Posts made by Mauritio

@dapose you're welcome.

Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
https://pubmed.ncbi.nlm.nih.gov/35257010/

Chlorogenic acid fed mice increase less in weight than controls mice on a high fat diet. AND weigh less than animals on a normal control diet.
https://pubmed.ncbi.nlm.nih.gov/20064576/

Might inhibit Mao a+b
https://pubmed.ncbi.nlm.nih.gov/29893510/

@bio3nergetic said in Apigenin:

It really isn't even a matter of "black or white," but the lack of distinction. It is meaningless to throw around NOS without knowing what type in what context. Apigenin can increase eNOS and improve circulation. In a inflammatory context, it can inhibit iNOS, which is what we need to keep in check ultimately.

Yes, well said. It's the bigger picture that matters.

@LucH said in Apigenin:

@Mauritio said in Apigenin:

apigenin

Api activates BKCa and SKCa, leading to cell hyperpolarization that is followed by an influx of extracellular Ca2+; together with the release of Ca2+ from the ER, this rise in [Ca2+]i directly activates NOS; and the increased NO synthesis is then responsible for the inhibition of angiogenic endothelial cell functions by blocking Akt phosphorylation.
https://doi.org/10.1111/j.1538-7836.2007.02615.x

Nitric Oxide Induces Metabolic Shift from Glycolysis
"Nitric oxide, even in the presence of oxygen, causes a metabolic shift to glycolysis, wastefully producing lactate from glucose" RP

You're over focusing on one point from an in-vitro study, when in fact apigerin has been shown to do the opposite of what you suspect (inducing glycolisis).

Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging
https://pubmed.ncbi.nlm.nih.gov/34114892/

Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway

https://pmc.ncbi.nlm.nih.gov/articles/PMC7212374/

Dates (polyphenols) activate FXR and modulate bile acids.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5749773/

It protects against cholestasis.
MoA: FXR modulation, TLR-4 inhibition,anti-oxidant

https://pubmed.ncbi.nlm.nih.gov/33620063/

Another study which also shows anti-fibrotic, anti cholestatic effects
https://pmc.ncbi.nlm.nih.gov/articles/PMC10967634/

High salt diet induces muscle loss via cortisol, if simultaneously given saline Solution, not if rats were given tap water.Maybe there's a Sweet Spot for Salt.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5409074/

@Serotoninskeptic thanks! That's basically what I've been doing for a while now. I posted a study showing benefts of MR after Just 6h! So if you only eat signifi­cant amounts of protein in the evening you have an18h window of "benefits". Intermittent protein fasting.

I feel bad for the normal person they've just adapted to high protein being healthy and now this...

@alfredoolivas The backbone is very similar not sure how to explain that to you

I think desiring an activation of mTOR is not good. Inhibiting would probably be more healthy. But seem people are more focused on mucsle gains than longevity.

@cs3000 said in My wild IdeaLabs nail test results - opinions ?:

so maybe ok considering very low ng concentration but for a boost with whats left a round of lipoic acid might be worth a try for a couple weeks. and avoiding zinc supplements during this time as seems to help retention (but needs replenishing after ofc). and 1g vit C a day might help (helps lead excrete a lot at least)

Sulfur groups bind it like the other heavy metals https://www.researchgate.net/publication/341867829_Investigating_the_role_of_sulfate_groups_for_the_binding_process_of_gadolinium_ions_in_glycosaminoglycans
(so lipoic acid which has 2 sulfur groups, msm, thiamine might be useful , as such low amounts from the macrocylcic type probably best not to take high amounts for long as run the risk of needed metal depletion, maybe a couple weeks would be significant)

Im not sure about lipoic acid. know that peat thought it might lead to heavy metal deposition in even more harmful places, althugh i dont understand why that wouldnt be the case with lets say, citric acid from orange juice or lactic acid from yoghurt...but given the relatively small amount of heavy metals ill probably skip it

theres this video of a guy going around who said he lowered his heavy metals by 75% using MSM so that might be something Ill try.
https://www.youtube.com/watch?v=r34x3jcRIo0
So far I feel like antioxidants help me the most and molybdenum for some reason ...

@DavidPS said in heavy metal chelation (sauna, DMSA):

Joe Cohen has an interesting video on his experience using MSM.

https://www.youtube.com/watch?v=r34x3jcRIo0

Peatbot: The context provided suggests that MSM (methylsulfonylmethane) can be tolerated in fairly large amounts, but it can also be toxic in those amounts. It is important to be cautious and to read actual research articles on MSM to understand its effects better. While some people take MSM for joint flexibility or as a sulfur supplement, it is not something that cells necessarily need, and it can be toxic if taken in excessive amounts. Therefore, it is advisable to approach MSM supplementation with caution and to be informed about its potential risks.

interesting i just came here to post the exact same video. i'm gonna take some msm Soon. its efficacy might also be due To the heavy metal -fungus connection that i previously posted About.

