Posts made by Mauritio

high protein = high mtor activation
high mtor=high aging

@Gaston Not really. I suspect that they might be responsible for my crazY hormone test results. But thats a wild Speculation. I take theh about 1/Week still.

Interesting.About 350 000 children become blind each year because of Vitamin A deficiency, and about half of them die within the next Year. I wonder if the immun deficiency associtated with Vit.-A-deficiency has something to do with it.
Even just a mild Vit.-A deficiency increases mortality in children.

"Mild vitamin A deficiency was directly associated with at least 16% of all deaths in children aged from 1 to 6 years"
https://www.sciencedirect.com/science/article/abs/pii/S0140673683906773

@Ecstatic_Hamster Im not sure about this one.. Here are 2 studies showing no or very little correlation to cancer. And even if they did, correlation ≠ causation. Sarcosine might be an endogenous anti-tumour factor and that could be the reason it' s high.it reduces methionine levels and strongly increases glycine's effects, both causes an anti-tumour effect. And i'm not sure these effects are taken into acc­ount in the in-vitro studies.

"Median sarcosine content in tissue was about 7% higher in matched malignant vs nonmalignant samples, which was significantly. Sarcosine values were not associated with tumor stage (pT2 vs pT3), tumor grade (Gleason score less than 7 vs 7 or greater) or biochemical recurrence. The lack of metastatic tissue samples was a study limitation."
https://pubmed.ncbi.nlm.nih.gov/21168877/

Serum sarcosine is not a marker for prostate cancer
pubmed.ncbi.nlm.nih.gov/20233752/

Here's a good explanation:
https://www.nature.com/articles/nrurol.2011.33

@haidut Wow.

Here are a few resources for further reading on uncoupling

"When mitochondria are “uncoupled,” they produce more carbon dioxide than normal, and the mitochondria produce fewer free radicals. Animals with uncoupled mitochondria live longer than animals with the ordinary, more efficient mitochondria, that produce more reactive oxidative fragments. One effect of the high rate of oxidation of the uncoupled mitochondria is that they can eliminate polyunsatured fatty acids that might otherwise be integrated into tissue structures, or function as inappropriate regulatory signals."
Ray Peat

https://lowtoxinforum.com/threads/vos-uncoupling-thread.5037/

https://lowtoxinforum.com/threads/uncoupling-increases-life-span-and-generates-more-mitochondria.29283/

https://lowtoxinforum.com/threads/uncoupling-increases-t3.40540/

https://lowtoxinforum.com/threads/uncoupling-metabolism-oxphos-may-treat-inflammatory-conditions.43555/

@war4512 said in Niclosamide reduces serotonin and glutamate:

Well, if you've noticed that your muscles are fuller, it’s probably because you are compensatorily consuming large amounts of glucose.

As i said susected its probably from higher glycogen synthesis, which was almost twice as high.

"Moreover, the NEN-treated mice exhibited higher glycogen synthesis rates (Table 1), which were further confirmed by a direct measurement of glycogen synthesis showing higher rates in both liver and muscle (data not shown)."
https://pmc.ncbi.nlm.nih.gov/articles/PMC4299950/

Another helpful supplement might be sarcosine. MR could lower its levels to begin with but on top of that it might be helpful to supplement it since it lowers methionine levels and shows some of the benefits of dietary restriction

"We also show that sarcosine feeding reduces Met levels in old animals and is a strong activator of macroautophagy in vitro and in vivo. Taken together, these data identify sarcosine as a potentially important biomarker of diet and aging in mammals and suggest that this metabolite plays a previously unappreciated role in mediating at least some of the beneficial effects attributed to DR on proteostasis."

https://lowtoxinforum.com/threads/sarcosine-is-uniquely-modulated-by-aging-and-dietary-restriction-in-rodents-and-humans.27355/#post-412356

@LucH said in Does brain shrinkage lead to dementia?:

@Mauritio said in Does brain shrinkage lead to dementia?:

But that doesn't really answer the issue I brought up...

We need tryptophan to form B3 when lacking.
Once again, it's a question of proportions. Why?
Note: Tryptophan has limited access to the brain, sometimes leading to migraines. See details below.

No need to use B3 for lowering Homocysteine if we bring enough B6. But B6 is exhausted if we suffer from low inflammation grade (like arthrosis). See the brol! (local expression inducing havoc).
Note: Homocysteine levels go up as methyl donors get used up. Idem when following HD B3.
=> 500 mg TMG 2x/d when required.

Additional info:
Tryptophan
Tryptophan has limited access to the brain, thus sometimes the cause leading to migraines.
Tryptophan must share the transport to brain with five other amino acids: tyrosine, phenylalanine, valine, leucine and isoleucine. So, for example, an excess or deficiency of tyrosine will inhibit the passage of tryptophan.

