World of Decline — Blog Reddit — Isochroma-Reborn Animescenes — Blog & Image Archive ChromaSubs — AniDB group profile Websites, Projects and Resources IsoChroma.com — archived website, August 2010 ChromaSubs — archived website, June 2006 Racetam Prices — archived supplier and price database, December 2013 Piracetam Experiences Coluracetam Experiences Online Profiles Doom9 AVSForum Shroomery Rollitup Talk-Polywell Steroid.com MESO-Rx / ThinkSteroids Steroidology MangaUpdates AniDB (profile disabled) AnimeSuki (profile disabled) BrainMeta (lost) CCleaner Community Lighting-Gallery — Google site search for Isochroma Biographical and Archival Sources Arraignment Hearing Transcript, December 18, 2000 Adjournment Hearing Transcript, January 16, 2001 Letter to the Editor by Jason Lalancette (Saanich), January 24, 2001, p. 9 Isochroma's Story (by IsochromasSuccessor) Isochroma Is Dead (by IsochromasSuccessor) Death Certificate (shared by IsochromasSuccessor) Isochroma on Learning and Writing (quoted by Kassem23) Selected Posts Racetams and Nootropics: It's Unsafe Not to Take Racetams Racetams as Preventive Brain Health Optimal Stack Piracetam Rage Wings of Freedom The Cure: Puddles in an Infinite Desert Depletors and Replenishers Piracetam as Neurolube Fully Saturated for the Rest of Life Speed, Power and Acceleration Blue Breaker: Memory Maker A Subtle Feeling of Excellentness Self-Experimentation and Experimental Ethics: Balance, Risk and Compensation Life as Full-Spectrum Experimentation The Reliable Factor: Brain Gloat Sleep and Dream Engineering: Piracetam Before Bed: Sleep Induction Nootropic Dreams NMDA Antagonists and Racetams: The Chemistry of Soul and Sleep Control Nootropic Dreamland Kitten Claws A Functional Windows Box in a Simulated Dreamworld Eternal Awake: I Choose to Stay Sunny Perceptual Engineering: The Edge Test and WarpSharp Unigradient Edge Effect and Colour Fineness Patchwork Enhancement of Audio Processing Colour Saturation at Specific Wavelengths Hormone Therapy and Medical Autonomy: Androgen Replacement Therapy (ART) Seeing the Stars Clearly Again Xenoandrogens Theory, Practice and the Right to a Healthful Life Light and Circadian Engineering: Light Is Life: The Mercury Bomb The Beauty of Mercury Vapor Streetlighting Compact Fluorescent Spiral Galaxy Version 12 (Lighting-Gallery) Spiral Galaxy Version 12 (Isochroma Blog) Metal Halide Safety? 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@haidut the MRS2 part caught my eye, because Ray Peat leaned the other way on magnesium in shock. In his eclampsia newsletter he said Ringer's lactate doesn't seem reasonable when the blood already holds so much lactate, and suggested a hypertonic Locke's solution with glucose and bicarbonate, writing "extra magnesium would seem desirable." If lactate is what opens MRS2 and loads the mitochondria with magnesium, did the paper test whether the outside magnesium level changes anything, or is it only the lactate-driven influx?

@haidut Ray Peat said almost this in his cholesterol article: "One of the basic functions of cholesterol seems to be the stabilization of mitochondria, preventing their destruction by stress." He tied the synthesis side to energy too: "Serious stress lowers ATP, magnesium, and carbon dioxide. When ATP and intracellular magnesium are decreased, cholesterol synthesis increases." In this study the cells ramped up production once the ER ran short. Did they check whether that ramp-up tracked the cells' ATP, or was the ER shortage enough by itself?

@thebiooracle I am now going to a community health center for dental health. It's the same where I work so I know the dentists are very good. I cannot say that for all community health centers. Some have awful providers. But the advantage is that the dentists do not make more money if you get more procedures done. It doesn't matter to them since they get a salary anyway. The fees and insurances are being paid by the State. That's why it's easier to decline x rays. And also I don't get unnecessary fillings.

@Harlock Ray Peat talked about cold hives on the radio in 2012: "Some people get hives just from getting cold or from exercising or from not eating soon enough. Just dropping your blood sugar works the same as cutting off the oxygen supply." He said the cell then makes lactic acid, which makes fat break down, and if that fat is unsaturated you get prostaglandins and more inflammation. Is yours worse when you've gone a while without eating?

