@engineer SSRIs have a much more generalized effect than a direct 5-HT1a receptor agonist since serotonin will be divided among all other receptors From another study 8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats [image: 1768918294031-3d46999d-9aad-44ea-8bf1-36bfb5e7c66b-image.png] Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis [image: 1768920594623-d36fbbc0-87ea-42bd-be31-d2f3fde2633a-image.png]

@Hearthfire Appreciate the detail. Great news on the vellus hair growth.

@sunsunsun Thanks for chiming in. The dosages really are not self-evident, ever. Given the general amount of animal studies wherein astrononimcal concentrations are being used to draw conclusions, it's difficult to say what is uncalled for timidness and waste of effort and what's straight out daftly excessive, wasteful and potentiall harmful at the other end. E.g. there are still people believing they need 5000 IU hGC per week when actually 250 IU (400IU max) every other day is pretty much enough for the whole effect. Also, IFN-y is only being used at 100mcg. Its precursor Interleukin-12 (IL-12) appears to must be used only in single digit mcg amounts, if at all. Have you gained any experiences with the thymic peptides? I'll restart with the Glu-Trp thymogen and begin with the TA1.

@Mauritio - I am a whole foods type of person. I encourage others to get their nutrients from food.

@engineer - Vitamin A & D is probably not the full story. Chris MasterJohn has a checklist which uncludes other things that you are probably doing as well. https://chrismasterjohnphd.substack.com/p/what-everyone-should-be-doing-for

@bio3nergetic said in The Vaccinated are Unvaccinated: allowed you to test negative I don't think anyone who spent a lot of time around test-happy receipients at the time or played around with the flow sticks in particular could believe there's any meaningful correlation there. But to be fair, the 'sensitivy' of 'pcr' and flow tests isn't claimed to be spectacular anyway. And a record of receipt was supposed to be indicative on its own.

Sharing this. Thx for posting.

https://bioenergetic.forum/post/60591

IL-6 isn't an "inflammatory protein". It is a transient signalling molecule of immune involvement..it raises when you go for a walk and eat a carb heavy meal, so is walking and eating inflammatory too? You can't look at cytokines in isolation..cytokines are not inflammation..they are the response to something like PAMP's e.g PRR's,TLR2/4, Dectin-1, CARD9, DAMP's e.g TLR-9, TNF-a, IL-β, hypoxia e.g chronic HIF-1a signalling , mitochondrial ineffiency e.g reduced PGC-1a, reduced OXPHOS that immune function has decided it doesn't have the energy or resources to resolve, so the threat assessment never reaches the resolution phase e.g IL-10, Tregs, M1-M2, SPM's like it would with food poisoning, wound healing, bacterial infections that induce aggressive acute immune function like c.difficile infections and waterborne illness Inflammation is the dysregulated response of immune function to a perceived threat that it does not have the facility to, or has not received the gating to resolve, so it just manages the situation. That "management" is the inflammation as it wastes NAD, forces longer windows of aerobic glycolysis, induces more hypoxia. Not cytokines .which means all these studies are particularly nonsense. Furthemore there isn't anything in cacao xanthines or polyphenols or any other polyphenol for that matter that can resolve inflammation. The keyword is resolve..it can transiently inhibit NF-kB through IKK, and it can push Nrf2(this would probably just result in even more redox stress though without resolution), but neither of these things equal resolution..without the signalling cacscade i mentioned earlier, there is no getting out of "inflammaging" or chronic inflammation and because inflammaging is largely driven by hypoxia through things like uncoupling of eNOS, BH4, mitochondrial inefficiency etc this is something you cannot reverse beyond a certain point or age..inflammaging to use the cringe term, is inevitable and you might as well just call it aging.

@DavidPS The criteria was to be 20 years old, and have information about the participants's atherosclerotic cardiovascular disease, dietary niacin intake or covariates. "Our research focuses on participants aged 20 years and older who completed an interview. Data analysis was conducted from July to September 2024. We excluded pregnant women or individuals with missing data on atherosclerotic cardiovascular disease, dietary niacin intake, or covariates. " Perhaps covariates includes obesity, but I don't know.

