Coffee dries out skin and eyes, like finasteride, dutasteride and accutane
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I've always wondered why coffee makes my skin and eyes dry.
I found an interesting study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10670875/
- Conclusions:
The hair growth promotion and anti-hair loss activities of six coffee pulp extracts, which were extracted under varying conditions of SFE, were examined. The SFE-4 extract showed the highest levels of phenolic compounds, flavonoids, caffeine content, and scavenging activity compared to others. These compounds could promote the cell proliferation and migration of HFDPCs, particularly during the anagen phase. The SFE-4 extract also stimulated potassium channel opening and MMP-2 expression, which could promote hair growth. In addition, the SFE-4 extract demonstrated a stronger inhibitory effect on SRD5A expression than finasteride and dutasteride, which decreased the synthesis of androgenic hormone in hair follicles and showed an anti-hair loss effect. The SFE-4 extract increased the expression of several genes, including CTNNB1, SHH, SMO, GLI1, and VEGF, to promote hair growth by extending the anagen phase and enhancing blood flow to the hair follicles. Based on our findings, SFE-4 is selected for further in vivo testing in volunteers and for development as a potential hair care product.
I'm writing through Google Translate
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the same thing happens with coconut oil, oranges, tea and cocoa.
they all seem to be 5α-reductase inhibitorsI'm writing through Google Translate
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@alex155 These foods are also quite high in salicylates. I get dry eyes/eye irritation and stinging when I eat too many salicylates
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@Korven
what's interesting is that I've been taking 100 mg of aspirin daily for many years (due to my illness) and this has never happened, lol)) -
@alex155 Ok then it's probably not the salicylates for you
I will leave this thread now, bye-bye!
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this also includes: taurine, carrots, b2... I'm not even mentioning that all these products cause a decrease in libido to zero (at least for me personally)
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@Korven
everything is fine, bro!
don't go) -
I forgot about the champignons
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Also zinc.
By the way, the cretins from lowtoxinforum who drink EGCG and zinc in such huge quantities...
How are they not dead yet? A cup of green tea destroys me, and I won't even mention zinc... I would die -
@alex155 I use egcg as a mouthwash and if I accidentally swallow some I get nauseous lol
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@eduardo-crispino
I think I would have thrown up too)) -
let's add a little cinnamon here for flavor...
https://pubmed.ncbi.nlm.nih.gov/27549514/
The protein expressions of prostate specific antigen, estrogen receptor α (ERα), androgen receptor (AR), 5α-reductase (5AR), and steroid receptor coactivator 1 were suppressed by treatment of CC. Immunohistochemical assays supported the western blot results, as the expressions of AR and ERα were down-regulated by CC treatment as well. Further in vitro experiments showed CC was able to inhibit proliferation of RWPE-1 cells by suppressing 5AR and AR. These results all together suggest CC as a potential treatment for BPH.
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how cleverly nature has conceived, to castrate you with natural products - 5α-reductase inhibitors, contained almost everywhere... but at the same time I have not found a single natural product that would be an inducer of 5α-reductase!
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not sure if the effect is from 5-AR inhibition.
https://pubmed.ncbi.nlm.nih.gov/23136995/ -
@PissBoy
the authors manipulate the concepts of "coffee" and "caffeine"
The abstract began with the words:"Coffee intake has been associated with a low risk of developing cancer, including prostate cancer, which is one of the most commonly diagnosed cancer in men."
and as it turned out, they used pure caffeine with water on the animals:
"Five-week-old male Wistar rats (n = 24) obtained from the central stock breeder of São Paulo State University – UNESP, Botucatu, SP/Brazil, were used in this study. The animals were maintained under controlled temperature and lighting conditions and received food and water ad libitum. The animals were randomized into two experimental groups (n = 12): a control group (CT) and a caffeine-treated group (CF) – three animals by cage. The treated group received caffeine (20 mg/l caffeine; Sigma
, Saint Louis, MO, USA) in the drinking water for 140 days, and the CT group received tap water only. The caffeine dose was chosen to simulate moderate human caffeine consumption (approximately 2–4 mg/kg/day) (Heckman et al. 2010). During the experiment, water and food intake and body weight were measured in the last day of each week."while my research shows the influence of coffee (beans) polyphenols, etc.