An update on this situation:
I had an abdominal MRI to rule out any adrenal or liver tumor issues, which came back totally fine.

So I think at this point the most likely explanation is what @cs3000 and T3Uncoupled suggested which is that my consumption of apple polyphenols caused a reactive overproduction in the opposed hormones. Apple polyphenols seem to have a slight anti-DHT effect and I took 2-3 capsules for several months.

Either this or the hormone test is complete trash, which I dont think.

Unfortunetly I had an MRT with contrast not knowing how bad they are. So thats another issue.
Fortunetly it was a macrocylcic contrast which seem to be lot easier to excrete and less likely to be deposited:

"...gadolinium associated with macrocyclic GBCA use is cleared more rapidly from tissues than that with linear agents. The gadolinium present after macrocyclic administration is 306-fold lower in the brain, skin and bone of patients compared with linear GBCA..."
https://pmc.ncbi.nlm.nih.gov/articles/PMC8837552/#Sec4

"Results Gadolinium deposition in brain tissue significantly varied with GBCA type (F = 31.2; P < .0001), with median concentrations of 0 μg gadolinium per gram of tissue (95% confidence interval [CI]: 0, 0.2) in gadoteridol-injected rats, 1.6 μg gadolinium per gram of tissue (95% CI: 0.9, 4.7) in gadobutrol-injected rats, 4.7 μg gadolinium per gram of tissue (95% CI: 3.5, 6.1) in gadobenate dimeglumine-injected rats, and 6.9 μg gadolinium per gram of tissue (95% CI: 6.2, 7.0) in gadodiamide-injected rats; a significant positive dose-signal intensity correlation was identified (ρ = 0.93; P < .0001)."

"... this washout appears to be more robust with macrocyclic agents, where the amount of retained gadolinium 52 weeks after supradiagnostic exposure was only 13% of the amount retained, as measured with ICP-MS at 5 weeks (103). In comparison, a more attenuated washout phenomenon was observed after gadodiamide administration, with 50% of the initially measured amount retained at 1 week still present 20 weeks after administration (96). Longer-term washout data are needed at common time points to permit comparability between agents and classes."
https://pubmed.ncbi.nlm.nih.gov/28640692/

I vaguely recall that the mechanism was Sirt3-dependant?

This is one of the beautiful intersections between the spiritual/religious and the physical. You could also view it as an argument for the compatibility—and perhaps even the interdependence—of science and religion: true religion leads to true science, and vice versa.

In short: The highest, both physically and spiritually, is the fire that does not consume you.

The Spiritual
When Moses encounters the burning bush in the Old Testament, God is portrayed as the fire that does not consume the bush. Similarly, this concept applies to us. God is the fire within us that does not consume us. Normally, you would think, "The more you burn, the more you're consumed." So, you might assume we must burn less to preserve ourselves.

However, with God, the more you burn without being consumed, the closer you are to Him. God burns away only the parts of you that are harmful or flawed, refining you in the process.

The Physical
Oversimplified, we are machines that burn calories to produce energy. Here again, you might think, "The more you burn, the more you are consumed," which aligns with the rate-of-living theory. But, just as with the spiritual, there is a proper kind of physical burning: the right metabolism. This is the burning that does not consume—it only consumes what is harmful or unnecessary.

This is where Peat's research comes in, disproving the rate-of-living theory. The thyroid hormone produces uncoupling proteins that separate energy production from heat production, consuming harmful free radicals and old cells in the process. Overexpressing uncoupling proteins has been shown to treat chronic diseases and increase life span in animals.
So you're physically increa­sing the heat/fire and it makes you healthier. Not only that: it also consumes the parts of you that are bad or unhealthy.

Of course, there is also an unhealthy way of increasing body temperature, as seen in conditions like cancer. Cachexia, for example, involves the body wasting away and consuming its own tissue for energy. This represents an unhealthy fire that consumes itself.

This is what Chat GPT made this text look like as an image:

No study but isn't it interesting that
Guggulsterone (C21H28O2) and
Pregnenolone (C21H32O2) are almost the same molecules.
That explains their similar effects.

Z-Guggulsterone alleviates renal fibrosis by mitigating G2/M cycle arrest through Klotho/p53 signaling
https://pubmed.ncbi.nlm.nih.gov/35123992/

"SIRT3 reduced the expression of stearoyl-CoA desaturase 1..."

https://pubmed.ncbi.nlm.nih.gov/31160717/

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

https://pubmed.ncbi.nlm.nih.gov/31269804/