Dandruff or scalp irritation? Try BLOO.
DAY 1:
Received my device today and immediately tried it at the following setting:
5min, at 80mW/cm2 over liver/gallbladder area
Didn't expect to feel anything. But right after it I felt pleasantly relaxed as if I had drank a beer or two.
1 h later I had a bile dump. Success.
Been having stuck bile issues for the last weeks since involuntary mold exposure.
So far so good for day 1 !
@CrumblingCookie thanks for the studies !
I have only briefly looked over them.But I think they don't use any reasonable intensities . At least I would hope that no one uses 1-25W/cm2 on their balls lol
The contraceptive study used Intensities from 1-2.2W/cm2 .
The testosterone studies I posted use around 20mW, so the difference here is the factor 100.
surely we can't derive many meaningful conclusions from that ,besides: don't overdo it.
@CrumblingCookie said in The pro-metabolic effects of ultrasound:
on as I remember studies which very clearly found that long enough ultrasonography (only 5-15 minutes iirc) on the testicles leads to infertility for about 1/2 year due to profoundly impaired spermatogenesis.
Source?
What do you guys think of laxogenin?
Its very similar to diosgenin, which increases DHT and DHEA.
And its available for purchase.
@16charactersitis Sure. I tried getting the one that the women on X was using, but it costs 100€ shipping to germany. So I bought this one, which is probably slightly more powerful and a bit more pricey.
It has 3 different Intensity settings:
80mW/cm2 (low)
800mW/cm2 (middle)
1600mW/cm2 (high)
It uses 1 MHz.
To replicate most studies the lowest setting will suffice. They mostly use 20-80mw/cm2. But for example the gallbladder study used 800mW/cm2 so the second setting works perfectly for that.
I mentioned the respective ultrasound settings they used in most studies or you can see them in the images.
https://www.tensshop.de/Ultraschall-Therapiegeraete/Ultraschall-Therapiegeraet.html
Nicotine acts on thyroid receptors.
"...nicotine and learning uniquely acted to increase TR activation..."
"Acute nicotine enhances learning and these effects may involve processes regulated by the transcription factor TRβ."
Ultrasound has an anti-catabolic effect in this study inhibiting myostatin.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8625684/
"LIPUS promotes exercise-induced muscle hypertrophy by facilitating protein synthesis and inhibiting the protein catabolism pathway."
https://pubmed.ncbi.nlm.nih.gov/28461063/
Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats
https://pubmed.ncbi.nlm.nih.gov/29273088/
Ultrasound Modulates the Inflammatory Response and Promotes Muscle Regeneration in Injured Muscles
https://link.springer.com/article/10.1007/s10439-013-0757-y
@jamezb46
Iron legion also sell it for much less.
https://iron-legion.com/products/xi-kt
"Conversely, 11-KT did not activate estrogen receptor-mediated transactivation in aromatase-expressed MCF-7 cells, whereas testosterone did following conversion to estrogen. 11-KT did not affect the estrogen/estrogen receptor -mediated cell proliferation of MCF-7 cells. Furthermore, it significantly inhibited cell proliferation when androgen receptor was transfected into MCF-7 cells."
https://academic.oup.com/jcem/article/101/10/3582/2764896#:~:text=Conversely%2C 11-KT did,into MCF-7 cells.
It also seems to be able to fill in for testosterone functionally. At least it does so when you chemically castrate men.
https://pubmed.ncbi.nlm.nih.gov/33974560/
It seems to generate more mitochondria in muscles . Which makes me wonder if it helps with exercise recovery and muscle growth ?!
"We conclude that absolute increases in UCP-3 protein content in the early adaptive phase were associated with the genesis of mitochondria containing a normal complement of UCP-3. "
https://pubmed.ncbi.nlm.nih.gov/15308491/
Peat mentioned 50-100 000 Hz as an effective healing frequency.
They noticed that it would heal infected tonsils as well.
@evan-hinkle i think I saw a study successfully using high frequency ultrasound for thyroid nodules , but can't find it right now.
@T-3 said in Adamantyl Ester Steroids: The Ultimate Androgen?:
I've seen the hepatoxicity concerns raised numerous times about oral androsterone on RPF/LTF (e.g. on the androsterone mega thread). What does everyone think about oral androsterone at 4 to 8 drops daily? Would that be "torching the liver"?
Have you looked for studies on that ?
