@wester130 well Ray wasn't fond of pituitary hormones so there's that

And androgens like DHT would also suppress them so I wouldn't say that's necessarily a bad thing.
Interestingly it only suppresses FSH and not LH.

@bio3nergetic yeah he wasn't the biggest fan of 5aDHP either. Which is understandable if you see the cancer studies. And Ray was pretty cautious when it comes to supplements in general.

There's very little studies on this metabolite ...

@wester130 like the sweet spot between dopamine and GABA with a little bit of progesterone in it.
I did not get those effects from allopreg.

Synchronicity strikes again!
I was thinking about messaging you to ask if you can bring back 5aDHP because I like it so much.
But 3aDHP seems close enough to try.

Does it have the some anti-prolactin effect as 5aDHP?

Welches Waschmittel verwendet ihr alle ?

Rapamycin might help schizophrenia by lowering mTOR.

Schizophrenics have increased 5ht6 activation which in turn activates mTOR.

"Further, 5-HT(6) receptor activation increased mTOR signalling in rodent prefrontal cortex (PFC). Linking this signalling event to cognitive impairment, the mTOR inhibitor rapamycin prevented deficits in social cognition and novel object discrimination induced by 5-HT(6) agonists. In two developmental models of schizophrenia, specifically neonatal phencyclidine treatment and post-weaning isolation rearing, the activity of mTOR was enhanced in the PFC, and rapamycin, like 5-HT(6) antagonists, reversed these cognitive deficits. These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control."
https://pubmed.ncbi.nlm.nih.gov/23027611/

Rapamycin increases klotho.

It is even more Peaty than I thought because it lowers phosphate. And phosphate activates mTOR. Rapamycin lowers phosphate and mTOR, decreasing calcification.

"Zhao et al. report that phosphate activates the mammalian target of rapamycin (mTOR) cascade in VSMCs, leading to downregulation of Klotho. Furthermore, rapamycin was shown to halt medial calcification. This effect was blunted in the absence of Klotho. Given the concomitant anti-atherosclerotic effects of the mTOR inhibitor, this agent has clinical potential as an inhibitor of intimal atherosclerosis and medial calcification."
https://pubmed.ncbi.nlm.nih.gov/26422620/

Here, it also increases klotho in aging mice. And it caused a huge increase in survival.

"All mice administered rapamycin survived the 12-week course, whereas 43% of the controls died."
https://pubmed.ncbi.nlm.nih.gov/37190667/

It decreased phosphate in humans.

"In the rapamycin group, serum phosphate was lower than in the CNI group with an increase in phosphate excretion and a reduction in its reabsorption."

@LetTheRedeemed Theres something weirdly Anti-Life (vita= life) almost satanic about their nedd to ascribe something toxic to every vitamin.

Day 8:
Last days felt hypothyroid, gained water weight.
Had rapamycin yesterday and today lost water weight. Weigh 650g less than yesterday morning, although I ate more than the days before.
Took rapamycin before work... Not a good idea. Was stressed and tired. Will return to after work.

I suspect that there might be a rebound mTOR effect after a few days of no rapa, hence the hypothyroid symptoms .

Or Maybe that's the "physiological insulin resistance" that is transient and materializes itself at the beginning of rapamycin treatment.
IIRC rapamycin caused water retention for tarmander as well but it went away.

Other than that my energy might be slightly higher but not sure yet.