Useful links *) Coenzyme et Cofacteur ne se lient pas par insuffisance de Thiamine (B1) (Coenzyme and cofactor do not bind due to thiamine (B1) deficiency) https://mirzoune-ciboulette.forumactif.org/t2015-vaut-le-detour-it-s-worth-the-detour#29416 *) B1 deficiency and Potassium Waste Thiamine Deficiency Causes Intracellular Potassium Wasting 04/23 By Elliot OVERTON, DIPCNM CFMP, author at “Hormones Matters” is a nutritional therapist and functional medicine practitioner based in the UK. https://www.hormonesmatter.com/thiamine-deficiency-causes-intracellular-potassium-wasting/ Thiamine deficiency causes intracellular potassium wasting. Excerpt: In short, the bioenergetic state of the cell governs its ability to retain potassium ions and structure water into a gel-like phase. A cell with plentiful ATP can maintain this ability, independent of the “sodium potassium pump”. On the other hand, cells lacking energy lose their capacity to retain potassium, intracellular water becomes “unstructured” and intracellular concentration of sodium ions increases and the electronic state of the cell is changed. This causes water to “leak” out of the cells into the extracellular space to produce a localized edema of sorts. Thiamine, playing a central role in energy metabolism, is partially responsible for maintaining healthy redox balance and a continuous supply of ATP. Hence, it is no wonder why a deficiency of this essential nutrient produces such drastic changes in the cellular electrolyte balance. *) Thyroïde B1 B2 B3 – Interaction entre les vitamines du groupe B et la thyroïde https://mirzoune-ciboulette.forumactif.org/t2018-comment-booster-votre-energie#29549 Thyroid hormone (thyroxine) regulates the enzymatic conversion of riboflavin into its active coenzyme forms. B2 is necessary for the regulation of thyroid enzymes: B2 helps to organify iodine (i.e. the incorporation of iodine for the production of thyroid hormones). *) Choline is a well-known methyl donor, but it cannot play a methyl-donor role until it is converted to betaine in the liver and kidneys. Avoid chronic high niacin exposure since it might induce a methyl pool depletion. Excessive nicotinic acid increases methyl consumption and hydrogen peroxide generation in rats https://www.tandfonline.com/doi/full/10.3109/13880209.2012.697175 https://www.nature.com/articles/hr2011133 *) Anti-Stress & Neuro-Protective Effects of Thiamine (B1) Mitochondrial Energy Uploaded thanks to Optimized Enzyme Communication https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712 Neuroprotective Effects of Thiamine Impact on mitochondrial respiration – Link with ATP production Power plant (power station generating electricity) The role of thiamin deficiency in lower brain dysfunction (dysautonomia) Nutrient deficiency & interaction of vitamins B Understanding nutritional & functional deficiencies (enzymatic metabolic block) How much and which kind of thiamine? (video Elliot Overton) How to proceed to avoid / limit a paradoxical reaction.

"GENERATIVE ENERGY: Restoring The Wholeness Of Life" is also now available. Amazon: https://a.co/d/jca7Tqh

@Mauritio [image: 1766957715962-screenshot-2025-12-28-at-1.33.53-pm.png]

@LucH - Excellent idea.

@jamezb46 the idea was that even though bakuchiol itself doesn't aromatize to estrogen, its estrogenic effects would essentially take the place of existing estrogen aromatized from different sources. The purpose of the AI would be to reduce aromatized estrogen elsewhere so that the bakuchiol in addition to existing hormones doesn't cause hyperestrogenic symptoms. Of course, this wouldn't be viable if bakuchiol is so estrogenic that an effective dose would exhibit an estrogenic effect greater than what would already be present. I also thought that DHEA became estrogenic at higher doses if there is already of lot of it present. Is that not true? Also, it's disappointing how Idealabs wasn't able to get a good enough Drupanol yield. Doing so would have brought them more into the lines of "exclusive supplement lab" and less of a "Sigma Aldrich rebadger". Maybe the new product has its own synthesis?