See too:
https://raypeat.com/articles/articles/gelatin.shtml
Both tryptophan and cysteine inhibit thyroid function and mitochondrial energy production, and have other effects that decrease the ability to withstand stress. Tryptophan is the precursor to serotonin, which causes inflammation, immunodepression, and generally the same changes seen in aging. Histidine is another amino acid precursor to a mediator of inflammation, histamine; would the restriction of histidine in the diet have a longevity promoting effect, too?

That answers my question even less lol ... I give up .

@war4512 said in Niclosamide reduces serotonin and glutamate:

@war4512 I’ll read more about niclosamide today because it seems to me that a single study is not necessarily conclusive on this matter. Especially since it was a study conducted on carp.

Agreed.
Of course there is glycogen depletion at first when you increase your metabolism. But if that was the cause the weight loss would have shown the next day and not the day after that . Plus glycogen is quickly refilled when having meals.

The opposite of what you said concerning glycogen might even be what's happening.
Subjectively I notice that I can go alittle longer between meals and my muscles look fulller.

The paragraph you quoted merely describes how niclosamide kills parasites.
Yes that happens through uncoupling, and yes if we uncoupled our metabolism too much we would die too (ever heard of DNP?) .
That does not make physhological ucoupling unhealthy . the lowering of ATP is made up for by increases in temperature and metabolism and reduction in oxidative stress.

I suggest you read about the basics and benefits of uncoupling and their effects on humans. Georgi has a lot of good content on that.

@DavidPS I know. But that doesn't really answer the issue I brought up...

They're catching up! They're using A combo of niclosamide and acetazolamide to treat cancer.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10214212/

I might have to change my opinion on Niclosamide. Today I woke up weighing 850g less! So not only did it not lead to weight gain when binging the same day, butit lead to drastic weight loss the next day.
The effects seemed to last quite long. As I felt warmer the day after and as I said sleep was great as well.
It seems to good for liver fuction. So maybe I'll do small (~ 25mg), infrequent doses for liver health regularly.

"SAH supplementation reduces Met levels and recapitulates many physiological and molecular effects of MetR."
https://pubmed.ncbi.nlm.nih.gov/35388610/

@DavidPS said in Does brain shrinkage lead to dementia?:

One strategy for slowing loss of brain structure is to reduce your homocysteine

What I dont understand is how. methionine restriction can be so healthy (also for the brain). when it causes hyperhomocysteinemia....

@war4512 said in Niclosamide reduces serotonin and glutamate:

@Mauritio said in Niclosamide reduces serotonin and glutamate:

Took 50mg niclosamide today . Resulted on strong fatigue and low energy. Hypoglycemia and hunger increase as well.
Probably better in the evening.

Do you take thiamine? I recommend taking it, as niclosamide can uniquely activate AMPK and disrupt the proton gradient. Higher glucose intake will likely have a compensatory effect, but it does not guarantee that the redox balance will return to normal levels.

I only take whatever is in a few drops ofEnergin.

l noticed thatmy Buteyko Pause increased significantly,meaning I could hold my breath longer. It seems to incre­aseCO2 not sure if via uncoupling or another mechanism. I suspect it might be a carbonic anhydrase inhibitor similarly to acetozolamide and Aspirin.next time ill probably try a snaller dose to avoid hypoglycemia.

Nobiletin for fatty liver:

1. Helps with fatty liver and fibrosis via increasing adiponectin and SOD while lowering MDA
   https://pubmed.ncbi.nlm.nih.gov/38073108/

2. Helps via modulating Nrf2
   https://pubmed.ncbi.nlm.nih.gov/38073108/

3. Helps via altering the gut microbiome
   https://pubmed.ncbi.nlm.nih.gov/37139957/

4. Helps via lowering oxidative stress and lipid peroxidation and increasing ATP.
   https://pubmed.ncbi.nlm.nih.gov/34695558/

5. Helps via increasing cholesterol to bile acids conversion ( increasing CYP7A1, and CYP27A1), increasing SCD1 and LXRa and lowering FAS.
   So should be good for people with high cholesterol ,low bile production/flow.

https://pubmed.ncbi.nlm.nih.gov/36985541/

Took 50mg niclosamide today . Resulted in strong fatigue and low energy. Hypoglycemia and hunger increases as well.
Probably better to take in the evening.

Edit: i ate an insane amount of food yesterday and still woke up weighing exactly the same as the day before .
I also slept very well and feel refreshed. Maybe taking it in the last part of the day is more sustainable. The malaise I felt yesterday might also be some sort of microbial die off.

"Nobiletin and tangeretin potently inhibited scratching behavior, as well as histamine-induced vascular permeability."

https://pubmed.ncbi.nlm.nih.gov/23938254/

@cs3000 ok thanks !