Coffee dries out skin and eyes, like finasteride, dutasteride and accutane
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Also zinc.
By the way, the cretins from lowtoxinforum who drink EGCG and zinc in such huge quantities...
How are they not dead yet? A cup of green tea destroys me, and I won't even mention zinc... I would die -
@alex155 I use egcg as a mouthwash and if I accidentally swallow some I get nauseous lol
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@eduardo-crispino
I think I would have thrown up too)) -
let's add a little cinnamon here for flavor...
https://pubmed.ncbi.nlm.nih.gov/27549514/
The protein expressions of prostate specific antigen, estrogen receptor α (ERα), androgen receptor (AR), 5α-reductase (5AR), and steroid receptor coactivator 1 were suppressed by treatment of CC. Immunohistochemical assays supported the western blot results, as the expressions of AR and ERα were down-regulated by CC treatment as well. Further in vitro experiments showed CC was able to inhibit proliferation of RWPE-1 cells by suppressing 5AR and AR. These results all together suggest CC as a potential treatment for BPH.
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how cleverly nature has conceived, to castrate you with natural products - 5α-reductase inhibitors, contained almost everywhere... but at the same time I have not found a single natural product that would be an inducer of 5α-reductase!
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not sure if the effect is from 5-AR inhibition.
https://pubmed.ncbi.nlm.nih.gov/23136995/ -
@PissBoy
the authors manipulate the concepts of "coffee" and "caffeine"
The abstract began with the words:"Coffee intake has been associated with a low risk of developing cancer, including prostate cancer, which is one of the most commonly diagnosed cancer in men."
and as it turned out, they used pure caffeine with water on the animals:
"Five-week-old male Wistar rats (n = 24) obtained from the central stock breeder of São Paulo State University – UNESP, Botucatu, SP/Brazil, were used in this study. The animals were maintained under controlled temperature and lighting conditions and received food and water ad libitum. The animals were randomized into two experimental groups (n = 12): a control group (CT) and a caffeine-treated group (CF) – three animals by cage. The treated group received caffeine (20 mg/l caffeine; Sigma
, Saint Louis, MO, USA) in the drinking water for 140 days, and the CT group received tap water only. The caffeine dose was chosen to simulate moderate human caffeine consumption (approximately 2–4 mg/kg/day) (Heckman et al. 2010). During the experiment, water and food intake and body weight were measured in the last day of each week."while my research shows the influence of coffee (beans) polyphenols, etc.
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@PissBoy I also don't like this part:
"Acknowledgments
The authors thank Dr. Wagner José Fávaro, Dr. Renee Laufer Amorim and Ivan José Vechetti Junior for important contributions to the manuscript. This article is part of the dissertation presented by Carolina Sarobo to the Institute of Biosciences – Sao Paulo State University (UNESP) – to receive the degree of Master of Science."
https://en.wikipedia.org/wiki/São_Paulo#Economy
As of 2014, São Paulo is the third largest exporting municipality in Brazil after Parauapebas, PA and Rio de Janeiro, RJ. In that year São Paulo's exported goods totaled $7.32B (USD) or 3.02% of Brazil's total exports. The top five commodities exported by São Paulo are soybean (21%), raw sugar (19%), coffee (6.5%), sulfate chemical wood pulp (5.6%), and corn (4.4%).[176] -
another study about EGCG and other inhibitors, including caffeic acid.
Chucky and all those who follow him (HG7) - enjoy your self-castration!https://pubmed.ncbi.nlm.nih.gov/11931850/
The enzyme steroid 5 alpha-reductase (EC 1.3.99.5) catalyzes the NADPH-dependent reduction of the double bond of a variety of 3-oxo-Delta(4) steroids including the conversion of testosterone to 5 alpha-dihydrotestosterone. In humans, 5 alpha-reductase activity is critical for certain aspects of male sexual differentiation, and may be involved in the development of benign prostatic hyperplasia, alopecia, hirsutism, and prostate cancer. Certain natural products contain components that are inhibitors of 5 alpha-reductase, such as the green tea catechin (-)-epigallocatechin gallate (EGCG). EGCG shows potent inhibition in cell-free but not in whole-cell assays of 5 alpha-reductase. Replacement of the gallate ester in EGCG with long-chain fatty acids produced potent 5 alpha-reductase inhibitors that were active in both cell-free and whole-cell assay systems. Other flavonoids that were potent inhibitors of the type 1 5alpha-reductase include myricetin, quercitin, baicalein, and fisetin. Biochanin A, daidzein, genistein, and kaempferol were much better inhibitors of the type 2 than the type 1 isozyme. Several other natural and synthetic polyphenolic compounds were more effective inhibitors of the type 1 than the type 2 isozyme, including alizarin, anthrarobin, gossypol, nordihydroguaiaretic acid, caffeic acid phenethyl ester, and octyl and dodecyl gallates. The presence of a catechol group was characteristic of almost all inhibitors that showed selectivity for the type 1 isozyme of 5 alpha-reductase. Since some of these compounds are consumed as part of the normal diet or in supplements, they have the potential to inhibit 5 alpha-reductase activity, which may be useful for the prevention or treatment of androgen-dependent disorders. However, these compounds also may adversely affect male sexual differentiation.
I'm writing through Google Translate
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That's not supposed to happen.
@ThinPicking said in Grant's rapid aging:
Fluid dynamics can be a helluva drug.
Follow the orange brick road.
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@ThinPicking Sorry, I use Google Translate and I don't understand what you mean.
