@Mauritio said in Vitamin A and D deficiency increases liver cancer:

o for anyone thinking vitamin A and D are poisons maybe ingest some Vitamin E at least.

I’d like to point out some inadequacy to remind:

High levels of vitamin E alpha (only one dimer) affect retinol binding protein (RBP). Excessive vitamin E could increase the concentration of vitamin A in liver by inhibiting RBP synthesis in hepatocytes.
We need 20-25 mg vitamin E per day, according to Chris Masterjohn. So I won’t take 400 UI every day but every 72 hours (+/ 2x/wk.), 3x if inflammation. There is U-shape effect with retinol:
An excess of vitamin A (or a vitamin D deficiency) prevents the formation of heterodimers: essentially homodimers (RXR-RXR) will be formed, leaving the VDR unoccupied and inactive. Zoëhlo (Pharmacologist). A deficit in Fe Zn Vit E or protein can exhaust the carriage, the storage and the use of vitamin A.
Useful links: Vitamin A is one of the Keys to a Tolerant Immune System? (in French, translator needed)
https://mirzoune-ciboulette.forumactif.org/t721-vitamine-a-la-cle-dun-systeme-immunitaire-tolerant#6555 Vitamin A works as an estrogen antagonist
The greatest use of vitamin A is at the level of production of pregnenolone, progesterone and the other steroid hormones associated with youth.
“Vitamin A is for the production of pregnenolone, progesterone, and the other youth-associated steroids”.
http://raypeat.com/articles/articles/alzheimers2.shtml

@TheRealPeater

@TheRealPeater said in I have been banned on the RPF for posting this study on Vitamin A...:

@Mauritio

This is a shame. I enjoyed my conversations with you and @Jam on the iodine threads.

I think I'm OK posting in both places as I'm happy to give a generalised Low A approach a go...no different to how I gave SSKI a go...

I'm not looking for a Great Wise Old Sage to shape my life, but I am happy to run with thoughts that interest me.

I think thats totally fine. Many people have reported feeling better on a low A diet, although Im not sure how much of that is due to the absence of vitamin A and not the absence of all kinds of other things.

I think its good that people get a feeling for how certains vitamins affect them. As Vitamin A can be anti-thyroid in higher doses, which is not a controversial opinion at all, just as this is not news, but has been said by Peat for decades.

@Mauritio said in Vitamin A quotes from Ray's favorite physiology book:

@Peatly said in Vitamin A quotes from Ray's favorite physiology book:

@Mauritio There are huge variations in results for vitamin A studies. I think Dr Peat’s recommendation, which is to be cautious if hypothyroid, seems reasonable. I would like to see that Iranian study replicated elsewhere – especially in regions where Billy Goat is blocking the sun.

Yes, I agree.
What does it have to do with the sun/ Vitamin D?

I was under the impression that being exposed to sunlight, for extended periods, increases your vitamin A requirements. I was thinking that if the sun is being blocked this might lower need?

Dr Peat talking about light exposure and vitamin A

This is the dentist Dr Peat mentions in that clip
Emanuel Cheraskin, M.D., D.M.D., late Professor of Oral Medicine at the University of Birmingham, AL.

The "ideal" daily vitamin A intake

Relationship of vitamin A and oral leukoplakia

@Peatly said in Mild Vitamin A deficiency decreases DHEA and Pregnenolone by 40%:

@Mauritio Thank you.

I just found this quote from the mega master newsletter

"Recently, the polyunsaturated oils have been identified as the main thing in cells that radiation interacts with, to cause cellular damage. Vitamin E, taken internally or even applied to the skin, has been found to reduce the damage produced by exposure to ultraviolet radiation, which is logical, since it interrupts the chain reactions of toxic free-radicals produced when unsaturated oils are oxidized by radiation or other injury. Aspirin has been found to have a similar effect in reducing the harmful effects which develop in the skin after sunlight overexposure. Coconut oil has been used for generations in “ suntan lotions, ” and whether it is absorbed through the skin or eaten as a food, it clearly has a protective antioxidant function. Carotene seems to work with vitamin E in the skin to reduce injury by ultraviolet radiation. Caffeine also has shown a protective action against radiation, but its mechanism of action isnʼt clearly understood." Townsend Letter for Doctors & Patients, June 1996, Page 83 – 85

Dr. Peat also said he stopped burning in the sun after supplementing vitamin D, getting lots of milk and limiting PUFA.

