@thebiooracle said: "It should be remembered that amino acids, especially in eggs, stimulate insulin secretion, and that this can cause hypoglycemia, which in turn causes cortisol secretion. Leucine is stimulating muscle turn over (new ones) when exceeding 2.5-3 g per take. It won't stimulate insulin too much if you eat some carbs at the same time. Never eat only protein without some carbs. 20 g is enough, from a tomato or an apple at the beginning of the meal. Asking AI to develop (ChatGPT) The Leucine Threshold and mTORC1 Activation • Fact: Consuming 2.5 to 3 grams of leucine per meal is the established threshold required to maximize muscle protein synthesis. • Mechanism: Leucine acts as the primary nutritional signal to activate mTORC1 (mammalian target of rapamycin complex 1), which initiates cellular translation and muscle tissue turnover. • Application: Whole proteins like eggs have a high concentration of highly bioavailable leucine, making them highly effective at reaching this trigger. Protein-Induced Insulin Secretion and Hypoglycemia • Fact: Amino acids (particularly arginine, lysine, and leucine) directly stimulate pancreatic beta cells to secrete insulin, independent of carbohydrate intake. • The Risk: In the absence of dietary carbohydrates (e.g., eating only eggs), this insulin secretion can cause blood glucose levels to drop. • The Counter-Mechanism: In a standard physiological state, the pancreas simultaneously secretes glucagon to stimulate hepatic glucose production (glycogenolysis) to keep blood sugar stable. However, if insulin secretion is highly sensitive or if hepatic glycogen stores are depleted, a drop in blood sugar can occur, prompting an emergency release of cortisol to restore homeostasis. The Role of Pre-Meal Carbohydrates (20g Context) • Fact: Introducing 20 grams of carbohydrates (such as from an apple or tomato) at the beginning of the meal alters the metabolic baseline before the protein is processed. • Mechanism: The incoming exogenous glucose matches the insulin response. The insulin stimulated by the amino acids is no longer acting "in a vacuum" on existing blood sugar; instead, it has immediate dietary glucose to shuttle into cells. • Outcome: This direct glucose supply buffers the system, ensuring that blood glucose concentrations do not fall below fasting levels, thereby preventing the hypoglycemic trigger that would otherwise necessitate a cortisol spike. Additional comment (LucH) Don’t trust AI and confirm with another source

Ive used lisuride a few times before It's not "feelable" in the same way as thyroid but IS effective I probably wouldn't buy it again due to cost, instead get something like bulk bromocriptine ($600 for a full GRAM) or bromantane (I hear this works great) or pramipexole (works, but not entirely Peaty)

@thebiooracle No, it does not. The data on human diets is not there. P.S. This paper is available as a free PDF download.

Peat called endotoxin "One nearly ubiquitous source of inappropriate excitation and energy depletion" and motor neurons have those really long axons to keep running. Was LBP already high when people were diagnosed, or did it climb as the disease went on?

@doram there exists stretches online, but for the real “stress” i.e; the equivalent to the stretching table, I think dead hanging with your hands strapped to the bar and weights attached to yourself, would be the best but I have no idea if that is feasible or not lmao; make sure you can put your feat on the ground to stop the tension. Crucifiction to grow your clavicles may work

@engineer quick lookup says ginger increases the effect of nitric oxide which can increase blood flow and erections

@Ecstatic_Hamster are yours with aura or without? Ray Peat wrote about William Brown from Burr's lab, who spent six months on a fat-free diet with a lot of the calories coming as sugar syrup every hour, plus skim milk and cottage cheese. "After six weeks on the diet, his migraines stopped, and never returned." He'd had them weekly since he was a kid, so I wouldn't write off sugar just for being fast.

Ciffee was actually shown to reduce cortisol long temr

He did bring it up a few times. In Nutrition for Women Ray Peat wrote "Manganese is needed to synthesize thyroxin, so a deficiency can interfere with thyroid function (coffee is a major source of manganese, and caffeine also stimulates the thyroid)." Pretty hard to hate manganese and drink that much coffee. The thing he warned about was supplements with big amounts of iron and manganese in them.

