@thebiooracle said: He wrote that it tends to locally activate thyroid secretion "by a variety of mechanisms, increasing cyclic AMP and decreasing serotonin in thyroid cells, for example, and also by lowering the systemic stress mediators." Interesting, thyroid mostly expresses PDE8, same form mostly present in leydig cells, inhibition of which significantly raises testicular steroidogenesis.

Have to add that after acid-base balance is restored, magnesium intake can be used to regain and sustain OXPHOS.

There's something fishy about Hans. He claims he's been doing all these self-experiments where he takes a mega dose of something for 2 weeks and does before and after blood tests, and frequently other tests like stool tests. If it were all true, he'd be practically living at a clinic! He says doctors are useless and that he pays for all his own private tests. But then makes a post about having a chat with his doctor, and discussing various results with him. He never posts his labs, as others have pointed out. He could just be making it all up, for all we know. What he does do, constantly, is try to make money off his claims. So I'm a bit dubious.

@jimmynelson said: When I was on cyproheptadine (very low doses) for a couple months I ate like a monster but I did have resolution of some long standing issues which I think were being held up in "healing" by stress hormones. What was this "very low dose?" When I first experimented with cypro, I tried doing 1mg per day. I only lasted a couple of weeks, as I had this zombie like tiredness that would persist for most of the morning. Might just have been very tired in general all day, can't really remember. I stopped, and things got back to normal. Later, I decided I would use some higher doses (starting at 4mg, going up to 8mg) and thought I would just push through the tiredness, however long it was. To my surprise, it was much milder this time, and only lasted about 3 days or so. After a while, some doses of cypro actually gave energy. I think there is something to an initial "loading dose." Others on the old RPF mentioned the same sort of thing, that 4-8 mg as a starting dose caused minimal tiredness, but 1 mg caused much more tiredness. I think some suggested cutting back to 1mg after a week or two of loading, but I just kept it at 4-8mg, and saw good results. I think one RPF member even said Dr. Peat recommended a loading dose protocol similar to this, but I never saw or heard any direct quote from Peat in this regard. Another potential option is selegiline. It's an MAO-B inhibitor, so it prevents the breakdown of dopamine, as opposed to being a Dopamine Agonist.

@wester130 I just do the medium high seat biking due to convinience. Should be higher tbh.

why are you so weird

racetams can have a comedown

Pineapple, kiwi, and papaya help with digestion.

@disfrutarlo Nose is fine for the bag, and for everyday breathing Ray Peat thought it was better. On a 2015 KMUD show he said "When you breathe through your nose, especially if you have a good long nose, you have better retention of carbon dioxide." Nearly 10 minutes in a lunch bag is a lot longer than the minute or two he usually talked about. Do you notice anything after, like feeling warmer or calmer?

Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults We found that LSM (liver stiffness measurement) increased significantly following physical exercise, observing clinically significant differences (≥1 kPa) in 1 in 5 subjects. Our study thus supports previous findings, strengthening the hypothesis that physical strain prior to LSM results in significantly higher LSM values and should be avoided prior to measurement. To our knowledge, only one other study has previously investigated the impact of exercise on LSM 8 , but includes only 7 participants. The study found a significant LSM increase 0 and 5 min after activity, while it returned close to baseline values after 10 min. Pulse increase during physical strain has been linked to increased blood flow through the liver, further suggesting that blood redistribution may increase LSM. In line with this, we observed that the increase in exercise-induced LSM was restricted to subjects with a pulse increase >40 bpm, whereas individuals with a low pulse increase (≤40 bpm) did not show signs of increasing LSM after activity, suggesting that only strenuous exercise inducing a high heart rate affects LSM values. Hence, 10 min of rest prior to LSM may be superfluous in most subjects if strenuous exercise is avoided. The low number of individuals (n=9) and short observation time following exercise preclude definitive conclusions, and further studies are warranted to strengthen recommendations regarding rest prior to LSM. Gender differences found in our study, i. e., significant LSM increase observed in males and not in females, also warrant further study to allow conclusions. https://pmc.ncbi.nlm.nih.gov/articles/PMC7723471/

iirc aspirin in later part of day and evening results in a more optimal cortisol cycle.

@Tskull bruh

@Meursault this is an easy finesse stay safe nigga

@FitnessMikey on the vitamin A question from your first post, Ray Peat thought the trouble people get from moderate amounts came through the thyroid. He wrote "I think the symptoms associated with moderate amounts of vitamin A in susceptible people are the result of temporary suppression of thyroid function, which can result from an excess of any unsaturated oil." And on the radio he said "if you have a good thyroid function as well as all of the essential nutrients, that's the main thing for quick stomach emptying, quick pancreatic secretions, quick peristalsis, and quick elimination." If he's right, that would fit the daily pâté bothering you more than 50g once in the morning smoothie.

@Mossy yes to much time upside down would prob be a negative for multiples different reasons, including would contribute to lower blood/energy flow to your legs, lying down/sleeping on a straight surface with your head at the same lvl or below as your torso is optimal for a more even blood/energy distribution toward all parts of the body. Anything that put to much pressure on a part of your skull, can conttribute to hair worsening on tha part of the skull.

@haidut Ray Peat had a line in his CO2 article that fits this. Naked mole rats and queen bees both live in closed spaces where the CO2 gets up to around 5 or 6 percent, and he wrote "Since queen bees and mole rats live in the dark, I think their high carbon dioxide compensates for the lack of light. (Both light and CO2 help to maintain oxidative metabolism and inhibit lactic acid formation.)" Did the preprint test the infrared at different CO2 levels, or is the CO2 part only in the model so far?

@sunsunsun interesting, still moggy concentrations!

@thebiooracle no different to cocoa, pomegranate juice or even caffeine

@lobotomize total inversion of reality going on in ur mind rn