@basebolt I’ll have to give lithium another try. I got some (orotate) to try and easy ADHD symptoms. I didn’t notice anything drastic, but maybe I didn’t get the dose right. Was doing 5mg daily.

@Phoenix007 I could only tolerate hcl at first, tried ttfd but my stomach got all upset. I had to slowly increase my hcl dose, together with magnesium.

Think it's called the paradox reaction, that you get worse until you get better. Took 2-3 months for me until I could take ttfd.

When there is money there is always a vested interest, ttfd got shilled massively by that elliot dude. That business 101, try to create some sort of monopoly and then shill your product - he has the ttfd without excipients.

Try ttfd it's not that expensive but be vigilant.

@wester130 Not sure, I don't wear glasses.

are your balls hot often or do you have a varicocele?

@sunsunsun said in 'Nutrition for Women' is now available on Amazon via Ray Peat Publishing.:

yeah because I engaged in the disgusting discourse myself before xD

@ThinPicking said in 'Nutrition for Women' is now available on Amazon via Ray Peat Publishing.:

I do but you're missing a humour.

I take it back. A bit.

@teamfortress https://bioenergetic.forum/post/64

@oven Be careful with aspirin once sunburned. It can be useful when taken prior to sun exposure to make you slightly less prone to burning, but afterwards hypoglycemia becomes a serious consideration. Try listening to your cravings when burnt instead of following a protocol.

@Kilgore
I didn’t say to eat 5-600 K/cal. as often read in a 5.2 diet. You’ve well done to attract the attention that when starving the body you could depress the metabolism (brain and thyroid). Always listen to the body reaction and adapt if required, otherwise metabolism will slow down (spare mode).
If we except people with glycemia problems, who shouldn’t follow a low-calorie diet, I said we shouldn’t eat less than 80 % of our needs, on a regular basis. Or you’ll pay it soon or later, with a lack of essential nutrients, on top of that. The problem is not to lose weight, but not to regain the lost weight and gain more on top of it as in 90% of cases.
So to be clear, what I mention:
a) 5 days, I advise to eat / take your usual intake. 100%
Mind the breakfast / the first meal as the insulin reaction of the first meal is going to impact the rest of the day.
If you eat less – no matter why – which I do not advise (no need here to lose weight), don’t eat less than 80 % of you metabolic needs (metabolism + physical expenditure). Focus then on nutrient-dense foods.
b) 2 days a week (not in a row) between 1200-1600 K/cal. So usually 2 meals.
Why this level and not 5-600 K/cal., as often read. Our 3 mains organs require that amount to function well (liver, hart & brain).
Note: If we combine 5.2 with 16.8 – what I try when want to lose excess weight (> 23 BMI), it’s ideal to take advantage (1)
NB: Most of us will have to make staples, to reload energy or to make it easier when encounting a Herxheimer reaction (detox reaction).
It's also normal to stall at some point during weight loss. 2 to 3 weeks is quite common. Don't rush things, or your brain will make you pay (slow-down mode). At that moment, 8-10 days after a pause, you can exercise, but in cardio mode, not in high intensity. For instance bike, quick walk (6 – 8 Km/H) or swimming.
A dynamic pace but manageable over a long distance (30 minutes). Avoid exceeding 120-140 heart rates (80% of MHR)
MHR: 220 – age.
For beginners, and to obtain a more accurate measurement, it is recommended to perform a supervised stress test.

Sources and References

The 16:8 diet, an intermittent fasting method, can potentially offer several brain-related advantages by promoting metabolic switching and autophagy, a cellular cleanup process. These mechanisms may enhance brain resistance to stress, improve cognitive function, and potentially slow down age-related cognitive decline.
Counter-indication: glycemia problems and brain disturbances (emotional instability). Mark Mattson, senior investigator for the National Institute on Aging, which is part of the US National Institutes of Health (NIH), has researched the health benefits of intermittent fasting, as well as the benefits of calorie restriction. According to Mattson, there are several theories to explain why fasting works:
http://fitness.mercola.com/sites/fitness/archive/2013/06/28/intermittent-fasting-health-benefits.aspx?e_cid=20130628_DNL_art_1&utm_source=dnl&utm_medium=email&utm_content=art1&utm_campaign=20130628#_edn6
Note (LucH): I don't take Dr. Mercola's advice for granted. Too biased. Not suitable for everyone.

