Reversal of hair loss in Mice with “sugar gel”
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I've seen some stuff about how potassium may be a key to reversing hair loss.
https://www.hairloss-research.org/carnitine-and-hairloss/
This patent pending oral minoxidil mimetic, (TRX2) developed by Dr. Whitfield, has had encouraging results in phase 2 trials (18 month point), released in October of 2011.
There were 59 participants, men and women affected by Androgenetic Alopecia.
Hair counts increased an average of 49.2%
Hair thickness increased 38.7%
Terminal hair change, (vellus to terminal) 36.4%
In all, 87% have reported cessation of hair loss.
Dr. Whitfield’s TRX2 formula is comprised of Carnitine, Branched Chain Amino Acids, Niacin, and potassium chloride. This formula can also be readily replicated at a higher potency by simply obtaining these ingredients separately, and even enhanced by using more advanced forms of Carnitine.
Our recommendation for Potassium Ion Channel restoration for hair growth consist of :
Optimized Carnitine with GlycoCarn: 1-2 capsules a day
Branched Chain Amino Acids-: 2-4 capsules a day
Niacin: 1 capsule a day
Potassium Citrate: 1 capsule a day
Thanks to the painstaking research conducted by Dr. Whitfield, the systemic stimulation of Potassium Ion Channel Function (minoxidil mimetic) can now be used as a sole intervention, or integrated into an existing hair loss treatment regime of natural DHT inhibitors and anti-inflammation agents. Although it is likely through the mechanisms identified by Dr. Whitfield, that both Carnitine and Branched Chain Amino Acids offer some benefit to hair loss on their own, it is the combination of the above mentioned compounds that would appear offer optimal benefit for both health and sustained hair growth.
This guy claims that potassium bicarbonate is the cure: https://medium.com/@baldnesscure14/the-actual-cure-for-male-pattern-baldness-c937879b872c
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@CrumblingCookie yeah good point. That is an aspect of hair loss I've almost never come across.
I'm wondering what I've been doing to my scalp biome by applying 35% alcohol everyday . But from the looks of it, it seems to work. My hair looks better. Even though I was worried that the alcohol might make it dry.
I think I'll use between 0.5-1% of NaB to be sure.
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@Hearthfire very interesting, thanks for sharing.
I didn't find anything on potassium bicarbonate and hair loss directly. But at the very least the bicarbonate should increase local CO2, which is helpful.
But the fungal connection is quite remarkable!
In this study, People with hair loss almost had a 10x higher prevalence of a fungal scalp infection called Malassezia. That correlation is so strong that it seems likely that there's causality as well."The prevalence of positive smears was significantly higher among subjects with hair shedding than among normal subjects (89.92% vs 9.52%, p<0.001).
https://pubmed.ncbi.nlm.nih.gov/16901187/In this study the difference was only 20% .
But they found that Malassezia, is higher on the top scalp in balding people than in the occipital region, which doesn't bald. So again there seems to be a connection between Malassezia and balding. Making potassium bicarbonate an intriguing option .
https://pubmed.ncbi.nlm.nih.gov/31240449/"The scalp commensal organism, Malassezia, has been recognized to be a source of oxidative damage. "
This might be one of the reasons why anti-oxidants help with hair loss.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6369642/Sodium butyrate is anti fungal, making it an even better candidate .
https://pubmed.ncbi.nlm.nih.gov/21911344/ -
@Mauritio i wrote about this months ago
https://bioenergetic.forum/topic/2492/what-is-the-link-between-potassium-and-baldness/9
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@wester130 Yeah your thread might be where I found that medium article, or I was searching on the other forum.
Welp, time to order some potassium lol. This has renewed my interest in it and moved it to the top of the list of things to try.
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Malassezia + demodex mites is what I think might be causing baldness in a large portion of balding people. Causing constant inflammation and damage, feeding on the sebum, and causing your scalp to over-produce sebum. Maybe its this constant attack that causes DHT to raise. Normal DHT levels would cause hair to grow, but balance gets out of whack when these parasites have overrun your scalp.
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@CrumblingCookie Are you aware of this potassium BHB product?
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@Mauritio I had tried the potassium bicarbonate (orally as well as externally as well as with the other things as described in that medium article) years ago for a very long time (more than half a year) and it did nothing in my case. I even tried those TRX2 capsules years ago for a year with no results (really expensive). Theoretically it sounds good, but in practice, at least for me, it did nothing.
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@Hearthfire regarding mites - This is why I use essential oils, they kill most mites
I mix essential oils into everclear to make a non-greasy topical
Most people don't use essential oils because they are greasy when mixed into a carrier oil
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@Hearthfire I think they are certainly a factor of many.
