@Ecstatic_Hamster That’s a good point. I forgot to say that you should only keep the alum directly on the canker sore for about 30 seconds. I’m not sure how much aluminum might be absorbed in that short time.

I notice an intense rise in estrogen within hours of consuming a seed-oil rich meal. Recently (this is a little TMI) I was on my period, which is usually light and painless. I had a big chicken kebab wrap, I could see it was dripping with pufas. That night I woke up to hot flushes, cramps and I bled through everything. This lasted for days after. So not worth it.

I remember reading awhile ago that injecting Hyaluronic Acid (HA) into a scar made it fade then come back, but injecting HA + CO2 made it go away. (https://pubmed.ncbi.nlm.nih.gov/37723352/). I think there's something about the combination that might be good even if you're not exactly dealing with scars. I'd look into carboxytherapy (it's a subcutaneous injection, but I think CO2 absorbs well enough through the skin even without that. there's little gels for a face mask you can get like from here

Otherwise I read that Vitamin A is needed in excreting calcium in the calcium cycle, so a topical vitamin A and D combo in coconut oil wouldn't hurt to try if you think calcification is involved.

have you combined it with K2?

@wester130 said in L citruline - yes or no?:

Apparently it is not as bad as arginine

Beyond the question of Peatiness of L-citruline, you could try watermelon and watermelon rind to get it from food. Being that I'm incredibly sensitive to supplements, I can juice watermelon rinds with no negative effects, but taking an L-citruline supplement definitely gives me the negative effects of low blood pressure and pulse, and excess NO. Maybe the NO from L-citruline would want to be avoided, from a Peat perspective, but that I don't feel those effects from watermelon makes me less concerned.

@Lejeboca Thanks a lot!

@aquarice I use temperature and heart rate and overall feeling to determine if a thyroid product is working.

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Mango and saffron

@16charactersitis

Exactly! The good old days lmao... retvrn!

How are people still making long-form podcasts with no time stamps😩

@mavuue lol understandable

Additional info
*) High dose Vit K can interfere with Vit E
They are all fat-soluble vitamins and can compete with each other for absorption into the micelle. Vitamins A and E are antagonists of vitamin K because they interfere with its absorption and metabolism.
Taking a high dose Vit K2 requires transporters that are in limited amount for transport in circulating lipoproteins for subsequent uptake by tissues.
How much is too much is not clearly defined.
By the way excess Vit E, K and Q10 leaves quinones but our liver has a limited capacity to deal with.
I never take Vit A supplement at the same time as the other lipovitamins.
*) These studies found that vitamin E can block the replication/infection caused by the entire family of beta-coronaviruses (of which SARS-CoV-2 is a member)! (Posted by Haidut)
a) Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase
https://doi.org/10.1101/2021.07.13.449251
b) Water-soluble vitamin E compounds directly inhibit SARS-CoV-2 replication and synergize with remdesivir
https://www.news-medical.net/news/20210715/Water-soluble-vitamin-E-compounds-directly-inhibit-SARS-CoV-2-replication-and-synergize-with-remdesivir.aspx
=> Take 75 IU - 100 IU orally, once daily, with a meal. Since vitamin E has a half-life of about 48 hours, this dosage can even be taken every other day and still achieve the same concentrations and, hopefully, the same antiviral effects. The study also found that alpha-tocopherol (vitamin E) was about 100-fold more potent/effective than Remdesivir against SARS-CoV-2 and other coronaviruses!
Comment from Yerrag, I think:
There are not many studies on substances with direct viral replication inhibition effects against SARS-CoV-2. Glycine, naringenin, vitamin D, quinine and possibly zinc are among these substances, but it would be great if there was a substance that could both provide direct viral inhibition as well as inhibit the proliferation of the COVID-19 once infection has already occurred. Well, it appears that vitamin E is one of those substances.
https://web.archive.org/web/20140222054542/https://enerex.ca/en/articles/new-old-findings-on-unique-vitamin-e
*) Too much of a good thing is bad?
There no real danger with high dose vitamin E.
But high repeated doses of vitamin E inhibit platelet aggregation. Need to be compensate with K1.
If you are bleeding from the nose, it is because you lack vitamin K1. Beyond 800 IU of vitamin E, vitamin E is opposed to the action of vitamin K, probably because the carrier is identical.
Alpha-tocopherol is preferably stocked in the liver. (Kayden and Traber, 1993; Traber et al., 1990).
Every 72 hours would be fine with 400 UI (at least 2 toco). 20-25 UI are needed per day, according to Chris Masterjohn.

More info on Vit E
https://mirzoune-ciboulette.forumactif.org/t30-vitamine-e-plus-qu-une-vitamine#60
Excerpt 1 (translator needed, in French):
Most studies show a beginning of preventive efficiency at doses of 100 IU /d in degenerative diseases. Braking of oxidative stress which is underlying the phenomena of senescence and the appearance of all degenerative pathologies: cardiovascular, cancers, osteoarthritis, osteoporosis, presbyacousis, cataract, macular degeneration, Parkinson and Alzheimer's diseases, etc…
Excerpt 2 :

Optimal contribution, without pathology, if under 40 years old: 100 IU per day. Contribution in case of supplementation in polyunsaturated fatty acids 100 IU per gram of EPA. - Therapeutic contribution: 400 - 500 IU every 5 days.
Mg/ UI conversion: 100 mg = 150 IU.
Personally, it’s 400 UI mixed toco every 3 days (+/ twice a week). 3x if inflammation.
Now Foods – E 400 – with mixed tocopherols. Softgels. + once a week K1 (mix K1 and K2). Vit K2 MK7 must be encapsulated (oxidation).

*) How Much and What Type of Fat Do You Need to Absorb These Fat Soluble Vitamins? Vitamin A, D, E & K
http://suppversity.blogspot.be/2014/05/vitamin-d-e-k-how-much-and-what-type-of.html

*) Adjusting Vitamin E Needs with Unsaturated Oil Intake
http://www.ncbi.nlm.nih.gov/pubmed/1763554
http://libgen.org/scimag/get.php?doi=10.1007%2Fbf01610340
"...The requirement for vitamin E is closely related to the dietary intake of polyunsaturated fatty acids (PUFA). By the protective mechanism to prevent PUFA from being peroxidized, vitamin E is metabolically consumed. In addition, PUFA impair the intestinal absorption of vitamin E. Therefore PUFA generate an additional vitamin E requirement on the order of 0.6, 0.9, 1.2, 1.5, and 1.8 mg vitamin E (RRR-alpha-tocopherol-equivalents), respectively, for 1 g of dienoic (omega-7), trienoic (ALA / GLA), tetraenoic (AA), pentaenoic, and hexaenoic acid (DHA). For this reason, the gross vitamin E content of food containing PUFA does not allow an evaluation of this food as a source of vitamin E. A suitable measure is the net vitamin E content, i.e., gross vitamin E minus the amount needed for PUFA protection. Therefore, some food-stuffs generally considered as vitamin-E sources, as concluded from their gross vitamin E content, cause in reality a vitamin E deficiency if not sufficiently compensated by other vitamin E supplying food constituents. Examples of the net vitamin E content of some fats and oils, fish and nuts are shown. Consequences for food composition data and food labeling and the problem of meeting the vitamin-E requirements are discussed."
Note: The author thinks 60mg intake of vitamin E daily is not only reasonable but warranted given the net content concept and the widespread consumption of PUFA.

*) Critique of the requirement for vitamin E1–3. Max K Horwitt. 2001
https://lowtoxinforum.com/attachments/am-j-clin-nutr-2001-horwitt-1003-5-pdf.1994/ (3 p.)
30 IU RDA in 1968 was halved by the next RDA Committee in 1989. The mean consumption of vitamin E by American men and women is 21.4 (± 7.2) and 16.5 (± 7.0) mol/d, respectively.
Note: As the mechanism by which phylloquinone (K1) is converted to K2 MK-4 is unknown, we cannot readily speculate how vitamin E supplementation influences the concentrations of these forms of vitamin K in extrahepatic tissue. While it is plausible that less MK-4 is produced because vitamin E supplementation reduces phylloquinone as a substrate in the extrahepatic tissue, vitamin E may also decrease MK-4 concentrations independently of phylloquinone.
NB: Vit E and K use the same transporter. So don’t take these supplements at the same time.

*) Besoins en AGPI? (Needs in PUFA?)
Les besoins réels en AG polyinsaturés surestimés ? (Real needs in PUFAs are over-exaggerated)
https://mirzoune-ciboulette.forumactif.org/t1581-les-besoins-reels-en-ag-polyinsatures-surestimes#18738
=> Beneficial omega-3 intake, beyond the short term? No. Why? (In French, translator needed)
Excerpt:
“All liquid oils [rich in] PUFA, with the exception of extra virgin olive oil, are toxic, [because in excess] and can cause hypothyroidism, inhibit the immune system, be involved in heart disease , cancer, diabetes, seizures, cysts, age spots and poor digestion. This includes all oils that are liquid at room temperature, except extra virgin olive oil. » Rita Lee, PhD.
“Anything that damages mitochondria affects energy production and the production of protective steroid hormones. » Ray Peat, PhD.

