@AlphaZance said: Metabolic stress drives the formation of AGEs, but Ray Peat has not addressed existing AGEs in foods. yes, but you didn't find the right doc. The etymology of the word glycation doesn't only rely on sugar. You d' better take care of "lipid glycation" and not only from sugar sources. Request for IA: glycation doesn't only rely on sugar but much more on fat alteration. Google answer: You are on the right track! While sugar drives classic glycation, fat alteration (lipoxidation) is a massive, often underappreciated driver of Advanced Glycation End-products (AGEs). The Lipid-AGE ConnectionLipoxidation: When fats oxidize, they create reactive, unstable molecules (like dicarbonyls). These intermediate compounds then cross-link with proteins just as sugar molecules do, directly forming harmful AGEs.The Maillard Reaction: Heat processing (such as frying or grilling) animal foods high in both fat and protein yields the highest levels of dietary AGEs. The Interplay: Both pathways are deeply connected under "carbonyl stress". How to Manage Both Sugar and Fat Risks To minimize the buildup of AGEs and slow down cellular aging, you can focus on a few evidence-backed lifestyle and dietary strategies: Watch Your Cooking Methods: Avoid cooking foods—especially meats and fats—at high temperatures. Steaming, boiling, or poaching creates significantly fewer AGEs than frying, broiling, or grilling. Balance Dietary Fats: The type of fat you eat matters. Clinical trials suggest that increasing consumption of monounsaturated fats (MUFAs) and Omega-3 fatty acids can help control and beneficially affect your glycation markers. Maintain Stable Blood Sugar: Even though fat oxidation is crucial, reducing refined sugar and fructose intake lowers the available "fuel" for traditional sugar-protein glycation.Leverage Antioxidants: Oxidative stress is the catalyst for fat alteration. Consuming antioxidant-rich foods or using targeted anti-glycation interventions helps neutralize free radicals. Scientific Sources & Evidence To dive deeper into the science of how fats and sugars alter your cells and skin, review these authoritative resources: [1, 2] https://www.lifeextension.com/wellness/aging/glycation https://www.skinnutritioninstitute.com/blog/glycation-how-fat-ages-your-skin-and-destroys-collagen-clone Glycation & Oxidation: Explore the exact breakdown of how lipid damage forms AGEs through Advanced Glycation End-products (AGEs): an emerging ... - PMC. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC4648888/&ved=2ahUKEwjPyLaG4-iUAxXlkP0HHRf_BQEQy_kOegoIAggACAEIJxAC&opi=89978449&cd&psig=AOvVaw2nBJNpgaZPrk0yj1bOffN0&ust=1780497191863000 Lipoxidation Pathways: Read about how both carbohydrates and lipids drive carbonyl stress at Glycation, oxidation, and lipoxidation in the development of ... Ibidem Cellular & Skin Impact: Understand how these molecular processes affect your skin's health and elasticity in Sugar is altering your skin in ways no anti-ageing serum can ... Ibidem

This guy is a born liar and a fraud. His 'expert' research is incredibly sloppy and cherry picked. He has a raging ego, extremely thin skin and a tedious need to be the singular guru on ALL life matters. I challenged him on his claims on his blog about how much vitamin C he takes. He claims he only uses natural, acerola-based vitamin C, and claims he typically takes 4 grams a day for a few days and then settles on 2-3 grams a day. I found the brand he takes, crunched the numbers and worked out that if he was telling the truth, he'd be spending up to $400 a MONTH on this one supplement. I pointed this out to him and he wrote back calling me a "dumbass" and saying "of course I don't spend that much money on Vitamin C". Which means he out-and-out lied. He's also now making vague claims in his updated book that he had leukemia in the past. Previously he only mentioned the thyroid cancer. But now, leukemia too, because his WBC was slightly off. He is desperate to convince people he was at death's door and single-handedly fixed his multiple life threatening diseases. He's a dishonest loser, who loves to throw in comments implying he's hot af. He isn't. He's vain, preachy and profoundly wide of Ray Peat's mark.

https://www.youtube.com/watch?v=H9QsAO4BU28

I’ve been using two drops 8mg of thymoquinone of the current formulation right before bed on my tongue. Sleeping extra good. Don’t wake up at all until alarm clock except some recent thunderstorms. I replaced 4 drops of Kuinone on tongue before bed. I like the effects of Tuinone better. More calming. For black seed oil seems like if you had an extra strength oil 7.5% TQ you’d need about a teaspoon of the product and would be getting lots of Pufa and other things that aren’t thymoquinone

Had to quit, after each smoke, my digestion got horribly worse… I came across this, and it makes sense: https://youtu.be/zZCgpw6_sRA?si=qcNsO9j7S8P_Aj-r Presently, I believe it’s the classic case of everything is bad when your health is outta wack. May try again when I think I’m doing good on every front.

