I find this a classic example of misinterpretation of scientific studies.
And there are way too many to discuss each one of those in their wrong conclusions.

D3 metabolism in rodents is known to be crucially different from D3 metabolism in humans.
It's beyond poor science to even directly convert these rodent findings to human equivalent doses.

This just feels like science-spam.
The findings themselves and the priorly known implications of hypothyroidism may be valid.
The conclusions (and motives for funding such studies) with regard to "vitamin D prevents it" are not.

@sneedful said in Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients:

@Mossy oh wait I said methylene blue fat thing that doesn't make sense cause u would be taking k2 mk4 instead. nvm. u get what I mean.

No worries.

Histological and biochemical study of the superficial abdominal fascia and its implication in obesity
Abstract
The advancement of liposculpturing and fascial flaps in reconstructive surgery has renewed interest in the superficial fascia of abdomen. Its histological and biochemical composition may play a vital role in maintaining strength and elasticity of the fascia. Hence, study of abdominal fascia for the elastic, collagen, and hydroxyproline contents is desirable to understand asymmetrical bulges and skin folds and in improving surgical treatment of obesity. Samples of superficial fascia were collected from of upper and lower abdomen from 21 fresh cadavers (15 males and 6 females). Samples were stained using Verhoeff–Van Gieson stain. Digital images of superficial fascia were analyzed using TissueQuant software. The samples were also subjected to hydroxyproline estimation. The superficial fascia was formed by loosely packed collagen fibers mixed with abundant elastic fibers and adipose tissue. Elastic contents and collagen contents of superficial fascia were significantly more in the upper abdomen than that in the lower abdomen in males. Hydroxyproline content of superficial fascia of upper abdomen was significantly more than that of lower abdomen in both males and females. The elastic, collagen and hydroxyproline contents of superficial fascia of upper abdomen were higher compared to the lower abdomen. This may be a reason for asymmetric bulging over abdomen and more sagging fold of skin in the lower abdomen than in the upper abdomen. This study may therefore be helpful in finding new ways to manage obesity and other body contour deformities.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5052227/

Muscle Pain: It May Actually Be Your Fascia
Ways to Relieve Fascia Pain
There are various strategies that work to loosen up painful knots, such as:

Heat therapy: Apply a heating pad to the affected area or take a warm shower or bath.
Yoga therapy: See a highly trained yoga therapist to get a regimen of yoga poses targeted to treat your area of pain. (Yoga therapy works in the same manner as physical therapy — the therapist creates a routine and you practice it at home between visits.)
Foam rolling: Try a foam roller, a cylinder of hard foam that you roll your body over to release tension. It’s a form of self-massage. You can also do this with a lacrosse ball.
Massage therapy: Schedule multiple therapeutic massage sessions with an experienced therapist who can find and apply pressure to release knots.
Acupuncture: The insertion of acupuncture needles into trigger points can cause tense tissue fibers to relax.
https://www.hopkinsmedicine.org/health/wellness-and-prevention/muscle-pain-it-may-actually-be-your-fascia

Yoga Poses for Myofascial Release | 5 Poses to Try
https://www.acefitness.org/resources/everyone/blog/5667/yoga-poses-for-myofascial-release-5-poses-to-try/

@yerrag
Well said Ye!
I would say heavy hitters in the militaristic approach to a balanced system would be Castor Oil packs on the skin over the liver.
Higher dose Aloe Vera Juice.
Oregano oil + activated charcoal.
Russian Sauna. Or fever.
And Swedish Bitters one shot in warm chamomile tea.
The big guns!
Have you ever tried clove tea for your lungs!!?? Supposed to be great!!!

Ah I unfortunately don't but thanks for letting me know.

@MarkusAllenUSA said in "The Puzzle of Aspirin and Iron Deficiency: The Vital Missing Link of the Iron-Chelating Metabolites":

@Insomniac

Do you agree with his conclusions about proper nutrition and excellent health?

I agree with his position that the medical system has ignored issues with cellular metabolism as a primary driver of disease.

Nobody is correct about everything and even brilliant people are pulled away from the truth due to biases but he offers a valuable perspective imo.

@cs3000 said in Thymus health:

Looks like a big health unlock , neutrophils are big players in autoimmune problems maybe the biggest, you see them showing up causing big damage in a wide range of health issues covid cystic fibrosis ulcerative colitis heart failure etc

and theyre highly destructive with different weapons, cytokine release, then they have proteases that degrade the structure surrounding the cell (if u inhibit neutrophil proteases in arthritis they dont develop arthritis at all https://pmc.ncbi.nlm.nih.gov/articles/PMC150852/ ), and they can form wild traps where they basically gut themselves & spill out strands of dna laced with proteins to form damaging webs like some kind of arsehole spiderman in the autoimmune situation

There is a lot I don't understand about the adaptive immune system and maybe it's this lack of understanding that betrays my view in seeing autoimmunity to be largely involved with B-cells.

In this regard, autoimmunity is not so much different from being very sensitive to stimulus that the immune system wrongly regards something that is endogenous as being foreign.

