@haidut ️

For Candida, you need to do a biofilm disruptor + a strong anti fungal, especially If you’ve had it for many years.

@LucH I suggest reading the text about azetidine and MBP . MBP is important myeline protein rich in proline. Proline substitution by azetidine changes its function. Proline,"queen of aminoacids" is heavily produced in pregnancy. Pregnancy on azetidine could end with weaker myelin function. Gluten and caseine are good sources of proline but it requires stomach acid production and gut digestion, next -carboxypeptidase/dipeptidylpeptidase or we can have problems with glutomorphins/casomorphins. Fact-checked by Grok 4 weeks ago Carboxypeptidase A1 Carboxypeptidase A1 (CPA1) is a zinc-dependent metalloprotease enzyme primarily produced in the pancreas as an inactive proenzyme If someone would like excellent article about proline-queen of aminoacids https://web.archive.org/web/20161125195452/http://www.twoje-odzywki.pl/l-prolina_-_krolowa_aminokwasow-a-33.html https://www.mdpi.com/1422-0067/21/20/7696 The Human Digestive Tract Is Capable of Degrading Gluten from Birth[...] " **. The gastrointestinal proteases involved in gluten digestion: elastase 2A, elastase 3B, and **carboxipeptidase A1 are present from earlier stages of life" cit. "From a nutritional standpoint, brown sugar contains slightly more minerals than white sugar: about 0.50% compared to less than 0.05%. These proportions are still negligible and have no real effect on health." They are important as a prebiotic factor. Lactobacilli need zinc, manganese. Some villi enzymes require zinc. Glyphosate is zinc chelator. Polyphenols from sugar cane support Bifidobacteria. https://pubs.aip.org/aip/acp/article-abstract/3186/1/020056/3333136/The-potency-of-juice-and-brown-sugar-cane?redirectedFrom=fulltext Research Article| January 30 2025 The potency of juice and brown sugar cane (Saccharum officinarum L.) as anti-diabetic sugar based on their mineral, phenolic, and flavonoid content AI Top 10 Health Benefits of Sugarcane Juice Sugarcane juice is ... Sugarcane is a nutrient-rich, natural energy booster packed with antioxidants, vitamins, and minerals that support hydration, liver function, and digestion. It acts as a natural diuretic, promotes oral health, and provides a quick, healthy energy source while aiding in skin health and boosting immunity. Here are the top 10 health benefits of sugarcane: Instant Energy Booster: The natural sugars (glucose and fructose) in sugarcane are easily absorbed, providing a quick, hydrating, and natural energy boost to fight fatigue. Supports Liver Function: It is known to help treat liver-related issues like jaundice by balancing bilirubin levels and keeping the liver functioning optimally. Kidney Health & Detoxification: As a natural diuretic, it helps flush out toxins and infections (UTIs) from the body while supporting kidney function. Improves Digestion: The high fiber content and potassium levels help maintain a healthy digestive system, preventing constipation and soothing stomach infections. Strengthens Bones and Teeth: High mineral content, including calcium, phosphorus, and magnesium, strengthens teeth, reduces bad breath, and promotes healthy bones. Promotes Skin Health: It contains Alpha Hydroxy Acids (AHAs) like glycolic acid, which act as natural exfoliants to treat acne, prevent aging, and reduce blemishes. Boosts Immunity: It is rich in antioxidants that help fight infections, reduce inflammation, and improve overall immune system strength. Manages Blood Pressure & Cholesterol: Potassium content helps lower blood pressure, while its fiber and antioxidant properties can help reduce LDL (bad) cholesterol levels. Combats Cancer Risks: The high concentration of flavonoids and phenolic compounds gives it antioxidant, anti-inflammatory, and anti-cancer properties, particularly for prostate and breast cancer. Supports Recovery from Fever: It is known to replenish body protein loss and helps in faster recovery from viral fevers and infections. https://www.ganeshdiagnostic.com/blog/amazing-health-benefits-of-sugarcane-juice For me cane sugar/juice is like birch tree, maple tree juice. And silica is among them.

@heyman i am not gooning anymore or cooming in real life femoids, my thyroid is working no need to take another supplement

@ThinPicking its not about me friendo, i do like coffee with cream milk and sugar but i still i understand its problematic longterm