Anecdotally I can say that I've noticed for years that anti-fungals like boron, MSM, etc. have decreased hair loss .
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@tubert thanks for your experience. I will add sodium butyrate first since I already own it. And after that maybe potassium bicarbonate. It's cheap and available so why not .
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@tubert Did you try it topically? The guy in the medium article put it in his shampoo as well as supplementing it with/after meals.
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Exactly. I watched a lot of Robert Cassar videos talking about parasites, found his channel on the other forum a few years ago. Good shampoo recipe for killing mites here, as well as being a great stimulating hair growth recipe: https://eartheracademy.com/course/stimulating-hair-growth-removing-scalp-toxicity-fungus-and-hair-mites/
@Mauritio said in Reversal of hair loss in Mice with “sugar gel”:
@Hearthfire I think they are certainly a factor of many.
Anecdotally I can say that I've noticed for years that anti-fungals like boron, MSM, etc. have decreased hair loss .
How do you use it? Just as a supplement? I've started taking MSM in pills and added some to my shampoo recently. I took boron 6 years ago or so as a way to boost testosterone/energy, and I do recall it having a good effect, but not mind blowing enough to continue (probably because my test levels are good already). Might have to try it again though for the hair benefits. I've seen some anecdotes online about minerals, especially trace minerals that we don't get a lot, that suggest they be a big factor in hair loss for some people. Seen a few people say they fully recovered from gray hair by taking minerals, and their hair got thick and changed texture.
I remember reading how fungus feeds on iron. I wonder if because people are so psy-oped by doctors/medical institutions about taking iron supplements and that we need a lot of iron, and the fact that it's put into foods as a vitamin, it's put into multivitamins, it's causing these fungus and other parasites to keep getting over fed. If we had the proper balance of other minerals to displace/replace and correct the high iron levels, maybe our scalps wouldn't be a weakened feeding ground?
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@Hearthfire I did it exactly like mentioned in medium. topically (i called it externally) as well as internally after every meal (not just heavily salted meals). But go ahead and try it yourself and report back
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@Mauritio
Have you been spraying it on, or applying it like shampoo?
Or getting the hair wet and making "rows" and applying it to the scalp at the base of each row? -
@Hearthfire I have used it orally.
I think heavy metals can cause fungus overgrowth since they bind and incorporate heavy metals. And we're certainly getting heavy metals from all kinds of angles.
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@AinmBeo said in Reversal of hair loss in Mice with “sugar gel”:
Or getting the hair wet and making "rows" and applying it to the scalp at the base of each row?
This without making it wet. I apply it to the scalp, massage it and spread it with my fingers and after that comb my hair to spread it and increase circulation.
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@CrumblingCookie said in Reversal of hair loss in Mice with “sugar gel”:
I've been wondering whether BHB or butyrate would be better energy substrates to hair follices rather than dextrose.
Possible role of β-hydroxybutyrate in inducing inflammation in alopecia areata
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@Gaston said:
Possible role of β-hydroxybutyrate in inducing inflammation in alopecia areata
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Serum BHB levels were found to be significantly elevated in patients with AA compared with healthy controls, with higher levels correlating with severity of hair loss. BHB treatment increased inflammatory cytokine production in outer root sheath (ORS) cells, mimicking the inflammatory conditions seen in AA.
Hmm. That's a flip side. So the BHB seems to be strongly immunostimulative. Not necessarily merely proinflammatory per se. That leads us down to question the possibilities of what is underlying such (auto)immunological responses in alopecia areata, which may be due to specific or indistinct pathogen infection. And whether tackling such infection is possible rather than feeding or suppressing the immune response against it.
I can't find BHB serum measurements at the standard labs. Knowing those before would of course be nice to figure out which scenario one's in.
@Gaston said:
Those are good offers for BHB. Unfortunately they don't sell butyrate or a-KG yet.
@Hearthfire said:
I've seen some stuff about how potassium may be a key to reversing hair loss.
Thanks. If I'm grasping it correctly the effects of the potassium only replaces the use of minoxidil: So in all cases where minoxidil proves to be of no benefit there would be no benefits from potassium either.
That and the AA/BHB-connection really points to wanting to first figure out the underlying mechanism of one's hair loss. Or to at least set up a plan of one's own trials as in "if not AA, then...", "if minoxidil, then K" or "if not minoxidil/K, then..." -
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@CrumblingCookie The potassium bicarbonate at least is anti-fungal as well, so it could have multiple pathways to regrow hair. While also being much healthier/safer than minoxidil (even though minoxidil is pretty proven as a safe drug in correct doses and application)