BUMP

@chudlord please, stop with the experiment. The only reason your body tolerated the halo for so long is due to the otherwise therapeutic substances you were consuming. The energy and focus you had were high adrenaline and cortisol, for a few days your body will manage, then the hangover will come. The intestal issues came due to the halo, arguing that is is unrelated is wrong. The substance creates extreme liver toxicity. The intestal issues and decreased appetite is your body’s reaction to the inability to produce bile, which would digest food. You cannot break down meals, so it is protecting itself by lack of appetite for eating. Before trying new substances, I would simply recommend asking AI or searching on ray peat wiki in the podcast archive section, if Peat or Haidut have not talked about it somewhere, more often than not, you will find some comment on it.

For more information check out the Modern Procer Project: https://modernprocer.com/synopsis.html And watch these four videos: https://www.youtube.com/watch?v=oTw1x66GZNM https://www.youtube.com/watch?v=h3wsXj1efH0 https://www.youtube.com/watch?v=H2KnZ6rNExo https://www.youtube.com/watch?v=cLkJK52uAFE

@Cicero said: Are bioplastics and plant-based materials safer than conventional plastics? In vitro toxicity and chemical composition https://www.sciencedirect.com/science/article/pii/S0160412020320213 Interesting, but I don't think the study would be all that relevant to any sort of real world use. From the Materials and Methods section- "Three grams of each were placed in one or two amber glass vials, depending on their volume. After adding 20 mL methanol (99.9% LC-grade, Sigma-Aldrich), samples were extracted by sonication in an ultrasound bath for 1 h at room temperature. We used methanol because we aimed at maximizing the extraction of chemicals without dissolving the material completely and to be able to compare our results with our previous study on conventional plastics (Zimmermann et al., 2019). The methanol was transferred into clean glass vials and 200 µL of the methanol extracts were retained for chemical analysis." For real world purposes, a solvent like water, vinegar, or ethanol would be much more appliable, to see how many of these chemicals could potentially leach out.

there are studies showing urinary excretion increases alot with certain foods. bananas are high but not high excretion. green beans are high and high excretion.

@MateLover87 said: I've since resumed iodine, but at a lower, more controlled frequency (2x/week) Thyroid and brain need 10-12 days (till 2 weeks) to adapt metabolism. Think of a dry sponge and water pouring onto its surface... Receptors needs to be progressively opened. When there is a virus: HD D3 5 000 UI x 2 for 2 days. Zinc 15 mg x 2 for 5 days. rice when there is diarrhea but with water evapored, not thrown away.

Funnily enough I've settled into the 1-2 times a week for vitamin E routine as well, just from going on how im feeling. Always nice to see research backing up "the feels."

@BearWithMe For start, try salted potato water. (They have to be without the skin, long cooked, for like an hour no problem and cut into small pieces). If you do it correctly, it will be rich in nutrients, easily digestible and will include alpha-keto-acids - these are incredibly special, they will look for “trashy” stuff in your body and turn it into proteins, Ray recommended them for people with problematic digestion to stabilise their organisms. As for liquids in general and cavity problems which you mentioned, first I reccomend drinking acidic drinks via a straw, secondly, wash teeth with baking soda and after every food use xynitol (but to not eat it, just leave it in your mouth for 2 minutes, than spit it all out - and only use it after sweet foods, your body will think that it is consuming sugar and xynitol is not sugar, so would raise your stress hormones). This will not solve all your problems but will at least give you some breathing room. I am not sure if it wasnt already mentioned, but you should try progest-e, pregnanelon and T3 (microdosing). Without hormonal intervention, your body will have problem stabilising itself, this should be your priority. Combined with the basics as of avoiding PUFAs and fiber (FYI pork and chicken fat are high in PUFAs thanks to their diet), it should set you on the right path.

@lobotomize said: according to the study nac can be used to recduce cystine No problem if you manage the dose and the interaction.

@TexugoDoMel kinda figured that was the case. I think Buddy still needs thyroid or some sort of intervention at this point too or he’ll never be a 120 year old Lean Balkan dairy farmer