@cs3000 said in Microplastics – known endocrine disruptors- found in blood, gonadal organs:

@Mauritio pectin interaction
https://phys.org/news/2022-06-interaction-nanoplastics-pectin-water-soluble-polysaccharide.html
https://www.sciencedirect.com/science/article/abs/pii/S2213343722009277

https://www.tandfonline.com/doi/full/10.1080/10643389.2023.2195798#d1e1308
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312509/

Thanks that's awesome.

Apples for the win (again).
And the amount was pretty small as well at 15mg/L .

"...ingested MPs can pass through the gut barrier, be translocated through the systemic circulation, and accumulate in distant tissues including the brain, liver, and kidney."
That's pretty concerning though. And I don't know if pectin would help with micro plastics once it has accumulated, since pectin doesn't absorb and should only take care of the MP that is present in the stomach or gut as long is it's present.

Maybe modified citrus pectin (MCP) would be a better option in that case because it actually does absorb.

Hi
I’ve been inquiring about nattokinase and serrapeptase (or serrapeptidase) because I wanted 15 years ago (I’m 71 years old) to attack fibrin plaques. These are the only enzymes supposed to do this job. They are proteolysis, as said by Yerrag, but with a specifity:

these enzymes only target died / necrosis tissues, not the wealthy ones.

At least there are supposed to do so, because after a while – let’s say +/ 6 weeks – I felt I had to stop: sensitive throat. Nothing important but enough to say the job had been done. I said to myself: better stop here if you don’t want a counter-side effect. Not really rationale.

By the way, you need to get informed on what is able to protect membranes (in short: Vit E, K and beta-carotene). But not at the same time !! (Vit E and K1 have anti-aggregation anti-coagulation effects). Thus mind with blood pressure medications.

Moreover, don’t trust the advantages given by a labo or a seller. Only from a medical study.

Info on serrapeptase
http://mirzoune-ciboulette.forumactif.org/t1251-agents-naturels-pour-lutter-contre-le-biofilm-bacterien#13696 (in French; translator needed but with interesting links, in English)
What is Serrapeptase? How does Serrapeptase work?
Serrapeptase reduces pain and inflammation in three different ways:

Serrapeptase breaks down fibrin, which is a protein involved in blood fluidity and coagulation. Serrapeptase reduces fluids associated with inflammation. This allows rapid drainage far from the inflammation site and leads to faster recovery times after an injury or surgery. Finally, the Serrapeptase has the ability to partially relieve pain by blocking the release of bradykinin in damaged tissues. Bradykinine is a protein responsible for triggering a painful response.
Comment (Luc): OK but not so effective in reducing the inflammation. The mechanisms of action of Serrapeptase (SP), on the sites of the various inflammatory processes consist fundamentally in a reduction in exudative phenomena (swelling with effusion of liquid) and inhibition of the release of inflammatory mediators. Thus interesting as extra agent. A facilitator (That makes it easier to recover).
Biofilm and Serrapeptase
A proliferation of bacteria prevents the mucosa of the small intestine from absorbing vitamins and minerals. This situation can prevent the large intestine from absorbing fats and amino acids. When they are invaded by a bacterial film, the intestines cannot return the bile salts to the liver, and the excess cholesterol is not recycled (...)
Some examples of selected products are given, all with enteric coating (or equivalent).
Note: Serrapeptase is easier to find than nattokinase.

About nattokinase, a member of Chris Kresser’s forum has reported (Prioris, April 4, 2014 at 5:41 pm)
In the case of a patient, with a poor arterial profile, former smoker and overweight, Chris Kresser advised, in the event of narrowed coronary arteries whose blood circulation is 70 % blocked:
Use nattokinase. It is a natural clot buster. It works. I had severe peripheral artery disease and could hardly walk. Nattokinase took away all the symptoms within a month. Been well for last 10 years. There are no side effects and no worry about taking too much. It takes a couple months to remove most of the blockage. Doctor’s Best brand is brand I use.
Take 4000 FU, 3 times a day on empty stomach for first months and then use when waking and going to sleep. You could also take some serrapeptase with it. Maybe 40,000 IU.
Long term maintenance is 2000 FU in morning and/or night (before bed is best time to take it).
If you want to research it further, look up fibrinolytic enzymes. Also look up cholesterol myths.
My other advice (prioris speaking):
do not take aspirin while taking it.
do not take vitamin K2 since it is a coagulant while clearing blockage
do not take blood pressure medications because they can irreparably damage your health.

