has anyone ever considered scar gels for hair loss? there is a lot of overlap with healing the skin and TGFb-1 many of them contain interesting ingredients that would stop inflammation in the scalp

@haidut There are many ways to deplete GSH in cancer cells e.g. arsenic AI Arsenic exposure causes significant glutathione (GSH) depletion by increasing reactive oxygen species (ROS) and directly binding to sulfhydryl groups, leading to oxidative stress and reduced antioxidant capacity in blood and tissues. Depletion of GSH sensitizes cells to arsenic-induced apoptosis, frequently utilized in cancer therapies (e.g., leukemia) to enhance the efficacy of arsenic trioxide. Mechanisms of Arsenic-Induced Glutathione Depletion Oxidative Stress: Arsenic exposure increases ROS, which consumes GSH, a crucial cellular antioxidant. Direct Binding: Arsenic binds directly to glutathione and other thiol-containing proteins. Inhibition of Synthesis: Exposure can reduce essential raw materials for GSH synthesis, such as cysteine and glutamate. Enzyme Activity: While glutathione-S-transferase (GST) activity might increase in response to stress, it often results in a net decline of the GSH pool. Significance of GSH Depletion Increased Toxicity: Lowered GSH levels render cells more vulnerable to arsenic toxicity. Cancer Therapy: GSH depletion (e.g., via Buthionine sulfoximine, BSO) enhances arsenic trioxide's ability to kill cancer cells, as shown in leukemia studies. Reduced Detoxification: Impaired GSH levels impair the body's ability to methylate and excrete arsenic. Consequences and Mitigation Oxidative Damage: Depletion causes significant decreases in brain and blood protective enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx). Therapeutic Approaches: Antioxidants or chelators, such as MiADMSA, have been shown to be effective in restoring GSH levels and reducing ROS induced by arsenic. gold nano-particles https://www.sciencedirect.com/science/article/abs/pii/S138589472501232X auranofin -indirectly https://pmc.ncbi.nlm.nih.gov/articles/PMC8777575/ silver nano-particles https://www.sciencedirect.com/science/article/abs/pii/S0378427410017984 https://thesilveredge.com/clinicalstudies/ selenite and selenate https://pubmed.ncbi.nlm.nih.gov/10406889/

@cedric good info

https://www.youtube.com/watch?v=VTchFM3wb68

@bio3nergetic We must remember that vit.A , retina/brain/LRAT require phospholipids/lecithin Lecithin forms cell mambranes and we lose it while aging Perhaps some forms of vit.A "toxicity" could be a lecithin deficiency AI Lecithin supplementation has shown potential in supporting retinal function, primarily through its role in enhancing the bioavailability of nutrients essential for eye health and as a component of specialized medical treatments. Lecithin, particularly in the form of lecithin-bound iodine (LBI) or phosphatidylcholine, is associated with improvements in retinal pigment epithelium (RPE) health, tear film stability, and the reduction of oxidative damage in the retina. Key Findings on Lecithin and Retinal Function: Retinal Pigment Epithelium (RPE) Protection: Lecithin-bound iodine (LBI) has been used in Japan to treat retinal diseases, including central serous chorioretinopathy. In studies, LBI was shown to prevent hypoxic damage to RPE cells and suppress inflammatory responses (such as CCL2 secretion), suggesting a protective effect on the retinal structure. Retinal Degeneration and Function: In animal models of retinal degeneration, a lecithin-containing diet improved retinal function, as evidenced by higher b-wave amplitude in electroretinography (ERG) tests compared to control groups. It was found to reduce the invasion of macrophages into the retina and decrease inflammatory markers. Enhancing Nutrient Absorption: Lecithin acts as an emulsifier that helps the body absorb and utilize fat-soluble vitamins, including Vitamin A, which is crucial for producing visual pigments in the retina and maintaining photoreceptor function. Exudative Age-Related Macular Degeneration (AMD): Research into the use of iodized lecithin tablets for exudative AMD indicated a potential positive impact, with studies reporting improved visual acuity and reduced retinal thickness in treated groups compared to control groups. Tear Film Stability (Dry Eye Disease): Sunflower lecithin supplementation has been shown to improve dry eye disease (DED) symptoms. As a rich source of phosphatidylcholine, it may enhance the lipid secretions from the meibomian glands, stabilizing the tear film. Retina Protection against Toxicity: Studies on rat retinas indicate that lecithin can help maintain the structural integrity of retinal proteins (specifically α-helix and β-sheet ratios) when exposed to oxidative stress, potentially reducing damage from, for example, chemotherapeutic agents like ifosfamide. Important Context: Lecithin-Retinol Acyltransferase (LRAT): Lecithin:retinol acyltransferase is an enzyme crucial for the metabolism of Vitamin A in the retina. It helps convert all-trans retinol to all-trans retinyl ester, a key step in the visual cycle. Limitations: While promising, some uses of lecithin, specifically lecithin-bound iodine, have limited clinical trials outside of Japan, and many findings are based on preclinical or older studies. In summary, lecithin supplementation, particularly when containing iodine or as a source of phosphatidylcholine, may support retinal function by improving structural integrity, reducing inflammation, and increasing the absorption of necessary nutrients, according to research.

