My pregnenolone experience so far
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@z_pav I've taken up to 500mg of Health Natura's pregnenolone per day without much difference in mood.
It's hard to tell what pregnenolone is doing when you're already in a compromised health state.
It's definitely unusual for pregnenolone if it's causing suicidal feelings. -
@z_pav I'm fairly certain pure pregnenolone shouldn't do this and should in fact ameloriate those symptoms. I don't know how pure health naturas product is, but I haven't heard bad things about it frequently. I would stay weary though. If you're very confident about it's purity, I would suggest taking a massive dose (several hundred milligrams to a gram). To my knowledge large amounts don't promote the estrogen pathway, but rather the progesterone related steroids instead, such as allopregnanolone, which should make you the opposite of suicidal. If things really are that bad I don't know if 50mg is enough to make a considerable difference. I wish you the best of luck. I would maybe try progesterone instead if you're really in an emergency. It's more reliable.
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some people recommend starting at higher doses because pregnenolone/progesterone can cause estrogen to come out of tissues and be eliminated, but in the process the blood levels are high and you can get issues.
maybe can also take aspirin and do other peaty things to help tolerability and see if it gets better after a week or two of taking. estrogen thickens blood. causes breast tissue pain.
peat also raised concerns about potent estrogenic impurities in pregnenolone and that prog is safer. haidut even mentioned yeast in the air landing on pregnenolone and producing estrogenic compounds. if you go the progesterone route, it is recommended to take it with dhea due it is potentially interfering with natural dhea pulsing in the body. iirc, 1 or 2 mg, no more or else it may shut down natural production.
progesterone and im assuming pregnenolone too can also instigate temporary release of thyroid hormone where you will become hyperthyroid from it for a little bit. maybe this is stressing your system
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low dose lithium can ease suicidality, calm the mind, increase bdnf, lengthen telomeres, and improve lifespan. keep it low like 0.1 to 4 mg. The carbonate, orotate, and chloride forms are all effective according to one study.
6 mg lithium chloride equals 1 mg elemental lithium.
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I seem to have issues with Pregnenolone as well. First day is great, second ok, by the third it increases my stress. Health natura COA shows a purity of 99.9% and I'm still thinking of trying it and see if I do better with it.
Progesterone may be a better option if Pregn cause sides. Many have issue with Pregn.
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@basebolt do u take it everyday
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@sunsunsun Yeah mostly
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@GRay said in My pregnenolone experience so far:
I seem to have issues with Pregnenolone as well. First day is great, second ok, by the third it increases my stress. Health natura COA shows a purity of 99.9% and I'm still thinking of trying it and see if I do better with it.
Progesterone may be a better option if Pregn cause sides. Many have issue with Pregn.
Many forget that Pregnenolone also blocks the cannabinoid CB1 receptor which plays a key anti-stress & anti-excitatory role. Blocking CB1 prevents endocannabinoids from doing their job which can cause various issues (eg depression, anxiety etc). Afaik progesterone doesn't block CB1. Alternatively, combine pregnenolone with pro-CB1/pro-endocannabinoid substances like...
- low dose THC or CBG
- Magnolia officinalis extract (magnolol & honokiol)
- Nutmeg water extract (FAAH enzyme inhibitors)
In addition to its common use as a kitchen spice, nutmeg is used in traditional medicine to treat anxiety and depression, in addition to being utilized as an antibiotic, analgesic, aphrodisiac, antidiarrhoeal, antioxidant and lipid-lowering agent.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7938946/ -
@wrl Pregnenolone sounds always great on paper. Unfortunately many have side effects with it. Perhaps Ray P was right about the impurity causing the issues, and that is why he stopped recommending it. Difficult to find a Pregnenolone with 100% purity.
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@basebolt I’ll have to give lithium another try. I got some (orotate) to try and easy ADHD symptoms. I didn’t notice anything drastic, but maybe I didn’t get the dose right. Was doing 5mg daily.