@Ilias-Ant hi, i suggest try eating a good amount of whole milk yogurt in the evening, up to a kilo and more untill you are full, sheep if available, no flavor or subpar ingredients added, if you add sugar i suggest add the very minimum for the yogurt not to taste acidic or bad

@Tskull vit b's are usually too underated i often wonder what is wrong with me just to realise i forgot to take b6 for a while (b6 is especially important/depletes rapidly when you have to preform 24/7). manganese/zinc also are often forgotten by me. ill be honest mate focus on deficiencies first . t3 has rarely helped me other than as i said give me a minor boost of preformance or spike my dyniphrin via having me ruminate if it is a bunk or if ray peat is a lie

@haidut Ray Peat wrote in his meat physiology article that "an excess of estrogen has been commonly associated with sarcopenia, muscular dystrophy, and atrophy of the skeletal muscles," and that meat scientists were the only people he knew of who called estrogen an anabolic steroid. He also had a cardiolipin point that fits the aging part: in young animals one site of cardiolipin holds palmitic acid, and "After that, as the animal's respiratory activity declines, the palmitic acid is replaced by linoleic acid." Did the paper look at what was in the cardiolipin that was left in the old muscle, or only how much of it there was?

@ravis Ray Peat wrote about TBI in The dark side of stress. He said "Traumatic brain injury, even with improvement in the short term, often starts a long-term degenerative process, greatly increasing the likelihood of dementia at a later age." The way he explained it, brain trauma lowers the enzyme that clears acetylcholine, so it builds up. In the same piece he wrote "Progesterone is being used to treat brain injuries, very successfully." You've only tried pregnenolone so far, right? Could be something to raise with the endo once the GH tests are back.

https://www.youtube.com/watch?v=YsMB0i5YTOc

@wester130 very good to know

@thebiooracle said: "It should be remembered that amino acids, especially in eggs, stimulate insulin secretion, and that this can cause hypoglycemia, which in turn causes cortisol secretion. Leucine is stimulating muscle turn over (new ones) when exceeding 2.5-3 g per take. It won't stimulate insulin too much if you eat some carbs at the same time. Never eat only protein without some carbs. 20 g is enough, from a tomato or an apple at the beginning of the meal. Asking AI to develop (ChatGPT) The Leucine Threshold and mTORC1 Activation • Fact: Consuming 2.5 to 3 grams of leucine per meal is the established threshold required to maximize muscle protein synthesis. • Mechanism: Leucine acts as the primary nutritional signal to activate mTORC1 (mammalian target of rapamycin complex 1), which initiates cellular translation and muscle tissue turnover. • Application: Whole proteins like eggs have a high concentration of highly bioavailable leucine, making them highly effective at reaching this trigger. Protein-Induced Insulin Secretion and Hypoglycemia • Fact: Amino acids (particularly arginine, lysine, and leucine) directly stimulate pancreatic beta cells to secrete insulin, independent of carbohydrate intake. • The Risk: In the absence of dietary carbohydrates (e.g., eating only eggs), this insulin secretion can cause blood glucose levels to drop. • The Counter-Mechanism: In a standard physiological state, the pancreas simultaneously secretes glucagon to stimulate hepatic glucose production (glycogenolysis) to keep blood sugar stable. However, if insulin secretion is highly sensitive or if hepatic glycogen stores are depleted, a drop in blood sugar can occur, prompting an emergency release of cortisol to restore homeostasis. The Role of Pre-Meal Carbohydrates (20g Context) • Fact: Introducing 20 grams of carbohydrates (such as from an apple or tomato) at the beginning of the meal alters the metabolic baseline before the protein is processed. • Mechanism: The incoming exogenous glucose matches the insulin response. The insulin stimulated by the amino acids is no longer acting "in a vacuum" on existing blood sugar; instead, it has immediate dietary glucose to shuttle into cells. • Outcome: This direct glucose supply buffers the system, ensuring that blood glucose concentrations do not fall below fasting levels, thereby preventing the hypoglycemic trigger that would otherwise necessitate a cortisol spike. Additional comment (LucH) Don’t trust AI and confirm with another source

Ive used lisuride a few times before It's not "feelable" in the same way as thyroid but IS effective I probably wouldn't buy it again due to cost, instead get something like bulk bromocriptine ($600 for a full GRAM) or bromantane (I hear this works great) or pramipexole (works, but not entirely Peaty)

@thebiooracle No, it does not. The data on human diets is not there. P.S. This paper is available as a free PDF download.

Peat called endotoxin "One nearly ubiquitous source of inappropriate excitation and energy depletion" and motor neurons have those really long axons to keep running. Was LBP already high when people were diagnosed, or did it climb as the disease went on?

@engineer quick lookup says ginger increases the effect of nitric oxide which can increase blood flow and erections

@Ecstatic_Hamster are yours with aura or without? Ray Peat wrote about William Brown from Burr's lab, who spent six months on a fat-free diet with a lot of the calories coming as sugar syrup every hour, plus skim milk and cottage cheese. "After six weeks on the diet, his migraines stopped, and never returned." He'd had them weekly since he was a kid, so I wouldn't write off sugar just for being fast.

He did bring it up a few times. In Nutrition for Women Ray Peat wrote "Manganese is needed to synthesize thyroxin, so a deficiency can interfere with thyroid function (coffee is a major source of manganese, and caffeine also stimulates the thyroid)." Pretty hard to hate manganese and drink that much coffee. The thing he warned about was supplements with big amounts of iron and manganese in them.