@what-about-bob Thanks. I like the summary. How everything all fits in from theae great minds and put together by Ray Peat into more practical lifestyle applicable ideas. I am appreciating how I see myself on the "applied technology" end of their contributions as I incorporate these ideas into my attempt to be my own doctor as I attempt to improve my health. I have been unable for the past 24 years to lower my blood pressure without using prescription medication. But I am seeing the light at the end of this tunnel. It is a long process of learning and I don't give up. Thanks to recent developments in science and technology, I may be able to lower my blood pressure finally using ideas from Peat and his predecessors. What has been helpful is my use of AI as an efficient research assistant and aggregator of concepts and minute details that my own limited human mind can't recall easily and utilize readily.

@sphagnum its probably totally fine now I just vowed to not buy stuff from them because their customer service around it sucked so bad, they refused to refund me because my bottle was expired, and that was annoying because logically the bottle being expired does not negate the fact they sold me a bad product, and secondly, I wasnt contacted properly about it, they could have sent me a letter via paper mail if I wasn't checking to see if they emailed me. The way their customer service person talked to me was just shameful from a good business perspective. I just dont have time for companies run by, staffed by people like that. for k2 I just buy it from idealabs, who get it from sigma or some other reputable supplier and just mix it in oil and bottle it. the only reason I do this instead of buying the powder myself and doing it is apparently k2 mk4 powder is sensitive to light and im too lazy to setup a darkroom mixing apparatus or something. im assuming idealabs mixes it in a darkroom if its required but I have no idea as no details like this are ever given. If I found out HN has some sort of amazing pregnenolne now I would cope and buy it, but they are just selling microbially produced pregnenolone, which isn't that big of a deal. I mean it's cool, and great and all, but I haven't seen any proof that microbially produced preg makes a better end product, and secondly it's funny actually because microbially produced citric acid is really le bad according to peaters.

health naturas Whole E is insanely good. i take 5 drops from the dropper and almost insantly within 3 minutes or so reduction in puffy nipple symptoms, super anti prolactin.

^^^^what he said. He’s always taking about his labs and dropping some numbers, but I’ve never seen them posted, especially not in a comprehensive fashion. Maybe they’re behind a paywall, I don’t know.

@Kilgore done

@engineer said in Peaty protein bars. Why do these not exist?: Why are there no Peaty protein bars and what is stopping someone from cornering the market with them? Not a protein bar, but I’ve used homemade gummy bears (gelatin, juice, honey or sugar, salt) as a Peaty substitution while mountain climbing or running errands.

@ethan Dangit they are the ones who blocked me for no reason.

Still one of my favourite posts. W sushi. W christmas. W bioenergetic forum

@engineer said in The Death of the Dollar: photonics engineer Excellent. Who needs a dollar or a noble metal when you can quant a corona. Or other miraculous feat. objectively has the best prospects future invention potential Prospector dependant.

Ok, I have something interesting to report. Yesterday I started with 20 drops in the morning like I've been doing since last Wednesday. However, later in the day I did 5 more due to some exercise earlier and some potential evening stress (A Christmas Carol play). Then I followed up with 5 more drops right before bed. I'm not sure if it was the 6 keto p4 or not, but I slept very soundly. Note that I also don't know what the half life of this stuff is. Anybody here know the half life?

@lobotomize said in growing taller potential studies: @Jennifer Sadly, Peat has made some wild anecdotal claims that really blur the line between reality and fiction. Examples include: He claimed a infertile woman ovulated after wearing his cardigan. A dog allegedly regrew an eyeball. He claimed to eat 10,000+ calories per day without gaining weight. I believe he grew. After switching from a plant-based diet to an ancestral one heavy in full-fat dairy and supplementing thyroid in my early 30s, my wisdom teeth erupted and I regained an inch of the almost four inches I lost when my spine collapsed in my 20s. I’ve grown another inch since. I just hope I don’t surpass my original height of just under 5’4”. I’ve always wanted to be short. My sibling is tall (6’4”) and I was one of the tallest kids in my class, until becoming vegetarian around 11/12 and I stopped growing.

@hwisdom It's not artifically fluorinated. It's treated obviously, like all ground water is. Otherwise you would be drinking pebble soup. But yes, it contains an amount of fluoride naturally, that is comparible to fluorinated water. So you are half right, and I take back my comment about you not drinking high fluroide water

My husband is 70 now. Still works full time and is very fit. He's always eaten that way. Basically naturally since he was a child. He only eats dinner and sometimes lunch depending if he goes out for lunch for his works but usually, he only eats once a day. He's very lean but never works out. I could never do it because I feel awful when intermittent fasting. I personally think it's different per individual.