I have chronic high blood pressure and it is the result of my neutrophils and macrophages of the innate immune system trying to get rid of heavy metal toxins and periodontal infections with no success, given the persistency of these insults where they don't get permanently removed or killed. It is like Groundhog Day for my immune system where they keep repeating their efforts to get rid of persistent insults that keep bouncing back. Yet I do not consider the inflammatory effects of this endless effort to be an autoimmune condition. But I blame the tenacity of heavy metals refusing to be swallowed up and excreted out, and the ability of synergistic bacteria and fungi to defend against attack by phagocyte activity by neutrophils and macrophages.

But lately I have used techniques and substances to assist my immune system to successfully get rid of the hitherto unremovable toxins and immortal infection. But I had to employ medically unorthodox techniques to achieve these.

Seems to me medical complex is guilty of spreading misinformation and disinformation to label as autoimmune, on the strength of their vaunted research which are in many cases made up stories to lead trusting souls astray.

Yet I do not wish to throw the baby with the bathwater, for a large part of the body of research is valid, and a good filter is needed to separate wheat from chaff.

@haidut

Yeah.

I ask about Georgi a few hours ago, and BOOM. He posts!

lot more studies about smoking

http://www.longecity.org/forum/topic/61248-the-intelligent-smoker-what-should-a-smoker-take-to-nullify-harm/#entry564686

https://web.archive.org/web/20150506014136/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389609

https://web.archive.org/web/20200519095149/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/

https://web.archive.org/web/20170725172009/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389478

https://web.archive.org/web/20170725172009/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389478

https://web.archive.org/web/20171029181630/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-16#entry390790

https://web.archive.org/web/20170725172009/https://www.longecity.org/forum/topic/38868-smoking-is-good-for-you/page-13#entry389717

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001541/ - Improves cognition

https://www.york.ac.uk/depts/maths/histstat/smoking.htm

https://cfrankdavis.wordpress.com/2015/08/06/william-whitby-smoking-is-good-for-you/

https://www.scribd.com/document/125915399/Smoking-is-Good-for-You?ad_group=&campaign=Skimbit%2C+Ltd.&content=10079&irgwc=1&keyword=ft750noi&medium=affiliate&source=impactradius

http://www.thetreeofliberty.com/vb/showthread.php?202165-Smoking-Helps-Protect-Against-Lung-Cancer&p=2362638

@cs3000
This stuff is all so fascinating to me! I had never seen that before in the old forum. I am a total novice lay person. I just like finding things that I heard Ray talk about and share with people like yourself who can run with these ideas! I personally love the quinones from Pau D’arco bark, cascara sagrada. I also love emodin from aloe Vera juice. Emodin is a natural hydroxyanthraquinone compound found in Aloe vera juice, specifically in the latex of the plant. Antibacterial, antifungal, and anticancer effects. But, yes! Thanks for diving into Kocks stuff and sharing! It’s helping me explore it more too!
Peace!

@Lejeboca - thank you for taking the time to respond. I got things twisted around in my mind and it is embarrassing.

I think of the relationship between the eNOS and iNOS isoforms of nitric oxide synthase as being analogous to Dr. Jekyll and Mr. Hyde. The "i" in iNOS is related to inflammation, ischemia and intoxication all of which are generally bad. Whereas the "e" is related to the endothelium and is very healthy to have on board. Caldwell Esselstyn had his cardiac patients eat greens all day to maintain high levels of eNOS as part of his successful plan to reverse heart disease.

In 1998, the Noble Prize in Medicine was awarded to 3 people for their work on NO (see press release). This encouraged people to supplement with L-arginine to lower their blood pressure. The excessive iNOS from the supplementation had long term consequences that were not good.

Incidentally, aspirin releases eNOS.
Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action (2009)

The role of melatonin in bone regeneration: A review of involved signaling pathways
Abstract
Increasing bone resorption followed by decreasing bone mineralization are hallmarks of bone degeneration, which mostly occurs in the elderly population and post-menopausal women. The use of mesenchymal stem cells (MSCs) has raised many promises in the field of bone regeneration due to their high osteoblastic differentiation capacity and easy availability from abundant sources. A variety of compounds, including growth factors, cytokines, and other internal factors, have been combined with MSCs to increase their osteoblastic differentiation capacity. One of these factors is melatonin, whose possible regulatory role in bone metabolism and formation has recently been suggested by many studies. Melatonin also is a potential signaling molecule and can affect many of the signaling pathways involved in MSCs osteoblastic differentiation, such as activation of PI3K/AKT, BMP/Smad, MAPK, NFkB, Nrf2/HO-1, Wnt, SIRT/SOD, PERK/ATF4. Furthermore, melatonin in combination with other components such as strontium, vitamin D3, and vitamin K2 has a synergistic effect on bone microstructure and improves bone mineral density (BMD). In this review article, we aim to summarize the regulatory mechanisms of melatonin in osteoblastic differentiation of MSCs and underling involved signaling pathways as well as the clinical potential of using melatonin in bone degenerative disorders.
https://www.sciencedirect.com/science/article/abs/pii/S0300908422002127

Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures
https://pubmed.ncbi.nlm.nih.gov/28130552/

tea is very high in fluoride. The more expensive teas are harvested from young shoots, which are much lower in fluoride due to less time growing to accumulate it. But that is the issue, the cheaper assam teas can have 2mg per cup.

@Lejeboca - I did not know that one could search Sci-Hub by ISBN. Thanks.