@alfredoolivas said in Are microdoses of mifeprestone the ultimate receptor level anti-glucorticoid?: it would likely occupy all progesteorone receptors, it's birth control, you can get it through online pharmacies I think. Then I don't think it's really worth the hassle. Id still be curious to hear how something like this feels and affects a person...

@CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: If it enhances autophagy through AMPK it should not be limited to mitophagy but also cover xeno-autophagy Good point. That might make it helpful for fighting infections. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: So a shift away from carbohydrates to FAO People often paint uncouplers as FAO-increasers. But they increase FAO and carb oxidation. The above article mentions it increasing TCA cycle, which can be fed by carbs and fat. It probably also depends on which tissues we are talking about. If you want to lean out your liver increasing FAO there is probably a good thing. @CrumblingCookie said in Peaty uncoupler vs. Ozempic who wins ? New study.: The MOA of BAM15 would then be a combination of inducing UCP and something along the line of metformin or berberine or spermidine (but lacking the Beclin-1 upregulation). (A comparison with resveratrol is less suitable since, although it lowers intracellular ATP through AMPK, I dare say its most important effect is through Sirt1) AMPK increases SIRT1. So BAM15 should do that, too.

@lobotomize yes but i think you'd have to be in somewhat decent shape to reap the benefits of cold showers. There is such a thing is cold resistance when it comes to thermogenesis and uncoupling. IIRC there was a study showing that grains of paradise were able to reverse that state in humans.

@Peatful my dog actually grew a lipoma of some sort when I added bluebonnet brewer's yeast powder to her diet.

@hawk1 I have similar concerns to you regarding suppression. So, despite that, I have also gone the nuclear route with 500mg a week of T isocaproate. Surprisingly, I haven't detected much suppression if any because vitamin E, pregnenolone/DHEA, and progesterone all work to oppose estrogen and prolactin which are the main underlying mechanisms behind endogenous shutdown. This is all because regular T aromatizes, unlike 11KT, which shockingly does NOT! So even if you're not already doing other Peaty things you are already in a low risk position.

@16characterstwas put some fish oil on the phone it will oxidise the evil blue light

Maybe the problem's above your complaint @gg12 . Hydrochloric acid.

@16characterstwas why would reduce endotoxin increase weight gain?

@sphagnum Orally with water. https://www.amazon.de/-/en/Singulares-Shell-Powder-Extra-Fine/dp/B07TD46XG5?th=1

@Gardner that post was after potato as starch meal so yor assumption is incorrect and secondly i take increased appetite as easy marker of increased vitality

@gg12 Does coffee deplete calcium ? Don’t think so Why is my sleep worse on days I drink coffee / it’s hard to fall asleep even if I drink it at 9am. I almost feel like the effects last for a day or two. Try less strong coffee or decaf (with cream and sugar.) And in small amounts. Then work your way up. I feel like it makes my metabolism too fast so I franticly eat starch slop to calm down the starvation. But this just makes issues worse in the long term. Have it with cream and sugar. makes all the difference in the world. Should I force a cup of coffee everyday and hope I adapt? I have SIBO , lactose intolerance, poor liver, bad liver glycogen etc just looking to get things up to speed again. No, forcing doesn’t work. But it does help with those and alot of things, not just because of the caffeine but also because of the nutrients, chlorogenic acid, etc. So start with decaf (still has some beneficial caffeine ) and in smaller amounts, then work your way up. Add some cream and sugar to balance out the caffeine and other components.

Or the other way around. Better to keep so-called soluble fibre low, to prevent LG

There's something fishy about this story.

@gg12 what @awawat said. Also other things to try: Goat milk; Ultra pasteurized (UP) milk which is often labeled UHT (Ultra High Temperature) milk; Buttermilk (tastes like unsweetened kefir) Try whichever appeals to you and whenever you feel like having some, then work your way up. Sweetened condensed milk is another great option. Good luck

@BearWithMe said in Mysterious gallbladder disease - can't digest fat for no apparent reason: salt might be necessary for stomach HCL production I don't add any salt now and cook food myself with no salt. My blood levels of CL are always showing in higher range. If I add salt my stomach feels irrtated or inflamed , it rather hinders stomach HCL production. But a bit of pickles with a teaspoon of brine can be very helpful occasionally .

@CrumblingCookie I agree with you on subclinical fungal infections. They're very hard to get rid of. I posted a study about fungi hiding in the gallbladder when attacked. Let that sink in.

@alfredoolivas said in Best thyroid type in context of combining with hormones?: you probably will convert t4 fine if you want to consider that. In light of this, and prior experience, will go with NDT. It's a more rounded product with other components including T1, T2, Calcitonin etc. Appreciate the input @alfredoolivas as it made me view things differently!

@user73636 said in Dietary calcium does not affect pyruvate dehydrogenase?: Your body maintains a very strict range of calcium in your blood regardless of how much you eat. Because of this: The quesiton is how does PTH (affected by dietary calcium) affect PDH.