@Luke said in Who's still doing a PUFA depletion detox diet? (long terms results, hopes dreams, future plans):

With chickens and eggs it's probably best to keep your own if possible and then feed them non-crap. Dr. Peat once mentioned in an interview that some farmer raised pigs and fed them non-crap, I think he mentioned potatos, fruit and coconut. And when they had the meat tested it was as low in PUFA as beef. I would guess it's the same with chicken. If you don't feed them the typical PUFA food, it will reflect the PUFA content in their own fat tissue and the eggs.

I'm not sure organic makes that much of a difference in that regard, because they are fed organic crap instead of conventional crap. But at least they have a chance to eat some worms or insects once in a while when they are outside instead of some cage.

Edit:
He also mentioned he would eat 4 or 5 eggs a day when he was in Mexico, because Mexicans feed their chickens leftovers from their own food. But he wouldn't eat more than one egg in the United States.

"Tokelauans and Pukapukans are very similar. Pigs and chickens on these atolls also eat large amounts of coconut. This is reflected in the unusually high concentration of short-chain fatty acids in their fat which in turn contributes to the saturated fat intake of the islanders."

I didn't even know it existed until now haha, but from what I've read they're slow release, right? So maybe it's not good for baths if it's too slow

For plants, there's the green pad co2 generator, which releases CO2 into the environment as it reacts with the humidity in the air. Very cool too

@sushi_is_cringe

Selenoneine? I remember seeing some relation to mercury detoxification, but I don't know much about this one in particular.

I remember Click saying that promoting butyrate-generating foods was just a way of recapitulating life as it was in selenium-rich soil, since selenomethionine is converted to α-keto-γ-methylselenobutyrate (KMSB) and works basically the same way as butyrate.

So supplementing selenomethionine mimics a Methionine restriction and also promotes an increase in keto acid similar to butyrate. Interestingly, consuming resistant starch increases butyrate production and also mimics Methionine restriction (and other amino acids like leucine, tryptophan, etc.).

Funny how it works haha

@Insr said in Iodine - too much!:

@TexugoDoMel

Since I have this iodine intolerance myself, I'd like to fix it.

As I mentioned in my log thread, I think my halogen exposure is a good deal lower than normal due to almost never eating bromide sources, and getting all my water from a well so I get no chlorine, and no flouride from my drinking, cooking, or bathing water.

But how about the weak antioxidant system idea. Is there a way to measure this to determine if I do have a weak antioxidant system? And what should I do about it?

Do you mean I should take Vit C, Vit E, and Selenium and I would be able to handle high iodine? I have in the past taken Vit C alongside my high iodine diet (I didn't know it was high at the time) and I still felt foggy and slow. My diet has been moderately high in selenium for a long time, but perhaps it needed to be even higher?

Or perhaps I have some unresolved source of inflammation. The only things I can think of are:

1. I live in a house that is probably moldy
2. I also eat a lot of grain products (all totally free of additives, bromides, and pesticides - much of it is homemade.)
3. I have some gum inflammation at times.

How high was your iodine intake before and how much do you consume now?

Well, you could try adding more antioxidants to your diet and see if that helps. In animal studies, they mitigate some of the damage from high iodine intake with vitamin C. But I suspect that you'll have to keep testing to find out where the problem is influencing your redox negatively.

If I have any suspicion of a micronutrient deficiency, I always start with it. But if I don't know I usually start with the micronutrients that can give the best results (in my opinion), so thiamine+magnesium to support the Pentose Phosphate Pathway and NADPH, other B vitamins (if I'm not mistaken, every protocol with iodine adds B2 and/or B3), minerals like potassium, etc..., while I try to support the antioxidant system by offering what's necessary for things like glutathione synthesis, melatonin (I know Peat didn't like it, but I don't have a problem) and if necessary exogenous antioxidants like vitamin C to support that period if it would benefit me.

This isn't medical advice, it's just what I usually do when I'm unwell.

