Posts made by Mauritio

@cs3000

@cs3000 said in After diet, exercise and sleep, using a sauna may be of the best things for health:

which fits with the anti metabolic things activating them mentions of estrogen nitric oxide,

Yes and the pro-metabolic things lowering them: progesterone, tetracyclines, selenium, methylene blue, ...

@cs3000 said in After diet, exercise and sleep, using a sauna may be of the best things for health:

here effects of heating mice + 2 degrees core temp on mitochondria complex activities in muscle , nice improvements regardless of stress hormones & hsp rising

Yes I suspect that as well. As I posted the effect on HSP is not large and fairly transient, which I'm not sure about for the mitochondrial effects. So maybe the ETC and metabolism in general benefits for a longer time.

@cs3000 said in After diet, exercise and sleep, using a sauna may be of the best things for health:

Elevating core temp to 39 (through exercise but designed in a way to not cause muscle damage), weirdly the HSP got peak elevation by 2 days after and sustained similar levels for a week

Wow that's weird.
I suspect HSP would not be elevated as long when the body temp is increased to that level via passive heating.
Ray said years ago that most of exercises benefits stem from the increase in temperature and you could get that from a warm bath. And looks like he was right.

@SpicyPeater said in screenshot of T3 Uncoupled post RE Coffee testosterone:

https://u.pcloud.link/publink/show?code=XZMyuc0ZdjYs4iDfpEBp7h6mvqwkxRQzJHKX

Reductionist BS...aka Twitter.

Very interesting human study on the effect of 60min. exercise (EX) vs. 60min hot bath at 40°C (PH).

Both were comparable in terms of elevating HSP70, but the elevation wasn't drastic and returned to baseline in about 2h.
The pro-inflammatory cytokine IL6 was elevated a lot more from exercise than the hot bath. So overall a hot bath seems to be safer than I thought and safer than exercise.

Interestingly just sitting in a hot bath for an hour increased their resting energy expenditure by 79%! That's what they found.

What makes the bath so good for tumors is the increase in temperature.
Both methods were comparable at raising core temperature.
But the bath was a lot better at increasing skin and muscle temperature compared to exericse!
https://pmc.ncbi.nlm.nih.gov/articles/PMC5605168/
@cs3000 @DavidPS

@James the ones on 5aDHP and its effect on cancer.

I foud Rays newsletter mentioning HSPs. It's called:

"Cumulative damage,
degeneration, & aging possibilities of reversal"

Here's a few relevant quotes:

"...it occurred to me that it
would be good to consider what happens when the body temperature is increased by external heat, beyond the level at which the organism functions optimally. "

"Partly, I’m thinking about the damage
that can be done by the increasing popularity of sauna treatments, and various kinds of “hyperthermic therapy for cancer,”

"Independently, estrogen and nitric oxide are
known to promote fibrosis and cancer, and now the basic role of HSP in fibrosis (Bonniaud, et al.,2017) and cancer is being recognized, and the drug companies are creating a variety of HSP inhibitors."

This quote I included because it's almost poetic and beautiful.

"...time is very relevant to the
organism—its present structure and properties reflect its previous states, and project its future tendencies and possibilities, its trajectory in life."

Now this is the most relevant point, which the studies you posted corroborated so beautifully:

"At bedtime, a mild warm bath can compensate for low internal heat production, increasing the metabolic rate and helping to increase glycogen stores and increase progesterone level, making
deep restorative sleep possible. But if the bath is too warm or too prolonged, or if estrogen’s influence is too great, the increased metabolic rate can
Intensify the inefficient metabolism further depleting energy stores, and leading to higher stress hormones. Having extra carbohydrate before and during the warm bath improves its therapeutic function, and decreases the risk of heat shock."

@Mauritio said in Studies showing cancer reversal / shrinking:

@cs3000 said in 2 studies showing cancer reversal / shrinking:

@cs3000 said in 2 studies showing cancer reversal / shrinking:

@Mauritio yep and i imagine daily would be even better, interesting that short duration was effective it does work broadly yeah
here it had less profound effect in a connective tissue cancer but still good
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499556/#s2title they did 10 minutes instead of 20 minutes .
I just saw something amazing actually when they tested it on breast cancer in vivo it almost didnt grow at all :

Here we go, big one
https://www.spandidos-publications.com/10.3892/or.2017.5591
great studies by these people exploring all the angles

Surprisingly going for more days of co2 weekly didnt give better effect, 2 days is enough,
but going for longer than 10 minutes does give more improvement (20 minutes worked better) in breast & bone cancer, effect peaks around there as 1 hr did not give better effect

• Additionally, in a preliminary study, no further decrease in tumor volume was observed with the 1-h treatment compared to the 20-min treatment
• For the CO2 therapy, there was no difference in effectiveness of frequencies of twice and five times per week; in addition, a twice-weekly treatment regimen was sufficient to inhibit in vivo tumor growth, even in MFH/UPS, which is a high-grade sarcoma cell line.

