https://bioenergetic.forum/post/60591

https://www.youtube.com/watch?v=_HZM0QiuUS8

@williambjr said in 15yo Son on Ray Peat Protocol: @Peatful i let him eat as much as he wants. I just didnt mention it Perfect

IL-6 isn't an "inflammatory protein". It is a transient signalling molecule of immune involvement..it raises when you go for a walk and eat a carb heavy meal, so is walking and eating inflammatory too? You can't look at cytokines in isolation..cytokines are not inflammation..they are the response to something like PAMP's e.g PRR's,TLR2/4, Dectin-1, CARD9, DAMP's e.g TLR-9, TNF-a, IL-β, hypoxia e.g chronic HIF-1a signalling , mitochondrial ineffiency e.g reduced PGC-1a, reduced OXPHOS that immune function has decided it doesn't have the energy or resources to resolve, so the threat assessment never reaches the resolution phase e.g IL-10, Tregs, M1-M2, SPM's like it would with food poisoning, wound healing, bacterial infections that induce aggressive acute immune function like c.difficile infections and waterborne illness Inflammation is the dysregulated response of immune function to a perceived threat that it does not have the facility to, or has not received the gating to resolve, so it just manages the situation. That "management" is the inflammation as it wastes NAD, forces longer windows of aerobic glycolysis, induces more hypoxia. Not cytokines .which means all these studies are particularly nonsense. Furthemore there isn't anything in cacao xanthines or polyphenols or any other polyphenol for that matter that can resolve inflammation. The keyword is resolve..it can transiently inhibit NF-kB through IKK, and it can push Nrf2(this would probably just result in even more redox stress though without resolution), but neither of these things equal resolution..without the signalling cacscade i mentioned earlier, there is no getting out of "inflammaging" or chronic inflammation and because inflammaging is largely driven by hypoxia through things like uncoupling of eNOS, BH4, mitochondrial inefficiency etc this is something you cannot reverse beyond a certain point or age..inflammaging to use the cringe term, is inevitable and you might as well just call it aging.

https://www.youtube.com/watch?v=dcFOsbHlbUw [image: 1767913940409-no_sir.png]

@sunsunsun [image: 1767911816711-08f0bf04-ca24-40fa-a367-51a962d1a1d2-image.png]

@sunsunsun said in Supplementation of L-Citrulline and Glutathione: @engineer im considering eating one of those mini watermelons + some of the rind , apparently it will give like 5g of citrulline Did you do it I can't decide if I should keep using citrulline or not

@DavidPS The criteria was to be 20 years old, and have information about the participants's atherosclerotic cardiovascular disease, dietary niacin intake or covariates. "Our research focuses on participants aged 20 years and older who completed an interview. Data analysis was conducted from July to September 2024. We excluded pregnant women or individuals with missing data on atherosclerotic cardiovascular disease, dietary niacin intake, or covariates. " Perhaps covariates includes obesity, but I don't know.

@lykos awww little bitch has an upset tummy?

@rope said in Cynoplus sources in US: @Ecstatic_Hamster Let us know if it gets delivered They said they are shipping soon. I shall.

Ok, so is N.O. le bad or not? I took the vintage formulation of N.O. Xplod and did close grip bench bress and got the sickest tricep pump

Context Indoor air contains 100 times more microplastics than previously estimated, according to this study. Every day, an adult inhales 68,000 microplastic particles, and a child nearly 47,000. This is one hundred times more than previously thought, according to the study from the University of Toulouse published in the journal PLOS ONE. https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0328011 2025 Researchers analyzed the air in homes, offices and cars and found extremely high concentrations of PM10 particles, which come from textiles, furniture, cables and carpets. NB: MPP and NPP: micro-plastic and micro-plastic particles Useful link (in French, translator needed) https://www.julienvenesson.fr/microplastiques-nanoplastiques-effets-sante/#:~:text=Effets sur le système respiratoire,et peuvent même les détruire. How to protect the brain: Optimize protection against neuroglia and inflammation Let’s say we’re going to try to protect both against stroke and Alzheimer's, although I am aware that this requires "scientific confirmation". “Amyloid plaques and tau protein deposits in the brain are considered the main biological features of Alzheimer's disease. Recently, myelin sheath degeneration has emerged as a new hypothesis and target in the etiology of Alzheimer's disease. A decrease in myelination and oligodendrocyte function precedes the pathological accumulation of amyloid and tau proteins.” (Graciani et al., 2023, Desai et al., 2009, Desai et al., 2010). Put differently, there is inflammation, with accumulation of a tau protein, degeneration of the myelin sheaths (which protect the nerves) and therefore poor conduction of nerve impulses. So, if we accept this hypothesis, we should try to calm things down (excitoxicity and neuro-inflammation via TNF-alpha, but not only that). Indeed, nothing is settled down, established in advance, or rigid if you prefer. Since nothing is set in stone, we're relying on probability: by addressing inflammation and protecting our communication channels, we aim to give the brain the tools to resist longer. It's not a guaranteed miracle cure, but a common-sense strategy to minimize damage. Electrical glitch or chemical short circuit? That's the big debate: which comes first? In the brain, everything operates in a loop: a malfunctioning ion channel (electrical) alters the release of neurotransmitters (chemical), and inflammation (chemical) then modifies the sensitivity of receptors (electrical). It's a vicious cycle. Protecting the Brain: Optimizing Protection against Neuroglia and Inflammation Since there is disruption in cellular communication, resulting in inflammation and impaired elimination of toxins and dysfunctional debris, I’ll suggest some approaches. Their relevance will vary depending on the individual's condition. Think of this as a toolbox. Here, I’ll simply mention a few molecules / clues from my own research. More details can be found at the link below. There’re probably other ones, like emoxypine succinate, although I’ve never heard of it before coming to this forum (not available in my country; unknown to VIDAL). Healthy membranes to facilitate blood circulation. Baby aspirin (325 mg) in case of insufficient fluidity. Anti-inflammatory and pro-metabolic. Mind side effects on platelet renewal. UCDA: Details on how Ursodiol acid protects the brain (with a physician prescription). Suggested optimization for these nutrients: resveratrol, Theracurmin, EGCG (green tea). B1, B9, B12, DHA and iodine. Betaine HCl if lazy digestion after the evening meal (with meat). Taurine *** and magnesium Physical activity Open to suggestions More details on this link if you want to go deeper with one molecule (in French) https://mirzoune-ciboulette.forumactif.org/t2161-le-cerveau-contamine-par-le-plastique-comment-s-en-proteger#30544 More info on taurine (in French) https://mirzoune-ciboulette.forumactif.org/t1866-infos-sante-divers-sce-2#29009 https://mirzoune-ciboulette.forumactif.org/t1840-quest-ce-qui-rend-la-taurine-si-importante#25227 (an article that explains the ins and outs of this amino acid).

@PissBoy the one from Keith Littlewood is supposed to be good

@evan.hinkle ok. I would always inquire if it's really 100% . But I also don't think that a little less should destroy the whole process. Yes it is irritating at first but I got used to it. Although it seems to make my skin quite dry.

@alfredoolivas how did the end product work out for you? Did it seem like it worked?

@alfredoolivas idk