@lykos (replying so others can see) I left it on indefinitely, didn't wash it off. If I felt I applied too much, I might wipe off the excess with a towel.

@yeyo12 My interpretation of the results were that caffeine co-administration with oxandrolone increased the absorption of the latter via inhibition of PGP.

I've read through this thread again and pulled out some interesting bits for me:

Selenium supplementation, via the metabolite through hydrogen selenite, breaks down collagen. On the plus side this may tackle (liver) fibrosis. The drawback is broken down collagen (hair, skin) and a therefore probably significantly increased demand for resynthesis from glycine, ascorbic acid, prolin (via ornithine/arginine/citrullin).

The control feed + cysteine studies in rodents and the GlyNAC studies in humans sort of tell the tale:
If not doing MetR + CysR then a regular diet supplemented with cysteine actually consistently looks better in several aspects including body composition, fat pads, strength, inflammation. Peculiar.
The control feed + cysteine in rodents resulted even in better looking markers than MetR + cysteine. Strange.

I surmise there must be crucially overlooked specific discrepancies in the transfer of mice study results to humans. Perhaps not least because glutathione is much more crucial for redox homeostasis and substance conjugation in non-ascorbic-acid-synthesizing humans in comparison to mice. Bridging to 4):

Regularly increased glycine and citrulline intakes to both balance the relative ratio to and the absolute uptake of Met and to scavenge methyl groups in the metabolism after absorption do appeal.
Very obviously, large protein intakes are bad for longevity not merely because of mTOR activation. Eating a typical protein composition but in low to moderate amounts only as in the previously quoted low-protein diets enhanced by extra glycine and citrulline (+proline) appeals. The latter will also benefit the maintenance and rebuilding of collagen structures and allow for use of selenium supplementation to reap to a large extent the quoted increase of fgf21.

@Mauritio said:

Glycine also lowers its absorption. Although it's more true to say that methionine lowers glycines absorption , IIRC up to 86% !
"...l-Met uptake is very potently inhibited by l-arginine, l-citrulline, l-lysine and l-isoleucine in the rat intestine 53. "

So if Met inhibits Gly absorption, and Cit inihibits Met absorption,
then Gly+Cit is ought to bring about win-win conditions.

@ThinPicking ok

@sphagnum
I thought warts were common in children and not so much in adults? German New Medicine has ideas on why we get warts and why on different limbs/hands or feet. For example, separation and distance anxieties relate to warts on feet; wanting to remain somewhere after moving, etc. I'm not sure the explanation for hands/fingers.

@tocovit I was reading about stacking Mildronate & Pyrucet, trying to figure out how much is known about how they might synergize or conflict. I read the entire 31-page Pyrucet thread at RPF/LTF and only saw a few people discussing it. Does anyone have any theories, studies, experiences or thoughts about stacking these two?

Is there any reason your dosing of these two is so moderate, given that you're going nuclear?

Your "moderation in moderation" is a commendable philosophy I can endorse.

I was hoping someone might have tried this stack and provide reports with doses like 500-1000mg Mildronate and 20-to-40 drops of Pyrucet per day, maybe divided by two BID.

Interesting post. Keen to see any updates.

@LucH You get enough cysteine from protein foods.

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
https://pubmed.ncbi.nlm.nih.gov/20871132/

Glutathione (GSH) drives cancer metastasis by promoting cell survival under hypoxia
https://haidut.me/?p=2816
https://doi.org/10.1158/2159-8290.CD-24-1556

When I was in Mexico City, I tried going to a pharmacy and stocking up on cynomel and cynoplus but the pharmacist told me I needed a prescription. I've heard some places have a doctor nearby that will prescribe whatever you needed but I didn't ask since I usually get it from meds.com.mx I figured I'd just get it once I got back home.

@alfredoolivas thank you, I will definitely look into it

@sunsunsun Hell no.

Elderberry and quinine synergistic against influenza virus.
https://pubmed.ncbi.nlm.nih.gov/40218964/

"Notably, six of the 32 compounds demonstrated significant antiviral activity in an in vitro TZM-bl assay against two strains of HIV-1 virus, CXCR4-dependent NL4-3 virus and CCR5-dependent BaL virus. "
https://pubmed.ncbi.nlm.nih.gov/39314315/

@sunsunsun Sushi is breaking bad 🙁

@TexugoDoMel, thanks for the tables. Interesting, indeed.
Do you have a reference paper for the tables?

@LucH

Thank you for the detailed response and for confirming what I was worried about, which is overdoing the vitamin E supplementation.

I have a 400 IU supplement, so I will be taking that 2-3x a week, depending on my inflammatory status! (I think I’ll start with 3)

@lobotomize do you have labs showing you have high rt3? I take 200mcg of t4 and I have no symptoms of high rt3, get enough selenium from diet and don’t eat more than 4g of pufa and you are fine

@user2 said in How many eggs?:

@GreekDemiGod said in How many eggs?:

@user2 It didn’t raise Testosterone when he ate an absurd amount of it, like 10+ daily.

how many eggs was he eating prior?

*He(Hans) consumed:

1000 eggs in 30 days 15 large oysters a day for 30 days 250g of beef liver for 30 days
But nothing was as health-promoting and anabolic as 5L of milk a day.*

@sunsunsun lmao

@Insr said in Low Glutamate Diet:

The low glutamate diet

I'd take 0.5 g taurine.

useful info:
B6 PLP and taurine
To dampen glutamate's excitatory effects in the brain, the body converts it into the inhibitory neurotransmitter GABA (gamma-aminobutyric acid).
Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, is an essential cofactor for the enzyme glutamate decarboxylase (GAD), which catalyzes this conversion of glutamate to GABA.
Deficit in B6 when suffering from low-grade inflammation.
GABA helps maintain a healthy balance between neural excitation and inhibition. A deficiency in B6 can lead to reduced GABA synthesis and neuronal hyper-excitability. Mind the excess of B6 PLP (break). Do not use B6 PNP (neuropathy when above RDA). High doses of the vitamin B6 form pyridoxine (PN) can cause brain and nerve problems, though the primary effect is damage to peripheral nerves.
Taurine
The amino acids that can help dampen or balance glutamate activity include taurine, L-theanine, and the branched-chain amino acids (BCAAs).
0.5 g 2x/d.
NB: When I take L-glutamine (in case of thin linen stomach => acidity is painful), I balance with taurine.

Most excellent and correct.

the only thing holding back is a handful of retards

Small engineering issue, no problem.

That’s great, @sunsunsun! Your dog is a lucky girl to be fed so well. 🙂