If you want other sources: Are PUFAs toxic? Video of Chris Masterjohn 30’ https://youtu.be/WRmUzYD8l7Q CM earned a PhD in Nutritional Sciences from the University of Connecticut in 2012 and currently researches the physiological interactions between fat-soluble vitamins A, D, and K at the University of Illinois, Urbana-Champaign. https://chriskresser.com/an-update-on-omega-6-pufas/ Eat real food and balance your diet. Avoid industrial seed oils. Don’t go overboard with the nut flours. Eat pre-formed EPA and DHA (white fish). Ray Peat PhD. – Kate Deering – Dr. Rita Lee – Etc. Huile de poisson et effet sur la thyroïde http://mirzoune-ciboulette.forumactif.org/t1388-huile-de-poisson-et-effet-sur-la-thyroide#15791 Effets anti thyroïde des oméga-3 (In French, translator needed) (See translation of the excerpt below) Excerpt: Translation (« Huile de poisson et effet sur la thyroïde » => Fish oil and effect on thyroid) • ALA administration results in a 22% reduction in T3, the most potent form of thyroid hormone. T4 to T3 conversion rates decrease by 56% in response to ALA ingestion. ALA even interferes with normal T3 levels if you pre-administer T4 into the cells. (2) 2. http://www.ncbi.nlm.nih.gov/pubmed/1815532 • Animals fed a high PUFA diet compared to a high SFA diet (with corn oil or lard) experienced a significant decrease in thyroid hormone response in PUFA-fed rats. (3) http://www.jbc.org/content/256/14/7113.full.pdf+html Excerpt 1 from: Arachidonic acid causes an uncoupling effect and inhibits cellular respiration https://www.sciencedirect.com/science/article/pii/S0891584999000349 “It is shown that arachidonic acid causes an uncoupling effect under state 4 respiration of intact mitochondria as well as a marked inhibition of uncoupled respiration. Excerpt 2 from: Unsaturated Vegetable Oils: Toxic http://www.raypeat.com/articles/articles/unsaturated-oils.shtml To defend the seeds from the animals that would eat them, the [PUFA]-oils block the digestive enzymes in the animals' stomachs. Their tendency to oxidize is very great. These oxidative processes can damage enzymes and other parts of cells, and especially their ability to produce energy. The enzymes which break down proteins are inhibited by unsaturated fats, and these enzymes are needed not only for digestion, but also for production of thyroid hormones, clot removal, immunity, and the general adaptability of cells. The risks of abnormal blood clotting, inflammation, immune deficiency, shock, aging, obesity, and cancer are increased. Thyroid and progesterone are decreased. Since the unsaturated oils block protein digestion in the stomach, we can be malnourished even while "eating well." *) Useful info: more to be read on my forum. Effets anti-thyroïde des oméga-3 Effets Immunosuppressifs des omega-3 https://mirzoune-ciboulette.forumactif.org/t2042-effets-anti-thyroide-des-omega-3#29683 Excerpt: No one disputes the benefits of omega-3s for reducing inflammation and counteracting an overactive immune response. But it's all about long-term use. Not to mention that some sources of omega-3s also provide omega-6s. This leads to the storage and release of amino acids. See the details in the post "Fatty Acids for Dummies," linked below. (15) You'll find further information in the links provided below.