@oliveoil yea i have tried gelatine, collagen, bone broth.. everything.. doesnt seem to make a difference

@edouard You live in a very beautiful place.

You accidentally turned yourself into a himbo. I'd get your other hormone levels checked out.

@BeamsOfEnergy I’ve used it both. Usually I use topically on my wrists. Take 5-8 drops. Although the first time I only tried two. As others have said it seems to become less potent after extended uses so I’m going to cycle it

Had a little less than 1/2 tsp in some water a couple of nights ago. It didn't put me to sleep but it was one of the better and more restful sleeps i've had recently, and yes i woke up gently/easy. I do wonder if there's any connection.

Have also been using baking soda in other ways for quite a while, just a bit in my coffees and juices, etc.

@metabolicmilk

I could not get vitamin E to mix with DMSO, I would not recommend this. Unless you’re talking about dissolving d-alpha tocopherol acetate in DMSO. That may well work, but according to Ray the acetate ester is about 50% as effective as the nonesterified tocopherols.

@wester130

my final solution

thiamine
niacinamide
magnesium taurate
potassium bicarbonate
caffeine - only 0.1%

@BeamsOfEnergy Yes i take 1 drop every hour

@LetTheRedeemed said in American presidential election 2024:

@yerrag well, there’s a trend amongst conservative evangelicals to embrace traditional Catholicism and orthodox denominations, it’s a meme now I’m sure you’re aware of, called tradcath. I don’t think it’s a conspiracy akin to the old WASP anti-Catholicism sentiments.

I mean I'm relatively the same; grew up rural southern anti-catholic, and the subsequent culture wars showed me that catholics were always my friend -- then found orthodox to be way more conservative. These two denominations were basically the reactionaries in all the color revolutions, and protestants were often at least a few of the thought leaders in the general pro-revolutionary direction. I'll always be protestant, but I have friends who have gone orthodox after being raised protestant.

Really the only churches thriving right now in America are orthodox and Charismatic.

@LetTheRedeemed said in American presidential election 2024:

@yerrag well, there’s a trend amongst conservative evangelicals to embrace traditional Catholicism and orthodox denominations, it’s a meme now I’m sure you’re aware of, called tradcath. I don’t think it’s a conspiracy akin to the old WASP anti-Catholicism sentiments.

I haven't been following, but I sensed that once bitter enemies in the 80s have come to share some unity in the face of assault by woke forces in a cascading torrent. The movement to relative Catholic thoughtfulness from the simplistic salvific magic bullet acceptance of Jesus as savior by Evangelicals is as significantly analogous to the move by Peatarians from the deer on headlights hexing by mainstream medicine. But that is far too little to make significant changes in the political scene, as heavily dominated by the majority who are conditioned to always be led by manufactured fears and can never be awakened to reality. Even when awakened, they can not act as action is always superseded by supplication to a messiah who will come to save them, which at best is being Christian, whether Catholic or Evangelical.

The main distinction of Jesus' New Testament is the call to "Love Thy Enemy." This is a radical departure from religions and philosophies and is the Achilles heel of Christianity. It has always been gamed and taken advantage of by Talmudist system lords, which over 2 millenia have gradually and consistently gained wealth and influence and power under the shadows, playing puppeteer to both secular and religious powers in the Christian sphere.

Between two protagonists, one that shows love for his enemy will keep losing to the one who considers himself entitled to treat his Gentile protagonist as a beast of burden by entitlement and privilege by his god.

One will always be magnanimous and merciful in victory, while the other will annihilate and wipe his adversary and hia descendants off the face of the earth.

Over time, all people of noble stock and good hearts and great courage have become extinct, leaving behind the meek to be made into pulp at the discretion of the class and race that remains on top.

I mean I'm relatively the same; grew up rural southern anti-catholic, and the subsequent culture wars showed me that catholics were always my friend -- then found orthodox to be way more conservative. These two denominations were basically the reactionaries in all the color revolutions, and protestants were often at least a few of the thought leaders in the general pro-revolutionary direction. I'll always be protestant, but I have friends who have gone orthodox after being raised protestant.

With all the Fentanyl being used to weaken and destroy the fiber of the heartland, it matters very little which denomination one is. It is a blur to them who inflict gradual extinction of peoples and culture.

Really the only churches thriving right now in America are orthodox and Charismatic.

Yet they are as good as sitting ducks.

