@Mauritio said in Rapamycin: Anti-aging and metabolic dream drug?:

Surprisingly this review argued that quinones would increase mTOR.
Because quinones increase Nrf2 which in turn increases mTOR.

What should we think of that ?
In theory that would cause a pro-cancer effect, but quinones do lot more than activating Nrf2 ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145749/

Here's a few studies that a quinone, thymoquinine to be precise, inhibits mTOR and thus has an anti-cancer effect.
https://pubmed.ncbi.nlm.nih.gov/37288949https://pubmed.ncbi.nlm.nih.gov/37288949/https://pubmed.ncbi.nlm.nih.gov/30259603/
https://pubmed.ncbi.nlm.nih.gov/36145344/

Very interesting . I guess the mechanism would be its oxidizing effects?

Ray talked about it a few times in his newsletter and it didn't sound positive.
Also methylglyoxal is a naturally occuring of glycolysis (not oxidative phosphorylation) so it should be higher in unhealthy people . Plus it can be converted into lactate, which is the body's way of detoxing it.

When you read studies on it, it doesn't sound encouraging, it's seen as cause of diabetes and other illnesses.
Shouldn't it be very good for diabetes if it's so pro-metabolic ? Maybe it rises as a defense mechanism .

"...MGO is linked to the development of diabetes, vascular complications of diabetes, and other age-related diseases."
https://pubmed.ncbi.nlm.nih.gov/31539311/

Methylglyoxal is a major cell-permeant precursor of advanced glycation end-products (AGEs), which are associated with several pathologies including diabetes, aging and neurodegenerative diseases.
https://pubmed.ncbi.nlm.nih.gov/25709564

Then there's this quote by Peat.
https://raypeatexplained.com/ray-peat-on-oxidation/#152124319605143112494046561751189594877

And this study showing dietary intake being associated with less low grade Inflammation.
https://pubmed.ncbi.nlm.nih.gov/36055771/

@yerrag not sure.

Looksmaxxer will love this one.
Calcium mixed with lidocaine improves jaw line contour.

https://pubmed.ncbi.nlm.nih.gov/34784131/

@bio3nergetic said in RFK Jr. Officially Nominated for HHS Secretary.:

After all, I "dare to think."

And I appreciate that doesn't mean you're always right and that is why many don't "dare" to do think in the first place.

@bio3nergetic It's always fascinating when people speak about something with such authority and confidence, when they really have no way of knowing that any of their conclusions are true.
So I think it's good for all of us to take a step back and realize again that these are just opinions (including mine) and nobody knows what's really going on .

Lidocaine helos with lungs cancer in this study via SIRT5 activation.

"...lidocaine treatment might inhibited the lung cancer progression through decreasing the SIRT5 mediated succinylation of HIST1H2BL."

https://www.nature.com/articles/s41598-024-73966-9

He might push for a (partial) legalization of psychedelics
https://x.com/RobertKennedyJr/status/1855756444521672823

Just imagine him banning PUFA I wonder what ray would have said to that...
https://x.com/RobertKennedyJr/status/1848499491151745180

This is epic.
Although I'm sure some cynical bastard is already typing :"Oh he's part of them, you think they would let him have power, if he really wanted to change things?"

I disagree , this time seems different.

RFK seems like a good guy. Wasn't there even somebody Peaty in his circle ? Or maybe that was nick Fuentes .

Hes definitely aware of the dangers of PUFA or seed oils as the right wingers say. And that health is the basis of everything .

Trump is putting together a good cabinet . RFK, Tulsi, Musk, Vivek, ...

It's also a nice move of synchronicity that at the same day trump was elected our
left-green German government collapsed. Wish we had guys like the US in the pipeline, but it doesn't look good.

@cs3000 said in Thymus health:

Looks like the main benefit of the Thymus could actually be from suppressing too much immune damage via t reg cells

That is such an interesting thought. Why wouldnt we have an organ whos purpose it is to dampen excessive inflammation, given chronic inflammation is a part of so many diseases.