@Luke

@evan.hinkle removing the old collagen can be helpful, yes, by forcing fresher collagen to be produced

@Mauritio - Thanks From AI Effects of Lactobacillus reuteri Lactobacillus reuteri (L. reuteri) is a well-studied probiotic known for its beneficial effects on gut health and immune function. Research indicates that L. reuteri can influence the production of IL-10 in several ways: Immune Modulation: L. reuteri has been shown to enhance the production of IL-10, which helps to reduce inflammation and promote a balanced immune response. Gut Microbiota Interaction: By modulating gut microbiota composition, L. reuteri can create an environment that favors the production of IL-10, contributing to improved gut health and reduced inflammatory conditions. Clinical Studies: Some studies have reported that supplementation with L. reuteri leads to increased levels of IL-10, suggesting its potential role in managing inflammatory diseases. How does Lactobacillus reuteri affect immune function beyond IL-10 production? Lactobacillus reuteri enhances immune function by increasing phagocytic activity in macrophages and boosting the secretion of nitric oxide and prostaglandin E2, which are crucial for immune responses. It also produces antimicrobial molecules like reuterin, which helps inhibit pathogenic microorganisms, contributing to overall immune health.

@sunsunsun Merci! Below is a summary in case someone in need will be reading this in the future: Introduction Combination of vitamins E+D about as effective as antibiotic for treating bacterial sepsis/infection daily 1-2k IU D3 + 8.75mg/kg (700-800mg) Vit E (d-alpha-tocopherol or mixed unesterified d-isomers of all 4 tocopherols) The tetracyclines protect against sepsis independently of their antibiotics effects Tetracyclines might be the preferred antibiotic treatment (i.e. doxycycline in a HED of 0.25 mg/kg (intraperitoneal route, so orally one would need ~0.4 mg/kg to achieve the same effects) Endotoxin/LPS is a major driver of blood clotting, sepsis, heart attacks and strokes Aspirin (although only acts downstream of the endotoxin/LPS cascade) Substances that can limit the amount of endotoxin/LPS produced and entering the blood: easily digestible food; avoiding “resistant” starches carrot salad, charcoal (*not really applicable after appendectomy) Niacinamide and vitamin E to help restore the gut barrier pregnane steroids (and especially bioidentical progesterone) to directly bind endotoxin in the bloodstream Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate least risky of FAS-Inhibitors is probably orlistat (Still severe side effects) aspirin might be good alternative; adding niacinamide + thiamine might improve its effectiveness against sepsis by improving glucose oxidation and reducing lipolysis respectively Inhibiting fatty acid synthesis reverses bacterial antibiotic resistance Aspirin (80mg-100mg daily) inhibited FAS by +50% Aspirin As A Cure For Sepsis excellent thread https://lowtoxinforum.com/threads/aspirin-as-a-cure-for-sepsis.15753/post-215210 Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis (!) Note: research involved in vitro work only + oral route probably not applicable after appendectomy see Haidut comment Caffene restores lowered cytochrome C oxidase activity + Caffeine restores cytochrome C damaged by sepsis one cup of coffee or about 80mg-100mg of caffeine probably better to do in recovery, not with acute sepsis DHEA Protects From Endotoxin Effects And Lethality single HED dose of as little as 5mg - 7mg DHEA daramatically increased survival of lethal endotoxins DHEA protects from endotoxin (even lethal doses) IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Full interview with Dr. Paul Marik his 2017 paper in question for early treatment protocol Vit C (1.5 g every 6 h for 4 days or until ICU discharge) Thiamine (200 mg every 12 h for 4 days or until ICU discharge) Hydrocortisone (50 mg every 6h for 7 days or until ICU discharge followed by a taper over 3 days) read on the other forum this one failed to replicate, although some studies exist that show somewhat sig improvement https://www.amjmed.com/article/S0002-9343(19)30699-0/fulltext s/o @mauritio T3 levels are a predictor of mortality from sepsis This study (and this one) shows that lactic acid is an independent risk factor for death due to sepsis. CO2 lowers lactic acid, T3 increases CO2. So it makes sense that T3 was so strongly correlated with survival in sepsis patients. -> improve CO2 / lower lactate (thiamin, niacinamide) This study shows a significant increase in survival time of people who take aspirin before hospitalization (by 1.3 days) Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections especially its activated form riboflavin '5 phosphate (R5P) minimum effective human equivalent oral doses for the combination of R5P and valine were approximately 0.2mg/kg and 25mg/kg respectively. This assumes bioavailability of 90% and 70% for R5P and valine. The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy "A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis" Septic Shock: Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock Anti-Serotonin (Cyproheptadine) + Aspirin Famotidine & Anti-histamines Protect Organs In (septic) Shock Both an H2 blocker (Famotidine, Cyproheptadine) and an H1 blocker (Chlorphenamine) were each offered protection Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation s/o Koveras Anti-Serotonin, Cypro, Tryptophan Metabolism, Vitamin C, Hydrocortisone, Thiamin https://lowtoxinforum.com/threads/do-not-forget-to-give-thiamine-to-your-septic-shock-patient.12006/ See also: Haidut on radiation exposure due to x-ray https://bioenergetic.forum/topic/3037/advice-on-lowering-endotoxin/18 https://bioenergetic.forum/topic/2140/any-info-on-sepsis-bacteremia-antibiotics-used/16 Citrulline to restore immune function after sepsis L-Citrulline restores immunity & T Cell mitochondria function acutely highest food sources: 1 cup of red flesh watermelon might have ~150mg per cup. or ~400mg for yellow flesh watermelon https://bioenergetic.forum/post/42939 Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats https://bioenergetic.forum/post/60444 (!) avoid mitophagy enhancers like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. (especially in the initial stage of sepsis) https://lowtoxinforum.com/threads/aspirin-in-the-context-of-endotoxin-tolerance.49865/