@user73636 Vit. K3 and C can bypass Q10 to cyt.c Vit .K3 is intermediate to K2 https://pmc.ncbi.nlm.nih.gov/articles/PMC5953218/

@alfredoolivas just bribe you doctor if you rich enough to import t3

@user73636 SIRT 1 binds to NAMPT and deactylates it, reactivating it https://bioenergetic.forum/topic/9084/microgram-doses-of-nicotine-improve-the-nad-nadh-ratio-independent-of-the-acetylcholine-receptor.-....big-increase-in-neurogenisis-improves-inflamation-cognition-blood-sugar-and-anxiety.-triples-bdnf-and-causes-a-30-fold-increase-in-doublecortin?_=1771443781283

Addendum: Phytol's major metabolite phytanic acid has a half life of 15-20 days! I couldn't really figure out my dosage and felt like effects lasted relatively long. I thought it had to do with a biphasic effect on GABA-A, which also makes things confusing sometimes . But I think it's probably the long half life. Not necessarily a deal breaker, just something to keep in mind.

@Chud said in Cynoplus sources in US: @Ecstatic_Hamster did you recieve it? I did. All good.

Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/

@Maximalus Chill. When buying candy online be used to long delivery times

@AlphaZance Thanks Treatments of old neurons with energy precursor and Nrf2-inducer restored GTP levels and size of vesicles in both genotypes. A Free/bound GTP levels (a) and bound/free GTP levels (b) in untreated old age (20 months) nTg neurons. Treatment of old age (23 months) nTg neurons increased the free/bound GTP levels in the cytoplasm and dendrites (c) and reduced the bound/free GTP levels (d). B In untreated old age (26 months) 3xTg-AD neurons, free/bound GTP levels (a) and bound/free GTP levels (b). In old age 3xTg-AD, the decay observed in free/bound GTP levels was restored to basal levels with combination treatment (c), reducing the bound/free GTP levels (d). Red arrows indicate accumulation of vesicles in both genotypes. C Treatment restored the free/bound GTP levels in old age nTg neurons. D In 3xTg-AD neurons, combination treatment prevented the decrease in free/bound GTP at middle and old ages. Each point is the mean of 7–10 fields from each mouse culture (N cultures). E A large increase in vesicles with bound GTP was observed in old age in both genotypes. Different lowercase letters and numbers indicate significant differences (p < 0.0001) after Tukey correction for multiple comparisons. F, G Treatment with nicotinamide and EGCG combination reduced the number of bound GTP vesicles in old age neurons in both genotypes (nTg: young 2 months and old 24 months; 3xTg-AD: 2 months and 18 months) [image: 1771192669693-a36d9d08-6f56-4545-889c-19b5359325ce-image.png] Treatment of age-related decreases in GTP levels restores endocytosis and autophagy (2025)

The Effect of Ergothioneine Supplementation on Cognitive Function, Memory, and Sleep in Older Adults with Subjective Memory Complaints: A Randomized Placebo-Controlled Trial (2025) Abstract Ergothioneine is a diet-derived antioxidant with emerging evidence of neuroprotective benefits, but no dose-ranging study has evaluated its effects in healthy older adults. In this 16-week randomized, double-blind, placebo-controlled trial, 147 adults aged 55–79 with subjective memory complaints received ergothioneine (10 mg or 25 mg/day ErgoActive) or placebo. The primary outcome was the change in composite memory (CNS Vital Signs). Secondary outcomes included other cognitive domains, subjective memory and sleep quality, and blood biomarkers. At baseline, participants showed slightly above-average cognitive function (neurocognitive index median = 105), with plasma ergothioneine levels of median = 1154 nM (interquartile range = 889.9). Plasma ergothioneine increased by ~3- and ~6-fold for 10 mg, and ~6- and ~16-fold for 25 mg, at weeks 4 and 16, respectively (p < 0.001). 25 mg ergothioneine showed a within-group improvement in composite memory at week 4 (p < 0.05), although this was not sustained. Reaction time improved in both groups, dependent on time. Other domains showed null or limited effects. Subjective prospective memory and sleep initiation improved dose-dependently, with significant effects at 25 mg (p < 0.05). Liver function improved and a within-group increase in telomere length was noted. In conclusion, ergothioneine supplementation was safe and well tolerated, with evidence suggesting some benefits in this cohort of healthy older adults. Longer trials in individuals with lower baseline ergothioneine or cognitive function are warranted. [image: 1771192596623-4ac86e7b-a668-461a-adad-aa8891d4c572-image-resized.png]

@cyberpeater22 said in is juice from concetrate good: No, why? You asked for advice and afterwards you became suspicious, not to say more. The same behavior ...

you aren't thinking coherently or logically. your logic is flawed and biased, just my 2c. Hope you would rethink this biased emotional behavior controlling you, it would benefit your future greatly.

@Gamma I think you could contact shipping forwarding services where you ship to them and they ship to you, if you ask them then maybe its possible for them to add new ice before shipping to you and this would allow you to buy raw grassfed frozen colostrum from USA and many other countries. I was thinking of doing this myself. It would also be ideal if the service can ship it fast to your country aswell ofcourse

@dapose i am too much of a retard to deal with making coffe in various way, and instant coffe tastes sour, thanks for your advice