Improving blood flow to the extremities (hands and feet) involves more than just "moving more." It requires a balance between the mechanical pumping of the heart and the biochemical signals that tell your blood vessels to open up (vasodilation). For someone focused on metabolic efficiency, the goal is to improve circulation without triggering excessive stress responses that can actually lead to peripheral vasoconstriction. 1. The Biochemical Trigger: The Role of CO2 Effective circulation depends on the Bohr Effect. For oxygen to leave your blood and enter your tissues (especially in the small capillaries of your fingers and toes), carbon dioxide (CO2) must be present. Vasodilation: CO2 is a powerful natural vasodilator. When your metabolic rate is high and you are producing CO2 efficiently, your blood vessels relax, allowing blood to reach the extremities. The Trap: Over-exercising to the point of "gasping for air" or hyperventilating actually flushes CO2 out of the system. This can cause the peripheral vessels to constrict, leading to cold hands and feet even while your heart rate is high. 2. Strategic Exercise Selection To optimize blood flow to the extremities, the type of movement matters. Resistance Training (Concentric Focus): Lifting weights or bodyweight movements (like squats or push-ups) creates a mechanical "pump" effect. Focus on the concentric (the lifting phase) to stimulate blood flow and metabolic demand without creating excessive tissue damage or systemic inflammation. Low-Impact Steady State (LISS): Walking at a brisk pace where you can still breathe through your nose helps maintain a high CO2 tension. This keeps the peripheral "gates" open longer than high-intensity sprinting might. Micro-Movements: If you spend long periods at a desk, simple calf raises or grip strengtheners are highly effective. The calves are often called the "second heart" because their contraction is essential for pumping venous blood back up from the feet. 3. Thermoregulation and the "Core-to-Extremity" Link Your body prioritizes keeping your internal organs warm. If your core temperature drops even slightly, the body will pull blood away from your skin and extremities to protect the center. Warmth as a Catalyst: Exercising in a warm environment or wearing adequate layers helps signal to the nervous system that it is "safe" to send blood to the periphery. Metabolic Rate: A robust oxidative metabolism keeps your internal "furnace" running. If your resting metabolic rate is low, your body will naturally be more stingy with blood flow to the fingers and toes. 4. Nutritional and Biochemical Support Circulation is also a matter of fluid dynamics and mineral balance. Magnesium and Calcium: Magnesium helps the smooth muscles of the blood vessels relax (vasodilation), while calcium helps them contract. Ensuring adequate magnesium intake can prevent the "clamping" of peripheral vessels. Sodium Balance: Adequate salt intake is necessary to maintain blood volume. Low blood volume makes it much harder for the heart to push blood all the way to the ends of the limbs. Short-Chain Fatty Acids (SCFAs): Compounds like butyrate can support mitochondrial health and gut integrity, which indirectly supports systemic blood flow by reducing the low-grade inflammation that can make vessels "stiff." Summary of Strategies Strategy Action Mechanism Nasal Breathing Breathe only through the nose during light exercise. Increases CO2 retention and vasodilation. Calf Raises Perform 20 reps every hour while sitting. Engages the "venous pump" in the lower legs. Temperature Check Keep the torso and neck warm. Prevents the "survival" vasoconstriction reflex. Mineral Balance Ensure sufficient Magnesium and Salt. Maintains blood volume and vessel flexibility.

@awawat there’s more where that came from ( ͡° ͜ʖ ͡°) Also, I would consider your rT3 levels if you’ve taken only T4 with no results for a while. Peat talked about success with low doses over a course of 6-24 months. Maybe you could play with higher ratios of t3 to t4 in your lunch and dinner doses. Danny Roddy probably has the most complied info on practical thyroid use, between convos with Peat, and feedback with health coaching. I think he might have a concise vid on using thyroid on YouTube

@uncover do I correctly remember that you had logged your aspirin+workout experiences, on the rpf?

I actually just realized Yucca also has a 3:1 4:1 ratio just like the carrot salad and bok choy

@LucH thanks. I prefer taking MK4. I have seen often people have side effects from the MK7

@Milk-Destroyer not really, just as a convenience to add to oatmeal if i dont have eggs for some reason. there’s no point when i can just drink 1L of milk for a protein drink giving 36g protein.

https://www.youtube.com/watch?v=H7Nmz7puMog

Thank you, @kilgore and @LetTheRedeemed ️.

low dose doxycycline or minocycline is basically a quinone supplement. amoxicillin should be taken as amoxicillin clauvinate for wider range of bacteria targeted

@jamezb46 literally something like what you've posted in the next paragraph as counter evidence you cultured swine

@engineer cabergoline increases noradrenaline though.