Context Indoor air contains 100 times more microplastics than previously estimated, according to this study. Every day, an adult inhales 68,000 microplastic particles, and a child nearly 47,000. This is one hundred times more than previously thought, according to the study from the University of Toulouse published in the journal PLOS ONE. https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0328011 2025 Researchers analyzed the air in homes, offices and cars and found extremely high concentrations of PM10 particles, which come from textiles, furniture, cables and carpets. NB: MPP and NPP: micro-plastic and micro-plastic particles Useful link (in French, translator needed) https://www.julienvenesson.fr/microplastiques-nanoplastiques-effets-sante/#:~:text=Effets sur le système respiratoire,et peuvent même les détruire. How to protect the brain: Optimize protection against neuroglia and inflammation Let’s say we’re going to try to protect both against stroke and Alzheimer's, although I am aware that this requires "scientific confirmation". “Amyloid plaques and tau protein deposits in the brain are considered the main biological features of Alzheimer's disease. Recently, myelin sheath degeneration has emerged as a new hypothesis and target in the etiology of Alzheimer's disease. A decrease in myelination and oligodendrocyte function precedes the pathological accumulation of amyloid and tau proteins.” (Graciani et al., 2023, Desai et al., 2009, Desai et al., 2010). Put differently, there is inflammation, with accumulation of a tau protein, degeneration of the myelin sheaths (which protect the nerves) and therefore poor conduction of nerve impulses. So, if we accept this hypothesis, we should try to calm things down (excitoxicity and neuro-inflammation via TNF-alpha, but not only that). Indeed, nothing is settled down, established in advance, or rigid if you prefer. Since nothing is set in stone, we're relying on probability: by addressing inflammation and protecting our communication channels, we aim to give the brain the tools to resist longer. It's not a guaranteed miracle cure, but a common-sense strategy to minimize damage. Electrical glitch or chemical short circuit? That's the big debate: which comes first? In the brain, everything operates in a loop: a malfunctioning ion channel (electrical) alters the release of neurotransmitters (chemical), and inflammation (chemical) then modifies the sensitivity of receptors (electrical). It's a vicious cycle. Protecting the Brain: Optimizing Protection against Neuroglia and Inflammation Since there is disruption in cellular communication, resulting in inflammation and impaired elimination of toxins and dysfunctional debris, I’ll suggest some approaches. Their relevance will vary depending on the individual's condition. Think of this as a toolbox. Here, I’ll simply mention a few molecules / clues from my own research. More details can be found at the link below. There’re probably other ones, like emoxypine succinate, although I’ve never heard of it before coming to this forum (not available in my country; unknown to VIDAL). Healthy membranes to facilitate blood circulation. Baby aspirin (325 mg) in case of insufficient fluidity. Anti-inflammatory and pro-metabolic. Mind side effects on platelet renewal. UCDA: Details on how Ursodiol acid protects the brain (with a physician prescription). Suggested optimization for these nutrients: resveratrol, Theracurmin, EGCG (green tea). B1, B9, B12, DHA and iodine. Betaine HCl if lazy digestion after the evening meal (with meat). Taurine *** and magnesium Physical activity Open to suggestions More details on this link if you want to go deeper with one molecule (in French) https://mirzoune-ciboulette.forumactif.org/t2161-le-cerveau-contamine-par-le-plastique-comment-s-en-proteger#30544 More info on taurine (in French) https://mirzoune-ciboulette.forumactif.org/t1866-infos-sante-divers-sce-2#29009 https://mirzoune-ciboulette.forumactif.org/t1840-quest-ce-qui-rend-la-taurine-si-importante#25227 (an article that explains the ins and outs of this amino acid).

@CrumblingCookie I've done it today again and half an hour later noticed a face lift effect also my mood seems to be better. I kept forgetting about it but I'll try to do it more often.