@jamezb46 The links for Fat Loss Agents (and their considerable downsides): DNP, GLP-1 Agonists and Meldonium, EPO, and Advanced Performance Protocols were pointing to the wrong place. I've fixed them. Fat Loss Agents (and their considerable downsides): DNP, GLP-1 Agonists -> https://dinkov-distilled.vercel.app/7d35b1da-57db-11f0-bef1-11c2aded3be7 Meldonium, EPO, and Advanced Performance Protocols -> https://dinkov-distilled.vercel.app/4cfd75bc-5307-11f0-8501-fb369bf0f4ea Please let me know if you find anymore and I'll fix those too. I took 5 years of notes and used AI to put the unsorted notes into topics. There are 87 topics to go through and I haven't proof read the whole thing yet so there are bound to be some mistakes. If you found some errors your welcome to go in and make a pull request to update them or send me exactly what I should change and I'll go in and do it. My goal was to take all the nuggets Georgi and Brad have given out over the years and put it in one place.

alfredoolivas said: "Interestingly, potent anabolic steroid trenbolone bound to the glucocorticoid receptor with an affinity almost as high as that of corticosterone, the endogenous glucocorticoid in the rat " [image: 1780232719779-0b15ecd0-f7da-4623-b05e-1ff7e885b4b9-image.jpeg] Corticosterone binds to the GR in hepatoma cells as MORE than cortisol. So at least in rat liver cancer cells, trenbolone has an equal affinity as cortisol on the GR, antagonising it.

@gg12 99% of people dont tolerate it. They simply never connect the dots of them being retarded feeling tired and gassey to the food they eat. Drink lac free low fat for a bit add glucose and then normal sugar to it

@ZackVegas https://www.meforum.org/middle-east-quarterly/why-arabs-lose-wars

Combined inhibition of dopamine D1/D2 receptors induces cognitive and emotional dysfunction through oxidative stress and dopaminergic neuron damage Results: Low-dose co-DR1/2I significantly increased MAO-B and ROS levels (p < 0.01) and decreased SOD activity (p < 0.01) in the substantia nigra, striatum, and hippocampus. MAO-B activity positively correlated with ROS (r = 0.916, p < 0.001) and negatively correlated with SOD (r = −0.685, p < 0.001), whereas ROS negatively correlated with SOD (r = −0.661, p < 0.001) in co-DR1/2I-treated mice. The medium- and high-dose groups exhibited spatial memory impairment (longer escape latency, p < 0.05) in the water maze and more anxiety-like behavior (reduced central zone time, p < 0.01) in the open field test; however, no abnormalities in motor coordination were observed in the rotarod test (p > 0.05). Immunofluorescence and WB confirmed a reduction in the dopaminergic neuron count after co-DR1/2I.

@bio3nergetic said:What one most likely witnesses is big med making matters worse, but walking away silently pointing at made-up villains. >> Sounds like Finasteride and Dutasteride

@gg12 even if people are eating a lot they can be nutrient deficient.

[image: 1780012319049-d6aadf94-b265-4c4d-be94-b4aaf49eeb67.jpeg] [image: 1780012319172-6d382b6b-c0bc-4d7a-b316-ca7b00c720ce.webp] [image: 1780012319260-b9183e31-0ea1-4cd8-9f61-b561fbdd2d98.jpeg] [image: 1780012319356-be85e5ad-85df-468a-a991-18b35b36aeb8.jpeg]

@Gaston Thirty ought six, carrot salad. [image: 1780011639454-55a687d1-f7bc-44b9-898d-1df8e6be50e1.jpeg]

Did 1.5mg earlier today and all that happened was my stomach hurting (not quite nausea, but close) and not feeling very hungry. For some reason, the libido effects are minimal to none, and I don't know why.

@JaCoolBruh thanks. do you know if its food grade ?

@engineer Fair, lol about the creatine

@engineer I took some androsterone a while back but like 1-2 drops every few days. I took pansterone daily for 1 month as well.

Bananas have high Malic, zero citric acid

@gg12 charlies company has soap on sale rn and ngl their soap is fiya