@LucH said in Chris Masterjohn: Salicylates are Toxic:

Still Trying to connect the dots

Indeed. That is the entire challenge — properly connecting the dots.

Useful info on magnesium:
High-Dose Vitamin D Depletes Magnesium – Carolyn DEAN, MD ND.
https://mirzoune-ciboulette.forumactif.org/t2130-dynamique-entre-vitamine-d-magnesium-et-calcium#30339

Excerpt 1:
Magnesium expert Andrea Rosanoff, Ph.D., is one of the few people who understands the dynamic between vitamin D, magnesium, and calcium. She makes it the subject of her 2016 article, “Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?”

Excerpt 2:
Magnesium is required for many steps in vitamin D metabolism, including its conversion from its storage form (which is also the supplement form) to its active form. This means that taking extremely high doses of vitamin D can lead to magnesium deficiency without anyone realizing it.

@PranaDeva I like to snack on parmesan, pickled cucumber, raisins, apples, dried mango. A few sticks of parmesan is tasty and good for teeth. Dried fruit is tasty but not so good for teeth.

@Cicero magnesium acetylsalicylate is more soluble?

@lykos, what LucH said. Along with fatigue and poor copper metabolism, having low iron despite adequate intake is another sign of an under-active thyroid. Despite my intake of iron-rich foods like red meat and supplementing with food-based iron, my ferritin was down to 6 and didn’t budge until I started taking thyroid (Armour). I was also diagnosed with mold toxicity and gut dysbiosis (SIBO), which cleared up when I targeted my thyroid. To rule out your symptoms being thyroid related, if you haven’t done so already, you may find it useful to track your temps (including extremities) first thing in the morning, and before and 20–30 minutes after you eat, and also your pulse rate, for two weeks. And in case you haven’t read it, here is Ray Peat’s article on TSH, temperature, pulse rate, and other indicators in hypothyroidism:

https://raypeat.com/articles/articles/hypothyroidism.shtml

Milk and oj as a base. B vitamins or liver sometimes. Mildronate or purycet. Walking. Enviroment is important.

@RandomUser I’ve tried both and think it’s worth trying both Cynomel and Tyronene. Ideally crush (pulverize) Cynomel then start off with no more than about a 1/16th of the powder with food and only very gradually increase the dose.
Cyproheptadine initially will make people sluggish or sleepy coz it reduces the stress hormones. Once (after weeks or months) the proper hormones start kicking in, eg thyroid, then it’ll still be working but not making you so tired.
As far as the aspirin maybe try starting taking it in smaller doses and not on an empty stomach. Taking it with baking soda, diluted in a little warm water, with gelatin or caffeine might also be things worth trying.
I’m cautious about MB and have only .once or twice tried a small dose because of Ray’s caveats. So can’t really tell any thing about it. I might try a little again at some point if i run out of other things that work.

@lobotomize-me said in "The dopamine system of healthy, highly creative people is similar to that found in people with schizophrenia":

antipsychotic medicine increases D2 density and lowers dopamine, so one can argue that high baseline dopamine reduces D2 density

BTW, I had some doubts about the statement above, so I've asked gpt to refine it...

"Antipsychotics block D2 receptors, which can lead the brain to upregulate D2 density over time. This suggests that the brain responds to dopamine levels dynamically: when dopamine signaling is low (due to receptor blockade), D2 density may increase; when dopamine signaling is chronically high, the brain may compensate by reducing D2 receptor density. Thus, baseline dopamine levels may influence D2 receptor availability through feedback mechanisms."

@Osteo said in Coffee and AMPK:

That's why I'm confused reading articles about how coffee diminishes cerebral blood flow... Or how coffee changes behavior..

Context matters.

Coffee is beneficial if you maintain a proper diet and a healthy lifestyle.

For someone (most average people?) who eats junk food, fast, or does keto, and undersleeps, coffee may be problematic...