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@PissBoy I also don't like this part:
"Acknowledgments
The authors thank Dr. Wagner José Fávaro, Dr. Renee Laufer Amorim and Ivan José Vechetti Junior for important contributions to the manuscript. This article is part of the dissertation presented by Carolina Sarobo to the Institute of Biosciences – Sao Paulo State University (UNESP) – to receive the degree of Master of Science."
https://en.wikipedia.org/wiki/São_Paulo#Economy
As of 2014, São Paulo is the third largest exporting municipality in Brazil after Parauapebas, PA and Rio de Janeiro, RJ. In that year São Paulo's exported goods totaled $7.32B (USD) or 3.02% of Brazil's total exports. The top five commodities exported by São Paulo are soybean (21%), raw sugar (19%), coffee (6.5%), sulfate chemical wood pulp (5.6%), and corn (4.4%).[176] -
another study about EGCG and other inhibitors, including caffeic acid.
Chucky and all those who follow him (HG7) - enjoy your self-castration!https://pubmed.ncbi.nlm.nih.gov/11931850/
The enzyme steroid 5 alpha-reductase (EC 1.3.99.5) catalyzes the NADPH-dependent reduction of the double bond of a variety of 3-oxo-Delta(4) steroids including the conversion of testosterone to 5 alpha-dihydrotestosterone. In humans, 5 alpha-reductase activity is critical for certain aspects of male sexual differentiation, and may be involved in the development of benign prostatic hyperplasia, alopecia, hirsutism, and prostate cancer. Certain natural products contain components that are inhibitors of 5 alpha-reductase, such as the green tea catechin (-)-epigallocatechin gallate (EGCG). EGCG shows potent inhibition in cell-free but not in whole-cell assays of 5 alpha-reductase. Replacement of the gallate ester in EGCG with long-chain fatty acids produced potent 5 alpha-reductase inhibitors that were active in both cell-free and whole-cell assay systems. Other flavonoids that were potent inhibitors of the type 1 5alpha-reductase include myricetin, quercitin, baicalein, and fisetin. Biochanin A, daidzein, genistein, and kaempferol were much better inhibitors of the type 2 than the type 1 isozyme. Several other natural and synthetic polyphenolic compounds were more effective inhibitors of the type 1 than the type 2 isozyme, including alizarin, anthrarobin, gossypol, nordihydroguaiaretic acid, caffeic acid phenethyl ester, and octyl and dodecyl gallates. The presence of a catechol group was characteristic of almost all inhibitors that showed selectivity for the type 1 isozyme of 5 alpha-reductase. Since some of these compounds are consumed as part of the normal diet or in supplements, they have the potential to inhibit 5 alpha-reductase activity, which may be useful for the prevention or treatment of androgen-dependent disorders. However, these compounds also may adversely affect male sexual differentiation.
I'm writing through Google Translate
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That's not supposed to happen.
@ThinPicking said in Grant's rapid aging:
Fluid dynamics can be a helluva drug.
Follow the orange brick road.
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@ThinPicking Sorry, I use Google Translate and I don't understand what you mean.
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@alex155 said in Grant's rapid aging:
yesterday I drank a can of non-alcoholic beer 0.5 (estrogen is evil, I know)
I went out to the balcony to smoke and suddenly felt the smell of a fresh summer wind, all my greenery became brightly colored, my soul became calm and pleasant memories from the past came flooding back, which I hadn’t felt for 8 years...
aspirin and coffee have destroyed all of this over the years, I feel like a robot...These experiences are connected alex. You've got to figure it out (I'm busy anyway). And you're right it's not all that simple, it's even more simple.
