@engineer Reporting back on this: CrumblingCookie said: Topical application on the lower abdomen reportedly does not bring about these tense and stressful cardiovascular sensations. Lower abdomen application consistently caused the same. Only more delayedly after a few hours in comparison to the rather fast onset by application on the chest/thorax. Surprisingly, however, it showed that increasing thyroid hormones alleviated this dis-ease. Assumedly and in line with many thoughts before this the extra DHT administration spotlights basic metabolic insufficiencies. Wouldn't limit this to thyroid hormones at all but expand the need for them into a wider picture of metabolic disturbances (which supplemental thyroid hormones may or may not cover-up in part). I.e. no shortcut to better health but more like a possibly powerful booster to override adverse effects from other supps or habits when already in good metabolic health IMO.

@rohmilchbubi said: I've completely updated the essay, improved its readability, and added images to better convey the subject matter. However, this is the final version. The site's yours?

He said he was going to get "hearing aids", he said he has "mild to moderate hearing loss".

@haidut I am wondering if it is really inflammation that is causing mitochondrial dysfunction and not the other way around. I have a large store of bacteria that I keep having to kill and each time there is a kill plenty of endotoxins are released and they are a major source of inflammation. And it suppresses mitochondrial activity to the point that even the conversion of cholesterol to pregnenolone and downstream prosuction of hormones and steroids are very much affected. To such effect that taking hormones like thyroid and pregnenolone and progesterone can hardly make a dent. I had to inhibit the nfkb inflammatory response using turmeric and black pepper in order to see my cholesterol level go down and my hormonal production go up. But it is hard to keep endotoxins low when there is a large colony of pathogenic microbes and in my case it is feom periodontal infection having translocated to my vascular and lymphatic system where it get more embedded over time especially as it gets protected by biofilms. One way I see out of this conundrum of killing pathogens by relying on our endogenous ROS from our own innate immune system and from use of pharma antibiotics or herbal antibacterials,, which all end up producing endotoxins; is to engage antibacterial peptides such as LL-37 in neutrophils and macrophages - to kill pathogens with the benefit of not leaving behind endotoxins that both inflame and cause oxidative stress. More sunshine to produce high levels of Vitamin D (50-80 ng/dl) together with plenty of butyric acid in the gut gives the body a high endogenous supply of LL-37 to achieve effective antimicrobial activity without endotoxic side effects.

@sunsunsun in case you don't already know, on the old rp forum Haidut said it can be a result of extreme hypothyroidism, over-training or over-excercising

@peatqqq maybe switch the Apple juice for orange juice if it appeals to you. Ray Peat used to caution about mold in (store bought) apple juice. And mold can cause or exacerbate all kinds of symptoms/conditions. I guess if you can juice the apples yourself you'd know that won't be a problem.

So then, Mitolipin to the rescue

Looks like Picard's work supports the "rate of living theory". For example, in his Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging hypermetabolism, defined as "increased energy expenditure", it is concluded that "a robust and specific temporal association be­tween hypermetabolism and premature cell death, aligning with pro­spective observations in the human literature where hypermetabolism increases mortality risk. Finally, our experimental modulation of OxPhos and total J_ATP suggest that total energy expenditure, rather than flux through mitochondrial OxPhos, may have a particularly influential ef­fect on cellular aging". Hmm... but the references that they use could be mined further for some gems.

@LucH A lot of good information, thank you.