Androsterone is an FXR agonist, which are used to treat liver disease. So if anything it should help the liver.
I thinks it's an interesting thought. But I don't really see the upside here. It mainly appeals to people because it's mysterious and hard to obtain etc.
I get it... the first email I send Ray was about an obscure progesterone/DHT mix of a designer steroid , which I'm surprised he even replied to 
But if you want DHT with a longer half life you can use 11ketoDHT.
I still think 11ketoT is an interesting option on paper. IIRC I saw a study suggesting it doesn't even aromatize.
@DavidPS Thanks!! Super cool. will try it out over the liver/ gallbladder.
I sometimes have cholestasis-like issues and hope it will help.
This study looks promising. It seems to help short term and long term with gallbladder contractility.
"LIPUS treatment obviously enhanced gallbladder contractility in response to CCK-8 stimulation and accelerated bile crystal clearance. It also reduced inflammatory cell infiltration and tissue edema, and promoted new capillary formation in the gallbladder, mitigating the progression of CGS. Furthermore, LIPUS restored CCKAR expression and improved the thickness of the gallbladder smooth muscle layer, providing a structural basis for increased smooth muscle contractility."
SETTING:
Intensity: 800 mW/cm²
Frequency: 3 MHz
Duty Cycle: 30%
@lobotomize-me it's in the name of science ..it's ok .
I have ordered a device already.
And I'll probably first try over liver or gut.
Maybe later thyroid or testicles.
@DavidPS thanks for sharing.
This women has spectacular results by applying it her head.
@serotoninskeptic yeah the ultrasound helps with bine growth AND vitamin K absorption so should be a good combo for fractures and so on .
At home devices are available in the price range of 50-200$/€
Peat rarely talked about ultrasound, but I suspect it can help metabolism by increasing local tissue heat and thereby mimicking a healthy metabolism for a while. There are also heat-independant effects, possibly through structuring the cellular water a la Gilbert Ling.
We're going dark Peat right away. But bear with me.
1.Ultrasound on balls.
This is only in vitro. But very impressive.
Ultrasound Increases Testosterone production in leydig cells by up to 80% .
Doubled StAR, the rate limiting enzyme for steroid production .
https://pubmed.ncbi.nlm.nih.gov/36613865/
Here's a rodent study showing 20 min/day for 7 days increased testosterone by 62%
1.5-MHz frequency, 1-KHz repetition pulse rate, 200-microseconds pulse width, 30-V peak-to-peak amplitude and 20-mW/cm2 intensity) applied to the skin for 20 min/day for 7 days
https://pubmed.ncbi.nlm.nih.gov/1823286/
Someone filed a patent for using ultrasound for testosterone enhancement in humans. Including protocols and safe dosages.
https://patents.google.com/patent/WO2022026607A1/en?oq=WO2022026607A1
2.Anti-septic (200 mW/cm2, 0.37 MHz, 20% duty cycle and 20 min)
They induced sepsis in mice.
After 5 days all of the mice were dead.
In the sepsis + ultrasound group half of the mice were still alive after 5 days. Not only that, they seemed to recover from sepsis and were still alive after 40 days!
https://www.umbjournal.org/article/S0301-5629(23)00093-5/fulltext
3.Ultrasound increases topical absorptionof substances.
Aspirins absorption was enhanced by a factor of 300 ! Topical aspirin anyone ?
Ultrasound also enhanced steroid absorption. I'm thinking Idealabs + ultrasound.
This might be useful for topical hair loss formulas like as well, since absorption can be an issue here.
https://pubmed.ncbi.nlm.nih.gov/8692734/
4.Other:
Ultrasound helps with Inflammatory bowel disease.
https://www.researchgate.net/publication/348880743_Non-invasive_peripheral_focused_ultrasound_neuromodulation_of_the_celiac_plexus_ameliorates_symptoms_in_a_rat_model_of_inflammatory_bowel_disease
Helps with osteoarthritis.
"Long-duration low-intensity ultrasound significantly reduced pain and improved joint function in patients with moderate to severe osteoarthritis knee pain."
https://pubmed.ncbi.nlm.nih.gov/30326947/
"Scientific evidence supports the use of LITUS to treat soft tissue injuries, and improve outcomes for musculoskeletal injuries and post-operative recovery."
https://pubmed.ncbi.nlm.nih.gov/30198009/