@war4512 https://www.youtube.com/watch?v=rKr9gjTgCbc&ab_channel=IvanCarsten-Topic

One of the most dopaminergic songs in history.

@Insomniac said in Tracking down the mysterious cause of Dr. Paul Saladino's shockingly rapid aging:

Not a single forehead wrinkle

What implies the lack of wrinkles in Haidut is low inflammation combined with a high level of subcutaneous fat. The fat fills the voids caused by aging. In thin individuals, age-related wrinkles tend to be excessively pronounced.

@Insomniac said in Tracking down the mysterious cause of Dr. Paul Saladino's shockingly rapid aging:

too much sugar

There is no evidence whatsoever to suggest that sugar (sucrose) or other carbohydrates cause accelerated aging.

@Insomniac High protein diet.

@zaaku said in How did you treat your NAFLD and how long did it take?:

Is this recommendation from personal experimentation or from a study? If it's from a study, could you please share it? I couldn't find it.

https://chrismasterjohnphd.substack.com/p/does-choline-deficiency-contribute

@zaaku said in How did you treat your NAFLD and how long did it take?:

In my understanding from reading Peat's work and some papers T3 is helpful in energizing the liver. Did you mean T4?

Reply

At low glucose levels, T3 shifts its metabolic effects, promoting catabolic processes. T3 increases glucose utilization, which can result in chronically low glucose levels, leading to the suppression of glycogen synthase expression.

Low glucose levels, in turn, lead to elevated glucagon levels.

Low blood glucose is a precursor to a stress response, further amplified by neurotransmitters and stress hormones.

Compensatory intake of more carbohydrates throughout the day can be highly beneficial, provided that the root cause of all problems is not excessive neurochemical signaling; treating this process will require time.

@the-MOUSE It depends on the case. In general, it's better not to consume more than 5g of PUFAs per day. If someone were to follow the proposed paradigm while supplementing with algal oil, I don't see a problem. DHA and EPA are better than linoleic acid and gamma-linolenic acid, not to mention osbond or arachidonic acid, because they are precursors to less harmful eicosanoids. DHA and EPA supplementation can be useful, but it really depends on the individual case. I believe that milk fat from grass-fed cows can provide the necessary amounts of DHA through alpha-linolenic acid.

@zaaku said in How did you treat your NAFLD and how long did it take?:

Triglycerides: 48mg/dL
Cholesterol, Total: 184mg/dL
Cholesterol, HDL: 68mg/dL
Cholesterol, LDL: 107mg/dL
TSH: 0.05µIU/mL (Used to be 2.3 before thyroid supp)
ALT: 27U/L
AST: 34U/L
GGT: 52U/L
Albumin: 5.06g/dL

Well, it’s likely that your NAFLD is already in an early stage. Continue with a high-carbohydrate diet—your very good triglyceride levels suggest a state of carbosis (preferential and highly efficient carbohydrate metabolism). The area for improvement is definitely excess weight, which you can reduce with an appropriate calorie deficit, leading to a genuine regression of NAFLD.

@zaaku said in How did you treat your NAFLD and how long did it take?:

Overall I feel significantly better than I used to and I think treating liver + glycogen storage is the final step for me. Sleep is deep and sound, though I wake up once in the middle to replenish sugar. Digestion is smooth with 1 BM per day (sometimes 2). I'm calm and patient and at peace pretty much all the time though I avoid excursions or putting myself in challenging situations because I know I become hypoglycemic. Even the daily walk with my dog leads to a little hypoglycemia midway through so sometimes I want to, sadly, cut it short.

Hypoglycemia, simply put, is a stress response. If possible, perform an OGTT (Oral Glucose Tolerance Test) and consider testing C-peptide levels to assess insulin secretion. To improve glycogen storage, you can supplement with creatine and more carefully control selenium intake by increasing the amount of seafood in your diet, especially those rich in copper.

During a walk or any other physical activity, try to consume easily digestible carbohydrates to prevent a stress response.

