@LucH Exactly; my first thoughts were it's completely theory-based and is designed to sound factual and kind of give hope, but I couldn't describe it in words; "buzz" is the perfect word thank you

@DavidPS Thanks, and as always thanks for the supplementary info, that's perfect.

@Ismail You're welcome

@CrumblingCookie sadly dopamine agonists are not usually prescribed to patients, even in Parkinsons, as they usually just prescribe Levodopa, so of course none of these drugs are commonly prescribed. Pramixepole is the new dopamine agonist and that increases noradrenaline, and as far as I know, Amantidine and especially memantine, are commonly prescribed off-label, for many conditions such as MS and depression. Why isn’t Bupropion a good DA reuptake inhibitor? It’s even combined with naltrexone, in a formula called Mysimba, which creates an anti-opioid, anti endotoxin, pro dopamine and noradrenaline effect

@William-Shat said in Effects of Maca on Physical Performance in Animals and Humans: flattered or baffled Humour in the middle.

https://www.sott.net/article/221013-Health-Benefits-of-Smoking-Tobacco https://www.sott.net/article/338885-A-comprehensive-review-of-the-many-health-benefits-of-smoking-Tobacco https://www.sott.net/article/139304-Lets-All-Light-Up https://www.sott.net/article/229156-Lies-Damned-Lies-400000-Smoking-related-Deaths-Cooking-the-Data-in-the-Fascists-Anti-Smoking-Crusade

Green Tea Catechins and Skin Health (2024) Green tea catechins (GTCs) are a group of bioactive polyphenolic compounds found in fresh tea leaves (Camellia sinensis (L.) O. Kuntze). They have garnered significant attention due to their diverse health benefits and potential therapeutic applications, including as antioxidant and sunscreen agents. Human skin serves as the primary barrier against various external aggressors, including pathogens, pollutants, and harmful ultraviolet radiation (UVR). Skin aging is a complex biological process influenced by intrinsic factors such as genetics and hormonal changes, as well as extrinsic factors like environmental stressors, among which UVR plays a pivotal role in accelerating skin aging and contributing to various dermatological conditions. Research has demonstrated that GTCs possess potent antioxidant properties that help neutralize free radicals generated by oxidative stress. This action not only mitigates cellular damage but also supports the repair mechanisms inherent in human skin. Furthermore, GTCs exhibit anti-carcinogenic effects by inhibiting pathways involved in tumor promotion and progression. GTCs have been shown to exert anti-inflammatory effects through modulation of inflammatory signaling pathways. Chronic inflammation is known to contribute significantly to both premature aging and various dermatological diseases such as psoriasis or eczema. By regulating these pathways effectively, GTCs may alleviate symptoms associated with inflammatory conditions. GTCs can enhance wound healing processes by stimulating angiogenesis. They also facilitate DNA repair mechanisms within dermal fibroblasts exposed to damaging agents. The photoprotective properties attributed to GTCs further underscore their relevance in skincare formulations aimed at preventing sun-induced damage. Their ability to screen UV light helps shield underlying tissues from harmful rays. This review paper aims to comprehensively examine the beneficial effects of GTCs on skin health through an analysis encompassing in vivo and in vitro studies alongside insights into molecular mechanisms underpinning these effects. Such knowledge could pave the way for the development of innovative strategies focused on harnessing natural compounds like GTCs for improved skincare solutions tailored to combat environmental stresses faced by the human epidermis.

@haidut yo, didnt you post something months or years ago on RPF about retinol destroying or detoxing micro plastics?

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@alfredoolivas it appears you are correct on that one! Finally, real progesterone.

Protein is also important for bones. [image: 1735924038351-ae0b3ce5-381c-4ffe-a068-05d5476f1726-image.png]

I believe boron might be important if you consume lots of iodine/iodide, to decrease oxidative stress. I wonder if kelp contains some boron as well.

@Mauritio - I do not recall any mechanism either. My focus was, and still is, on easy dietary changes to extend healthspan.

@DavidPS Thanks for posting. It's nice to see which products you and others are using. Cheers!

@haidut said in IDEALABS STUDY: Estrogen causes prostate cancer (PC), DHT and/or aromatase inhibitor may stop/treat PC: PL24-0935_24DEC24 Haidut have you ever used DHT either transdermally or sublingual?