Wikipedia says milk is up to 3% trans fats. Where's that 2% figure from? I'm skeptical about the fat metabolism in general. It's unclear if harmful fats are excreted or metabolized.

@Gaston 😞

@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:

anybody tried sodium selenite and selenomethionine and can compare them ?

*) Forms of sélénium
The forms of selenium exist in 3 major forms:

Yeast Sodium (selenite or selenate) Amine acid (Selenio-Methionine or Cysteine).
Selenate or seleno-methionine (SM) are generally found on the market. Specialists classify the Se in two main categories: organic and inorganic. The inorganic salts would be supposed to be less well absorbed by the tissues. If we only refer to SM and Selenate, this is not really true, as several studies have shown it. (4)
*) Biodisponibility
The degree of absorption of selenite is less, but sufficient, of the order of +/ 50 to 60 % against 75 % for selenomethionine. (2)
What form is the best?
Selenium in any form whatsoever, that it comes from food or supplements, organic or inorganic, is used by the body for the synthesis of selenoproteins after being first metabolized in hydrogen selene, selenium cellular storage. The surplus of selenium is converted into methylated metabolites and excreted by urine and breath. Excessive accumulation of hydrogen selenial can cause its oxidation, resulting in the production of reactive oxygen species (ROS) resulting in oxidative toxic effects in the body. (o)
All forms of selenium are well absorbed, but the absorption of selenomethionine is the best. They use the same active transport mechanism as for methionine, one of the 9 essential amino acids which can only be obtained by food, which increases the effectiveness of absorption of selenomethionine compared to the inorganic forms of the selenium.
*) Recommended Daily Supply
Currently recommended nutritional supply (RDA) in adults is 55 micrograms/day. Daily needs are 55 mcg (AJR). 1 mcg /kg of weight is optimal. Diet (1) provides around 50 % of needs if you eat meat or legumes. A single nut from Brazil / Amazon covers needs (…). In the event of pathology / detox, 200 - 300 mcg can be prescribed punctually. “Too Much of A Good Thing is Bad!”
=> Selenium supplementation should not be taken every day (half-life). Except in particular cases, in the event of a detox for example, therefore punctually (2 to 300 mcg per day, in detox cure). But in this case, a contribution of curcumin would be desirable to reduce hepatic toxicity due to the impact on dehydrogenase enzymes. Taking different forms of selenium is interesting, especially in the event of cancer prevention (recurrence). If you exceed +/ 100 mcg/ L in the blood serum, you impact the operation of certain dehydrogenase enzymes, especially required in the Krebs cycle.
*) More details on this post, with sources and references.
Selenium: Too much of a good thing is bad. Forms and enzymes
https://mirzoune-ciboulette.forumactif.org/t1953-selenium-too-much-of-a-good-thing-is-bad#27971 (in French ) translator needed but with references from studies in English)

Sources et Références
0) Toxicité hépatique due à l’impact sur les enzymes déshydrogénases
Rôle protecteur de la curcumine
Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. 2005
PMID: 15881869
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly.
2) http://www.hc-sc.gc.ca/ewh-semt/pubs/water-eau/selenium/index-fra.php
Avec références d'études.

@LucH ok gotcha

5 Supplements To Inhibit IL-11 (animal studies)
https://www.youtube.com/watch?v=nYbJj3uRn1I

One of the comments on YouTube:

Thx Richard for this interesting presentation.Actually it's not necessarily the curcumin but the other ingredients in turmeric that are responsible for the inhibition of IL-11.
So the whole food is always more potent than any supplement. By the way piperlongumine also inhibits IL-11. I take them every day in my coffee and in meals combined with olive oil ,black pepper and ginger.

@cs3000 said in Microplastics – known endocrine disruptors- found in blood, gonadal organs:

@Mauritio pectin interaction
https://phys.org/news/2022-06-interaction-nanoplastics-pectin-water-soluble-polysaccharide.html
https://www.sciencedirect.com/science/article/abs/pii/S2213343722009277

https://www.tandfonline.com/doi/full/10.1080/10643389.2023.2195798#d1e1308
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312509/

Thanks that's awesome.

Apples for the win (again).
And the amount was pretty small as well at 15mg/L .