Unlike other nutrients such as some vitamins, which can be megadosed without too many problems, the effect of iodine depends on the overall status of the organism. Cofactors are extremely important; if iodine was the problem, the Japanese wouldn't even exist anymore.

Too much iodine in the presence of other halogens in the tissues? You'll have a bad experience.
Too much iodine with a weak antioxidant system? You'll have a bad experience

Since iodothyronines can be used as antioxidants (sometimes even more potent than vitamin C and E), I believe that there is a possibility that a person will experience symptoms of hypothyroidism with high doses of iodine if too much of T3 and T4 are being “hijacked” to be used as antioxidants.

@Insr said in Bloodwork shows elevated TPOAb (Hashimoto's disease):

By the way, I just ran across this post:

@TexugoDoMel said in Thyroid Log:

@GreekDemiGod

Iodine is very important but remember that iodine displaces bromide and fluoride and can cause unpleasant symptoms precisely because of this. It's a good idea to adjust the amount of selenium too, as there's a good chance you'll feel unwell when supplementing with iodine if you're deficient in selenium.

Could this explain why I feel lots better with low iodine?

I don't think so, because:

Flouride
I have drunk primarily well water (which is also filtered through a berkey filter) - so this is not fluoridated water. I know there's some flouride exposure from stuff like orange juice when they add water to the concentrate in the factory, but other than that, I'm not getting much flouride. I've drunk almost exclusively water from that well for 4 years, and 50% of my daily water intake was from that well for 8 years before that. So I must be much lower in fluoride exposure than typical.

Bromide
I eat almost exclusively homemade food, almost never any additives, and mostly organic. I hardly ever eat bread that isn't homemade. So I think my bromide exposure is extremely low compared to typical. That has been the case for a good 8 years.

Selenium
Up until recently I've eaten plenty of eggs, meat, some seafood, and brazil nuts (though brazil nuts are probably not the selenium powerhouses people claim) - so my selenium intake has been consistently higher than what is probably typical.

Is it really iodine?
By the way, I just recently tried an experiment where I increased the iodine back up to see what would happen and it made me feel awful, very low thyroid feeling.

Honestly I can't tell you if it's your case, I just mentioned the most common negative things attributed to iodine. I also don't know your exact routine but many people overestimate how much they avoid, depending on where you live even if you filter the water you drink you bathe in fluoridated/chloridated water every day if you don't use filters everywhere else in the house too.

The possibilities are varied. It could be those things I mentioned before, it could be iodine consumption increasing oxygenation (which isn't good if it's not accompanied by an antioxidant system in order because it increases ROS), or several other interactions. In general, I'm just skeptical when people attribute everything to iodine because I've never seen anyone who attributes their symptoms to iodine consume a lot of it, which makes me believe that the problem has another origin.

@jamezb46

This “deplete PUFA in 30 days” is a pseudo-depletion and would only maintain the result if you didn't eat PUFA and if you didn't access your body fat at great/moderate intensity.

What gives fat-free this result is the up-regulation of de novo lipogenesis which dilutes the PUFA as long as the diet is maintained. I have no doubt that the amount of total PUFA decreased, but the fact that a meal replenishes levels almost everywhere already indicates a problem, probably if they put the monkeys in the study on a fast would have the same result depending on the levels of PUFA stored in body fat. When you deplete a rat of PUFA, which has a fast metabolism, it sometimes takes weeks to get it off EFAD (triene:tetraene to <0.4), not one meal.

Most studies use a fat-free diet or fat-free + hydrogenated coconut oil diet, but these are not the best diets for accelerating PUFA depletion.

@serotoninskeptic

I think that any risk is quite low compared to other tools such as x-rays or CT scans. I remember seeing a study correlating an increase in thyroid cancer with an increase in ultrasound of thyroid, but I couldn't tell if it was a consequence of more people being diagnosed or if it was the very cause of the cancer increase.

Why don't you try going without supplements for a month and redoing the tests? The honey diet you're on, sunbathing, etc. should help restore levels quickly.

@Pooooop

That would be IGF-1, which is anabolic, and not GH. Insulin increases IGF-1 levels and fasting increases GH levels