Interesting effects
*) Many of the pharma antiviral drugs used caffeine as adjuvant.
Caffeine Is a Strong Antibacterial Agent
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125025
"...Caffeine and aminophylline had the ability to inhibit many strains of pathogenic bacteria."
http://www.ncbi.nlm.nih.gov/pubmed/8700184
"...Three purine nucleoside analogues, penciclovir (PCV), acyclovir (ACV) and ganciclovir...”
*) Caffeine Lowers Parathyroid Hormone (PTH)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207951/
PTH increases when calcium intake and blood levels fall. Its role is to get more calcium in the blood. PTH does this by increasing calcium absorption from the intestine by increasing conversion of vitamin D3 into the "active" vitamin D called calcitriol. However, PTH also increases prolactin so the net effect can be quite detrimental to the bone. If a person gets PTH as a drug and does not also increase calcium intake then it will shed their bones by elevating prolactin.
Conclusion:
A physiological high dose of caffeine inhibits PTH secretion in human parathyroid cells, possibly due to a decrease of the intracellular level of cAMP. The observation demonstrates a functional link between caffeine and parathyroid cell function.
*) Caffeine is a dopamine agonist and is expected to reduce prolactin, as dopamine agonists do.
https://raypeatforum.com/community/threads/caffeine-lowers-prolactin.2818/
As a follow up on my previous post on caffeine being a dopamine agonist, it follows naturally that it is expected to reduce prolactin (as dopamine agonists do):
http://onlinelibrary.wiley.com/doi/10.1002/hup.470040106/abstract
The study on life extension said 200mg every 4-6 hours. Other studies used different amounts for different purposes. For me (Haidut), 200mg every couple of hours works just fine without bringing in a stress reaction.
Note: The other studies are showing increased prolactin from 500mg caffeine per day but lower prolactin from 1,000mg+ per day.
*) Coffee is anti-inflammatory and good for diabetes (DT2 & DT3)
https://doi.org/10.1093/ajcn/nqy295
Results
Compared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (−8.7%), IGFBP-3 (−2.2%), estrone (−6.4%), total estradiol (−5.7%), free estradiol (−8.1%), leptin (−6.4%), CRP (−16.6%), IL-6 (−8.1%), and sTNFR-2 (−5.8%) and higher concentrations of SHBG (5.0%), total testosterone (7.3% in women and 5.3% in men), total adiponectin (9.3%), and HMW adiponectin (17.2%). The results were largely similar for caffeinated and decaffeinated coffee.
Conclusion
Our data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways.
Comment: While it is known to be a factor in hypertension, recent studies show that, within reasonable limits, coffee actually has a hypotensive effect! A beneficial effect is seen with just two cups a day (between 2 and 4 cups).