"...ingested MPs can pass through the gut barrier, be translocated through the systemic circulation, and accumulate in distant tissues including the brain, liver, and kidney."
That's pretty concerning though. And I don't know if pectin would help with micro plastics once it has accumulated, since pectin doesn't absorb and should only take care of the MP that is present in the stomach or gut as long is it's present.

Maybe modified citrus pectin (MCP) would be a better option in that case because it actually does absorb.

Makes sense when B1 is needed for mitochondrial respiration, but not the only one needed.

@haidut 👍 😊 👏 thank you

Just my simplified take on arthritis, as more and more I am swayed to think that there is only arthritis, and that arthritis is caused by low metabolism, and very much so because CO2 deficiency from low mitochondrial metabolism makes the ecf acidic, enough so that some salts, urate salts being one, precipitate, and cause the formation of crystals that cause wear and tear on our joints.

I profess ignorance though, on the matter of the different forms of arthritis, as when I attempt to understand the different forms of arthritis, the explanations given in the literature always lead to draw blanks, which makes me either an embecile thet fails to comprehend or simply that the literature is just playing on words and terms that give different names to a banana. The added complexity is a ploy to distract from the one true cause of arthritis, if I may dare say so.

Which is why Ray points to hypothyroid as the cause of arthritis, which I first thought of as a rather simplistic explanation. But if I can relate to cause and effect, and dig deeper into it, it is not as complicated as it appears to be.

The key is acid base balance. As simple as that. When we have an abundance of CO2 because our body makes a lot of it at our disposal, we have the best pH buffer available for our lungs and kidneys to manage acid base balance. When alkaline, it can turn into an acid called carbonic acid, and when acidic, CO2 can turn into bicarbonate. This is based on Le Chatelier's principle, where the direction of a reaction is in the direction of the stress that it relieves.

What better way to provide a surfeit of CO2 in our body than to be producing energy using mitochondrial oxidation. Vitamin B1 is a crucial link in a chain of nutrients and substances and processes that enable mitochondrial oxidation. Simply being deficient in one link makes rhe chain broken, and a broken chain only leads to low metabolism, and the resulting imbalance in pH, usually acidic, will just cause the formation of salt crystals that irritate and inflame and destroy tissues.

I know enough how to monitor my acid base balance, so I know what remedial actions to take to keep my acid base balance from being chronically in an imbalanced state. Many bad things happen in a chronic state of acid base imbalance.

I have high uric acid, yet I don't have any arthritis, much less gout. Only because my optimal acid base balance keeps uric acid crystals from forming.

I don't have tachycardia (high heart rate) because my heart muscle pumps well and isn't strained because the muscle contracts and relaxes effortlessly because of good acid base balance.

I don't fear cancer because I believe that an acidic ecf is what causes regulatory and harmless and commensal microbes to turn into virulent parasites that cause cancer to develop.

Yes, vitamin B1 is important, but such studies are subordinate to putting all the pieces of rhe puzzle together to form a whole picture. This is where we need work on, as without this perspective one can end up taking one supplement after another and not progressing from his poor state of health.

Interesting. Several years ago my gut was absolutely nuked by max dose clindamycin after a nasty infection that almost caused me to lose the use of an eye. The result was weeks of c difficile -like symptoms. The only thing that fixed it was boulardii.

But then there is the fact that it is literally the most unpleasant food ever concoted by man.

Brown Rice Inhibits Development of Nonalcoholic Fatty Liver Disease in Obese Zucker (fa/fa) Rats by Increasing Lipid Oxidation Via Activation of Retinoic Acid Synthesis

Abstract
Background
White rice and its unrefined form, brown rice, contain numerous compounds that are beneficial to human health. However, the starch content of rice can contribute to obesity, a main risk factor for nonalcoholic fatty liver disease (NAFLD).

Objectives
We investigated the effect of rice consumption on NAFLD and its underlying molecular mechanism.

Methods
We randomly divided 7-week-old male obese Zucker (fa/fa) rats, an animal model of NAFLD, into 3 groups (n = 10 each) fed 1 of 3 diets for 10 weeks: a control diet (Cont; AIN-93G diet; 53% cornstarch), a white rice diet (WR; AIN-93G diet with cornstarch replaced with white rice powder), or a brown rice diet (BR; AIN-93G diet with cornstarch replaced with brown rice powder). Liver fat accumulation and gene expression related to lipid and vitamin A metabolisms, including retinoic acid (RA) signaling, were analyzed.

