@alfredoolivas said in Pro Metabolic Substances Tier List:

Thyroid (T3/T4

@alfredoolivas What does your thyroid dosing look like? How much T3/T4 a day? how many times a day and do you recommend any specific brand?

Thanks for the post

@alfredoolivas said in Experiments with transdermal hormones:

Since you're using less common solvents and a long list of excipients, you'll need to make sure every excipient is fully miscible with each other and that your active ingredient dissolves properly in the solvent.

DMI and Propylene Glycol aren’t widely used in labs, so there’s little to no published data on how well hormones like testosterone dissolve in them. And when it comes to other excipients like squalane and IPM, there’s absolutely no data at all on how they interact with DMI or Propylene Glycol. Additionally, there is no data on how IPM interacts with squalane, for example.

Chat GPT is very, very bad at estimating data. It won't estimate figures unless you force it to, for this precise reason. Therefore, ignore its solubility and penetration figures.

The only realistic way you may achieve this is ordering an excess of all of these ingredients and figuring out the miscibility of the active ingredient and excipients by trial and error; and even if you do this, you will have no idea if the active ingredient exists as crystals inside the gel, or if it is dissolved inside the solvent. Pharmaceutical gels are designed to have the active ingredient to be either crystalline or dissolved in the gel; when it's crystalline, the crystals will sit on top of the skin and absorb into the skin, creating a more local effect. When the API is dissolved in the gel, it goes systematic.

You’ve raised some good points :

Miscibility Concerns:
I plan to conduct small-scale miscibility tests for all solvent/excipient combinations before scaling up. If phase separation occurs, I’ll explore emulsifiers or adjust ratios to achieve homogeneity.

Solubility:
propylene glycol (PG) is well-documented for steroids like testosterone, with solubility typically ranging from 50–100 mg/mL. DMSO is also widely used and can dissolve testosterone at high concentrations (>200 mg/mL).

Crystalline vs. Dissolved API:
If undissolved crystals are present, I’ll adjust the solvent blend or increase co-solvent ratios.

@brightside @alfredoolivas

I have been looking into transdermal solutions again.

All of these have reasonable solubility ( ChatGPT & Claude estimate ~200-250mg/mL, good Penetration ( 50-60% ) and offer slow/gradual release. Curious about your thoughts on the following :

Formula 1: Deep Penetration & Sustained Release (Balanced Absorption)

• Absorption Speed: Medium-Slow (6-12 hours release)
• Penetration Depth: High

Ingredients (50mL Batch)

• Dimethyl Isosorbide (DMI) (40%, 20mL) – Main solvent for dissolving steroids, slows absorption for extended release.
• Isopropyl Myristate (IPM) (30%, 15mL) – Reduces greasiness, enhances skin penetration without irritation.
• Squalane (Olive-derived or Shark-derived) (20%, 10mL) – Improves deep penetration, nourishes skin, prevents irritation.
• Oleic Acid (5%, 2.5mL) – Softens skin barrier, increases steroid absorption into the bloodstream.
• D-Limonene (Optional for extra penetration boost) (5%, 2.5mL) – Natural terpene that enhances drug diffusion through the skin.

Formula 2: Ultra-Slow Absorption with Max Penetration (Longest Release)

• Absorption Speed: Slow (12-24 hours release)
• Penetration Depth: Very High

Ingredients (50mL Batch)

• Dimethyl Isosorbide (DMI) (35%, 17.5mL) – Slows absorption, ensures deep penetration.
• Methyl Laurate (30%, 15mL) – Highly lipophilic carrier for long-lasting absorption.
• Squalane (20%, 10mL) – Extends absorption duration, prevents skin irritation.
• Oleic Acid (10%, 5mL) – Opens up skin for better steroid absorption.
• D-Limonene (5%, 2.5mL) – Boosts penetration into the bloodstream.

Formula 3: Balanced Medium Absorption with High Efficiency

• Absorption Speed: Medium (4-8 hours release)
• Penetration Depth: High

Ingredients (50mL Batch)

• Propylene Glycol (30%, 15mL) – Dissolves steroids well, enhances penetration.
• Isopropyl Myristate (IPM) (30%, 15mL) – Keeps formula lightweight, prevents stickiness.
• Squalane (20%, 10mL) – Slows absorption, extends release time.
• Oleic Acid (10%, 5mL) – Improves steroid solubility & absorption.
• D-Limonene (10%, 5mL) – Provides a terpene boost for enhanced penetration.

@Regina Taking Vitamin E is also super important during DNP usage. To protect from the added FFA

@wester130 grow bigger while losing fat. It's working.i feel like my bones are growing

@Kilgore anti E

@yeyo12 there was a post on old rpf about how using honey removes the smell. If you want a DMSO formula Id use 70 DMSO : 20 Vit E : 10 honey

@yeyo12 using those ingredients I would do

20% IPM
50% alcohol
30% Vitamin E

Are you opposed to DMSO?

I have created a solution of

25mg Tren
25mg Test
5mg Progesterone
5mg DHEA
5mg Exemestane

Per ml

I used DMSO & Coconut Oil in about a 90:10 ratio. This is mostly to stop the stinging/skin irritation from pure DMSO. They don't mix great so you need to shake before use. I would have preferred to use Vitamin E if I had on hand.

It is working great so far. Definitely a lot stronger than my higher T experiments in the past.

I have noticed zero sides from the Tren.

It has been about 4 weeks

I'll add some KB exercises like
KB Halos
Kettlebell Sots Press
Kettlebell Bottoms-Up Press
Kettlebell Windmill
Kettlebell Figure 8
Kettlebell Turkish Get-Up (TGU)
Kettlebell Dead Stop Clean
Kettlebell Curtsy Lunge with Press
Kettlebell Tactical Lunge
Kettlebell Half Snatch
Kettlebell Suitcase Carry
Kettlebell Russian Twist
Kettlebell Rotational Swing
Kettlebell Side Lunge with Rotation
Kettlebell Around the Body Pass
Kettlebell Woodchopper