@Ismail Yes, I eat a fairly low fat diet normally, mostly saturated. Going below 15% of calories from fat seems to cause gut irritation for me, though, so I try to stay between 15-25% ideally. I know even with saturated fat there's a concern of activating TLR4. I do use the carrot salad pretty frequently (and mushroom soup works well too). Using olive oil instead of coconut oil on the carrot salad seems to help somewhat, as Danny and Ray suggested in one of the Generative Energy podcasts. Maybe the olive oil polyphenols have an anti-inflammatory effect, or there could be some benefit to balancing out saturated fat with MUFA. Regarding high-dose thiamine: I've noticed substantial cognitive benefits from 1800mg thiamine daily on memory, but it doesn't seem to improve mood at all
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Latest posts made by herayclitus
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RE: Endotoxin Inflammation Stack
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RE: Endotoxin Inflammation Stack
@mostlylurking Thanks for sharing this--I think it's definitely a leaky gut issue, as alcohol aggravates it worse than anything else. I have been taking thiamine HCl and gelatin as well. Magnesium tends to irritate my gut but I might try it again in a lower dose
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RE: Endotoxin Inflammation Stack
@Ismail I took it for 2-3 days until symptoms subsided. I think increasing fat and protein helped, I might have dropped those too low before. For carbs, I tend to tolerate well-cooked starches better than whole fruit, but I still get a fair amount of carbs from juices
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RE: Endotoxin Inflammation Stack
@LucH I think zinc and methylene blue were the most impactful supplements for me. As far as diet, getting at least 1g/kg protein per day, adequate saturated fat, and easily digestible carbs helps. The carrot salad is also helpful
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Endotoxin Inflammation Stack
(obviously not medical advice)
I've been dealing with some chronic inflammatory symptoms recently that seem to be endotoxin-related (anhedonia, loss of appetite, nausea, low-grade fever, difficulty sleeping, diarrhea, migraines, etc.) I found not getting enough protein and fat to be the main triggers.
This stack worked for me almost as well as antibiotics:
- Zinc, 120mg
- Quercetin, 1g
- Methylene blue, 2mg
- Aspirin, 1g
- T3, 12μg (split into 2 doses)
- Cyproheptadine, 3mg (in the evening)
The dosing for everything is pretty modest, except for the zinc (I think the high-dose zinc is essential though)
I was curious if anyone else had a similar experience, and what worked for you -
RE: Spinach vs Carrot Salad
@wtpyrucet One of the benefits of the carrot is the antimicrobial compounds it contains. Raw spinach is very often contaminated with E. coli, so it's not likely to affect the gut flora in a good way. If you digest it well, it can be a good source of fiber though
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Protein and the Randle cycle
I'm wondering how protein oxidation fits in with the Randle cycle. Haidut has pointed out in some interviews that oxidizing amino acids for fuel produces inflammation by generating too much ammonia, potentially a reason high-protein diets haven't worked well for some. Also Broda Barnes noted that excessive protein consumption had a thyroid-suppressive effect (something I've noticed myself). I'm also wondering if oxidizing protein could interfere with fat and carb oxidation in a similar way to the Randle cycle, and if this could help explain the apparent anti-thyroid effect of high protein diets.
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RE: Best type of Thiamine
@temple-of-salt FWIW I found regular thiamine HCl to work well for improving memory and cognitive function. For more serious problems, benfotiamine might be worth trying. Solaray and Life Extension have decent sources of both.
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Non-English recordings of Ray?
Ray Peat evidently spoke Spanish and Russian, if not others. Are there any recordings of him speaking languages other than English?
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Amino acid cheat sheet
I thought it might be helpful to have a table of all the main amino acids in one place with their physiological properties. Hopefully this will prove useful. Take a look and let me know if I missed anything: