@engineer said: Therefore, what I'm wondering about is a strategy to ease the switch from FAO to glucose oxidation. Hi, your analyze if fine but it won't do the job whenever you stress. I can develop if needed (adrenalin => cortisol => no glycolysis allowed). Of, course your body must be accustomed to lipolysis and ketosis. It takes time (progressively improved). If you don't manage this staple very well, your brain is going to slow carburation down. When going out of a real fast (3-4 days), the return must be very progressive with carbs. It seems you've got problems too to manage insulin spike, if I decode well. It won't function well if ....

Ray was asked the difference in effect between using T and using DHT: https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-669099 Q: What is the major difference in impact between testosterone and dht? Assuming all the foundational stuff is sorted first (-thyroid good, calcium intake, etc.) Peat: Stress and inflammation increase the risk that testosterone will turn to estrogen.

@jamezb46 thanks @jamezb46 @sunsunsun @lobotomize @bio3nergetic

@lobotomize

bgpharmadrugs?

@jd_au said: Keep it simple folks. Still fine for you. However, when taking HD B1, there is a protocol to follow. In short, there is interaction between several vitamins and trace elements. I then asked AI to help clarify the why and the how for other readers. AI says, as if LucH were speaking to JD: Glad it has lasted for you, JD! That is fantastic personal success, and it actually makes perfect sense given the specific combination you used. When you take thyroid hormone alongside thiamine, you are directly addressing the systemic metabolic bottleneck. In the bioenergetic framework Dr. Ray Peat talked about, low thyroid impairs the liver's ability to clear excess estrogen. High estrogen triggers nitric oxide, which over-relaxes (smoothes out) the blood vessels in the lower extremities, causing blood to pool and forcing the heart to beat faster to compensate (POTS). By taking thyroid and thiamine together, you restored cellular energy and vascular tone simultaneously, which is why your results have been so stable. However, for other readers looking to replicate this, it is crucial to understand why standalone High-Dose Thiamine (HD B1) protocols usually require cofactors. Skipping them can cause issues for the average person due to several factors: Magnesium is Mandatory: Thiamine cannot be converted into its active, usable form (thiamine pyrophosphate) without magnesium. Mega-dosing B1 alone rapidly depletes magnesium stores. This frequently triggers severe muscle cramps, anxiety, and heart palpitations, which people often mistake for a worsening of their POTS. The "Paradoxical Reaction": High doses of B1 can kickstart dormant mitochondrial pathways so suddenly that it causes a temporary, severe flare-up of autonomic symptoms. Adequate magnesium, potassium, and baseline nutrition help buffer this transition and prevent a metabolic shock. B-Complex Imbalance: Flooding the system with massive doses of a single B vitamin can eventually create a functional deficiency in other B vitamins (like B2 and B3) that share the same cellular energy pathways. In short, JD's success is a great example of the bioenergetic approach working perfectly because the underlying thyroid and estrogen pieces were addressed. But for most people starting a high-dose thiamine protocol on its own, skipping cofactors like magnesium is a frequent cause of metabolic stalls or severe symptom regressions. Keep it simple, but keep the underlying biochemistry in mind!

@jd_au said: I learned a tremendous amount from that forum. Amazing place really. He didn't have to run it as was or is to maintain the business, in fact it's probably detrimental to that. I have a bulging folder of screenshots that I've referred to many times over the years. Maybe there's a highlights with humour thread in there. flip flopped @bot-mod said: [image: 1729690076468-97noxc.jpg] Footwear tbd.

Rinsing oats may remove some surface starch, but it will not remove most of the starch. The gas and gut activity may simply be from the high fiber content. If the kidney discomfort continues, it would be best to have it checked.

@George-Adams Hi, I drink structured water but I don’t think it’s going to have an impact on my sleep I explain: I fill an earthenware pitcher with tap water and let the chlorine evaporate. Then, when my thermos with the magnetic metal base is empty, I transfer the water into it. I avoid letting tap water sit at temperatures above 22–24°C to prevent potential bacterial growth during heatwaves. Note; last year I used mineral water (500 mcg trace elements maxi), but I no longer do so (plastic nanoparticles), except for my coffee machine (limescale). Make a search with: Masaru Emoto Japanese searcher and living water (youtube video) I’ve written a post on living water in French on a forum where I no longer go, 20 years ago (restricted access + commercial cookies). Mémoire de l’eau : eau vibrée – eau vitale. 1ère partie : Mémoire de l’eau. 2ème partie : La biodynamisation ou l’énergie vitale 3ème partie : Eau vibrée. Technique de fabrication 4ème partie : Emploi de l’eau vibrée eau organique. Importance de l'eau pour la vie 5ème partie : eau de source – source de vie. 6ème partie : La dynamique de l'eau 7ème partie : Santé et terrain biologique 8ème partie : Alimentation et bio-électronique. If you have trouble (awoken at 2-3 a.m.) it's said to be a problem with liver. overloaded. Not the only possibility.

Pure aspirin powder, especially when dissolved cleanly in warm water or a metabolic substrate like orange juice is absorbed primarily in the upper GI tract, ensuring it never reaches the small intestine as a concentrated solid. The aspirin in this study and the ones like it utilize enteric coated aspirin. Known as Bayaspirin the enteric coating utilizes methacrylic acid copolymer, often branded as Eudragit, along with other excipients like Titanium Dioxide, plasticizers, and synthetic dyes. Pretty nasty, pretty irritating especially a concentrated, focused amount of it on the intestinal lining. This kinda crap reminds of the 1918 or so studies where enormous amounts of aspirin were used and it was then said aspirin was terrible for the body.

@sunsunsun said: I learned this from Chris Masterjohn's article where he explains it has to do with CoA and if you are taking b6 it is a good idea to take b5. After reading Sunsunsun’s comment on B5/CoA, as a likely kinetic bottleneck in cellular energy and side-effects on nerve cells, I decided to go deeper in the mechanism. Here are the main points (excerpts) if you are taking HD B6 or trying to optimize the energy levels, when talking about interaction from some supplements like betaine (as a traffic controller) or the Choline-Egg-TMG Connection (role in cell energy & signaling). Summary of the pathway In short, B6 PLP acts as the accelerator pedal for creating cysteine. If you step on that pedal with 20–25 mg of PLP, you must dramatically increase the supply of Vitamin B5 (at a 2:1 ratio) to prevent the system from exhausting. The extra B5 safely captures the excess cysteine, escorts it into Coenzyme A production, and prevents the cellular energy depletion that triggers a neurological shutdown. [image: 1786964093985-bottelneck-b5-coa.png] Even before I even introduce the higher-dose B5 (200 mg), my setup was already highly defensive. The combination of TMG, Choline/Eggs, and periodic Methyl-B9/B12 creates a massive upstream buffer. It actively prevents a massive, sudden tidal wave of cysteine from hitting the B5 pathway all at once, while Inositol protects the nerve membranes. Further details can be found on my forum to see how I manage and more, e.g.: “How I Manage Brain scrambling following admin issues” in order to block “the noise”, enhance alpha brain waves and synergize GABA-like effects when combining magnesium bisglycinate (1.3 g), L-theanine (200 mg), taurine powder (500-1000 mg). NB1: You’ll need caffeine to go through the doc (10 pages docx), with references. NB2: These references don’t go through when I post here on bioenergetic forum.

I've been reading about acerola supplements. It seems quite common that they are made from unripened acerola cherries. Because at the unripened stage, it contains more vitamin C. I wonder if this is problematic? Reminds me of Ray Peat's reservations about coconut water, pointing out that it's often made using unripe coconuts because they contain more liquid. Instinct tells me consuming unripened fruit, even in dried powder form, aint so smart.

@Mauritio What effects did you notice from 3a-DHP and at what doses?

If it's a tolerable price and you can tightly control the concentrations (at least 2 things in the ingredients could easily kill you) without attracting crippling attention, it's an obvious winner. Maybe reduce the alcohol, replace it with glycerol and add some menthol or citrus extract.

@ThinPicking lol. 80s metal and 30s science

@sunsunsun said: "private equity is le bad" The context necessitating the drive is somewhat le bad. @LucH said: Yes, thorne researh has been sold to P&G. Recently, mind. https://www.nutraceuticalbusinessreview.com/procter-gamble-acquires-thorne-for-3-8bn-in @LucH said: Yes, it could be true. Not a proof; not yet the beginning of ... Why? A former employee who's got problems and has been fired. We know all how it begins. https://www.supplysidesj.com/market-trends-analysis/investment-firm-to-acquire-thorne-shares-in-680-million-deal- [image: https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd2b63c60-6a84-4eab-8b74-9a1ec15f379e_474x284.png] No one can argue they're not handy with operating cost and the rest. Onwards and upwards

@Mossy areata though

@LunaticRed any updates?

@ChroncStresChris said: Any ideas? Hi, HD riboflavin is a good choice but drowsiness is a side effect. I cite: High-dose riboflavin (vitamin B2) may improve sleep quality by reducing perceived stress, fighting cellular oxidative stress in the brain, and supporting the nervous system and energy metabolism. [1, 2, 3] Symptom Check: Drowsiness is not a standard toxicity symptom of B2, but clinically reflects a sudden parasympathetic shift or "rebound fatigue" when a chronically exhausted nervous system finally drops its stress drive. [1, 2] What I would manage and how I see the problem: Every other day 200 mg B2. 3 times a week a B50 complex (co-enzymed) (the 3 other days). Not every day. Mg bisglycinate powder 2 x 1.3 g at the beginning. Then 3x when accustomed. You’ll probably need beginning with half the dose when suffering from SIBO (tolerance). Don’t force the speed or your brain will register it as a toxin. L-theanine 200 mg 1 hour before bed. To help relax and improve deep sleep. One week later, we'll see for dysbiosis and energy. Explanation: The Reason: Magnesium acts as a natural brake for the nervous system. It works hand-in-hand with B2 to stabilize the mitochondria and prevent the "emergency brake" feeling that causes daytime fatigue. Smaller, frequent doses maximize intestinal absorption and prevent bowel tolerance issues (diarrhea), while the glycine bound to the magnesium acts as an inhibitory neurotransmitter to calm her fried nervous system. The L-Theanine (200 mg) Knockout: L-theanine increases alpha brain waves and blocks glutamate receptors. This directly dampens the neurological "noise" and hyper-arousal caused by her high estrogen and chronic stress, allowing her to transition into deep sleep Splitting the dose B2 (in 2 takes 100 mg, the same day). The B2 / B-Complex Alternate Balance: High-dose B2 pushes the mitochondrial and liver pathways hard. Giving it every other day prevents her system from getting overwhelmed (+ rate-limited assimilation). The B50 co-enzymed complex on the off-days ensures her body has the necessary cofactors (like active B6, B9, and B12) to actually utilize that energy without hitting a metabolic bottleneck. When the sleep gets better, we’ll manage dysbiosis. You’ll probably have to calm over-reaction from the stomach linen with plant extract from melissa and curcumin (both are here required but only in the liquid form, otherwise curcumin is irritable). We call it: EPS (Extrait de plantes standardisées) (Plant extract liquid). Very soft approach for irritable bowels. They are generally available as an alcohol-free oral solution and can be prescribed as a custom blend tailored to individual needs. PS: You need a plan. If you try one molecule after the other, it won't match. Let me see how you see it / how you perceive the pieces of advice.

I have tried some Cytomel later in the PM, and it doesn’t seem to disturb my sleep architecture like PM Armour does, So is the T4 the problem? I got my hands on NP thyroid, and this week I will try that and see if I have the same issue. By the way, has anyone noticed that NP Thyroid has actually the same formula as the original Armour?