@sunsunsun let us know

More info on the way how coco acts... How does coconut oil can stabilize or protect ingested PUFA from oxidation? Key ideas Coconut oil is not just resistant to oxidation but it can stabilize membranes. Coconut oil protects against the inflammation caused by endotoxins (but don’t use coco in case of a detox at the beginning of the process because it could amplify the immune reaction). SFA has an impact on enzyme expression when use in high amount (far from the ratio 2:2:1 for SFA/MUFA/PUFA). If you have a high intake of LA (omega-6), it can compete with ALA (omega-3) for the enzymes that are responsible for converting ALA into anti-inflammatory eicosanoids. SFAs like lauric acid (from coconut oil) don’t require desaturases. Thus, adding coconut oil won’t inhibit PUFA processing by competing for those enzymes, because SFAs don’t undergo desaturation. Coconut oil is 90 % SFA with 2/3 MCT oil. Adding coconut oil may help protect membranes by giving a spatial and stabilizing protection, improving membrane packing. ! Caveat: Balance is Key: Too much of a good thing is bad. How does coconut oil can stabilize or protect ingested PUFA from oxidation? Coconut’s structure, primarily consisting of saturated fats, is less susceptible to the chemical reactions that cause oxidation. Not just opposing resistance or fragility to oxidation (rancidity) but the way SFA can stabilize membranes. Coconut oil can indirectly protect PUFAs from oxidation by stabilizing the overall lipid environment and potentially influencing PUFA metabolism. (1) Saturated fat content, particularly medium-chain fatty acids (MCFAs) like lauric acid, can help to pack and stabilize cell membranes, making them less susceptible to the damaging effects of oxidation. Additionally, coconut oil's unique fatty acid profile and natural antioxidants may further contribute to its resistance to oxidative damage. When adding SCFA in a meal having some PUFA, it forms a tighter packing; when incorporated to tissues, it reduces the space available for PUFA chains to move and react with free radicals, thus stabilizing the membrane and protecting PUFAs from oxidation. Ray Peat, making a extrapolation in “Unsaturated fatty acids: Nutritionally essential, or toxic?” Question to AI How can SFA from coconut oil stabilize and thus protect incorporated fat in membrane? A clue: When incorporated to tissues, it reduces the space available for PUFA chains to move and react with free radicals, thus stabilizing the membrane and protecting PUFAs from amplifying ROS. Detailed answer on the link. https://mirzoune-ciboulette.forumactif.org/t2109-english-corner-coconut-oil-stabilizes-or-protects-ingested-pufa-from-oxidation#30204

@Mauritio said in Random, interesting studies: anything that has alot of polyphenols with the aspirin should work. Yes, to counteract excess oxidation and then inflammation. But we need to optimize mucin thickness with glutamine (and taurine to counteract the excitotoxcity in the brain). I take half a teaspoon of taurine and the same with glutamine powder, one hour before bedtime, when I feel a stomach acidity. No glutamine if you suffer from dysbiosis (suspicion of candidiasis: it feeds the bacteria). When it's nervous, L-theanine 225 mg and 1 tsp collagen do the job (cramp). Never take SSRS as a usual med...

If you want other sources: Are PUFAs toxic? Video of Chris Masterjohn 30’ https://youtu.be/WRmUzYD8l7Q CM earned a PhD in Nutritional Sciences from the University of Connecticut in 2012 and currently researches the physiological interactions between fat-soluble vitamins A, D, and K at the University of Illinois, Urbana-Champaign. https://chriskresser.com/an-update-on-omega-6-pufas/ Eat real food and balance your diet. Avoid industrial seed oils. Don’t go overboard with the nut flours. Eat pre-formed EPA and DHA (white fish). Ray Peat PhD. – Kate Deering – Dr. Rita Lee – Etc. Huile de poisson et effet sur la thyroïde http://mirzoune-ciboulette.forumactif.org/t1388-huile-de-poisson-et-effet-sur-la-thyroide#15791 Effets anti thyroïde des oméga-3 (In French, translator needed) (See translation of the excerpt below) Excerpt: Translation (« Huile de poisson et effet sur la thyroïde » => Fish oil and effect on thyroid) • ALA administration results in a 22% reduction in T3, the most potent form of thyroid hormone. T4 to T3 conversion rates decrease by 56% in response to ALA ingestion. ALA even interferes with normal T3 levels if you pre-administer T4 into the cells. (2) 2. http://www.ncbi.nlm.nih.gov/pubmed/1815532 • Animals fed a high PUFA diet compared to a high SFA diet (with corn oil or lard) experienced a significant decrease in thyroid hormone response in PUFA-fed rats. (3) http://www.jbc.org/content/256/14/7113.full.pdf+html Excerpt 1 from: Arachidonic acid causes an uncoupling effect and inhibits cellular respiration https://www.sciencedirect.com/science/article/pii/S0891584999000349 “It is shown that arachidonic acid causes an uncoupling effect under state 4 respiration of intact mitochondria as well as a marked inhibition of uncoupled respiration. Excerpt 2 from: Unsaturated Vegetable Oils: Toxic http://www.raypeat.com/articles/articles/unsaturated-oils.shtml To defend the seeds from the animals that would eat them, the [PUFA]-oils block the digestive enzymes in the animals' stomachs. Their tendency to oxidize is very great. These oxidative processes can damage enzymes and other parts of cells, and especially their ability to produce energy. The enzymes which break down proteins are inhibited by unsaturated fats, and these enzymes are needed not only for digestion, but also for production of thyroid hormones, clot removal, immunity, and the general adaptability of cells. The risks of abnormal blood clotting, inflammation, immune deficiency, shock, aging, obesity, and cancer are increased. Thyroid and progesterone are decreased. Since the unsaturated oils block protein digestion in the stomach, we can be malnourished even while "eating well." *) Useful info: more to be read on my forum. Effets anti-thyroïde des oméga-3 Effets Immunosuppressifs des omega-3 https://mirzoune-ciboulette.forumactif.org/t2042-effets-anti-thyroide-des-omega-3#29683 Excerpt: No one disputes the benefits of omega-3s for reducing inflammation and counteracting an overactive immune response. But it's all about long-term use. Not to mention that some sources of omega-3s also provide omega-6s. This leads to the storage and release of amino acids. See the details in the post "Fatty Acids for Dummies," linked below. (15) You'll find further information in the links provided below.

