@sushi_is_cringe

If you want to understand Western philosophy

The World as Will and Representation - Schopenhauer (written when he was about 26)

@happyhanneke It potentiates the effect of the caffeine meaning any caffeine co-adminstered with the MB makes the effect of the caffeine as if you had taken approx a 10x dose of caffeine. So, if you take MB with 10 mg caffeine, you get an effect from the caffeine as if you had taken 100mg caffeine.

@CO3 Lactoferrin probably

@CO3 Do you have any actual evidence that 7mg (likely 0.1 mg/kg) is "high dose"? It's used at 15-60 mg per diem for all sorts of mental health disorders and was used at doses far beyond that in world war I for months.

@alfredoolivas

Well since most of the pregnenalone that is taken orally is converted to progesterone derivatives, I'm not sure if that would confound the calculation.

If 10-15x pregnenalone in circulation is what is needed to prevent testicular atrophy, then you're probably never going to be able to get there with oral supplementation since most of it is converted to progesterones. But, maybe that's fine because progesterone can also save the testes.

Why not just do transdermal pregnenalone or testosterone to the testes (or both) together with an AI like androsterone? If someone wants to try this, it would be very useful.

@alfredoolivas

Yes, but its downstream effects are inhibiting T production.

I wonder if Ray’s suggestion to use Pregnenalone to safeguard the gonads would work to preserve their steroidogenic potential even in the presence of high levels of circulating androgens?

And if that did work, perhaps using topical Pregnenalone, k2, and caffeine on the scrotal skin would be even more effective.

@alfredoolivas

I have the study.

"Anabolic" effects of methandienone in men undergoing athletic training

G.R Hervey October 1976, Published in The Lancet

100 mg Dbol per diem for 6 weeks. LH, FSH had no statistically significant decline, but testosterone fell by about half. That suggests that there is primary transient hypogonadism because there is enough LH, FSH in the blood but the testicles are not producing enough testosterone. That leads me to think that there is some negative feedback directly in the testicles.

It could also be that there is excessive conversion to estrogen, but I think the testicles are also being inhibited.

@Milchkanne I injected some 8 month old peptides that were sitting in my fridge. Didn’t get any injection site reactions but felt extremely weird after. Panic attack the next day and low blood pressure. Would not recommend

@LucH

Interesting take. Thanks for the info. But what about nicotine then? I found a company selling wood toothpicks soaked in 3mg nicotine. Could be interesting.

Can you link to any studies showing that 500-600mg Niacinamide daily caused any insulin resistance? IIRC that amount of niacinamide can increase NAD+ levels by up to 24x, which I think you're suggesting might be excessive.

@gg12 if you have camu camu powder and Niacinamide I would go with those