@Ismail said in Endotoxin Inflammation Stack:
@mostlylurking I wish I could get back the feeling I had when I used Elliot Overton’s Thiamega B1 supplement. I split the capsule into 4, and took after each meal I had, I felt such a sudden energy boost, like I could achieve anything.
I tried the next day, however it didn’t give me the same energy.
I can only surmise I may have “depleted” something whilst high dosing the B1, so I took it with a b-complex as well as magnesium. Still didn’t give the same energy boost.
Any idea what I may be missing? In terms of possible co-factors that help the uptake of B1? Thanks 🙏
Elliot Overton's Thiamax B1 is a TTFD product. I was unable to tolerate it because my glutathione level was very low due to my high oxidative stress level (caused by my mercury toxicity). TTFD uses glutathione to work so if you are deficient, it can make the situation worse. I learned from Elliot Overton that taking thiamine hcl does not lower glutathione and it can actually improve glutathione status. So I stuck with thiamine hcl and follow Dr. Costantini's protocol. My glutathione status normalized in about 4 months (blood testing). I still high dose thiamine hcl; I've still got the mercury problem, but I'm pretty much without negative symptoms now; actually, I'm fine. High dose thiamine hcl (+magnesium glycinate and other b vitamins) normalized my entire digestive tract. Even though my gut bacteria was severely damaged by the Bactrim antibiotic, things got sorted out pretty quickly once I attained my optimum dose of thiamine hcl per Dr. Costantini's Therapy info (based on body weight).
@herayclitus said in Endotoxin Inflammation Stack:
@mostlylurking Thanks for sharing this--I think it's definitely a leaky gut issue, as alcohol aggravates it worse than anything else. I have been taking thiamine HCl and gelatin as well. Magnesium tends to irritate my gut but I might try it again in a lower dose
Are you drinking alcohol? As long as you do that, you will have problems.
Wernicke Encephalopathy "Thiamine deficiency is characteristically associated with severe alcohol use disorder. Although Wernicke encephalopathy mostly affects people who have a thiamine deficiency due to chronic alcoholism, various other causes include severe malnutrition, hyperemesis gravidarum, prolonged parenteral nutrition, malignancies, immunodeficiency syndromes, liver disease, hyperthyroidism, and severe anorexia nervosa. Chronic alcohol consumption may cause thiamine deficiency due to impaired absorption of thiamine from the intestine...."
"A common inciting event that precipitates WE is an acute infection. Other triggers include prolonged carbohydrate or glucose loading in the presence of thiamine deficiency. In general, patients who receive glucose should also be administered thiamine at the same time."
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I've had Wernicke's encephalopathy (fall 2020). I was borderline thiamine deficient even though I was taking 100mgs of thiamine hcl daily and I don't drink alcohol. But my intake of orange juice and fruit was pretty high. And my oxidative stress level was high because of heavy metal toxins (mercury mainly) - high oxidative stress gobbles up thiamine. And then I took Bactrim antibiotic for a UTI. That's all it took; I nearly died. But then I read up about thiamine, found Dr. Costantini's website, implemented what I learned, and managed to pull myself back from the brink.
I found the information on Dr. Costantini's website most helpful. He treated Parkinson's Disease patients with high dose thiamine hcl. There is a connection between gut disbiosis and acquiring Parkinson's Disease. I had suffered with multiple gut disbiosis issues for many years: poor esophageal peristalsis, very low stomach acid, SIBO, leaky gut, constipation/diarrhea, almost universally reactive to foods and environmental toxins. I did not understand that there is a connection between gut disbiosis and Parkinson's Disease until I studied it online.
I'd like to suggest that you spend some time at Dr. Costantini's website; read the Therapy page, the FAQs, the About Dr. Costantini, and watch the patient videos.