And they found the cancer regressed below baseline with 20 minutes applications, in all of the mice

And they even said two of the breast cancer tumors disappeared @haidut

Bone tumors also got smaller below baseline
.... this is happening fast over a few days / weeks ... amazing

it did not work as well on a rarer aggressive sarcoma tumor. but slowed growth with this (which the table doesnt show)

• in addition, a twice-weekly treatment regimen was sufficient to inhibit in vivo tumor growth, even in MFH/UPS, which is a high-grade sarcoma cell line.

• In the current study, the most significant antitumor effect was observed in the MDA-MB-231 breast cancer model. At the end of treatment, all treated tumors in the MDA-MB-231 model were smaller than pre-treated tumors, and notably, two of the six tumors in the 20-min group had disappeared

Additionally, using a treatment frequency of twice per week, tumor volumes were smaller with a treatment interval of 3 and 4 days than with a treatment interval of 2 and 5 days.
We also found that transcutaneous CO2 application was ineffective when applied at a distant site relative to the tumor location. Therefore, the CO2 therapy should be applied to the body surface close to the tumor location.
We previously developed an alternative system for CO2 application that can access deep-seated tumors using intra-arterial infusion of saturated CO2 solution (20). These findings suggest that continuous treatment, twice per week with an interval of 3 + 4 days, applied to the local site of the tumor, provides the best antitumor effect for transcutaneous CO2 application.

So 20 minutes, enhanced by a co2 capturing gel locally to the tumor site, 2 times per week, every wednesday and sunday (3 & then 4 days), gives max effectiveness

sounds like simple glycerol/glycerin + water could work for the gel,
or sodium alginate
(majority water as long as its thick enough to not run down skin)
https://patents.google.com/patent/JPWO2004002393A1/en?oq=WO2004%2F002393

• A viscous liquid prepared using 2 parts by weight of sodium alginate as a thickener and 98 parts by weight of purified water as water is impregnated into a 4 cm diameter polyester nonwoven fabric, and this is immersed in a 1% calcium chloride aqueous solution to support the nonwoven fabric. A hydrogel film of calcium alginate as a body was prepared, and this was adopted as a carbon dioxide absorption aid 4

• An appropriate amount of the carbon dioxide absorption assisting material 4 is applied to a 5 mm diameter scratch on the left back of a 37-year-old woman, a left hand is put in the sealed envelope 2, and carbon dioxide is supplied to the sealed envelope 2 by the carbon dioxide supply device 3 to 10 seconds at a rate of 200 milliliters / second, and then 5 minutes at a rate of 20 milliliters / second. When the auxiliary material was washed away, the pain felt before touching the water completely disappeared, and the wound healing promoting effect was confirmed.

• A 48-year-old man's 5cm square carbon dioxide absorption aid 4 is affixed to the left back of the 48-year-old man, and without putting anything on the right back, each hand is put in the two sealed enclosures 2a and 2b, and each enclosed enclosure Carbon dioxide was first supplied to the material 2 from the carbon dioxide supply device 3 at a rate of 200 milliliters / second for 10 seconds and then at a rate of 20 milliliters / second for 7 minutes.
  The man's hands quickly became warm, but the left back felt warmer than the right back.

Gel + ~ 7 Liters of co2 gas sealed in a 20cm long plastic bag was enough for pain reduction and wound healing effect in this woman

I am going through the studies that this Takeshi guy did and there's some interesting ones. Not sure if that one has been shared.

CO2 therapy was just as effective as radiation therapy for this oral squamous cell carcinoma.
But CO2 and radiation combined was a lot more effective. And I suppose CO2 made the radiation a lot safer, as can be seen by the rescued white blood cell count.

https://www.spandidos-publications.com/or/40/1/434

Very interesting! RP right again.

So tumor prevention/treatment can be as simple as taking a hot bath and a CO2 bath once or twice a week.

I'm wondering where do heat shock proteins come into play here? They must be raised significantly...

I couldn't find peats newsletter on HSPs but here's the one on body temperature:
https://wiki.chadnet.org/body-temperature-inflammation-and-aging.pdf

Only tried it once.
It feels pretty strongly anti-cortisol.
Also the next day my libido was a little higher and my muscles looked pretty full.

Thats all , I'm trying Melanon and lanosterol now so might be some time until I get back to 3aDHP.

