Reversal of hair loss in Mice with “sugar gel”
-
@Mauritio I had tried the potassium bicarbonate (orally as well as externally as well as with the other things as described in that medium article) years ago for a very long time (more than half a year) and it did nothing in my case. I even tried those TRX2 capsules years ago for a year with no results (really expensive). Theoretically it sounds good, but in practice, at least for me, it did nothing.
-
@Hearthfire regarding mites - This is why I use essential oils, they kill most mites
I mix essential oils into everclear to make a non-greasy topical
Most people don't use essential oils because they are greasy when mixed into a carrier oil
-
@Hearthfire I think they are certainly a factor of many.
Anecdotally I can say that I've noticed for years that anti-fungals like boron, MSM, etc. have decreased hair loss .
-
@tubert thanks for your experience. I will add sodium butyrate first since I already own it. And after that maybe potassium bicarbonate. It's cheap and available so why not .
-
@tubert Did you try it topically? The guy in the medium article put it in his shampoo as well as supplementing it with/after meals.
-
Exactly. I watched a lot of Robert Cassar videos talking about parasites, found his channel on the other forum a few years ago. Good shampoo recipe for killing mites here, as well as being a great stimulating hair growth recipe: https://eartheracademy.com/course/stimulating-hair-growth-removing-scalp-toxicity-fungus-and-hair-mites/
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
@Hearthfire I think they are certainly a factor of many.
Anecdotally I can say that I've noticed for years that anti-fungals like boron, MSM, etc. have decreased hair loss .
How do you use it? Just as a supplement? I've started taking MSM in pills and added some to my shampoo recently. I took boron 6 years ago or so as a way to boost testosterone/energy, and I do recall it having a good effect, but not mind blowing enough to continue (probably because my test levels are good already). Might have to try it again though for the hair benefits. I've seen some anecdotes online about minerals, especially trace minerals that we don't get a lot, that suggest they be a big factor in hair loss for some people. Seen a few people say they fully recovered from gray hair by taking minerals, and their hair got thick and changed texture.
I remember reading how fungus feeds on iron. I wonder if because people are so psy-oped by doctors/medical institutions about taking iron supplements and that we need a lot of iron, and the fact that it's put into foods as a vitamin, it's put into multivitamins, it's causing these fungus and other parasites to keep getting over fed. If we had the proper balance of other minerals to displace/replace and correct the high iron levels, maybe our scalps wouldn't be a weakened feeding ground?
-
@Hearthfire I did it exactly like mentioned in medium. topically (i called it externally) as well as internally after every meal (not just heavily salted meals). But go ahead and try it yourself and report back
-
@Mauritio
Have you been spraying it on, or applying it like shampoo?
Or getting the hair wet and making "rows" and applying it to the scalp at the base of each row? -
@Hearthfire I have used it orally.
I think heavy metals can cause fungus overgrowth since they bind and incorporate heavy metals. And we're certainly getting heavy metals from all kinds of angles.
-
@AinmBeo said in Reversal of hair loss in Mice with “sugar gel”:
Or getting the hair wet and making "rows" and applying it to the scalp at the base of each row?
This without making it wet. I apply it to the scalp, massage it and spread it with my fingers and after that comb my hair to spread it and increase circulation.
-
@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
I've been wondering whether BHB or butyrate would be better energy substrates to hair follices rather than dextrose.
Possible role of β-hydroxybutyrate in inducing inflammation in alopecia areata
-
@Gaston said:
Possible role of β-hydroxybutyrate in inducing inflammation in alopecia areata
-
Serum BHB levels were found to be significantly elevated in patients with AA compared with healthy controls, with higher levels correlating with severity of hair loss. BHB treatment increased inflammatory cytokine production in outer root sheath (ORS) cells, mimicking the inflammatory conditions seen in AA.
Hmm. That's a flip side. So the BHB seems to be strongly immunostimulative. Not necessarily merely proinflammatory per se. That leads us down to question the possibilities of what is underlying such (auto)immunological responses in alopecia areata, which may be due to specific or indistinct pathogen infection. And whether tackling such infection is possible rather than feeding or suppressing the immune response against it.
