@Conundrum Following. From my observations, low libido and erectile dysfunction are often caused by low free testosterone.
I have an online friend, he has been dealing with low libido and ED for ages. He has good Total Testosterone levels (in the 600 ng/dL range), yet his free T is in the lower half.
The only measure that made his libido return was taking HCG injections.

Seems like free Testosterone has to be in the upper half of the normal range, for libido to work as it should.

I also managed to increase my Total T (up to 590 ng/dL), yet my free T remains low (10 pg/mL).

@izkrov Yeah that's Ray's take on it. It's important to understand the TRT community has very different views, and actually isn't that compatible with ours. We do "patch work" here to mix some of the ideas in the TRT community with bioenergetics.

Standard TRT protocol is usually something like 120 up to 250 a week. Typically test cypionate. 4mgs won't raise blood levels which is what the TRT is purposed for.

Of course this can cause issues. For one, test cypionate is a longer acting ester. Your levels won't mimic the diurnal rhythm. I don't think we've yet fully understood the implications of this. Most of the "bros" seems to think this is good, because longer esters mean more stabilized androgens at a higher level.

But this could have serious adverse effects too. Like being at an increased risk of hyperestrogenicity, clots, stroke, and the like. It will have a prolonged suppression on the HPTA as well, lowering fertility (unless you take hCG, which has it's own set of risks) and eventually upstream hormones like P5, P4, and DHEA.

@SexyPizza I think just PG and VitE would work for most things. Maybe if your vitamin E oil is too thick you could add some oleic acid to thin it out, but other then that you should be good.

Or you could try oleic acid (OA) + PG + Limonene. But I generally don't see the need of adding two lipid-based solvents together. That's just my 2 cents, I'm very far from an expert in this regard. @brightside seems far more knowledgeable in this area. He seems to be well versed in making emulsions, which would enhance the penetration of lipid-based solutions even more than free base.

Which ever way you decide, these solutions will be extremely "nonvolatile." So you're looking at something that will have a more slow, but continuous, absorption rate. Which I think is probably good, especially for people who only want to dose one time per day. The only downside is it will take a while to dry on skin.

So I would give application site at least 30 minutes of air time to dry before putting on a shirt or pants. And if you're pressed for time and can't wait that long, you could always gently wrap the application site in plastic wrap before putting clothes on over it.

@b1 said in Effect of Aspirin on Male Hormones, Testicular and Epididymal Histology In Mice:

@GreekDemiGod
So take iron supplements or consume more iron to counteract this?

I personally wouldn't. Iron supplements are dangerous, and it can be a potent oxidizer. Almost as bad as PUFA.

Unless you've got cancer, there's never really a reason to take more than 1,000mg a day. Even less in most cases will work. 500mg is enough to lower stress and free fatty acids.

@Crypt-Keeper are you joking?? dutasteride?

DMSO is dangerous anyway and does not necessarily increase absorption

IPM increases absorption by 11 times,

@oldchem Makes so much sense, thank you! Also worth mentioning since my brain injury I put on about 20lbs in the past 2 years, so have more bodyfat than before so this is all starting to make sense.

Prioritize metabolism
Eat sufficient calories with high nutrient dense foods
Do high T behavior (lift weights, run businesses, fuck chicks)