I second the caution against cysteine supplementation .

There was a study that showed the same life extension from just using glycine. HED was 50g. So cysteine is not necessary.

If you want to increase glutathione you could simply take ergothioneine which increase it drastically and also increase life span by about 25%.

If you want to increase antioxidants generally, you could take selenium or selegiline which have strong anti-oxidant capacity. Selegiline also increases life span by about 25% .

And remember adding just 0.2% cysteine to the diet, abolishes the benefits of methionine restriction. So it is by no means harmless. Especially since methionine can be converted to cysteine so it's almost impossible to be deficient in it.

@wester130 well Ray wasn't fond of pituitary hormones so there's that

And androgens like DHT would also suppress them so I wouldn't say that's necessarily a bad thing.
Interestingly it only suppresses FSH and not LH.

@bio3nergetic yeah he wasn't the biggest fan of 5aDHP either. Which is understandable if you see the cancer studies. And Ray was pretty cautious when it comes to supplements in general.

There's very little studies on this metabolite ...

@wester130 like the sweet spot between dopamine and GABA with a little bit of progesterone in it.
I did not get those effects from allopreg.

Synchronicity strikes again!
I was thinking about messaging you to ask if you can bring back 5aDHP because I like it so much.
But 3aDHP seems close enough to try.

Does it have the some anti-prolactin effect as 5aDHP?

Welches Waschmittel verwendet ihr alle ?

Rapamycin might help schizophrenia by lowering mTOR.

Schizophrenics have increased 5ht6 activation which in turn activates mTOR.

"Further, 5-HT(6) receptor activation increased mTOR signalling in rodent prefrontal cortex (PFC). Linking this signalling event to cognitive impairment, the mTOR inhibitor rapamycin prevented deficits in social cognition and novel object discrimination induced by 5-HT(6) agonists. In two developmental models of schizophrenia, specifically neonatal phencyclidine treatment and post-weaning isolation rearing, the activity of mTOR was enhanced in the PFC, and rapamycin, like 5-HT(6) antagonists, reversed these cognitive deficits. These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control."
https://pubmed.ncbi.nlm.nih.gov/23027611/

Rapamycin increases klotho.

It is even more Peaty than I thought because it lowers phosphate. And phosphate activates mTOR. Rapamycin lowers phosphate and mTOR, decreasing calcification.

"Zhao et al. report that phosphate activates the mammalian target of rapamycin (mTOR) cascade in VSMCs, leading to downregulation of Klotho. Furthermore, rapamycin was shown to halt medial calcification. This effect was blunted in the absence of Klotho. Given the concomitant anti-atherosclerotic effects of the mTOR inhibitor, this agent has clinical potential as an inhibitor of intimal atherosclerosis and medial calcification."
https://pubmed.ncbi.nlm.nih.gov/26422620/

Here, it also increases klotho in aging mice. And it caused a huge increase in survival.

"All mice administered rapamycin survived the 12-week course, whereas 43% of the controls died."
https://pubmed.ncbi.nlm.nih.gov/37190667/

It decreased phosphate in humans.

"In the rapamycin group, serum phosphate was lower than in the CNI group with an increase in phosphate excretion and a reduction in its reabsorption."

@LetTheRedeemed Theres something weirdly Anti-Life (vita= life) almost satanic about their nedd to ascribe something toxic to every vitamin.

Day 8:
Last days felt hypothyroid, gained water weight.
Had rapamycin yesterday and today lost water weight. Weigh 650g less than yesterday morning, although I ate more than the days before.
Took rapamycin before work... Not a good idea. Was stressed and tired. Will return to after work.

I suspect that there might be a rebound mTOR effect after a few days of no rapa, hence the hypothyroid symptoms .

Or Maybe that's the "physiological insulin resistance" that is transient and materializes itself at the beginning of rapamycin treatment.
IIRC rapamycin caused water retention for tarmander as well but it went away.

Other than that my energy might be slightly higher but not sure yet.

@Mauritio said in Vitamin A and D deficiency increases liver cancer:

So for anyone thinking vitamin A and D are poisons maybe ingest some Vitamin E at least. Unless that has reached poison status as well. I'm not up to date .

It has happened . You can't make this stuff up.
https://raypeatforum.com/community/threads/love-your-liver-livestream-161-toxic-vitamin-e-testimonials.53292/

"It seems that an "empty/unbound androgen receptor" is the worst thing as far as glucocorticoid signalling - and that even androgen antagonists interacting with the androgen receptor can reduce that glucocorticoid signalling."
https://raypeatforum.com/community/threads/panquinone-liquid-triquinoyl-quinone-mix-for-lab-r-d.11566/page-8#post-292585