What risingfire said. With thyroid energy, I feel like I have all the time in the world, like I did when I was a child—it’s as if time moves slower when my thyroid is functioning optimally—and I feel an excitement to do things, but it’s accompanied by this sense of calm or peace, while adrenaline energy feels like there isn’t enough time in the day to get everything I want done, like time is flying by, and there’s usually this background feeling of anxiety, a fear of my own mortality, really. With both energy sources, I have moments of euphoria, which made distinguishing between the two and adjusting my diet and thyroid dose accordingly quite challenging in the beginning so going by my temps (including temps of extremities—cold feet, hands, nose and/or ears are a telltale sign that adrenaline is compensating for thyroid and cutting off circulation to them to keep the core and vital organs warm), pulse rate and slightly more involved but very helpful is evaporation rate, i.e., average total fluids consumed and eliminated via sweat vs urine in a 24 hr period.

why are you eating a not-varied diet in the first place

@Thyrotic Hey, did you survive?

As a counterpoint, I think I've crashed my estrogen with both androsterone and 11kDHT in the past but never noticed anything with my joints because I was taking boron at the same time.

Talk with AI (Claude) How efficient is the intake of a MK4 supplement, (with enough fat, hereby 25 g fat with some MUFAs), when taking 1 mg (1 000 mcg) K2 MK4? Question of vehicle only? No intermediate change into menadione, I suppose, since there is no digest process. Need a confirmation, whenever there is a target amount limited to 2-3 mg K2 supplement. Note: 2 takes of 1 mg MK4 at breakfast and midday meal, with 1 000 UI D3 (both at the same time, AKA 2 x 1 000 UI D3). Brain target. AI says (Claude): Summary: A moderate amount of D3 and K2 are co-absorbed in the same chylomicron pathway; so simultaneous intake is fine. Brain target and dose adequacy: 2 mg/day total is a reasonable range for a brain-focused protocol. Step 1 — Chylomicrons (intestinal phase, 0–4h postprandial) Step 2 — Chylomicron remnants → liver (4–6h) Step 3 — VLDL → IDL → LDL (hepatic re-export, hours to days) A possible route for extra-hepatic tissue supply is that part of the K-vitamins are re-packed into LDL, which forms a major transport system from the liver to peripheral tissues. ScienceDirect This is the key insight for your brain target — the liver processes the chylomicron-delivered MK4 and re-exports it via VLDL, which is then progressively remodeled into IDL and LDL for peripheral tissue delivery. Agarose gel electrophoresis of lipoprotein fractions after K2 supplementation revealed distinct chylomicron bands and variations in VLDL and HDL mobility, influenced by dietary lipids and VK2 supplementation. Wiley Online Library

COX-2 is overexpressed in advanced stages of tumors. Aspirin starts inhibiting COX-2 meaningfully after dosages of about 500mg (better would be >1g). Aspirin vindicated as an anti cancer drug. "Most solid tumors express the cyclooxygenase-2 (COX-2) protein, a target of NSAIDs. COX-2 overexpression in tumorsis considered a predictor of more advanced stage disease and of worse prognosis in a number of studies investigating solid malignancies. Therefore, NSAIDs are evaluated as anti-cancer drugs." Artificially overexpressing COX-2 makes mice more prone to developing tumors and knocking it out makes them less likely to develop tumors. "Both COX-1 and COX-2 are involved in tumor vascularization. COX inhibitors can directly affect angiogenesis [47]. " "Thus, COX-2 may be the cause of progression of estrogen-dependent breast cancer either directly by stimulating tumor cell proliferation, or indirectly by upregulating aromatase activity [60]. " "Part of the rationale for combining NSAIDs with chemotherapy involves circumvention of chemotherapy resistance mechanisms." https://pubmed.ncbi.nlm.nih.gov/16945549/ COX-2 inhibition makes chemotherapy (5-fluorouracil) more effective in vitro. https://pubmed.ncbi.nlm.nih.gov/21163769/

@alfredoolivas yeah im aware. Me and my son use this account. We are not on here though mainly the raypeat forum. And the reason i give him t3 is because his ATP production is bad.