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@alex155 said in Grant's rapid aging:
yesterday I drank a can of non-alcoholic beer 0.5 (estrogen is evil, I know)
I went out to the balcony to smoke and suddenly felt the smell of a fresh summer wind, all my greenery became brightly colored, my soul became calm and pleasant memories from the past came flooding back, which I hadn’t felt for 8 years...
aspirin and coffee have destroyed all of this over the years, I feel like a robot...These experiences are connected alex. You've got to figure it out (I'm busy anyway). And you're right it's not all that simple, it's even more simple.
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ah, I think I get it! you mean that beer was supposed to castrate me even more than tea polyphenols and coffee?)
surprisingly, beer increased my libido yesterday and I understand why!
Ray wrote about this, that estrogen can cause hypersexuality and it is true) -
@alex155 said in Coffee dries out skin and eyes, like finasteride, dutasteride and accutane:
you mean that beer was supposed to castrate me even more than tea polyphenols and coffee?)
No. I mean it "hydrated" you. This is a complex, circadian and behaviour dependant phenomenon. The meme of water bottles next to a body diagram is a nonsense depiction.
How you then act on that understanding can be simple. Get your head around it and you'll tolerate coffee etc.
surprisingly, beer increased my libido yesterday and I understand why!
Unsurprising to me given your current reaction to coffee. Cheers!
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@CrumblingCookie said in What's up with the EGCG health potion trending on RPF?:
Maybe someone with more dedicated brain activity to spare can look into that more profoundly.
@bot-mod said in What's up with the EGCG health potion trending on RPF?:
I'm far too busy.
@alex155 said in Coffee dries out skin and eyes, like finasteride, dutasteride and accutane:
another study about EGCG and other inhibitors, including caffeic acid.
Heisenberg.
God dammit. I'm coming back to this later.
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@alex155 What if you are simply deficient in Zinc?
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@Kvirion I tried zinc, it also dries the skin, because it is an inhibitor of 5α-reductase
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@Kvirion https://pubmed.ncbi.nlm.nih.gov/33878855/
Conclusions: Based on our results, the combination of arginine and zinc tested in our study could represent a good therapeutic option for the treatment of AGA and TE and it might represent a valid alternative to finasteride.
but there is also this study: https://pubmed.ncbi.nlm.nih.gov/30772815/
Zinc is essential in the regulation of a variety of physiological and biochemical events in the organism. It plays a critical role in maintaining the cell membrane integrity, protein-carbohydrate-lipid metabolism, immune system, wound injury and in the regulation of a number of other biological processes associated with normal growth and development. Physiological and biochemical levels of many hormones are affected by zinc metabolism. Therefore, growth impairment, hypogonadism, and some endocrine diseases are associated with the deficiency of zinc. These effects of zinc are considered versatile. Zinc increases the synthesis of the growth hormone and its number of receptors; thus, it is an important mediator in the binding of this hormone to its receptor. Found in a large quantity in the pancreas tissue, zinc has a part in the regulation of the effect of insulin. Zinc is involved to much more thyroid hormone metabolism such as hormone synthesis, receptor activity, conversion of T4 to T3, and production of carrier proteins. The low levels of zinc and high levels of leptin in obese individuals point to a critical relationship between zinc and leptin. Zinc is related to enzyme activity to melatonin synthesis. Melatonin has regulatory activity for zinc absorption from gastrointestinal system. Zinc particularly affects the conversion of testosterone to dihydrotestosterone, as 5α-reductase that is involved in this conversion is a zinc-dependent enzyme. In consideration of these relations, zinc is accepted to play critical roles in the endocrine system. The aim of the current review is to draw attention to the effects of zinc on the endocrine system.
there is an opinion that zinc inhibits 5ap in high quantities, and increases it in small quantities, but I tried both methods, but the effect is the same - dry skin
I'm writing through Google Translate
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Can anyone explain this study? https://pubmed.ncbi.nlm.nih.gov/8279712/
neutralized zinc (zinc gluconate + arginine)
does arginine neutralize zinc? zinc gluconate is bad because arginine neutralizes zinc gluconate? I don't get it.
Abstract
Zinc has been implicated in steroid endocrinology of the prostate gland; and 5 alpha-dihydrotestosterone (DHT) is believed to express androgenic responses in the prostate. To note the effect of neutralized zinc (zinc gluconate + arginine) on the prostate, 50 sexually mature rats, weighing 325 +/- 20 g, were divided into five groups as follows: (1) control, (2) sham, (3) castrated, and injected intraprostatically with (4) 10 mg neutralized zinc, and (5) 20 mg neutralized zinc. Results indicated significant reduction (P < 0.05) of prostate weight, 5 alpha-reductase activity, and total protein and DNA concentrations in treated prostate tissue; no significant change in weight and histological structure of testes, epididymides, and seminal vesicles; and no significant effect on progeny and blood testosterone level of treated animals. These results suggest that direct application of neutralized zinc to the prostate offers a new modality for treatment of prostatitis without affecting spermatogenesis.
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@alex155
Zinc gluconate + arginine is a veterinarian castration product injected into the testisall 12 testes contained dark red, well-demarcated regions involving 25% to 100% of the testicular parenchyma (Figure 3). Histologically, these regions were characterized by severe, acute, coagulative necrosis with extensive acute hemorrhage. The inflammation and injury often extended beyond the testes into the tunics and epididymis; adjacent vessels showed evidence of vascular injury and thrombosis. - link
The zinc is an antiseptic like spermicide and the arginine, as a nitric oxide precursor facilitates the inflammation permanently damaging the testis.