*) The Health-Promoting Effects and the Mechanism of Intermittent Fasting
J Diabetes Res. 2023 doi: 10.1155/2023/4038546
Health Benefits of IF
IF can trigger autophagy, a cellular process that helps remove damaged cells and promotes tissue regeneration, potentially contributing to longevity and disease prevention.

Insulin sensitivity (HbA1c) Weight Loss by people with high BMI Reduced Inflammation (improving gut health and a healthy gut microbiome) Cellular Repair and Protection

*) Health Benefits of Intermittent Fasting
Microb Physiol 2024. https://doi.org/10.1159/000540068
There are many benefits in losing weight; boosting immunity; countering the risks of diabetes, cancer, and cardiovascular diseases; and slowing the process of ageing. IF studies in animal models suggest that the process induces longevity, improve metabolic health, and positively influences hormonal changes. IF also seems to influence inflammatory reactions, lipid metabolism, and insulin sensitivity.

Other sources
 CMAJ April 8, 2013
http://www.cmaj.ca/site/earlyreleases/8apr13_intermittent-fasting-the-science-of-going-without.xhtml
 Prostate Cancer Prostatic Diseases 2010;13:350-5
http://www.nature.com/pcan/journal/v13/n4/full/pcan201024a.html
 CMAJ March 20, 2013
http://www.cmaj.ca/content/early/2013/03/25/cmaj.109-4437
 Eurekalert, Study finds routine periodic fasting is good for your health, and your heart, April 3, 2011
http://www.eurekalert.org/pub_releases/2011-04/imc-sfr033111.php
 Free Radical Bio Med 2007;42:665-74
http://www.sciencedirect.com/science/article/pii/S089158490600801X
 International Journal of Obesity 2011;35:714-27
http://www.nature.com/ijo/journal/v35/n5/full/ijo2010171a.html
 Washington Post December 31, 2012
http://www.washingtonpost.com/national/health-science/fasting-may-protect-against-disease-some-say-it-may-even-be-good-for-the-brain/2012/12/24/6e521ee8-3588-11e2-bb9b-288a310849ee_story.html?tid=wp_ipad

@nicemushroom17 """Ich bin mir nicht sicher, ich schaue definitiv gut in die Augen der Menschen, besonders bei Frauen, zu denen ich mich hingezogen fühle, oder ob sie ein guter Mensch sind."""
so i will recommend you try out l reuteri as it raises oxytocin similar to gazing into a partners eyes or ejaculation it. you can ferment your own dairy with it so to not need to buy it often

context : l reuteuri is a bonding hormone which raises testosterone and has many benefits only downside from it is that you may become more complaint if it is paired up with high serotonin. as if you believe everyone around you loves you and you love them you may be more receptive to general requests or worse so be aware

@LucH

Thanks for the info!

There are some animal studies on restricting only omega-6, and the effect is to increase the metabolism of omega-3 and decrease that of omega-6:

Fifteen weeks of n-6 PUFA deprivation compared with adequate diet decreased the mean unesterified plasma concentration of n-6 PUFAs by 84% (Table 1). The change in the total unesterified n-3 PUFA concentration was statistically insignificant, although unesterified DHA and EPA concentrations were increased by 53% and 79%

The total n-3 PUFA concentration in brain was increased by 15%, reflecting largely an 11% increased DHA concentration (Igarashi et al. 2009). Expression of enzymes of the 20:4n-6 cascade, cPLA2-IVA and COX-2, was downregulated, whereas expression of DHA-preferring calcium independent iPLA2-VIA (Garcia and Kim 1997; Strokin et al. 2004; Ramadan et al. 2010; Basselin et al. 2011) and of 15-lipoxygenase (LOX) was up-regulated (Kim et al. 2011).

COX-2 mRNA was decreased significantly (−23%, p b0.05) (Fig. 3A) in the n-6 PUFA deprived rats compared with adequate rats, as was COX-2 protein (−32%, pb0.05) (Fig. 3B). The deficient diet did not change COX-1 or mRNA significantly

@Hearthfire said in why is the search function in lowtoxinforum locked behind a paywall:

I really do miss the Ray Peat Forum.

Maybe this one could e/acc with the addition of a 'Political Talk, Alternative World Theories' category and schizoid recruitment drive.

@Milk-Destroyer 1. Yep, 25 capsules and you're right, might've been an issue with the supplement. Although i noticed some positive results like whiter teeth which makes me think it might not be the supplement.

