Cinnamon smell for the win. "The strategy of using flavor/fragrances compositions such as cinnamon flavor and cinnamon mint may be useful to protect widespread of SARS-CoV-2 in their daily lives." https://pubmed.ncbi.nlm.nih.gov/39835268/

Very interesting. Despite its magnificent effects on healthspan, it lacks in the department of life extension. There isnt many studies on it and in the ones that exist, the results aren't very impressive. But a 8.5% life span increase in females is still decent. And at least in males it increased health span. So for better anti aging proposes it would be good to combine NMN with something that will likely increase lifespan as well, like selegiline, rapaymcin or ergothioneine.

@jamezb46 said in High-Fat Diet Triggers Memory Decline Within Days: I usually get about 2-3g per day for context. You will find the same gaslighting when it comes to studies "showing" that high saturated fatty acid diets cause inflammation. All of those "high SFA" diets are confounded by PUFA. Good point. But only a few look under the hood of such studies... @Corngold gotta wonder what the result would be if it was 90% saturated fat instead of 36%. It should look better, but it is still far from perfect. 60% fat is not a healthy amount... I guess.

@FTMarinetti does it lower DHT

@Gaston I got 30g for less than 30€ , I think that's ok. Cheap enough to give it a try.

He also has a curious obsession with hemodialysis. Light mockery is fine I think, obviously. Just decode what you're mocking, lest ye become the mocked.

Allulose can foster the growth of beneficial bacteria and stimulate the production of short-chain fatty acids. THE ROLE OF ALLULOSE AND SUGAR ALCOHOLS IN GUT MICROBIOTA MODULATION AND METABOLIC HEALTH: A REVIEW 2025

@bio3nergetic thank you, I think it's okay to share the link. its in the name of science

@Ecstatic_Hamster pretty sure protein intake translation to increased muscle protein synthesis doesnt even begin topping out until 75-100g protein at one meal . irrespective of increased ammonia which maybe signals incomplete but not totally stopped protein utilization for better pathway

I try to remain within the ranges that Dr. Peat mentions in Gelatin, stress, longevity (2009) Gelatin (the cooked form of collagen) makes up about 50% of the protein in an animal, but a much smaller percentage in the more active tissues, such as brain, muscle, and liver. 35% of the amino acids in gelatin are glycine, 11% alanine, and 21% proline and hydroxyproline. The 1936 Cyclopedia of Medicine (G.M. Piersol, editor, volume 6) mentions the use of gelatin solution to quickly control nosebleeds, excessive menstrual bleeding, bleeding ulcers (using three doses of 18 grams as a 10% solution during one day), and bleeding from hemorrhoids and the lower bowel, and hemorrhage from the bladder. But since Selye's work relating the thrombohemorrhagic syndromes to stress wasn't known at that time, gelatin was thought of as a useful drug, rather than as having potentially far-reaching physiological effects, antagonizing some of the agents of stress-induced tissue damage. Although I pointed out a long time ago the antithyroid effects of excessive cysteine and tryptophan from eating only the muscle meats, and have been recommending gelatinous broth at bedtime to stop nocturnal stress, it took me many years to begin to experiment with large amounts of gelatin in my diet. Focusing on the various toxic effects of tryptophan and cysteine, I decided that using commercial gelatin, instead of broth, would be helpful for the experiment. For years I hadn't slept through a whole night without waking, and I was in the habit of having some juice or a little thyroid to help me go back to sleep. The first time I had several grams of gelatin just before bedtime, I slept without interruption for about 9 hours. I mentioned this effect to some friends, and later they told me that friends and relatives of theirs had recovered from long-standing pain problems (arthritic and rheumatic and possibly neurological) in just a few days after taking 10 or 15 grams of gelatin each day. In some of the older studies, therapeutic results improved when the daily gelatin was increased. Since 30 grams of glycine was commonly used for treating muscular dystrophy and myasthenia gravis, a daily intake of 100 grams of gelatin wouldn't seem unreasonable, and some people find that quantities in that range help to decrease fatigue. For a growing child, though, such a large amount of refined gelatin would tend to displace other important foods. The National Academy of Sciences recently reviewed the requirements for working adults (male and female soldiers, in particular), and suggested that 100 grams of balanced protein was needed for efficient work. For adults, a large part of that could be in the form of gelatin. If a person eats a large serving of meat, it's probably helpful to have 5 or 10 grams of gelatin at approximately the same time, so that the amino acids enter the blood stream in balance.

@Samyo the disconnect in pharma is the pill needs to do it all when in most realities it is a holistic effort. so whatever works has to work really well so that even the most normie goyslopped pufa eater gets at least some results

Well seen, for the impact of deiodination. When halogens take the place of iodine on thyroid receptors, it's hard to get the right amount of active hormones (T3). And the problem is all the more serious / harmful for women: fight between thyroid and breasts to capture circulating iodine. iodal would be then required; not just the RDA (150 mcg; much higher). A protocol must be followed. Halogens: Fl > Cl > Br> I. (stronger force of attraction for bromine). In iodine-sufficient areas, the adult thyroid traps about 60 μg of iodine/day, either from dietary iodine or from iodine released during thyroid hormone therapy. But much higher for iodine when there is inflammation or an immune reaction (mastocytose). Additional info Why does bromine displace iodine? The bromine displaces the iodine from sodium iodide as it is further up in group 7 and therefore more reactive than iodine. Iodine is lower down in group 7 and therefore less reactive than chlorine and bromine. Electronegative elements have the property to remove electrons form the elements to which, it is attached. Fluorine is an extremely powerful oxidizing agent. The oxidizing power of the halogens varies in the order: F2 > Cl2 > Br2 > I2 The order of reactivity is chlorine > bromine > iodine. This is because chlorine could displace bromine and iodine, bromine could only displace iodine, but iodine could not displace chlorine or bromine. Explaining the trend: When an element in group 7 takes part in a reaction, its atom's outer shells gain an electron and form negatively charged ions, called anions. The less easily these anions form, the less reactive the halogen. When the atoms become larger, the outer shell becomes further from the nucleus. The force of attraction between the nucleus and the outer shell decreases. An outer electron is gained less easily. The halogen becomes less reactive. Source: BBC - Halogen displacement reactions https://www.bbc.co.uk/bitesize/guides/zg337p3/revision/3#:~:text=The order of reactivity is,not displace chlorine or bromine.

@alfredoolivas said in The pro-thyroid effects of ethanol (lowered TSH & reverse T3, increased uptake and thyroid receptor expression): A possible mechanism for this effect is ethanol’s interaction with the thyroid system. Rather than increasing thyroid hormone secretion, ethanol appears to remove obstacles in the thyroid hormone pathway, allowing more of it to enter cells and activate its receptor. Firstly, in humans, ethanol appears to lower TSH without affecting circulating thyroid hormone levels. This suggests that it increases the thyroid gland’s sensitivity to TSH signals. Great thread. Just don't forget to pay the piper. There may be other ways to "remove obstacles" if and while a debt is paid. https://leadtheway.substack.com/p/thyroid-and-water-homeostasis

@DavidPS Would a "27% increase in fat oxidation" really be a good thing? Wouldn't that FAO increase in turn decrease OXPHOS, per the Randle cycle?

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