Good one.

I believe it may be an estrogen problem for most of these people. All the papers by Mawson I've read seem to point towards an increase in retinoic acid at the particular diseased site, or a dis-regulation of retinoid signalling like in glioblastoma.

From this Ray article it seems estrogen is responsible for triggering certain inflammatory immune response like the chitinase enzymes etc. I wouldn't be surprised if it did the same with retinoic acid needlessly at the site of inflammation.

I think a lot of their benefits are as you say blunting the immune response but also I'd add a reduced endotoxin load. They all seem to do bad ("detox reactions") without any binders.

@Zofia said in RHEUMATOID ARTHRITIS:

I forgot to mention I am currently taking Vitex and it's helped my PMS significantly. I was doing progesterone for a while but it became too tedious with RA hands.

Honestly, I keep my PUFA very low, I have also been told it can take up to 4+ years to get rid of in the tissues. I eat all home-cooked meals, even if I have some PUFA it's less than 3-4g. How do you know what does of Niacinamide works for you? Currently, I'm at 500mg and feel good, mostly getting sugar from fruit or honey.

I really like that explanation of CRP, makes complete sense.

Yes, I've been thinking of seeing one but it's a hit or miss of course. So with the appropriate amount of thyroid, you were able to put the disease into remission?

Thank you for all the reading! I'll be reading it all. I've also come across SIBO being treated with high-dose thiamene, up to 600mg.

I've never taken Vitex myself so I have no personal experience with it. Some say it can be estrogenic. I do use a couple of blats of progesterone every night; one blat rubbed into my gums, the other blat mixed with equal parts coconut oil and done vaginally. The total of 2 blats equals about 40mg of progesterone (in vitamin E).

I've been a lunatic avoiding pufa for 9 years. I don't eat out. My husband thinks I'm nuts. But it's better than being closed up in a facility for the incapacitated.

Regarding the niacinamide: Ray Peat always recommended doses of 90mg for niacinamide. I took two doses of niacinamide each day, each 200mg for 7 years. But then, I decided to switch to 100mg 4Xday. After that one change, I lost about 35 pounds in about 8-10 weeks. I think it's because the more frequent smaller doses made my body work better. I was very surprised when I finally weighed myself because my clothes fit differently.

"I really like that explanation of CRP, makes complete sense."
I think that the whole RA thing is caused by inflammation. Inflammation is caused by poor oxidative metabolism. If you can correct what's interfering with the oxidative metabolism, the inflammation disappears and your body will heal itself. I think that it really is that straight forward.

"Yes, I've been thinking of seeing one but it's a hit or miss of course. So with the appropriate amount of thyroid, you were able to put the disease into remission?"
I don't know where you are. I'm in the U.S. Pharmacies here receive prescriptions from doctors, fill them, and the patients pick them up. If the situation is similar where you are, the pharmacists know which endos/doctors prescribe desiccated thyroid already. If NP Thyroid by Acella is available in your country, you could ask pharmacists near you which doctors are prescribing it (or Armour brand or other?). This research would shorten your doctor hunt quite a bit.

Yes, the right dose of a good desiccated thyroid med (NP Thyroid by Acella) completely resolved my rheumatoid arthritis. Ray Peat wrote that this was common knowledge back in the olden golden days, before the medical industry mucked things up so badly.

ARTHRITIS AND NATURAL HORMONES
A very healthy 71 year-old man was under his house repairing the foundation, when a support slipped and let the house fall far enough to break some facial bones. During his recovery, he developed arthritis in his hands. It is fairly common for arthritis to appear shortly after an accident, a shock, or surgery, and Han Selye's famous work with rats shows that when stress exhausts the adrenal glands (so they are unable to produce normal amounts of cortisone and related steroid hormones), arthritis and other "degenerative" diseases are likely to develop.

But when this man went to his doctor to "get something for his arthritis," he was annoyed that the doctor insisted on giving him a complete physical exam, and wouldn't give him a shot of cortisone. The examination showed low thyroid function, and the doctor prescribed a supplement of thyroid extract, explaining that arthritis is one of the many symptoms of hypothyroidism. The patient agreed to take the thyroid, but for several days he grumbled about the doctor 'fixing something that wasn't wrong' with him, and ignoring his arthritis. But in less than two weeks, the arthritis had entirely disappeared. He lived to be 89, without a recurrence of arthritis. (He died iatrogenically, while in good health.)"