Posts made by Mauritio

Only tried it once.
It feels pretty strongly anti-cortisol.
Also the next day my libido was a little higher and my muscles looked pretty full.

Thats all , I'm trying Melanon and lanosterol now so might be some time until I get back to 3aDHP.

I second the caution against cysteine supplementation .

There was a study that showed the same life extension from just using glycine. HED was 50g. So cysteine is not necessary.

If you want to increase glutathione you could simply take ergothioneine which increase it drastically and also increase life span by about 25%.

If you want to increase antioxidants generally, you could take selenium or selegiline which have strong anti-oxidant capacity. Selegiline also increases life span by about 25% .

And remember adding just 0.2% cysteine to the diet, abolishes the benefits of methionine restriction. So it is by no means harmless. Especially since methionine can be converted to cysteine so it's almost impossible to be deficient in it.

@wester130 well Ray wasn't fond of pituitary hormones so there's that

And androgens like DHT would also suppress them so I wouldn't say that's necessarily a bad thing.
Interestingly it only suppresses FSH and not LH.

@bio3nergetic yeah he wasn't the biggest fan of 5aDHP either. Which is understandable if you see the cancer studies. And Ray was pretty cautious when it comes to supplements in general.

There's very little studies on this metabolite ...

@wester130 like the sweet spot between dopamine and GABA with a little bit of progesterone in it.
I did not get those effects from allopreg.

Synchronicity strikes again!
I was thinking about messaging you to ask if you can bring back 5aDHP because I like it so much.
But 3aDHP seems close enough to try.

Does it have the some anti-prolactin effect as 5aDHP?

Welches Waschmittel verwendet ihr alle ?

Rapamycin might help schizophrenia by lowering mTOR.

Schizophrenics have increased 5ht6 activation which in turn activates mTOR.

"Further, 5-HT(6) receptor activation increased mTOR signalling in rodent prefrontal cortex (PFC). Linking this signalling event to cognitive impairment, the mTOR inhibitor rapamycin prevented deficits in social cognition and novel object discrimination induced by 5-HT(6) agonists. In two developmental models of schizophrenia, specifically neonatal phencyclidine treatment and post-weaning isolation rearing, the activity of mTOR was enhanced in the PFC, and rapamycin, like 5-HT(6) antagonists, reversed these cognitive deficits. These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control."
https://pubmed.ncbi.nlm.nih.gov/23027611/

Rapamycin increases klotho.

It is even more Peaty than I thought because it lowers phosphate. And phosphate activates mTOR. Rapamycin lowers phosphate and mTOR, decreasing calcification.

"Zhao et al. report that phosphate activates the mammalian target of rapamycin (mTOR) cascade in VSMCs, leading to downregulation of Klotho. Furthermore, rapamycin was shown to halt medial calcification. This effect was blunted in the absence of Klotho. Given the concomitant anti-atherosclerotic effects of the mTOR inhibitor, this agent has clinical potential as an inhibitor of intimal atherosclerosis and medial calcification."
https://pubmed.ncbi.nlm.nih.gov/26422620/

Here, it also increases klotho in aging mice. And it caused a huge increase in survival.

"All mice administered rapamycin survived the 12-week course, whereas 43% of the controls died."
https://pubmed.ncbi.nlm.nih.gov/37190667/

It decreased phosphate in humans.

"In the rapamycin group, serum phosphate was lower than in the CNI group with an increase in phosphate excretion and a reduction in its reabsorption."

@LetTheRedeemed Theres something weirdly Anti-Life (vita= life) almost satanic about their nedd to ascribe something toxic to every vitamin.

Day 8:
Last days felt hypothyroid, gained water weight.
Had rapamycin yesterday and today lost water weight. Weigh 650g less than yesterday morning, although I ate more than the days before.
Took rapamycin before work... Not a good idea. Was stressed and tired. Will return to after work.

I suspect that there might be a rebound mTOR effect after a few days of no rapa, hence the hypothyroid symptoms .

Or Maybe that's the "physiological insulin resistance" that is transient and materializes itself at the beginning of rapamycin treatment.
IIRC rapamycin caused water retention for tarmander as well but it went away.

Other than that my energy might be slightly higher but not sure yet.

@Mauritio said in Vitamin A and D deficiency increases liver cancer:

So for anyone thinking vitamin A and D are poisons maybe ingest some Vitamin E at least. Unless that has reached poison status as well. I'm not up to date .

It has happened . You can't make this stuff up.
https://raypeatforum.com/community/threads/love-your-liver-livestream-161-toxic-vitamin-e-testimonials.53292/

"It seems that an "empty/unbound androgen receptor" is the worst thing as far as glucocorticoid signalling - and that even androgen antagonists interacting with the androgen receptor can reduce that glucocorticoid signalling."
https://raypeatforum.com/community/threads/panquinone-liquid-triquinoyl-quinone-mix-for-lab-r-d.11566/page-8#post-292585

@djledda which OJ by EDEKA do you mean ? I'll be there tomorrow so might check it out.

Thanks for the oysters as well.

@Purp1eOne thanks for the suggestions. i measured below the laptop and i got values of up to 100uT !!! So i think some action is warranted on my side. Ill check if they ship to europe as well. and see if that thing helps.

I checked below my chromebook as well and the radiation doesnt go over 1uT. Insane difference.

@haidut very interesting there has long been studies showing a connection between low membrane unsaturation in animals and life exptency. Low membrane unsaturation causes uncoupling, so that checks out.

Btw calling DNP a benign uncoupler is problematic.
I know what you mean by it (being the mechanism of action). But many people will read this as :

"haidut said it's safe so I can buy some random yellow powder from China, hope that it's DNP, and take way too much of it."

I've had that discussion before and it's surprisingly hard to convince some people that taking DNP might kill you.
A simple dosing error on bad day might do that. DNP accumulates from day to day making overdosing more likely. You have no idea what you get from China, if it's not tested. And people go on body building forums and get their dosing recommendations from those type of guys. Maybe the reason for them not posting anymore after a while is not just that because they loose interest in following up if you know what I mean...

@haidut Fascinating !
The researchers mentioning wood animals made me think of T3 as an anti-hibernation hormone. When animals seek to hibernate they can't use curiosity so they seek out certain foods high in PUFA to decrease thyroid hormone.

This is from a study I previously posted on the RPF, mostly for highlighting Vitamin E succinate's remarkable effects on liver carcinoma.

A small part of the study was dedicated to the effect that a vitamin A+D deficiency had on liver carcinoma development in mice.

As you can see once the concentration of vitamin A went low the tumor size drastically increased.
There is a treatment though: vitamin E (succinate)! Even on a low Vitamin A and D diet VES was able to restore the health of the mice. So for anyone thinking vitamin A and D are poisons maybe ingest some Vitamin E at least. Unless that has reached poison status as well. I'm not up to date .

"Fig. 5 shows that increased carcinogenesis resulted from vitamins A & D deficiency. This is in agreement with the effects of deficiency in mammals. But it is of note that Diets 31, 32 & 33 in
are vitamin A deficient and yet HCC, in the presence of extra E-Su, development was low or non-existent. (Vitamin A was 12,800, 2560, 500, and 50 i.u. in diets 2, 28, 27 and 31 to 34 respectively in ..."

https://www.sciencedirect.com/science/article/pii/S2352385917302621

I found a new clementine juice. And it's pretty good.
It's this one here
https://www.fooodz.de/beutelsbacher-clementinensaft-700-ml

I found it in a local organic shop. But I have ordered a few more online. The price is quite steep. But I think it's the same online as in the store.