@DavidPS Thanks, there is also complementary story https://www.mdpi.com/1422-0067/26/17/8655 Ivermectin Binds to the Allosteric Site (Site 2) and Inhibits Allosteric Integrin Activation by TNF and Other Pro-Inflammatory Cytokines by Yoko K. Takada 1 andYoshikazu Takada 1,2,3,*ORCID 1 Department of Dermatology, University of California School of Medicine, Research III Suite 3300, 4645 Second Ave., Sacramento, CA 95817, USA 2 Department of Biochemistry and Molecular Medicine, University of California School of Medicine, Research III Suite 3300, 4645 Second Ave., Sacramento, CA 95817, USA 3 VA Northern California Health Care System, 150 Muir Road, Martinez, CA 94553, USA * Author to whom correspondence should be addressed. Int. J. Mol. Sci. 2025, 26(17), 8655; https://doi.org/10.3390/ijms26178655 Submission received: 1 August 2025 / Revised: 28 August 2025 / Accepted: 1 September 2025 / Published: 5 September 2025 (This article belongs to the Section Molecular Immunology) Abstract Ivermectin (IVM), a broad-spectrum anthelmintic agent, has anti-inflammatory properties, and affects cellular and humoral immune responses. We recently showed that multiple pro-inflammatory cytokines (e.g., FGF2, CCL5, CD40L) bind to the allosteric site (site 2) of integrins and activate them. 25-Hydroxycholesterol, a pro-inflammatory lipid mediator, is known to bind to site 2 and induce integrin activation and inflammatory signals (e.g., IL-6 and TNF secretion), suggesting that site 2 is critically involved in inflammation. We showed that two anti-inflammatory cytokines (FGF1 and NRG1) bind to site 2 and inhibit integrin activation by inflammatory cytokines. We hypothesized that ivermectin binds to site 2 and inhibits inflammatory signaling by pro-inflammatory cytokines. A docking simulation predicts that ivermectin binds to site 2. Ivermectin inhibits the integrin activation induced by inflammatory cytokines, suggesting that ivermectin is a site 2 antagonist. We showed that TNF, a major pro-inflammatory cytokine, binds to integrin site 2 and induces allosteric integrin activation like other pro-inflammatory cytokines, suggesting that site 2 binding and integrin activation is a potential mechanism of the pro-inflammatory action of these cytokines. Ivermectin suppressed the activation of soluble β3 integrins by TNF and other pro-inflammatory cytokines in a dose-dependent manner in cell-free conditions. Binding to site 2 and the inhibition of binding of inflammatory cytokines may be a potential mechanism of anti-inflammatory action of ivermectin.

@LetTheRedeemed https://www.diningandcooking.com/2025190/new-study-suggests-link-between-cheese-and-long-life/ " The study, published in the Journal of Agricultural and Food Chemistry, suggested that fermented dairy products such as cheese could contribute to longevity and health." https://www.guentensperger-kaese.ch/en/post/news-cheese-and-life-expectancy

I have ordered a-pinene and phytol from the above website. We'll see if it arrives since the whole process was kind of weird. @cs3000 have you tried supplementing a/b-pinene? It seems to have some interesting properties. Maybe could be used as a cancer prevention. Another possibility: use pinus cembra essential oil. It's ~40% a-pinene and ~10% b-pinene, with other terpenes like limonene making up the rest. Theoretically it should be safe to ingest a drop of the essential oil, if diluted and organic. I haven't tried it yet, but can attest to its calming effects just from inhaling it. In this study it increases life span just from inhaling it in flies under certain conditions. https://www.nature.com/articles/srep28540

@LucH I understand, there is no way for you to assess the unique situation of my father; I was just curious if you cycled this like the others. I appreciate the additional information.

@alfredoolivas I know that small amount are good but I do not pay attention so much to the "dosage of food." May that list is more handy https://www.nejm.org/doi/pdf/10.1056/NEJM199308053290619?articleTools=true

@Luke

@Mauritio - Thanks From AI Effects of Lactobacillus reuteri Lactobacillus reuteri (L. reuteri) is a well-studied probiotic known for its beneficial effects on gut health and immune function. Research indicates that L. reuteri can influence the production of IL-10 in several ways: Immune Modulation: L. reuteri has been shown to enhance the production of IL-10, which helps to reduce inflammation and promote a balanced immune response. Gut Microbiota Interaction: By modulating gut microbiota composition, L. reuteri can create an environment that favors the production of IL-10, contributing to improved gut health and reduced inflammatory conditions. Clinical Studies: Some studies have reported that supplementation with L. reuteri leads to increased levels of IL-10, suggesting its potential role in managing inflammatory diseases. How does Lactobacillus reuteri affect immune function beyond IL-10 production? Lactobacillus reuteri enhances immune function by increasing phagocytic activity in macrophages and boosting the secretion of nitric oxide and prostaglandin E2, which are crucial for immune responses. It also produces antimicrobial molecules like reuterin, which helps inhibit pathogenic microorganisms, contributing to overall immune health.