I also recommend Masterjohn's article. A very valuable tip.

https://chrismasterjohnphd.substack.com/p/start-here-for-fatty-liver-disease-0a3

@the_black_jew You are obsessed with me.

Ingredients (for about 6 pancakes):

• 1 cup chestnut flour (approx. 120g)
• 15g dark cocoa powder
• 1 egg
• 1 cup skimmed milk
• 30g honey
• A pinch of salt to taste (I use potassium salt, 70/30%)
• 1 teaspoon coconut oil for frying

Preparation:

Sift the chestnut flour and salt into a bowl. Gradually pour in the milk, whisking the batter continuously.
Add the egg, cocoa powder, and honey, mixing until fully combined. The batter should be relatively thick.
Heat a frying pan and grease it lightly with coconut oil. Use a ladle to pour the batter onto the pan, spreading it into a pancake.
Cook the pancakes for a short time, about 1–2 minutes on medium-high heat, until set.

Serve with traditional Italian-style date-coffee spread:

• 6 fresh Medjool dates (about 150g, pitted)
• If using dried dates, soak them in warm water for 10–15 minutes to soften.
• 1 shot of espresso (approx. 40 ml)
• 1/2 americano (approx. 75 ml) – made with espresso + 35 ml water

Preparation:

Let the brewed coffee cool slightly.
Place the dates in a blender, pour in the coffee, and blend into a smooth paste.
Serve the pancakes with the date-coffee spread.
Optional Beverage:
Accompany the meal with coffee mixed with 20g of gelatin.

Nutritional Values:

If the recipe yields approximately 6 pancakes, the nutritional values per pancake are:

• Energy: ~137.5 kcal
• Protein: ~4.3 g
• Fat: ~2.6 g
• Carbohydrates: ~23.6 g

Adding 40g of date spread per serving contributes:

• Energy: ~112 kcal
• Protein: ~0.9 g
• Fat: ~0 g
• Carbohydrates: ~29 g

Overall Nutrition Cronometer Profile for the Meal:

@gg12 said in "Orthorexic Sequence" – My Personal Experience with OCD:

I suffer with OCD as well. I know part of it is physiological but part of it seems to fall in m own hands with how I react to my thoughts. I have let my OCD grow in the unconscious for far too long and have had manic states lately. I am surrounded b people in poor health. My family just follows the massmedias agenda eating PUFA getting shots etc. I try to stay healthy but the food supply is so poor and my obsessive thinking doesnt help. I have heard of somatic illiness and I wonder if thats what OCD does sometimes. I do worry my OCD is a sign of a serious endocrine problem but I also know OCD loves to try and look for ways to protect you.

Yes, stress reactions driven by obsessive behavior or thoughts, combined with compulsions, are standard symptomatic manifestations in OCD. Have you perhaps tried cyproheptadine? It is incredibly effective for cortisol-related symptoms, as excessive muscarinic signaling can cause insensitivity to CRH, leading to high levels of CRH, which in turn results in elevated ACTH and cortisol levels. Excessive glutaminergic signaling is also noteworthy, as it is excitotoxic and exacerbates OCD symptoms. Serotonin is particularly relevant in the case of OCD.

Generally, what I can recommend for OCD includes anticholinergic and antiserotonergic medications, along with an appropriate diet low in tryptophan, oleic acid, and PUFA. Ensure adequate intake of proline and glycine, proper supplementation with vitamin D3, and consider exploring GABAergic substances, which exert a neurochemical effect opposite to that of glutamate, inhibiting nervous system activity and thereby reducing symptoms. Magnesium and zinc also have invaluable effects.

I have also heard about microdosing ketamine, which inhibits the activity of the glutaminergic system. Personally, I have used cyproheptadine, which alleviated my symptoms, although it did not alter orthorexic behaviors, which I view as positive. I do not believe it is rational to label justified, even if excessive, health-conscious behavior as pathological—unless it becomes a source of stress or results in malnutrition, which is rare.