Niclosamide a pro-metabolic drug that deserves more attention IMO.

It's an uncoupler, TLR4 antagonist , anti-fungal, Anti-viral, neuroprotective ,helps diabetes and fatty liver .. you name it. It shares structural similarity to aspirin as well.

I'm going to link the thread where we discussed our experiences with it on the former RPF:
https://lowtoxinforum.com/threads/niclosamide-for-fat-loss-uncoupling.42781/

This study shows that it lowers serotonin and glutamate in physhological doses.
Maybe that's why some people reported better sleep and mood on it.
It should be helpful for people with excessive itching, as in seasonal allergies .

"Additionally, the levels of mGluR1, mGluR5, 5-HT2, and TRPV1 were significantly reduced."

It might also have anti-fibrotic effects since it antagonizes the 5HT2 receptor.

https://pubmed.ncbi.nlm.nih.gov/38994087/

I think he's even somewhat improving his appearance by all types of cosmetic tricks.
IIRC he had hair transplant, hair coloring, Botox (?) , testosterone injections, facial fillers ,...

If all of that is necessary to not look like the walking dead, I'd second guess my approach.
And that is even while is taking some pro-metabolic things like testosterone and NAD.

What I like is that he's honest about what he does and take . There is something truly scientific about that.

I've never thought of this but MR could be incorporated before and after scheduled stressful events, like surgeries. And it seems to be effective.

"Furthermore, we demonstrate the potential of short-term preoperative MetR as a simple intervention to ameliorate vascular remodeling after vascular surgery."

https://pubmed.ncbi.nlm.nih.gov/39511181/

A new study showing MR increases lean mass, CO2, energy expenditure and especially glucose oxidation.

"MR mice also have increased insulin sensitivity along with increasing indirect calorimetry markers such as energy expenditure, oxygen consumption, carbon dioxide production, and glucose oxidation."

https://pubmed.ncbi.nlm.nih.gov/38279509/

@Sunniva said in Bile can serve as a reservoir for funghi, making them harder to treat:

(DMSO) inhibits the germination of Candida albicans

That is so interesting . You just helped me to connect the dots.
Several times when I used Melanon topically on the area above my liver/gallbladder I experienced fungal die off. I attributed it to apigenin or naringenin, but it might as well be the DMSO.
Apigenin and naringenib are also anti-fungal. They're also small molecules, but not hydrophilic. But still Melanon should be a very effective anti fungal applied topically.
https://pubmed.ncbi.nlm.nih.gov/29346565/
https://pubmed.ncbi.nlm.nih.gov/33934490/

If the gallbladder is so hard to reach for anti-fungals maybe topical is the way to go.
Maybe using some anti-fungal IdeaLabs supplements over the gallbladder would be good, ideally one that uses DMSO as a solvent.

Alternatively dissolving MSM in DMSO should help. It is a small, hydrophobic molecule and it dissolves in MSM so it might be very potent if delivered directly to the gallbladder via topical application.

@DavidPS thanks I sent you a request .

@DavidPS Thansk. I cant open this link. I think it's a sci hub issues. Most sci hub domains don't work for me anymore. And the ones that do work don't give me Andy results for the above link. Would you mind posting the PDF ?

@yerrag I took Haarlem oil daily for a while.
I believe it contains turpentine and sulfur. I got less and less of an effect as time went on so I stopped. But I recently reintroduced it and found that cycling it, seems to maintain its effects.

@DavidPS

i tried sending it to Google lens which send me to a Chinese website, which was semi helpful. Then i googled some of the Authors mentioned and it might be this study.

https://pubmed.ncbi.nlm.nih.gov/31061538/

@sneedful said in Bile can serve as a reservoir for funghi, making them harder to treat:

EGCG at slightly alkaline pH is effective against candida. maybe some sort of liposomal egcg that makes it into the bile would work

EGCG is a small/medium sized molecule and only slightly water soluble. So there are better candidates than it. Maybe when it forms complexes with other molecules it makes it more water soluble .