@zaaku, what helps me during these "bad energy" encounters is making sure I breathe through the nose only and only with the frequency of 12-24 breaths per minute. This is to activate the hippocampus rather than the amygdala, which evokes the fight-or-flight response and which is activated when we breathe fast. Humming (for about 5 seconds at a time) calms me down too.

@16characterstwas I absolutely was. I still remember the exact date this started, because very significant and stressful event happened on that day. It was more than 20 years ago. And every time I experience another big stressful event, my health gets a little worse, never to return to its previous state.

Progesterone can only do good, especially after taking hellacious finasteride, I would be grateful my body can produce any amount and leave it alone. For men, in the short term progesterone's benefits might not be obvious, but in the medium and long term it is spectacular. What to definitely avoid and keep low is estrogen, which progesterone is good at doing.

@sunsunsun gracias

@pondfountain chronic caffeine consumption negates the Ach-increasing effects of caffeine. Chronic caffeine treatment reduces caffeine but not adenosine effects on cortical acetylcholine release The results indicate that prolonged consumption of high doses of caffeine causes changes in the responsiveness of cholinergic neurons to caffeine. The change is not shared by adenosine, through whose recognition sites caffeine is believed to act. It is therefore possible that the adaptive changes following repeated caffeine administration involve either only the coupler-transducer mechanism activated by the antagonist, or effects unrelated to receptors.

You’ll see that, in addition to any androgen binding to GR, you’ll have two potent anti-catabolic factors: mTOR and PGC-1α; GR negatively regulates both To put it very simply, REDD1 negatively regulates mTOR, and FOXO1 is largely regulated by PGC-1α. Although they function “separately,” they can converge since REDD1 not only inhibits mTOR but also increases FOXO1. You can make them resistant to catabolism by inhibiting FOXO1, and abolish the effects of GCs by inhibiting REDD1. Not surprisingly, type 1 fibers—rich in mitochondria and OXPHOS—are resistant to stress-induced atrophy (glucocorticoids, energy deprivation, etc.) but are also resistant to hypertrophy. Glycolytic fibers, on the other hand, which are prone to energy deficits because they have few mitochondria and rely on glycolysis, are sensitive to stress but are also sensitive to hypertrophy due to greater GR and AR density. [image: 1786057988696-d19493b6-4e2d-43de-ad03-f365e0eb848c-image.jpeg]

@sunsunsun Indeed! Hence my need to call out my generalizing.

@Ena Re: antifungal/antimicrobial effect of lovastatin. It looks like lovastatin (LOV) potentiates other antifungals rather than having that effect by itself. "LOV single treatment was unable to inhibit C. albicans strains except the ERG3 and ERG11 double mutant. LOV and itraconazole (ITZ) combination was capable of inhibiting the C. albicans planktonic cells and biofilms synergistically including the ITZ resistant mutants." --- From the abstract to Lovastatin synergizes with itraconazole against planktonic cells and biofilms of Candida albicans through the regulation on ergosterol biosynthesis pathway.

Has anyone tried well cooked mushrooms? There are many people reporting that it shifts the test/e2 ratio incredibly favorably, (better even than AIs). I hate to keep spamming Hans’ substack, but he’s run bloodwork pre-post mushroom experiments, and shown test/e2 rations above 20:1, (might have been 30:1 I don’t remember). Myself personally, (no bloodwork) but since I’ve added 3oz of well cooked mushrooms to each meal, I’ve seen nothing but improvement, (less puffy, zero constipation, reduction in inflammation, better mood etc).

Drinking milk without mixing with ice also makes me have symptons of bruxism.

There is also morphogenic resonance going on of the Ray Peat ideas thoughts energetic expressions consciousness and all. The more of us talking about these ideas working towards pro metabolic higher metabolic lives etc… we are spreading these ideas into the Aether and scientists influencers kids people are getting seeded these ideas and they resonate with them. Resonance, it happens constantly in culture, through marketing magic but also just by morphogenic fields. I mean people are trending towards rays ideas because they are more or less the right direction of full spectrum truth. And big brains like Georgi and some of the folks here are broadcasting electron flow awareness out to the universe! Grab a tank of co2 and a glass of milk and tune in! Plagiarism is constantly an annoying part of life also.

@CrumblingCookie thanks for your response. I was thinking it might be fungal, but due to the fact, I have bangs and its not on my forehead and concentrated around my jaw, I am certain it’s hormonal. That’s why spironolactone , metformin, and inositol reduce it. I agree with mold I will look into that. I’m also looking into getting a gut microbiome and Dutch test. My partner also recommended taking iodine. I’ll give you feedback once I have more results. In the middle of my 30 day cleanse my cheek acne has reduced, but I still have some jaw acne so hopefully that’s a sign that it’s a combination of hormonal and gut so time will tell, thank you!

https://www.youtube.com/watch?v=hk8JjlZn7Iw

@sunsunsun i think so yes.

@BioEclectic that claim makes sense based on the ability of b6 to cause neuropathy. less muscle control via nerve damage leads to atrophy of muscles.

https://youtu.be/E2GcCtfd8q8 [image: new-black-hole-neutrino_600.gif]

@sunsunsun Yeah but the point is that the spoons are inaccurate for the exact reason you mentioned XD as well as density etc