While I never experienced TMJ, I did go through a phase of teeth grinding. Mine was a result of caloric deficiency leading to hypothyroid symptoms.
I was experimenting with fasting, and when I was eating I had a diet that didn't contain nearly as many calories as I thought it did. As someone with a fast metabolism, it was a recipe for disaster.

Fortunately for me, its how I found Peat's work. Some of my other symptoms (the feeling of high stress hormones) lead me to the possibility that I was experiencing hypothyroidism. I did the Achilles tendon reflex test, and eventually came upon Ray.

I started tracking calories with cronometer, and increased my intake of starches in particular. It was tough at first, but I forced myself to eat more, specifically carb dense foods like rice and concentrated fruit juice. Fasting had kind of destroyed my ability to "feel" hunger so it wasn't fun eating at times.

I don't even know when the grinding stopped, but at some point I realized that when I forgot to put in my mouth guard before bed, I wasn't waking up with the edges of my teeth feeling rough anymore. Now and again if something happens and I don't eat enough, I won't feel hungry but I notice the stress horomones stirring up. If I don't correct it before bed, some grinding comes back. If I'm well fed, though, no issues ever.

just got some gaba powder. have some dmso too.... hmmmm... transdermal gaba applied to scalp to cross into brain.... hmmmm ... interdasdting.....

@Milchkanne Speaking as an American, I had one package confiscated by Customs back in 2020 or 2021. Probably because it had Ivermectin. They sent me a notice asking me for a bunch of paperwork. I didn't respond. Then they just went ahead and destroyed it. They said that because I'm an individual, not a company, I don't have to pay for the cost of the destruction.

More recently I ordered medication from an Indian pharmacy. It was nothing controversial. This was just after the Trump administration said that they were putting all packages through customs. The de minimis rule was over. Drugs require prescription with the drug and all of that. Despite all that, I got it in about six weeks. It should have taken about two weeks, but it took six weeks. I did actually get it.

I probably would consider ordering overseas again. I think they're probably just so backed up and busy they're just letting packages through anyway.

@DavidPS Thanks for your reply. Yes I'm aware of the iNOS bashing but reckon it's partly a chicken-and-egg problem – i.e. is removing the substrates to NO solving the underlying inflammatory issues or merely hiding them? Is keeping furniture in your house the actual fire hazard or is that only an issue because there are smoldering floorboards?

In any case I think Cit/Arg are daft ways for wanting to reduce hypertension, akin to trying to lower blood pressure by riding a continuous niacin-flush wave.
In the long run, however, Cit helps to maintain eNOS functionality. Which is universally accepted as beneficial? I deem Cit to be greatly preferred over Arg because of its greater systemic distribution beyond the tissues of initial exposure (GI lymphatics, liver).

And I see Cit in the context of glycine because Cit's ultimately a substrate for proline, complementing Gly's impact on systemic vasculature and collagen structures, which then leads back to the contexts in this thread.
I'm thinking of reasonable amounts of Cit: 1-2g to make up for what should be provided by enterocytes in good health + an amount to achieve about 2g of Pro. So in overall not more of perhaps 3-5g Cit per day.

I don't have an answer to the Arg/Lys and shingles/viral phenomena. I strongly suspect it's also a workaround to suppress immunological or excitatory pathways which ought to be cleared up from another angle.
One thought towards this is that since Arg is a precursor to Pro perhaps these peeps could also benefit from more Gly availability – because a greater ratio of Pro (or of ascorbic acid for that matter, or especially both in combination) may use Gly for collagen synthesis and in doing so rob other cells and tissues of what little amount of Gly had been available to them for their respective functions. In some circumstances elevated (OH)Pro deposits seem to be a culprit and are alleviated by more Gly, like in liver fibrosis by chronic alcoholism in rodents (link, link). In people with metabolic syndromes, plasma Gly's also been found to be depressed and it raises upon introducing physical improvements but, reciprocally, supplementing Gly by itself helps to bring about physical improvements of various aspects of metabolic syndrome (link, link).