I can't find BHB serum measurements at the standard labs. Knowing those before would of course be nice to figure out which scenario one's in.
@Gaston said:
Those are good offers for BHB. Unfortunately they don't sell butyrate or a-KG yet.
@Hearthfire said:
I've seen some stuff about how potassium may be a key to reversing hair loss.
Thanks. If I'm grasping it correctly the effects of the potassium only replaces the use of minoxidil: So in all cases where minoxidil proves to be of no benefit there would be no benefits from potassium either.
That and the AA/BHB-connection really points to wanting to first figure out the underlying mechanism of one's hair loss. Or to at least set up a plan of one's own trials as in "if not AA, then...", "if minoxidil, then K" or "if not minoxidil/K, then..." -
-
@CrumblingCookie The potassium bicarbonate at least is anti-fungal as well, so it could have multiple pathways to regrow hair. While also being much healthier/safer than minoxidil (even though minoxidil is pretty proven as a safe drug in correct doses and application)
-
@CrumblingCookie What about ornithine a-ketoglutarate? I'm leaning towards trying this rather than BHB.
https://www.bulksupplements.com/products/l-ornithine-a-ketoglutarate-okg-powder
-
@Mauritio
I put it on this morning.
Is there any reason to wash it off?
It does not seem leave a mess on the hair, after it dries. -
@AinmBeo No I just leave it in. This should increase absorption .
It's surprisingly practical. Even the sugar version is growing on me. Its sticky first, but after drying it works a little like a hair gel.Which version are you using ?
Im gonna add sodium butyrate this weekend .
-
@Gaston said:
What about ornithine a-ketoglutarate?
Good find. I can't wrap my head around it all atm so maybe someone else may elucidate.
I remember ornithine works for scavenging/converting ammonia to urea and that less ammonia spares a-KG for more energy from the TCA. Then ornithin-aKG could be doubly beneficial.It would be great if anyone can find the equivalent study to this study Intermediary metabolism of the human hair follicle but done on the dermal papilla.
According to this ex vivo/in vitro study the human hair follicles (and skin) mainly rely on- aerobic glycolysis of glucose, i.e. predominantly foregoing mitochondrial oxphos which only accounts to about 10% of all the glucose used up.
- energy from glutamine by peripheral consumption of circulating amino acids or protein catabolism.
So glutamine and glucose seem to be an equally important energy substrates for hair follicles.
Replacing the 1% glucose with 1% L-glutamine may be an option. Or using both L-Glut and glucose in combination, which in the study above lead to much higher follicle ATP content than only glucose (in case that higher ATP content is a good thing and not sign of a backlog).Yet I'm thinking that feeding other substrates (like a-KG) directly into the mitochondrial TCA of skin or hair follicles could unleash significant, additional metabolic energy capacities.
-
@Mauritio
I am doing:
• Dextrose: 1 g
• B3 niacinamide: 1 g
• Vodka/Ethanol: 1 oz
• Distilled h2o: 2.3 oz
By the way, is there any reason not to do this every day? -
@CrumblingCookie I discussed the hair metabolism in this post
https://bioenergetic.forum/post/41937I've read the study you linked.
And I'm not sure glutamine is necessary . It gives a small energy boost, but maybe it also has it's draw backs (ammonia, inflammation?) .It does increase total ATP content, but it also inhibits glucose utilization, indicating that they're competing for oxidation. Maybe glutamine is an emergency fuel.
Also glutamine is being converted to a ketoglutarate, which can feed the TCA cycle . But as we know this is a minor source of energy in the HF so I wouldn't focus on it too much . And it's partially taken care of by the current formula already.
But I'm gonna look into it more.In wondering what other more benign amino acids do for the hair, like glycine ?
-
@AinmBeo I'd use NMN if possible.
Topical niacinamide does not stimulate hair growth based on the existing body of evidence
https://pubmed.ncbi.nlm.nih.gov/31955438/Sure that's kind of the point.
