https://www.sott.net/article/221013-Health-Benefits-of-Smoking-Tobacco

https://www.sott.net/article/338885-A-comprehensive-review-of-the-many-health-benefits-of-smoking-Tobacco

https://www.sott.net/article/139304-Lets-All-Light-Up

https://www.sott.net/article/229156-Lies-Damned-Lies-400000-Smoking-related-Deaths-Cooking-the-Data-in-the-Fascists-Anti-Smoking-Crusade

Green Tea Catechins and Skin Health (2024)

Green tea catechins (GTCs) are a group of bioactive polyphenolic compounds found in fresh tea leaves (Camellia sinensis (L.) O. Kuntze). They have garnered significant attention due to their diverse health benefits and potential therapeutic applications, including as antioxidant and sunscreen agents. Human skin serves as the primary barrier against various external aggressors, including pathogens, pollutants, and harmful ultraviolet radiation (UVR). Skin aging is a complex biological process influenced by intrinsic factors such as genetics and hormonal changes, as well as extrinsic factors like environmental stressors, among which UVR plays a pivotal role in accelerating skin aging and contributing to various dermatological conditions. Research has demonstrated that GTCs possess potent antioxidant properties that help neutralize free radicals generated by oxidative stress. This action not only mitigates cellular damage but also supports the repair mechanisms inherent in human skin. Furthermore, GTCs exhibit anti-carcinogenic effects by inhibiting pathways involved in tumor promotion and progression. GTCs have been shown to exert anti-inflammatory effects through modulation of inflammatory signaling pathways. Chronic inflammation is known to contribute significantly to both premature aging and various dermatological diseases such as psoriasis or eczema. By regulating these pathways effectively, GTCs may alleviate symptoms associated with inflammatory conditions. GTCs can enhance wound healing processes by stimulating angiogenesis. They also facilitate DNA repair mechanisms within dermal fibroblasts exposed to damaging agents. The photoprotective properties attributed to GTCs further underscore their relevance in skincare formulations aimed at preventing sun-induced damage. Their ability to screen UV light helps shield underlying tissues from harmful rays. This review paper aims to comprehensively examine the beneficial effects of GTCs on skin health through an analysis encompassing in vivo and in vitro studies alongside insights into molecular mechanisms underpinning these effects. Such knowledge could pave the way for the development of innovative strategies focused on harnessing natural compounds like GTCs for improved skincare solutions tailored to combat environmental stresses faced by the human epidermis.

@Mauritio said in Niacinamide as effective as minoxidil at treating “androgenic” hair loss:

@Mossy I stopped using them topcically, because it was such a mess to apply. But looking backon it that was because of the apple juice i diluted it in.
So maybe I'll give the polyphenols another run mixed with niacinamide and glucose and water.

I hear you. If there's one thing I've learned over the years with these topicals, at least for me, they're impossible to use on a regular basis, apart from during sleep, due to the mess.

The glucose would seem to be a mess, no matter the form. On those lines, I've been thinking of using the common D-Ribose supplement, as opposed to the much more expensive variant of it used in the studies.

there's human trials

cognitive improvement
https://www.ls-corporation.co.jp/wp-content/uploads/2022/10/ergothioneine_congitive.pdf

and over 1 year, with people aged > 60
https://www.medrxiv.org/content/10.1101/2024.07.08.24310085v1.full.pdf

f92ec67d-100b-4fa5-a512-86ba1002478b-image.png
at 6 months, and still gaining at 12 months

. Following ET intake, an increase in Z-scores was observed in RAVLT assessments (immediate and delayed recalls), which evaluates learning ability and memory (Figure 4a&b). In contrast, no significant increase was observed in Z-scores across all NCA components, in the subjects given the placebo.
Block design scores, which assess visual-motor coordination and problem-solving skills, declined over time in both ET and placebo groups (Figure 4g). Although not measured at baseline, Z-scores of SDMT (written format) in the ET group showed a trend to increase from visit 7 to visit 14 (Figure 4i)

(at 4 weeks visit 1 ergo group also had a better lymphocyte-neutrophil ratio)
dec0b3e9-1154-4776-acb4-5b5f54bd831c-image.png

@haidut

yo, didnt you post something months or years ago on RPF about retinol destroying or detoxing micro plastics?

The Insane Biology of: Humans

This article appeared in my inbox. More support for apigenin protecting the liver.

Apigenin as an emerging hepatoprotective agent: current status and future perspectives (2024)

d2d64e2f-533e-4b0b-be95-813d96a150c3-image.png

@alfredoolivas it appears you are correct on that one! Finally, real progesterone.

@alfredoolivas
Thanks, interesting.

The problem with this study is that it considers the level of TSH below 8–9 mIU/L "normal"...

Protein is also important for bones.
ae0b3ce5-381c-4ffe-a068-05d5476f1726-image.png

I believe boron might be important if you consume lots of iodine/iodide, to decrease oxidative stress.

I wonder if kelp contains some boron as well.

@Mauritio - I do not recall any mechanism either. My focus was, and still is, on easy dietary changes to extend healthspan.

@DavidPS Thanks for posting. It's nice to see which products you and others are using. Cheers!

@haidut said in IDEALABS STUDY: Estrogen causes prostate cancer (PC), DHT and/or aromatase inhibitor may stop/treat PC:

PL24-0935_24DEC24

Haidut have you ever used DHT either transdermally or sublingual?

I've made my first secondary batch, using two table spoons of liquid whey /l from the BioGaia tablets batch:
(cow milk full fat, this time without cream. Again no inuline or starch. 12grs dextrose/l)
No whey separated at all.
The whole product is almost like a watery emulsion. Like almost liquid jello.
There's no particular smell. No particular taste. Very neutral. Totally different from my primary BioGaia tablet batches with their strong separation and tangy, cheesy flavor.
It made me wonder if there was any L.reuteri in the whey I had used.
Is this normal?

The pH is ≤4.0. So there's clearly been production of lactic acid.

Maybe I'll add half a gram of l-glutamine if that may help the reuteri to survive and duplicate even when not competing with other bacteria.

Accidentally, whilst looking for GABA-producing microbacteria (L. reuteri does not contribute, the small amount it produces merely helps its acid resistance. But it feeds of glutamine for that, much more than off glutamate),

The pH of the jars in which I had added 1g/l L-Glutamin is also ≤4.0.
Tastewise the L-Glut supplemented yoghurt is distinctly more sour!