Dandruff or scalp irritation? Try BLOO.
@Milk-Destroyer said in Olive leaf extract increases T3 + T4, lowers TSH:
Seems great but if it is so great what can we expect to be the downsides?
It might be too adrenergic for some. Lokzo made a video about it increasing noradrenaline.
Although it also increases T and lowers cortisol.
Another interesting compound contained in olives is hydroxytrosol.
It has been shown to be one of the strongest anti-oxidants and it inhibits MAO-B, increasing dopamine .
"In-silico molecular docking study followed by MMGBSA binding free energy calculation revealed that HXT has a strong binding affinity for MAO-B in comparison to MAO-A. Moreover, rasagiline and HXT interacted with the similar binding sites and modes of interactions. Additionally, molecular dynamics simulation studies revealed stable nature of HXT-MAO-B interaction and also provided information about the amino acid residues involved in binding. Moreover, in vitro studies revealed that HXT inhibited MAO-B in human platelets with IC50 value of 7.78 μM. In vivo studies using MPTP-induced mouse model of PD revealed increase in DA levels with concomitant decrease in DA metabolites (DOPAC and HVA) on HXT treatment. Furthermore, MAO-B activity was also inhibited on HXT administration to PD mice. In addition, HXT treatment prevented MPTP-induced loss of DA neurons in substantia nigra and their nerve terminals in the striatum. HXT also attenuated motor impairments in PD mice assessed by catalepsy bar, narrow beam walk and open field tests. Thus, the present findings reveal HXT as a potential inhibitor of MAO-B, which may be used as a lead molecule for the development of therapeutics for PD."
This study shows that sarcosine lowers brain serotonin, while increasing GABA.
I took 500mg today. It was quite nice. My mood increased and my muscles looked fuller , also my skin and hair looked better . As if I had taken a big dose of collagen.
So far so good. It wasn't too exciting but it also wasn't sedating so actually a nice balance.
"Pretreatment of sarcosine (600 mg/kg, i.p.) non-significantly improved learning and memory deficits induced by non-competitive NMDA receptor antagonist MK-801, significantly increased the GABA and decreased the 5-HT levels (p<0.05)."
https://pubmed.ncbi.nlm.nih.gov/25710578/
It inhibits carbonic anhydrase, leading to higher CO2 retention.
"Apigenin and eriocitrin were identified as new potent inhibitors of human carbonic anhydrase VA isozyme."
https://pubmed.ncbi.nlm.nih.gov/25590364/
It seems to inhibit MAO. A more than B, which could lead to some problems for Some people, so that's .something to keep in mind. I wouldn't say that the overall effect of apigenin is serotonergic, given its effect on dopamine and Serotonin Receptors.
"Inhibition of MAO-A by galangin was about 36 times more selective than MAO-B, while apigenin selectivity for MAO-A vs. MAO-B was about 1.7fold. "
https://pubmed.ncbi.nlm.nih.gov/25412041/
It seems to activate Dopamine D2 receptors.
"Furthermore, intraperitoneal administration of haloperidol (0.2 mg/kg), a dopamine D(2) antagonist, blocked the apigenin (25 mg/kg)-induced decrease in immobility in the forced swimming test. These behavioral and biochemical results indicate the antidepressant properties of apigenin, which may be mediated by the dopaminergic mechanisms in the mouse brain."
There's just so many interesting studies on apigenin, I just had to make a thread on it.
"In vivo administration, spinally or systematically, of the 5-HT1A antagonist WAY-100635 inhibited the apigenin-induced antiallodynia and antihyperalgesia. In vitro, apigenin acted as a positive allosteric modulator to increase the efficacy (stimulation of [35 S]GTPγS binding) of the 5-HT1A agonist 8-OH-DPAT."
https://pubmed.ncbi.nlm.nih.gov/34030210/
2.Here it shows binding affinity to 5HT-1a +2a. I suspect it antagonizes SHT 2
"The binding affinity estimations identified the superior interacting capacity of apigenin over safranal for 5HT1A/5HT2A receptors over 200 ns MD simulations. Both compounds exhibit oral bioavailability and absorbance. In the rodent model, there was a significant increase in the overall mobility time in the FST, while in the EPMT, there was a decrease in latency and an increase in the number of entries for the treated and HC rats compared with the DC rats, suggesting a reduction in depressive/anxiety symptoms after treatment."
https://pubmed.ncbi.nlm.nih.gov/36557792/
It lowers mTor making it good for... well basically everything. Especially anti-aging or if you want to enhance the effect of a low protein diet or weaken the damage of a high protein diet
"...the levels of mammalian target of rapamycin (mTOR) were increased in chronic restraint stress mice and inhibited by apigenin. "
.://pubmed.ncbi.nlm.nih.gov/29902617/
Here's another study showing Oleuropein's pro- thyroid effect. It increased T3 and T4 in BPA-treated rats, while lowering TSH. It also had an anabolic effect on the bone.
lt gets even better:oleurupin is a carbonic anhydrase inhibitor-both isoenzymes. So it increases CO2 retention in the body.It's not quite as strong as acetazolamide,but it is pretty good for a natural phenol.
https://pubmed.ncbi.nlm.nih.gov/34483220/
Speaking of which there is a study that screened a few natural substances for the same activity, unfortunetly i cant get the full-text, but it includes some interesting substances like apigenin or
caffeic acid. Apigenin has been shown to be a carbonic anhydrase inhibitor in other studies already.
https://pubmed.ncbi.nlm.nih.gov/35306678/