Yes, Cypro was interesting for me too. I think it helped my poops but made me moody and tired to the point where it wasn't really worth it.

You're right, I've stopped everything except thyroid. Interestingly, 50mg Niacinamide makes the diarrhoea from milk less severe. It's still diarrhea so still pretty shit lol

Appreciate your help 🙂

https://testonation.com/2020/06/26/the-high-acetylcholine-syndrome/

@Phoenix007 I’ve been taking close to 7 grams daily (massive amounts, honestly which probably sky rockets brain acTH levels) and I don’t even remember what kind of stupidity led me there. Looking back, it tanked my first quarter year exam scores. I made a lot of dumb mistakes, not because I didn’t know the material, but because I lacked focus and flow.

The likely culprit? Acetylcholine. High levels of it can suppress dopamine, which is essential for flow states. I’ve noticed the same pattern in my game logs: I usually play better toward the end of a match. That makes sense, since acetylcholine gradually declines during prolonged activity, letting dopamine take the lead again.

@teamfortress too many 5-ar inhibitors bro...

https://pubmed.ncbi.nlm.nih.gov/11380153/

Abstract

Hamster flank organ growth, as measured by an increase in the area of the pigmented macule, is androgen-dependent. When flank organs of a castrated hamster are treated topically with testosterone, the flank organ becomes larger and darker. Since this growth is known to be dependent on the intracellular active androgen, 5alpha-dihydrotestosterone (DHT), inhibitors of 5alpha-reductase which converts testosterone to DHT can inhibit the growth of the flank organ. Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid and myristoleic acid, as well as other natural compounds, including alizarin and curcumin, are 5alpha-reductase inhibitors and inhibited flank organ growth. Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders.

@alfredoolivas Do you also have such strong adrenaline and fatigue symptoms when you take doxycycline?

50mg two Times per day

sr 9011 looks interesting/peaty check this thread out https://lowtoxinforum.com/threads/stenabolic.27227/
a list of its benefits mentioned

All the effects observed for SR9009 derive from REV-ERB (NR1D1, NR1D2) activation in the body.

REV-ERB affects the circadian behavior of mice, altering their activity and sleep patterns [R].

Besides its effect on the circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production [R, R].

REV-ERB is mainly found in liver, muscle, and fat tissue:

Liver: REV-ERB affects the rhythm of 90% of the about 900 genes under circadian control in mice liver. It turns off the genes that produce glucose without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduces the inflammatory response (by affecting macrophage production) [R, R, R, R].

Muscles: REV-ERB promotes the burning of fat, increases the activity of mitochondria, and promotes the generation of new while decreasing the destruction of old mitochondria [R].

Fat cells: REV-ERB turns off the genes responsible for storing fat and decreases triglyceride production [R].
In animal and cell studies, SR9009:

Increased oxygen consumption [R]

Decreased generation of new fat cells in the liver [R]

Decreased production of cholesterol and bile acids in the liver [R]

Increased the number of mitochondria in muscle [R]

Increased glucose and fatty acid use in muscle [R]

Decreased fat storage [R]

All three posters above in this thread raise some very good points.

The problem I have with a term like "dopamine fasting" is that the proponents - although well-meaning - make it sound like dopamine release is the villain. It doesn't ask the question why people, increasingly in my observation, feel the need to consume what is called supernormal stimuli in order to increase their dopamine levels. The current dopamine fasting trend sounds like high dopamine releases are the problem itself and not just a symptom.

OP mentions the anecdote with the kid that gave up computer games after abstaining for 30 days. I know people like that from real life, so it's not just anecdotes. But what happens if you abstain for 30 days and your problems are still the same after those 30 days - whether the problem is hormonal or psychological? Wouldn't you just continue doing the same stuff as before? My guess would be that the kid lost the desire for computer games, because he spent time with friends, maybe playing some sports, spent more time outside, and realized that this is actually better than counter strike.

I remember in one episode of the GE podcast Danny asked Dr. Peat about porn addicts, and Peat said something like "I think they just need a girlfriend". While that may have been a partial joke and is not as easy as it sounds, I think there's also some truth to it. If you have the experience that "the real thing" is better, more fullfilling and less shallow than pixels on a screen, that might abolish your desire for the fake alternative.

I have tried meditation in the past and it helps me to just deal with life and become calmer. I have never looked into any connection to thyroid function, so I don't have any input here. The only thing I know is that experienced meditators have more gray matter in the prefrontal cortex and a better connectivity between certain brain areas.