@Mike_Fave Glad to see u on this forum ur a good youtuber

@Amazoniac said in Toward a Better Understanding of Reactive Oxygen Species: The ROS linked to fat metabolism can arise partly from parallel effects, such as structural or functional perturbations and up-regulation of alternative ROS-producing enzymes (NOX, XO, COX, LOX, CYP2, etc.). I suppose that here we're mainly talking about excess PUFA loaded in adipocytes (AA cascade). When we stress or have a diet (fat loss). If we remain under 10 g PUFA/day, preferably 5-6 g, it would be OK. Edit: fine, the picture on ROS effects. (downloaded) ROS concentration & deleterious effects on cells. The next question is: What about when corn / soy food (from real food) is eaten, with LPS by-side load. Otherwise, it remains a theory. 1° In presence of ALA (thiol antioxidant) or a lipoprotection (A D3 K2 + vit E). 2° The same with aspirin or WWB.

@lobotomize said in less salt = more social bell curve?: Coincidentally, when I'm sick, I'm also extremely social Hi, Not the same when you feel tired. Energy is derived towards temperature. Why aggressive when you lack Na? Na is required for osmolarity and balance. Brain function is impaired. This imbalance disrupts cognitive control, leading to irritability, confusion, and reduced impulse control. You may possibly feel as if your were threatened too (survival instinct) if you've already lived such a deficiency.

@Mossy, I bet your potato soup is delicious! The bacon is a splurge I only get periodically, but I found ways to stretch it. The fat from 1 lb of it is enough to roast 4 lb of potatoes or kabocha squash, for example, then I just chop up the bacon, add it to the (seasoned) roasted veggies, add cheese, top it with some sour cream, and my dad gets at least 6 meals out of it. I get the woodland over conventional for purely ethical reasons. I’m a bad Peater—I’m not concerned about PUFA in whole foods, especially when the food is as nutritious as animal proteins.

@CurmudgeonApple Bro blocked me?? @sunsunsun please forward this messsage: "I don't care what studies the authors cited or what their subjective opinion is. The objective fact, we know in humans, is that in this subset of patients, prolactin was lowered by 66%. Vitamin E doesn't need to directly interact with the pituarity to exert it's effects. It blocks the production of fatty acid metabolites, and their metabolites, and the encompossing effects of them all. This directly can reduce serotonin/prolactin. So instead of asking the involvement of vitamin E in prolactin, ask your self what do these fatty acid metabolites do? for example; Omega 3 metabolite blocked by vitamin E, increases prolactin https://pubmed.ncbi.nlm.nih.gov/3921344/ "

https://www.youtube.com/watch?v=F_CLYkVSb6E

#BIOENERGETICFRIDAY[image: 1769807397165-img_2571.jpeg]

@heyman Yes it is

@Insr just to give you the full rabbit hole… https://www.dancingwithwater.com/ I’m not affiliated with that company. I’m just a gardener that’s gone down the water rabbit whole for many years! I’m very wet! Ha! JK. For thousands of years people have made reference to living water. It has spiritual as well as philosophical and scientific connotations. The fact that the term has survived so many generations is an indication of deeper significance. It implies there is living water AND that there is something other than living water. Can water lose its life? If so, can the life be returned to water? These are powerful questions that deserve more than philosophical answers. Dancing with Water: The New Science of Water is an investigation into water’s liquid crystalline phase where water molecules exist in a repeating geometric array similar to the molecular pattern found in a solid crystal. Although the molecules remain independently mobile, they respond as a coherent “whole.” This is living water–an organized network that responds to its environment carrying signals and supportive vibratory information to the life forms it supports. Living water has existed on Earth for millions of years. As the foundation of life, it is one of Mother Earth’s finest creations. But the degree to which water can support life depends on the degree of life force in the water. Water can be vibrantly alive or it can be barely alive, just like the inhabitants of the Earth. Although much of the water on the planet today has been mistreated to the point that its life hangs by a drop, understanding a few simple concepts can return water’s life force. The first step is to restore the liquid crystalline network. Then, the addition of frequencies/information completes the task. The term, full-spectrum living water is a phrase used by the authors of Dancing with Water to refer to living water that carries the full spectrum of life supporting frequencies. Several factors contribute to the overall process. Movement or turbulence – which creates vortices. Some form of gentle, organizing energy (this can be supplied by magnets and paramagnetic materials some geometric shapes and many methods of concentrating life force (for example, orgone energy devices Mineral ions (salts). These anchor the life force in water and help water to hold vibratory information. Stillness — a period following movement during which water develops coherence. Vibratory information — frequency-based input, including the very important resonance of the Earth. When these elements come together (and they can do so in many ways) water becomes a living, liquid crystal with the full spectrum of life supporting enhancements. The process is outlined in the book, Dancing with Water, with instructions for providing these elements in such a way that they result in full-spectrum living water—Earth’s finest gift—water that supports life to its fullest. That’s all from her website… great stuff. Investigate your own local water before you go slamming too much of it. And look at the pipes in your home. Hard water (like my town) has tons of great minerals in it but lots of fluoride too. Thyroid crusher! You may be able to set a two liter of your tap water out over night and off gas a lot of the chlorine gasses and get pretty decent water. Drip coffee is a good way to filter water and transform it into food! Yay! ️