Improving blood flow to the extremities (hands and feet) involves more than just "moving more." It requires a balance between the mechanical pumping of the heart and the biochemical signals that tell your blood vessels to open up (vasodilation). For someone focused on metabolic efficiency, the goal is to improve circulation without triggering excessive stress responses that can actually lead to peripheral vasoconstriction. 1. The Biochemical Trigger: The Role of CO2 Effective circulation depends on the Bohr Effect. For oxygen to leave your blood and enter your tissues (especially in the small capillaries of your fingers and toes), carbon dioxide (CO2) must be present. Vasodilation: CO2 is a powerful natural vasodilator. When your metabolic rate is high and you are producing CO2 efficiently, your blood vessels relax, allowing blood to reach the extremities. The Trap: Over-exercising to the point of "gasping for air" or hyperventilating actually flushes CO2 out of the system. This can cause the peripheral vessels to constrict, leading to cold hands and feet even while your heart rate is high. 2. Strategic Exercise Selection To optimize blood flow to the extremities, the type of movement matters. Resistance Training (Concentric Focus): Lifting weights or bodyweight movements (like squats or push-ups) creates a mechanical "pump" effect. Focus on the concentric (the lifting phase) to stimulate blood flow and metabolic demand without creating excessive tissue damage or systemic inflammation. Low-Impact Steady State (LISS): Walking at a brisk pace where you can still breathe through your nose helps maintain a high CO2 tension. This keeps the peripheral "gates" open longer than high-intensity sprinting might. Micro-Movements: If you spend long periods at a desk, simple calf raises or grip strengtheners are highly effective. The calves are often called the "second heart" because their contraction is essential for pumping venous blood back up from the feet. 3. Thermoregulation and the "Core-to-Extremity" Link Your body prioritizes keeping your internal organs warm. If your core temperature drops even slightly, the body will pull blood away from your skin and extremities to protect the center. Warmth as a Catalyst: Exercising in a warm environment or wearing adequate layers helps signal to the nervous system that it is "safe" to send blood to the periphery. Metabolic Rate: A robust oxidative metabolism keeps your internal "furnace" running. If your resting metabolic rate is low, your body will naturally be more stingy with blood flow to the fingers and toes. 4. Nutritional and Biochemical Support Circulation is also a matter of fluid dynamics and mineral balance. Magnesium and Calcium: Magnesium helps the smooth muscles of the blood vessels relax (vasodilation), while calcium helps them contract. Ensuring adequate magnesium intake can prevent the "clamping" of peripheral vessels. Sodium Balance: Adequate salt intake is necessary to maintain blood volume. Low blood volume makes it much harder for the heart to push blood all the way to the ends of the limbs. Short-Chain Fatty Acids (SCFAs): Compounds like butyrate can support mitochondrial health and gut integrity, which indirectly supports systemic blood flow by reducing the low-grade inflammation that can make vessels "stiff." Summary of Strategies Strategy Action Mechanism Nasal Breathing Breathe only through the nose during light exercise. Increases CO2 retention and vasodilation. Calf Raises Perform 20 reps every hour while sitting. Engages the "venous pump" in the lower legs. Temperature Check Keep the torso and neck warm. Prevents the "survival" vasoconstriction reflex. Mineral Balance Ensure sufficient Magnesium and Salt. Maintains blood volume and vessel flexibility.

I actually just realized Yucca also has a 3:1 4:1 ratio just like the carrot salad and bok choy

@jamezb46 literally something like what you've posted in the next paragraph as counter evidence you cultured swine

@engineer cabergoline increases noradrenaline though.