@lykos (replying so others can see) I left it on indefinitely, didn't wash it off. If I felt I applied too much, I might wipe off the excess with a towel.

@yeyo12 My interpretation of the results were that caffeine co-administration with oxandrolone increased the absorption of the latter via inhibition of PGP.

@ThinPicking ok

@tocovit I was reading about stacking Mildronate & Pyrucet, trying to figure out how much is known about how they might synergize or conflict. I read the entire 31-page Pyrucet thread at RPF/LTF and only saw a few people discussing it. Does anyone have any theories, studies, experiences or thoughts about stacking these two?

Is there any reason your dosing of these two is so moderate, given that you're going nuclear?

Your "moderation in moderation" is a commendable philosophy I can endorse.

I was hoping someone might have tried this stack and provide reports with doses like 500-1000mg Mildronate and 20-to-40 drops of Pyrucet per day, maybe divided by two BID.

Interesting post. Keen to see any updates.

@LucH You get enough cysteine from protein foods.

Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
https://pubmed.ncbi.nlm.nih.gov/20871132/

Glutathione (GSH) drives cancer metastasis by promoting cell survival under hypoxia
https://haidut.me/?p=2816
https://doi.org/10.1158/2159-8290.CD-24-1556

When I was in Mexico City, I tried going to a pharmacy and stocking up on cynomel and cynoplus but the pharmacist told me I needed a prescription. I've heard some places have a doctor nearby that will prescribe whatever you needed but I didn't ask since I usually get it from meds.com.mx I figured I'd just get it once I got back home.

@sunsunsun Sushi is breaking bad 🙁

@TexugoDoMel, thanks for the tables. Interesting, indeed.
Do you have a reference paper for the tables?

@LucH

Thank you for the detailed response and for confirming what I was worried about, which is overdoing the vitamin E supplementation.

I have a 400 IU supplement, so I will be taking that 2-3x a week, depending on my inflammatory status! (I think I’ll start with 3)

@user2 said in How many eggs?:

@GreekDemiGod said in How many eggs?:

@user2 It didn’t raise Testosterone when he ate an absurd amount of it, like 10+ daily.

how many eggs was he eating prior?

*He(Hans) consumed:

1000 eggs in 30 days 15 large oysters a day for 30 days 250g of beef liver for 30 days
But nothing was as health-promoting and anabolic as 5L of milk a day.*

@sunsunsun lmao

@Insr said in Low Glutamate Diet:

The low glutamate diet

I'd take 0.5 g taurine.

useful info:
B6 PLP and taurine
To dampen glutamate's excitatory effects in the brain, the body converts it into the inhibitory neurotransmitter GABA (gamma-aminobutyric acid).
Pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, is an essential cofactor for the enzyme glutamate decarboxylase (GAD), which catalyzes this conversion of glutamate to GABA.
Deficit in B6 when suffering from low-grade inflammation.
GABA helps maintain a healthy balance between neural excitation and inhibition. A deficiency in B6 can lead to reduced GABA synthesis and neuronal hyper-excitability. Mind the excess of B6 PLP (break). Do not use B6 PNP (neuropathy when above RDA). High doses of the vitamin B6 form pyridoxine (PN) can cause brain and nerve problems, though the primary effect is damage to peripheral nerves.
Taurine
The amino acids that can help dampen or balance glutamate activity include taurine, L-theanine, and the branched-chain amino acids (BCAAs).
0.5 g 2x/d.
NB: When I take L-glutamine (in case of thin linen stomach => acidity is painful), I balance with taurine.

Most excellent and correct.

the only thing holding back is a handful of retards

Small engineering issue, no problem.

That’s great, @sunsunsun! Your dog is a lucky girl to be fed so well. 🙂

@sunsunsun it works only to absorb the steroid

but are you absorbing the ester too??

wouldn't the digestion destroy the ester?

They are not pathogenic, have never been isolated

See Stefan Lanka