Dandruff or scalp irritation? Try BLOO.
@AinmBeo said in Reversal of hair loss in Mice with “sugar gel”:
Or getting the hair wet and making "rows" and applying it to the scalp at the base of each row?
This without making it wet. I apply it to the scalp, massage it and spread it with my fingers and after that comb my hair to spread it and increase circulation.
@Hearthfire I have used it orally.
I think heavy metals can cause fungus overgrowth since they bind and incorporate heavy metals. And we're certainly getting heavy metals from all kinds of angles.
Da ich wohl jetzt auch Milch vertrage ... Welche ist die beste Milch ?
Ich trinke gerne Berchtesgadener Land.
@tubert thanks for your experience. I will add sodium butyrate first since I already own it. And after that maybe potassium bicarbonate. It's cheap and available so why not .
@Hearthfire I think they are certainly a factor of many.
Anecdotally I can say that I've noticed for years that anti-fungals like boron, MSM, etc. have decreased hair loss .
@Hearthfire very interesting, thanks for sharing.
I didn't find anything on potassium bicarbonate and hair loss directly. But at the very least the bicarbonate should increase local CO2, which is helpful.
But the fungal connection is quite remarkable!
In this study, People with hair loss almost had a 10x higher prevalence of a fungal scalp infection called Malassezia. That correlation is so strong that it seems likely that there's causality as well.
"The prevalence of positive smears was significantly higher among subjects with hair shedding than among normal subjects (89.92% vs 9.52%, p<0.001).
https://pubmed.ncbi.nlm.nih.gov/16901187/
In this study the difference was only 20% .
But they found that Malassezia, is higher on the top scalp in balding people than in the occipital region, which doesn't bald. So again there seems to be a connection between Malassezia and balding. Making potassium bicarbonate an intriguing option .
https://pubmed.ncbi.nlm.nih.gov/31240449/
"The scalp commensal organism, Malassezia, has been recognized to be a source of oxidative damage. "
This might be one of the reasons why anti-oxidants help with hair loss.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6369642/
Sodium butyrate is anti fungal, making it an even better candidate .
https://pubmed.ncbi.nlm.nih.gov/21911344/
@CrumblingCookie yeah good point. That is an aspect of hair loss I've almost never come across.
I'm wondering what I've been doing to my scalp biome by applying 35% alcohol everyday . But from the looks of it, it seems to work. My hair looks better. Even though I was worried that the alcohol might make it dry.
I think I'll use between 0.5-1% of NaB to be sure.
@cs3000 said in Studies showing cancer reversal / shrinking:
In the modern trial ~40% of the people got complete remission of their tumors taken orally daily, without dietary changes mentioned just added vitamin C. Koch injected it just 1 time into muscle, then waited a couple weeks and repeated that twice more if needed
Nice can you link this trial ?
Is the vitamin C there to help it cycle between reduced and oxidized ?
@CrumblingCookie
Great points !
Butyrate could indeed feed the TCA cycle and increase scalp ATP.
It's a small molecule and very water soluble so it should be possible to add it to my formula.
I found an in vitro study that directly corroborates what you said :
Here's another study showing sodium butyrate increases autophagy and inhibits mTOR.
https://pubmed.ncbi.nlm.nih.gov/37686278/
Since these beneficial effects seem to depend on the AMPK-mTOR-autophagy axis that might explain biotin's strong anecdotal evidence for helping hair.
Biotin increases AMPK and thus inhibits mTOR and induces autophagy.
@AinmBeo you can still buy the exact same stuff. It's just labeled as research chemical. Similarly to idealabs.
Somebody else posted a study (I reposted it somewhere too) that Niacinamide did NOT have beneficial effects on hair health.
Based on other studies Im starting to think that they're not interchangable when it comes to all effects. I think they both have benefits though .
I have previously posted studies showing finasteride/dutasteride can cause penile fibrosis, down regulation of the androgen receptor and upregulation of the estrogen receptor.
This study showed that even after discontinuation of dutasteride for 6 months, men that took it long-term still show signs of infertility like decreased semen volume I and motility.
If that is true for dutasteride than it's probably true finasreride as well, since they share the same mechanism of action.
"Long-term use of dutasteride may lead to male infertility by persistently impairing semen volume and sperm motility."
https://ecerm.org/m/journal/view.php?doi=10.5653/cerm.2024.07675
@cs3000 Nice, was that just methylglyoxal. Or also 6 months of vegan , low protein diet ?
Anybody else like the graphs kind of don't reflect what Georgi is saying ?
@AinmBeo I don't know, wouldn't count on it.
Apple polyphenols have humans studies showing their effectiveness, that's why I'm going with them.
Update :
I had a weird reaction to Propylene glycol. After I added it the formula it gave me estrogenic symptoms like anxiety and puffy
face and nipples. I could not find any studies on it being estrogenic , quite the contrary actually . There are some studies showing it might be progestogenic.
I have removed it anyways from the formula.
I have since then slightly increased ethanol to 35%, to make up for propylene and to increase polyphenols absorption, since they don't dissolve completely.
I also noticed that adding sugar makes my hair a little sticky. So I have created a new batch without the sugar as well, only containing NMN, apple polyphenols and ethanol. I can leave this formula in my hair and it looks good, not even a need to rinse it.
So it's very practical for every day life .
I think I'll make a separate batch including the sugar for maximum effects that I'll use when I don't have to leave the house.
I'm thinking about adding biotin to the formula for increased local glyocgen synthesis.
Current formula:
35% ethanol
1% NMN
1% Apple polyphenols
(1% of dextrose)
Rest: Water
add taurine ,caffeine,... to your liking
Sodium butyrate supplementation increases FGF21