@SpaceManJim Depends when you ask. Right now it’s NDT.

@Kate21 I’m inspired, tell me more about Chris Hemsworth

@edouard

I stopped taking the DHT not long after making this post because it was freaking me out. However, the past few weeks I've been experimenting with using Stearic Acid as my main fat source and the green stools have returned. So I'm assuming it just means very fast transit time. I'm going to tentatively say it seems like a good thing, stomach bloat is way down, and fast transit time should be a good thing according to the Peatarian view.

Also I changed my user account to this.

@Corngold

Funny that this can be taken towards radical individualism or radical social-ism. I keep seeing the horseshoe theory everywhere...the limits of the individual are the limits of the group, and group size and number needs to be considered.

I have recently been brushing up against this in a lot of different areas as well. Although I do not think about it in terms of a horseshoe, but more of a hub-and-spoke. As in a bicycle wheel. Actually it's a recursive hub-and-spoke.

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Source is: https://x.com/HUMANMAXXING/status/1848831481046568967/photo/1

The hubs (more stationary, "sources" of power), have a more "female" quality. The spokes (protruding, "ejaculatory", exploratory, more varied (in terms of measured IQ for example)) have a more "male" quality. I think this maps really well onto the fact that males are a sub-variation of females (we still have nipples, fused labial scar on underside of genitals, etc...). @LetTheRedeemed had mentioned a similar sexed evaluation of the social hierarchy. As opposed to a "vulgar dialectic" of equal yin and yang. Individualism or socialism is as such a question of what place in the system is within your view. In the design of computer architecture management, an often-used dictum is "cattle, not pets". But this is myopic because you need pets to manage the cattle. Call it "sheepdogging".

The center might be called The Party. The periphery might be called the Mass Line.

Funny that this can be taken towards radical individualism or radical social-ism.

The founding fathers were generally preachers towards individualism, but their individualism was indisputably enabled oftentimes by slave plantations or other structures. Hence the dissonance between Jefferson calling slavery a "hideous blot", designing Monticello in such a way as to see slaves as little as possible, yet still continuing the practice. Without this social structure their time at the constitutional convention and such would have been spent doing menial labor in the maintenance of clothing, housing, food. The "individualist", let's go with "software entrepreneur", is a phenomenon made possible by an incredibly socialized manufacturing and commodification of computers.

Today a greater individualism is materially enabled by a vast socialized, standardized, electrical and communications grid. As Lenin said, "Socialism is Soviet Power plus Electrification of the Whole Country". Standardization of shipping containers. And so on.

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(This is from the video: "modes of production": https://www.youtube.com/watch?v=HbjZlKqDCMA)

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It increases dopamine .

"MPTP-induced reduction of dopamine contents in the striatum and hippocampal CA1 region was improved by nobiletin administration (50mg/kg i.p.). Acute intraperitoneal administration of nobiletin also enhanced dopamine release in striatum and hippocampal CA1,..."

https://pubmed.ncbi.nlm.nih.gov/24316474/

NOB could restore memory impairment via the improvement of neurogenesis by ameliorating neuroinflammation in the hippocampushttps:

//pmc.ncbi.nlm.nih.gov/articles/PMC10181043/

I put DHT GEL on my Nether-Regions: Insane EQ, Painful B*ners, Masculinity, and SIDE EFFECTS

https://www.youtube.com/watch?v=xy_c1MlByao

@sneedful said in vitamin k2 mk4 levels elevated in covid patients, k2 mk7 and k1 depleted:

is it because k2 mk7 and k1 are being rapidly converted into k2 mk4 which is then detected at high levels in blood?

No, I don't think so. K2 MK7 is preferably used for clotting problems. More soluble and also "reactive". Reactive to ox-agression.
But mind the peremption of K2 MK7: very fragile (3 months) if not well encapsulated and protected by e.g. rosmarinus.

Source: Chris Masterjohn
There is reason to think MK-7 would be better at supporting blood clotting.
“MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.”
https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/

It's advised not to take vitamin E at the same time as vitamin K when taking high dose.
Since I take 1 mg (1 000) K2 MK4 at breakfast, I never take vit E at the same time. 2x/wk for 400 UI mix toco.