@sunsunsun Merci! Below is a summary in case someone in need will be reading this in the future: Introduction Combination of vitamins E+D about as effective as antibiotic for treating bacterial sepsis/infection daily 1-2k IU D3 + 8.75mg/kg (700-800mg) Vit E (d-alpha-tocopherol or mixed unesterified d-isomers of all 4 tocopherols) The tetracyclines protect against sepsis independently of their antibiotics effects Tetracyclines might be the preferred antibiotic treatment (i.e. doxycycline in a HED of 0.25 mg/kg (intraperitoneal route, so orally one would need ~0.4 mg/kg to achieve the same effects) Endotoxin/LPS is a major driver of blood clotting, sepsis, heart attacks and strokes Aspirin (although only acts downstream of the endotoxin/LPS cascade) Substances that can limit the amount of endotoxin/LPS produced and entering the blood: easily digestible food; avoiding “resistant” starches carrot salad, charcoal (*not really applicable after appendectomy) Niacinamide and vitamin E to help restore the gut barrier pregnane steroids (and especially bioidentical progesterone) to directly bind endotoxin in the bloodstream Inhibiting fatty acid synthesis (FAS) dramatically improves sepsis survival rate least risky of FAS-Inhibitors is probably orlistat (Still severe side effects) aspirin might be good alternative; adding niacinamide + thiamine might improve its effectiveness against sepsis by improving glucose oxidation and reducing lipolysis respectively Inhibiting fatty acid synthesis reverses bacterial antibiotic resistance Aspirin (80mg-100mg daily) inhibited FAS by +50% Aspirin As A Cure For Sepsis excellent thread https://lowtoxinforum.com/threads/aspirin-as-a-cure-for-sepsis.15753/post-215210 Baking Soda Dramatically Increases Antibiotic Effectiveness, Could Help In Sepsis (!) Note: research involved in vitro work only + oral route probably not applicable after appendectomy see Haidut comment Caffene restores lowered cytochrome C oxidase activity + Caffeine restores cytochrome C damaged by sepsis one cup of coffee or about 80mg-100mg of caffeine probably better to do in recovery, not with acute sepsis DHEA Protects From Endotoxin Effects And Lethality single HED dose of as little as 5mg - 7mg DHEA daramatically increased survival of lethal endotoxins DHEA protects from endotoxin (even lethal doses) IV B1+Vit. C+ Cortisone Prevents Septic Induced Death Full interview with Dr. Paul Marik his 2017 paper in question for early treatment protocol Vit C (1.5 g every 6 h for 4 days or until ICU discharge) Thiamine (200 mg every 12 h for 4 days or until ICU discharge) Hydrocortisone (50 mg every 6h for 7 days or until ICU discharge followed by a taper over 3 days) read on the other forum this one failed to replicate, although some studies exist that show somewhat sig improvement https://www.amjmed.com/article/S0002-9343(19)30699-0/fulltext s/o @mauritio T3 levels are a predictor of mortality from sepsis This study (and this one) shows that lactic acid is an independent risk factor for death due to sepsis. CO2 lowers lactic acid, T3 increases CO2. So it makes sense that T3 was so strongly correlated with survival in sepsis patients. -> improve CO2 / lower lactate (thiamin, niacinamide) This study shows a significant increase in survival time of people who take aspirin before hospitalization (by 1.3 days) Vitamin B2 Remarkably Effective Against Endotoxin, Sepsis, And Other Bacterial Infections especially its activated form riboflavin '5 phosphate (R5P) minimum effective human equivalent oral doses for the combination of R5P and valine were approximately 0.2mg/kg and 25mg/kg respectively. This assumes bioavailability of 90% and 70% for R5P and valine. The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy "A group of drugs that target PDHC activation, including dichloroacetate (DCA), thiamine, amrinone, ciprofloxacin, and TNF-binding protein (TNFbp), have been shown to ameliorate the symptoms of sepsis" Septic Shock: Serotonin Is The Likely Cause Of Septic And Anaphylactic Shock Anti-Serotonin (Cyproheptadine) + Aspirin Famotidine & Anti-histamines Protect Organs In (septic) Shock Both an H2 blocker (Famotidine, Cyproheptadine) and an H1 blocker (Chlorphenamine) were each offered protection Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation s/o Koveras Anti-Serotonin, Cypro, Tryptophan Metabolism, Vitamin C, Hydrocortisone, Thiamin https://lowtoxinforum.com/threads/do-not-forget-to-give-thiamine-to-your-septic-shock-patient.12006/ See also: Haidut on radiation exposure due to x-ray https://bioenergetic.forum/topic/3037/advice-on-lowering-endotoxin/18 https://bioenergetic.forum/topic/2140/any-info-on-sepsis-bacteremia-antibiotics-used/16 Citrulline to restore immune function after sepsis L-Citrulline restores immunity & T Cell mitochondria function acutely highest food sources: 1 cup of red flesh watermelon might have ~150mg per cup. or ~400mg for yellow flesh watermelon https://bioenergetic.forum/post/42939 Anti-inflammatory Effect of Low-Intensity Ultrasound in Septic Rats https://bioenergetic.forum/post/60444 (!) avoid mitophagy enhancers like menaquinone (K2), urolithin-A or mitochondrial uncouplers like DNP, BAM15, methylene blue, theobromine etc. (especially in the initial stage of sepsis) https://lowtoxinforum.com/threads/aspirin-in-the-context-of-endotoxin-tolerance.49865/

@Mike_Fave Glad to see u on this forum ur a good youtuber