see the effects of phagocytosis by neutrophils and macrophages using respiratory burst, which consume plenty of oxygen that lead to sharp temporary drops in spO2. Even eosinophils consume large amounts of oxygen to produce ROS that spewed at larger pathogens. Energy is needed for these white blood cells to protect us from pathogenic insults, and it is plausible that vitamin C does as much as glucose does to provide an emergency boost to strengthen our immune system.

[Don't know how to attach an image here. Unless it is in the form of a url]

@haidut

I think that adopting just another Peaty routine to my nutritional lifestyle has helped me. This routine is in eating well cooked leafy greens. The vitamin K, as well as calcium and magnesium, has helped me. I had been eating leafy greens for quite some time now, and when I had bronchitis, I put myself in a year long downward cycle that involved heart failure. From being at the ICU, I thought my recovery would be difficult, if not impossible.

But I am now back to having healthy lungs and a healthy heart, like I was before. It speaks to having a lifestyle that prepares one to bounce back from a heart failure easily. Having all the nutrients we need met, and by eating whole foods, is the simplest way to be resilient. Vitamin K is just one nutrient though. We need them all, and I for one, like to keep things simple. And for me, the simplest lifestyle is to have all our nutritional needs met by food, clean air, and sunshine.

I used to rely on supplementation when I lived in the US, but before I came back to the Philippines, I vowed to stop all supplementation and make food my medicine.

Except for vitamin E and C and some B vitamins, I have no deficiency to worry about and my body has been more resilient.

Vitamin K from leafy greens is adequate. I don't have a reason to want K2 supplementation. But if I ever go back to live in the US, I may have to rely on more supplementation given that I don't trust the food ecosystem there to be able to supply nutrients adequately. It is very much a wasteland of industrial food.

@haidut

I have to get a lot of sun exposure at or around mid-day sun to get the most vitamin D produced by the skin and eyes.

I started this right before my cat my ankle and since I never had a bite wound on the skin on top of an ankle bone, I didn't know until know how to heal from such a wound. It's been 3 months since that bite and it's only now thst the wound is closing.

I think the myelin sheath may have been damaged when my body was exposed to a week of taking orally cinnamon bark oil. This left me ataxic and I walk like drunk and have drop foot. Megadosing thiamine is somewhat effective, but something is still lacking to fully heal.

I think vitamin D may be all that's needed to effect the healing on a damaged myelin sheath. When my ankle wound heals, I will resume a daily midday sun exposure of about an hour in my koi pond, where I am exposed to the sun. It may take a while, but I hope that vitamin D is the missing ingredient in my recovery from ataxia.

@haidut Empathy is a tricky process, especially in our culture that negates it. It requires good health, and ample biological energy. If the organism is faced with a detrimental situation in which most of the energy is required to keep itself alive, less energy can be used for the perception of other minds. In Mind and Tissue Ray talks about forming a "dominant" for other people as a brain process for acquiring impressions of other people`s internal life. It is probably one of the most energy-requiring process in the cerebral cortex, and something like endotoxin should be able to switch it off almost immediately.

“You know, the hardest thing in the world for a person may be to free himself of his
double, his automatic tendency to see himself, his faults, his shortcomings, his secret
deviance in everyone he meets; but even more difficult is to liberate himself from the
constant company of his double! And only from the moment when the double is
overcome is the road open to free communication with another! "It is then for the first
time that mind, heart, and word are revealed, making it possible truly to hear what it is
that makes the person one has encountered tick….An open heart and open and intelligent
hearing detect and understand in the other that which the individual had been unaware
of in himself, and which merely dully exhausted and tormented him from some
undiscovered part of his insides!" (Ukhtomksky)

@haidut very interesting there has long been studies showing a connection between low membrane unsaturation in animals and life exptency. Low membrane unsaturation causes uncoupling, so that checks out.

Btw calling DNP a benign uncoupler is problematic.
I know what you mean by it (being the mechanism of action). But many people will read this as :

"haidut said it's safe so I can buy some random yellow powder from China, hope that it's DNP, and take way too much of it."

I've had that discussion before and it's surprisingly hard to convince some people that taking DNP might kill you.
A simple dosing error on bad day might do that. DNP accumulates from day to day making overdosing more likely. You have no idea what you get from China, if it's not tested. And people go on body building forums and get their dosing recommendations from those type of guys. Maybe the reason for them not posting anymore after a while is not just that because they loose interest in following up if you know what I mean...