Results
Hepatic lipid values were significantly decreased in the BR group compared with the Cont group, by 0.4-fold (P < 0.05). The expression of genes related to hepatic fatty acid oxidation, such as carnitine palmitoyltransferase 2, was approximately 2.1-fold higher in the BR group than the Cont group (P < 0.05). The expression of peroxisomal acyl-coenzyme A oxidase 1 and acyl-CoA dehydrogenase medium chain was also significantly increased, by 1.6-fold, in the BR group compared with the Cont group (P < 0.05). The expression of VLDL-secretion-related genes, such as microsomal triglyceride transfer protein, was also significantly higher in the BR group (2.4-fold; P < 0.05). Furthermore, aldehyde dehydrogenase 1 family member A1, an RA synthase gene, was 2-fold higher in the BR group than the Cont group (P < 0.05).

Conclusions
Brown rice prevented development of NAFLD in obese Zucker (fa/fa) rats. The beneficial effects of pregelatinized rice on NAFLD could be manifested as increased fatty acid oxidation and VLDL secretion, which are regulated by RA signaling.
https://www.sciencedirect.com/science/article/pii/S002231662200339X

@haidut
I had also read your previous post on that 300mg-biotin-per-day study and can attest by my own experience that there really are things opening up at thrice daily doses of about 100mg B7.
Practically, however, I ran into a few issues. What are your opinions on these?

Biotin:

I don't understand how study participants could cope for so long with such high doses, since B7 competes with B5 for uptake? Especially with regard to restoration of myelin sheaths, cell membranes and endogenous fatty acid synthesis they are both interdependent. I kept running into deficiency of one or the other and had to alternate both at least once every few days. I felt that at such high doses, purity and fillers really become a significant issue. I've tried different brands because of this and they ranged from awful (with excessively much MCC) to something-is-still-off. Pharmaceutical quality in general is only >97.5% purity which by itself I consistently find totally inadequate in many cases. Perhaps related to 2). My GI system and BMs became unbearably upset by high biotin doses. I suspect biotin exhibits inhibiting effects on aminooxidases similar to thiamin (thiamin metabolites) through displacement of enzymatic flavoproteins? I'm convinced much of the beneficial effects in Antonio Costantini's high-dose-thiamin therapy stems from MAO inhibition in the ganglions.

Riboflavin:

Are such high bolus doses really sensible in people who are unaffected by that recognized genetic riboflavin transporter defect?
.1) I have noticed much better effects and tolerability from single digit mg doses continually (3-4x) throughout the day instead of higher doses twice or once daily.
.2) Someone on the forums reported to have had his actual serum/blood FAD and FMN levels tested with different amounts of B2 and that their ratio and the absolute value of FAD totally plumetted from high doses of B2, whereas FAD and also his symptoms improved with low doses.

Side note: I have used B2 in amounts up to 2grs for clostridioides prophylaxis because of the studies on its redox effects and the aerobic-anaerobic gradient of the intestinal lining and its microbes. While such amounts are probably really not harmful, they made for purging and very awful BMs.

Hope you are doing well! And thanks for all the work!

@haidut thank you

Makes sense to me, but surely not alone HaidutBot.

It's almost old hat now, people referring to the gut as a 'second brain'. And sure enough, I could send myself to a psychologically uncomfortable place simply by eating orange peel (for example).

And allegedly there's another stop on the axis.

@ThinPicking said in Are Polls a Good Idea?:

https://www.mdpi.com/1424-8220/22/23/9115
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075501/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002343/
https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.040499
https://www.sciencedirect.com/science/article/abs/pii/S0306987719307145
https://www.sciencedirect.com/science/article/pii/S1568163721002865
https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00278/full

@Jakeandpace
Yes I do now. It definitely makes a difference.

I'm just concerned to suggest it to someone else with masses in his colon that shouldn't start bleeding. I read in previous studies that aspirin does not cause bleeding but for me this definitely was the case.
This family member is really in a bad state so I'm not sure if it's even worth it anymore.

@Mauritio Appreciate it. That was the conclusion I had arrived to as well but I have heard some people do t3 only. If you don't mind sharing what dose t3/t4 did you find works for you?