Dandruff or scalp irritation? Try BLOO.
Chlorogenic Acid Inhibits Lipid Deposition by Regulating the Enterohepatic FXR-FGF15 Pathway
https://pubmed.ncbi.nlm.nih.gov/35257010/
Chlorogenic acid fed mice increase less in weight than controls mice on a high fat diet. AND weigh less than animals on a normal control diet.
https://pubmed.ncbi.nlm.nih.gov/20064576/
Might inhibit Mao a+b
https://pubmed.ncbi.nlm.nih.gov/29893510/
@bio3nergetic said in Apigenin:
It really isn't even a matter of "black or white," but the lack of distinction. It is meaningless to throw around NOS without knowing what type in what context. Apigenin can increase eNOS and improve circulation. In a inflammatory context, it can inhibit iNOS, which is what we need to keep in check ultimately.
Yes, well said. It's the bigger picture that matters.
apigenin
Api activates BKCa and SKCa, leading to cell hyperpolarization that is followed by an influx of extracellular Ca2+; together with the release of Ca2+ from the ER, this rise in [Ca2+]i directly activates NOS; and the increased NO synthesis is then responsible for the inhibition of angiogenic endothelial cell functions by blocking Akt phosphorylation.
https://doi.org/10.1111/j.1538-7836.2007.02615.xNitric Oxide Induces Metabolic Shift from Glycolysis
"Nitric oxide, even in the presence of oxygen, causes a metabolic shift to glycolysis, wastefully producing lactate from glucose" RP
You're over focusing on one point from an in-vitro study, when in fact apigerin has been shown to do the opposite of what you suspect (inducing glycolisis).
Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging
https://pubmed.ncbi.nlm.nih.gov/34114892/
Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway
Dates (polyphenols) activate FXR and modulate bile acids.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5749773/
It protects against cholestasis.
MoA: FXR modulation, TLR-4 inhibition,anti-oxidant
https://pubmed.ncbi.nlm.nih.gov/33620063/
Another study which also shows anti-fibrotic, anti cholestatic effects
https://pmc.ncbi.nlm.nih.gov/articles/PMC10967634/
High salt diet induces muscle loss via cortisol, if simultaneously given saline Solution, not if rats were given tap water.Maybe there's a Sweet Spot for Salt.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5409074/
@Serotoninskeptic thanks! That's basically what I've been doing for a while now. I posted a study showing benefts of MR after Just 6h! So if you only eat significant amounts of protein in the evening you have an18h window of "benefits". Intermittent protein fasting.
I feel bad for the normal person they've just adapted to high protein being healthy and now this...
@alfredoolivas The backbone is very similar not sure how to explain that to you