Topics created by Mauritio

@Mauritio said in Glycine is an anti-biotic, restores sensitivity to antibiotics:

In light of this thread, the findings of this old thread by haidut are even more interesting.

https://lowtoxinforum.com/threads/gut-bacteria-overgrowth-drives-cocaine-addiction-glycine-can-reverse-it.48285/

I'm puzzled. How can glycine be helpful if it feeds the bacteria? Aren't we supposed to deprive the bacteria of its food source to have an antibiotic effect such that the bacteria would just not be able to multiply and become a thriving colony by being deprived of its food source? How is providing more gelatin going to help?

It increases dopamine .

"MPTP-induced reduction of dopamine contents in the striatum and hippocampal CA1 region was improved by nobiletin administration (50mg/kg i.p.). Acute intraperitoneal administration of nobiletin also enhanced dopamine release in striatum and hippocampal CA1,..."

https://pubmed.ncbi.nlm.nih.gov/24316474/

NOB could restore memory impairment via the improvement of neurogenesis by ameliorating neuroinflammation in the hippocampushttps:

//pmc.ncbi.nlm.nih.gov/articles/PMC10181043/

I've contacted IdeaLabs regarding there being a measurement error:

"It is not an error. We actually run 3 independent tests on each sample to weed out outliers and then average the results. The high DHT and androsterone make sense considering their precursors DHEA-S is 10x the upper limit of the range. It may be worth doing some blood work for those that are very high and see what the doctor has to say about it if they come back high again.
The tests you have seen from bodybuilders are most likely either in blood or urine and those are not reliable as they do not reflect cellular levels. Cells often accumulate steroids in concentrations up to 100 times higher (e.g. DHEA) than what is present in blood and the hair test is a good surrogate for tissue levels.
http://haidut.me/?p=2104"

@Mauritio said in Vitamin A and D deficiency increases liver cancer:

o for anyone thinking vitamin A and D are poisons maybe ingest some Vitamin E at least.

I’d like to point out some inadequacy to remind:

High levels of vitamin E alpha (only one dimer) affect retinol binding protein (RBP). Excessive vitamin E could increase the concentration of vitamin A in liver by inhibiting RBP synthesis in hepatocytes.
We need 20-25 mg vitamin E per day, according to Chris Masterjohn. So I won’t take 400 UI every day but every 72 hours (+/ 2x/wk.), 3x if inflammation. There is U-shape effect with retinol:
An excess of vitamin A (or a vitamin D deficiency) prevents the formation of heterodimers: essentially homodimers (RXR-RXR) will be formed, leaving the VDR unoccupied and inactive. Zoëhlo (Pharmacologist). A deficit in Fe Zn Vit E or protein can exhaust the carriage, the storage and the use of vitamin A.
Useful links: Vitamin A is one of the Keys to a Tolerant Immune System? (in French, translator needed)
https://mirzoune-ciboulette.forumactif.org/t721-vitamine-a-la-cle-dun-systeme-immunitaire-tolerant#6555 Vitamin A works as an estrogen antagonist
The greatest use of vitamin A is at the level of production of pregnenolone, progesterone and the other steroid hormones associated with youth.
“Vitamin A is for the production of pregnenolone, progesterone, and the other youth-associated steroids”.
http://raypeat.com/articles/articles/alzheimers2.shtml

I already tried it and it seems to be work fine with MCT oil.

Desktop is preferable because the laptop has a cord that has an inline transformer that puts out an electrical field.

Interesting. Several years ago my gut was absolutely nuked by max dose clindamycin after a nasty infection that almost caused me to lose the use of an eye. The result was weeks of c difficile -like symptoms. The only thing that fixed it was boulardii.

5 Supplements To Inhibit IL-11 (animal studies)
https://www.youtube.com/watch?v=nYbJj3uRn1I

One of the comments on YouTube:

Thx Richard for this interesting presentation.Actually it's not necessarily the curcumin but the other ingredients in turmeric that are responsible for the inhibition of IL-11.
So the whole food is always more potent than any supplement. By the way piperlongumine also inhibits IL-11. I take them every day in my coffee and in meals combined with olive oil ,black pepper and ginger.

But then there is the fact that it is literally the most unpleasant food ever concoted by man.

Beneficial bacteria inhibit cachexia

Muscle wasting, known as cachexia, is a debilitating condition associated with chronic inflammation such as during cancer. Beneficial microbes have been shown to optimize systemic inflammatory tone during good health; however, interactions between microbes and host immunity in the context of cachexia are incompletely understood. Here we use mouse models to test roles for bacteria in muscle wasting syndromes. We find that feeding of a human commensal microbe, Lactobacillus reuteri, to mice is sufficient to lower systemic indices of inflammation and inhibit cachexia.

Eating with an open mouth helps greatly with digestion. It also improves taste. I always breathe in deeply a few times with an open mouth before I drink OJ. You should try it.
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@Mauritio Nice find! Thank you.

I get mine from L-reuteri (see) and I have not had any negative side effects.

Store bought mushrooms are most likely grown in manure contaminated with waste from industrial processing of cattle and the like.

@Crypt-Keeper
yes

@TheRealPeater

@TheRealPeater said in I have been banned on the RPF for posting this study on Vitamin A...:

@Mauritio

This is a shame. I enjoyed my conversations with you and @Jam on the iodine threads.

I think I'm OK posting in both places as I'm happy to give a generalised Low A approach a go...no different to how I gave SSKI a go...

I'm not looking for a Great Wise Old Sage to shape my life, but I am happy to run with thoughts that interest me.

I think thats totally fine. Many people have reported feeling better on a low A diet, although Im not sure how much of that is due to the absence of vitamin A and not the absence of all kinds of other things.

I think its good that people get a feeling for how certains vitamins affect them. As Vitamin A can be anti-thyroid in higher doses, which is not a controversial opinion at all, just as this is not news, but has been said by Peat for decades.

@Kvothe said in Vitamin A increases T3 by more than 60% in humans!:

Some dude posted this study on RPF. In rats, an equivalent dose was enough increases TSH and suppress T3. I personally experienced that anything over an extra 5.000IU can be suppressive for a mildy hypothyroid person.

https://link.springer.com/content/pdf/10.1007/s00394-022-02945-5.pdf

0db5dde3-7db7-4cfb-8447-a8fe77b96aba-grafik.png

Well that dude (sinatra) probably has the study from this thread here (https://bioenergetic.forum/post/12395) where I posted it a few days before him, it's interesting that he did not post the main study of this very thread or any of the other pro-vitamin A things I posted.
The HED of about 30k IU per day is still realtively high. And i agree that this can make you hypo, which peat has said for decades.
On the other hand the study, which this thread is about (human study, not rat) shows clear benefits in a similar dosage.

@Mauritio said in Vitamin A quotes from Ray's favorite physiology book:

@Peatly said in Vitamin A quotes from Ray's favorite physiology book:

@Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun.

Yes, I agree.
What does it have to do with the sun/ Vitamin D?

I was under the impression that being exposed to sunlight, for extended periods, increases your vitamin A requirements. I was thinking that if the sun is being blocked this might lower need?

Dr Peat talking about light exposure and vitamin A

This is the dentist Dr Peat mentions in that clip
Emanuel Cheraskin, M.D., D.M.D., late Professor of Oral Medicine at the University of Birmingham, AL.

The "ideal" daily vitamin A intake

Relationship of vitamin A and oral leukoplakia

@Mauritio

yeah I guess so. This stuff is confusing you know. My tests all come back normal for the most part. TSH 0.4 and good T4 and T3 yet I feel a swollen thyroid. Wtf