Thanks for the heads up on IL-11. It seems that it not only extends lifespan by almost 25% but it also extends healthspan. There are anumber of ways to increase lifespan by 10% but 25% is much less common.
807c445b-cc68-44cf-9bc6-3ccd7974578b-image.png

IL-11 inhibition is similar in effect to rapamycin (Sirolimus).

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

@LetTheRedeemed said in "Glucose Loading" protocol, a la Dr Stephens - A Critique:

@yerrag

That carbohydrates raise serotonin as a matter of certainty is dependent on the idea that carbohydrates always raise insulin, which I would say isn't always the case.

I agree, Ray has stated on multiple occasions that to reduce the insulin spike from protein, to consume a sugar item approximately 15 minutes before the meal (meal also well balanced with carbs).

So I would agree also that certain conditions be met for sugar to raise insulin, or indeed be problematic as I’ve described. I would assume Clearly there’s more to the mechanism than is being described here. Also, I don’t know that insulin itself is the only problem. When I did some “high insulin” experiments (eating the most “insulinergic” foods recorded in databases), I felt great. Ray himself has implied insulin can be good if I remember correctly (also if I remember Georgi correctly).

I’d like to know the mechanisms of action for excess sugar raising serotonin more specifically.

A keyword search with the DocSearch+ app in my phone shows much of what Peat has to say to say about insulin to be negative.

Perhaps you recalled Ray in his March 2021 newsletter saying this:

Many years ago Gaetan Jasmin (1956, 1968)
showed that low blood glucose intensifies abnor-
mal inflammatory reactions, and that increasing
blood glucose minimizes dangerous anaphylactoid
reactions. It’s the oxidation of glucose (producing
carbon dioxide), which is favored by warmth and
the right amount of insulin, that can prevent
inflammation (Razavi Nematollahi, et al., 2009;

Also:

W. Adamkiewicz showed that reducing blood
glucose with insulin greatly intensified aller-
gic reactions, while increasing blood glucose
prevented deadly anaphylaxis, but weakened
resistance to infection. Energy metabolism
governs the effectiveness of the immune
process, including the avoidance of autoim-
munity (Gaber, et al., 2017).
Metabolic energy is involved in every
aspect of the covid infection, but that has been
denied or ignored because of a traditional,
ideological understanding of immunity.

Sep. 2021 Ray Peat Newsletter

He qualified with "the right amount of insulin (first citation)" which I believe to not be the case when blood sugar is not well-regulated, with yoyos from high to low.

Although I have not heard Ray consider insulin as a stress hormone, I would consider it to be such, and the less of it the better although I would be hesitant to be deprived of it, in an emergency situation. But that is the nature of stress hormones, to be there in emergencies and only in emergencies, and not to be availed of regularly.

Re: serotonin and insulin, a search result:

At puberty, there is a sudden increase in the
incidence of depression, especially in girls.
Increased adrenaline, like increased cortisol, is a
feature of depression, stress, and inflammation;
mobilizing fats, it can become part of a vicious
circle, in which free fatty acids cause insulin resis-
tance, activating the stress reactions. Increased
serotonin is a feature of inflammation, shock,
stress, and depression, and, like histamine, is tied
very closely to estrogen's effects.

Feb 2001 Ray Peat Newsletter

I thought this was a 'new' EH, but as it's the same one. Just reread the related note on RPF. And let it be. (Please. If I must.)

And this thread is a disgrace. Careful with the ether.

Makes sense when B1 is needed for mitochondrial respiration, but not the only one needed.

Appropriate?
.
13f34891-cda5-4d50-9a1d-cee94e6bfc6b-image.png

@Shar_to_the_dae Cool, you'll love it, are you from the spanish or french side?

Many times without any problem. I swim with the sensations and adapt the solutions to each situation.

Friends, to all naysayers: you are going too far with your thinking.

I use AI to get answers faster and what I do today to help myself and others with health, I could do maybe in 5 years of intensive learning without AI.

I do not refer to all the beautiful theories because they are not relevant to my reality. In reality, to get real benefit from AI, you have to learn to work with it correctly. Just like the difference between one person and another person searching for answers on Google.

For example, using AI to get an answer to a question like "How to treat anxiety?" And applying his answers is as bad as searching on Google and acting on the first result. It uses me as a much more effective and faster research tool than Google.

And all the naysayers with the beautiful theories: I understand that you don't use search technology to learn. Do you only use old books that gather dust?