@Insr allelopathy is real so there's probably an equivalent for plant-animal interactions.

Hi everyone.
This is my new batch:

1.5% Dextrose 1.5% Dexpanthenol 1% L-Lactic Acid 1% Potassiumbicarbonate (to buffer part of the LA to lactate and provide potassium) 0.5% 1% Glycerine (to increase viscosity and skin adhesion of the solution + emulsification) 0.5% 0.8% alpha-Bisabolol (antiinflammatory + antimicrobial + humectant + reductant) 0.6% Vitamin E (equals 15mg=22IU per 2.5mL) (needs an extra solubilizer!) 0.4% Allantoin (antiinflammatory + proliferative + keratolytic + humectant) 0.33% L-Threonine (as a source for protein energy + L-Glycine) 0.05% Pirocton olamine (antifungal to counteract the topical glucose. This is more of a preemptive measure as I lack the diagnostics to discover or evaluate fungal influences) 0.05% Centella asiatica oil (needs an extra solubilizer!) (for collagen synthesis and inhibit collagen type III fibrosis) 0.002% Apigenin (for HDACi. Equals 5mg per 2.5mL; maybe needs more. If in capsules with fillers: Must be soaked in alcohol first, then filtered, then added. Otherwise the blend will be cloudy and looking "yeasty" and application will leave visible filler particles on the hair) 0.002% Green tea extract powder (50% EGCG) (for HDACi. Use alcoholic filtrate) 0.45% (w/w) 0.5% Rokonsal BSB-N: Benzyl alcohol, glycerine, benzoic acid, sorbic acid (as antibacterial + antifungal preservative) 5% Alcohol (Ethanol 96%) (for solubility of pirocton olamin and some mediocre solubility of bisabolol). -> about pH 4.5

Edit:
I've worked through it again and adjusted the text above. Here's why:

| Glycerine 0.5% is enough since 1) the dexpanthenol already provides a good texture, 2) the preservative also contains some glycerine, 3) it's not useful as an emulsifier for any of the ingredients here. | alpa-Bisabolol is an oil and insoluble in water or glycerine. We need a solubilizer for it or will float on top. Or just bodge it with alcohol in which it is somewhat soluble and leaves a film on top. 0.5% is still very generous as I've seen commercial skincare sera recipes with only 0.1-0.2% bisabolol (racemic). | Vitamin E oil (natural): This needs a solubilizer if we want to have it pretty. Ethanol disperses just a part of into a milky solution. It still floats on top as small oily droplets. | Allantoin 0.4% is generous. Probably a reduction to 0.1-0.2% would still be fine. It's fairly water-soluble; up to 0.5%. | L-Threonine is probably fairly useless here. I'd rather include L-proline and ascorbylpalmitate. | Centella asiatica oil: Needs a solubilizer like PEG-40 hydr. ricinus oil or something more natural. Otherwise it floats on top. | Rokonsal only 0.45% (w/w, ie. about 0.4% v/v); a little less because its aqueous solubility threshold is about 0.6%. | Pirocton olamine (powder) is requires a 1-10% alcohol solution for solubility. It's insoluble in water and glycerine. | Green tea / EGCG. I've added this to complement the Apigenin.

So, overall it's not the prettiest blend yet because I haven't used solubilizers. I'm a beginner in the world of cosmetics/skincare manufacture. The benzoic/sorbic acid preservative smells slightly almondy-fruity-sweet-alcoholic. One may choose to cover that with other fragrances or use a different preservative.

Will see how it goes with this one. Any thoughts and suggestions?

Drinking tahiti lemon juice balances things out for me. Makes eating potatoes less likely to develop into depression/sadness/suicidal.
I think there's more to explore in this combination.
Potatoes and tahiti lemon juice

@16characterstwas thanks

@Mulloch94 my thinking with the progesterone was to support the upstream hormones bc im supplementing a downstream, so if my E drops too low, it could potentially aromatize, iirc progesterone has strong antiestrogenic effects but can increase estrogen in men as well...

I guess I have a "High T" phenotype (wide face and frame, low voice, large hands and pretty decent muscular development) but I have some gyno and have very little body hair, which seems in line with low 5ar. i also smoked weed chronically for years durring developmental periods which is why I think my 5ar is fucked.

to me it seems smarter to start with something that powerful enough to reach escape velocity with regards to my 5ar like exogenous DHT, then when my 5ar is sorted try T... but honestly if i get what i want from DHT i dont see any reason to play around with more hormones and risk suppression.

@heyman thanks for sharing.

@Meursault said:

would eat one meal all day often and it was just when we had time. Also wouldn't drink much water. then try make up for it on days off.

That's not how sufficient drinking and good homeostasis of bodily fluids and electrolytes works btw.
If you are on of those people who simply don't drink water because they forget and/or because it tastes boring I don't know how that can be taught.

@Meursault said:

Liver markers (Bilirubin, ALP, ALT, GGT) all came back within range

That never excludes functional liver issues. It simply means whatever's going on is not killing the liver cells very much.

Since I've currently been reading up on B5 pathways ("hammer") everythings looks a nail to me as in lack of B5 causes strong somnolence, irritability, insomnia. Its transport protein also carries biotin and iodide into all bodily tissues hence there's a lot of possibilities wrt wakefulness, energy and endocrine and thyroid hormone secretions.

Depending on the parameters range of the urinary organic acids test you have ordered there should be a lot of insight to be gained about which steps of the TCA aren't running well enough. E.g. elevated lactic/pyruvic/3-hydroxyvaleric/-propionic/oxalic/xanthurenic acid etc.
Will be interesting to see what that shows.

@Mulloch94 Thank you

@abokapo0514
Someone asked Ray Peat about that topic:

Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-396712

Ray on varicocele:

"I think they develop because of an excess of cortisol relative to DHEA and pregnenolone. That imbalance is likely to occur with low protein intake, low thyroid, and low vitamins D and A."

So I would make sure I’m getting enough
Protein (milk, eggs, jello, chicken wings, liver, seafood, shellfish..)
Thyroid hormone
Vitamin D (Orange juice, sunlight..)
Vitamin A (liver, eggs..)
in my diet.

@Androsclerozat I think it's the screen itself - can't be good to look INTO light for hours.

GrtiDK2XoAAoxr4.jpg

https://www.nature.com/articles/2261278b0.pdf

Read sleepless harvest in the top left.

Youtube Video

Bletchley

the final solution for gynecomastia? we need a faustian gynecomastia peater to try it.

@Mulloch94

I know gray hair doesn’t automatically mean copper deficiency. But does copper deficiency automatically mean gray hair?

Try to avoid mixing everything together, first experiment with individual substances. This then results in an individual dosage profile and protocol. The current selection and dosages don't make much sense - some even counteract each other (piracetam - caffeine [no stimulants with racetams]).
Modafinil is great, would be a far better choice than the other.

Red light, when shined right on the thyroid gland, also seems to help lower thyroid antibodies in many subjects as well.

So a hypothetical good protocol for this would be something like:

Cynoplus + Aspirin to lower inflammation and TSH.

Myo-inositol + selenium to lower thyroid antibodies

Red light to augment the effects of all the above

Avoid excessive iodine usage. It causes thyroid gland inflammation

Watch for possible gut interactions. Don't eat foods that aren't digested well. You may need to eliminate shit like gluten & fodmaps.

@samson I'm going to restore aromatase and 5α-reductase naturally by removing blockers.
and the beer was just for testing, glyphosate is not used in my country