COX-2 is overexpressed in advanced stages of tumors. Aspirin starts inhibiting COX-2 meaningfully after dosages of about 500mg (better would be >1g). Aspirin vindicated as an anti cancer drug. "Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpression in tumorsis considered a predictor of more advanced stage disease and of worse prognosis in a number of studies investigating solid malignancies. Therefore, NSAIDs are evaluated as anti-cancer drugs." Artificially overexpressing COX-2 makes mice more prone to developing tumors and knocking it out makes them less likely to develop tumors. "Both COX-1 and COX-2 are involved in tumor vascularization. COX inhibitors can directly affect angiogenesis [47]. " "Thus, COX-2 may be the cause of progression of estrogen-dependent breast cancer either directly by stimulating tumor cell proliferation, or indirectly by upregulating aromatase activity [60]. " "Part of the rationale for combining NSAIDs with chemotherapy involves circumvention of chemotherapy resistance mechanisms." https://pubmed.ncbi.nlm.nih.gov/16945549/ COX-2 inhibition makes chemotherapy (5-fluorouracil) more effective in vitro. https://pubmed.ncbi.nlm.nih.gov/21163769/

skin surface way is capacitive coupling https://pubmed.ncbi.nlm.nih.gov/8200888/ this showed effect i dont have the info on their approach rn. non fusing fractures for 11+ months 6/10 fused vs 0 The non-union healed in six of the ten patients who had been managed actively but in none of the patients who had been managed with the placebo unit. https://www.semanticscholar.org/paper/Capacitively-coupled-electrical-stimulation-results-Abeed-Naseer/bc78f0db97ce86d9fc64d5487b91cee839744c8d 11 of non unions unified by 15 weeks applied through steel plates on the skin - healed if the plates were within 8cm of each other The only significant factor determining the success of healing was the distance between the plates; a distance of eighty millimeters or less resulted in healing in all cases https://pubmed.ncbi.nlm.nih.gov/8458140/ partial limb regeneration https://pmc.ncbi.nlm.nih.gov/articles/PMC4683620/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3495370/

@user73636 sounded like a gimmick at first but its well studied theres a lot on it, decent amount from japan , another way to get it without a machine is buying some elemental magnesium metal sticks or ribbons (safer to avoid as fine powder tho unless stored right). can add a stick or ribbon chunk to water and it will make hydrogen bubbles (added a small amount of malic acid to speed up getting past the oxide surface and a bit more hydrogen , then rinsing after drinking. i added it without malic and it still bubbled) https://bioenergetic.forum/topic/9291/hydrogen-dissolved-in-drinking-water-or-via-gastric-acid i reckon 200ug hydrogen at once would be good. trying to figure out how much a 10cm 130mg ribbon would give. max water saturation you can get is 1mg - 1.5mg per L but it reacts slow and without a lot of acid it forms a black layer. i read some papers where they dipped it for a short time and it had effect still

@LunaticRed I shave my arms and apply it there and the inside of thighs currently.

@cs3000 I interesting ! Oleanolic acid sounds interesting, too. I took ursolic acid today for the first time. And it caused some hair loss but also a profound sense of relaxation that haven't felt in a while.

"Phytates are not a health concern for those who eat a varied and balanced diet. However, for those on a poor, monotonous diet, high levels of phytates increase the risk of mineral deficiencies, which is why various techniques are used to reduce phytate levels in food." I guess the question is, why would someone take to a variation of a "a poor, monotonous diet". And could that include some interpretations of advisories found around bioenergetics.

does the free acetyl also have this interactions with CAII?

@sphagnum I wouldn't worry about the ratio, just consume enough Calcium and Magnesium foods/supplements to your well-being and tolerance. Also in the cited study above, the ratio is 2.3, not 2:3, so it's more than two times elemental calcium than magnesium. 2:1 seems to be the recommended ratio in health institutions. Calcium to Magnesium Ratio Higher Than Optimal Across Age Groups Objectives The ratio of calcium to magnesium (Ca: Mg) intake has gained immense attention in recent years, since a ratio above 2:1 has been associated with increased risk of metabolic, inflammatory and cardiovascular disorders. The objective of this study was to assess Ca: Mg ratios across age groups and to determine the relationship between Ca: Mg ratios and markers of inflammation. https://pmc.ncbi.nlm.nih.gov/articles/PMC6574898 Calcium: magnesium intake ratio and colorectal carcinogenesis, results from the prostate, lung, colorectal, and ovarian cancer screening trial Conclusion Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5. https://pmc.ncbi.nlm.nih.gov/articles/PMC6889387 Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study Our findings suggest that high dietary intake of Mg is associated with an increased risk of dementia mainly among older adults with low Ca:Mg intake ratios. Proper balance of Ca to Mg in the diet may be critical to the relationship between Mg intake and risk of dementia. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12362

@LunaticRed said in Fatty acid oxidation drives senescence: I recommend you to use Claude-opus-4-6-search instead of Gemini3, it's more powerful and better at searching information Thanks for the info. I appreciate. Here is a link for my first try / search on Vit k2 MK4 (in French): AI Conversation No. 3: HD Vit. K2 MK4 to target vascular, cerebral and hormonal aspects. https://mirzoune-ciboulette.forumactif.org/t2185-conversation-avec-lia-n3-hd-vit-k2-mk4-pour-cibler-les-aspects-vasculaire-cerebral-et-hormonal#30719 Need [image: 1775046783689-aa.emoticon-coffee.gif]